KEGG   ENZYME: 1.14.14.79
Entry
EC 1.14.14.79               Enzyme                                 

Name
docosahexaenoic acid omega-hydroxylase;
CYP4F3B;
CYP4V2;
docosahexaenoate,NADPH:O2 oxidoreductase (22-hydroxydocosahexaenoate forming)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
docosahexaenoate,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (22-hydroxydocosahexaenoate-forming)
Reaction(IUBMB)
docosahexaenoate + [reduced NADPH---hemoprotein reductase] + O2 = 22-hydroxydocosahexaenoate + [oxidized NADPH---hemoprotein reductase] + H2O [RN:R10795]
Reaction(KEGG)
R10795
Substrate
docosahexaenoate [CPD:C06429];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]
Product
22-hydroxydocosahexaenoate [CPD:C20855];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]
Comment
A cytochrome P-450 (heme-thiolate) protein isolated from human eye tissue. Defects in the enzyme are associated with Bietti crystalline corneoretinal dystrophy. The enzyme also produces some 21-hydroxydocosahexaenoate. Acts in a similar way on icosapentaenoic acid.
History
EC 1.14.14.79 created 2014 as EC 1.14.13.199, transferred 2018 to EC 1.14.14.79
Orthology
K07427  docosahexaenoic acid omega-hydroxylase
K17726  phylloquinone omega-hydroxylase / docosahexaenoic acid omega-hydroxylase / leukotriene-B4 20-monooxygenase
Genes
HSA: 285440(CYP4V2) 4051(CYP4F3) 8529(CYP4F2)
PTR: 100609185 744981(CYP4V2) 748117(CYP4F3) 748531(CYP4F2)
PPS: 100967411(CYP4F2) 100969141(CYP4F3) 100985937(CYP4V2)
GGO: 101125692 101135418 101142243 101152881
PON: 100172140(CYP4V2) 100434096 100437847 100453229
NLE: 100579320 100588006 100602871 115836096 115836968
MCC: 696520(CYP4V2) 718349 719317
MCF: 102130440(CYP4F3) 102134301(CYP4F2) 102141321(CYP4V2)
CSAB: 103234079 103234089 103236636
CATY: 105594263 105601614 105601627
CJC: 100408123(CYP4V2) 100411160 100412575(CYP4F2)
MMU: 102294(Cyp4v3)
MCAL: 110300005
MPAH: 110337006
RNO: 266761(Cyp4v3)
MCOC: 116069215
MUN: 110558009
CGE: 100750743
PLEU: 114701165
NGI: 103750492
HGL: 101716986
CCAN: 109684291
OPI: 101524068
CFA: 102152484(CYP4V2)
VVP: 112934751
AML: 100468607
UMR: 103681006
UAH: 113262286
ORO: 101378686
ELK: 111144567
MPUF: 101684052
EJU: 114206180
FCA: 101097556
PYU: 121039710
PBG: 122471005
PTG: 102960154
PPAD: 109250992
AJU: 106982209
HHV: 120237797
BTA: 510156(CYP4V2)
BOM: 102268997
BIU: 109553482
BBUB: 102394892
CHX: 102188826
OAS: 101116121
ODA: 120865741
CCAD: 122432373
SSC: 100113469(CYP4V2)
CFR: 102512100
CBAI: 105067667
CDK: 105102385
BACU: 102999883
LVE: 103081363
OOR: 101278344
DLE: 111173427
PCAD: 102990897
PSIU: 116746666
ECB: 100056687
EPZ: 103543058
EAI: 106840365
MNA: 107534032
HAI: 109395858
SHON: 118993095
AJM: 119036852
MMF: 118623007
PALE: 102883230
RAY: 107510438
MJV: 108396407
TMU: 101342431
MDO: 100014017
GAS: 123251454
SHR: 100917708
PCW: 110222598
OAA: 100090407
GGA: 415121(CYP4V2)
PCOC: 116238901
MGP: 100549160
CJO: 107313678
APLA: 101790057
ACYG: 106035235
TGU: 100230859
LSR: 110484918
SCAN: 103825461
PMOA: 120497991
OTC: 121331412
PRUF: 121360302
GFR: 102033190
FAB: 101813952
PHI: 102107875
PMAJ: 107203122
CCAE: 111927975
CCW: 104690591
ETL: 114067779
FPG: 101918235
FCH: 102054486
CLV: 102094289
EGZ: 104129484
NNI: 104021298
ACUN: 113479206
TALA: 104358687
PADL: 103922516
AAM: 106484032
AROW: 112964066
NPD: 112949823
DNE: 112986138
AMJ: 102563402(CYP4V2) 102563645(CYP4V2) 102570586
TST: 117878349
ACS: 100557625
PVT: 110077895
SUND: 121931691
PBI: 103052236
PMUR: 107302659
TSR: 106542020
PGUT: 117680125
VKO: 123036294
GJA: 107121984
XLA: 100337567(cyp4v4) 444482(cyp4v2.1.L)
XTR: 100485929(cyp4v2.1) 780124(cyp4v2.2)
DRE: 558851(cyp4v8) 562008(cyp4v7)
CCAR: 109073701
IPU: 108260937 108269274(CYP4V2)
EEE: 113579251
TRU: 101061436
LCO: 104917763
NCC: 104952998
CGOB: 115011785
ELY: 117254651
PLEP: 121942358
SLUC: 116051748
ECRA: 117954687
PFLV: 114569292
GAT: 120824559
PPUG: 119218150
MSAM: 119898795
CUD: 121508566
MZE: 101485601
ONL: 100703355
OAU: 116312391
OLA: 101162575
OML: 112137079
XMA: 102237202
XCO: 114145628
XHE: 116720394
PRET: 103461721
GAF: 122829941
NFU: 107374000
KMR: 108231369
AOCE: 111582916
CSEM: 103384330
POV: 109641907
SSEN: 122771630
HHIP: 117767577
LCF: 108901662
SDU: 111216661
SLAL: 111663247
XGL: 120800930
HCQ: 109510969
MALB: 109968238
LOC: 102683375
PSPA: 121297888
ARUT: 117409049
LCM: 102361464
CMK: 103178199
RTP: 109916600
BFO: 118407885
BBEL: 109477858
APLC: 110987520
SKO: 100375440
ACOZ: 120951683
AAG: 5567661
AALB: 109411363
ALAB: 122715191
BBIF: 117211931
BVK: 117239101
BVAN: 117165994
BPYO: 122577027
MGEN: 117222071
NMEA: 116427591
ATD: 109606373
ZCE: 119831326
CLEC: 106672025
FCD: 110862369
HAZT: 108679188
DPTE: 113793077
CEL: CELE_Y80D3A.5(cyp-42A1)
CBR: CBG_20323(Cbr-cyp-42A1)
BMY: BM_BM7159(Bma-cyp-42A1.1) BM_BM8635(Bma-cyp-42A1.2)
TSP: Tsp_10837
PCAN: 112556660
BGT: 106065596
GAE: 121378638
CRG: 105323364
MYI: 110451224
PMAX: 117331221
LAK: 106156039
EPA: 110235098
 » show all
Reference
1  [PMID:22772592]
  Authors
Nakano M, Kelly EJ, Wiek C, Hanenberg H, Rettie AE
  Title
CYP4V2 in Bietti's crystalline dystrophy: ocular localization, metabolism of omega-3-polyunsaturated fatty acids, and functional deficit of the p.H331P variant.
  Journal
Mol Pharmacol 82:679-86 (2012)
DOI:10.1124/mol.112.080085
  Sequence
[hsa:285440]
Other DBs
ExplorEnz - The Enzyme Database: 1.14.14.79
IUBMB Enzyme Nomenclature: 1.14.14.79
ExPASy - ENZYME nomenclature database: 1.14.14.79
BRENDA, the Enzyme Database: 1.14.14.79

DBGET integrated database retrieval system