KEGG   ENZYME: 1.14.15.4
Entry
EC 1.14.15.4                Enzyme                                 
Name
steroid 11beta-monooxygenase;
steroid 11beta-hydroxylase;
steroid 11beta/18-hydroxylase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
steroid,reduced-adrenodoxin:oxygen oxidoreductase (11beta-hydroxylating)
Reaction(IUBMB)
a steroid + 2 reduced adrenodoxin + O2 + 2 H+ = an 11beta-hydroxysteroid + 2 oxidized adrenodoxin + H2O [RN:R02726]
Reaction(KEGG)
Substrate
steroid [CPD:C00377];
reduced adrenodoxin [CPD:C00662];
O2 [CPD:C00007];
H+ [CPD:C00080]
Product
11beta-hydroxysteroid [CPD:C01058];
oxidized adrenodoxin [CPD:C00667];
H2O [CPD:C00001]
Comment
A heme-thiolate protein (P-450). Also hydroxylates steroids at the 18-position, and converts 18-hydroxycorticosterone into aldosterone.
History
EC 1.14.15.4 created 1961 as EC 1.99.1.7, transferred 1965 to EC 1.14.1.6, transferred 1972 to EC 1.14.15.4, modified 1989, modified 2014
Pathway
ec00140  Steroid hormone biosynthesis
ec01100  Metabolic pathways
Orthology
K00497  steroid 11beta-monooxygenase
K07433  steroid 11beta-monooxygenase / corticosterone 18-monooxygenase
Genes
HSA1584(CYP11B1) 1585(CYP11B2)
PTR464437(CYP11B1) 745937(CYP11B2)
PPS100971238(CYP11B2) 100971586(CYP11B1)
GGO101142418 115930159
PON100459910 100461139
NLE100605657 115830633
MCC695793(CYP11B1) 695914(CYP11B2)
MCF102136659(CYP11B1) 102137301(CYP11B2)
CSAB103237546(CYP11B1) 103237547(CYP11B2)
CATY105581188 105581294
PANU101002490 101002842 116276421
TGE112630213 112630247
RRO104679773 104679775
RBB108536535 108536550
TFN117078861 117079172 117079174
PTEH111535654
CJC100415304(CYP11B2) 100415667(CYP11B1)
SBQ101048076
CSYR103276447 103276450
MMUR105867373 105867374
LCAT123644516 123644520
OGA100948075 100948396 100958146
MMU110115(Cyp11b1) 13072(Cyp11b2)
MCAL110310257 110310258
MPAH110334511 110335023
RNO24294(Cyp11b2) 353498(Cyp11b3) 500892(Cyp11b1)
MCOC116073894 116082436
MUN110544545 110562757
CGE100771648 107977023
MAUA101823339 101823606
PLEU114684742 114684743
MORG121461414 121461416
MFOT126503589 126503590
AAMP119823440 119823447
NGI103748431 103748432
HGL101700701 101701311
CPOC100379213(Cyp11b2) 100727186 111755182
CCAN109681807 109681816
DORD105992320 106002066
DSP122125332 122125344
NCAR124991075 124991346
OCU100328543(CYP11B2) 100342863
OPI101518686
TUP102471986 102492986
CFA482071(CYP11B2)
CLUD112662131
VVP112911200
VLG121499022
AML100478197
UMR103680551
UAR123779294 123796461
ELK111146729
LLV125098158 125099244
ORO101364874
EJU114204069 114204070
ZCA113911085 118356903
MLX118015252
NSU110578976
FCA101097790
PYU121024468 121043245
PBG122496110 122496111
LRUF124507499 124507515
PTG102972244
PPAD109258417
AJU106989683
HHV120227687
BTA112449566 282422(CYP11B1) 787628
BOM102272939 102280195
BIU109568177 109568372 109568377
BBUB112577757 112579063
CHX102188238 102188517
OAS101102377 767576(CYP11B1)
ODA120859420
CCAD122451091
SSC110260194
CFR102517728
CBAI105077899
CDK105106427
VPC102532708
BACU103009357
LVE103089121
OOR101286768
DLE111165107
PCAD102988484
PSIU116742421
ECB100063612 100063645
EPZ103543718
EAI106827552 123275604
MYD102752229
MMYO118670722
MNA107542744
PKL118718613
HAI109390820
DRO112315587
SHON118988945
AJM119064760
PDIC114514446
PHAS123833011
MMF118643316
RFQ117033759
PALE102881458
PGIG120588772
PVP105302023 105310134
RAY107507877
MJV108400067
TOD119232024
SARA101544036
LAV100654178
TMU101354125
DNM101424711
MDO100032885
GAS123255806
SHR100930767
PCW110214194
OAA100082065
TGU116807520
LSR110479458
PHI102113159
FPG101918505
FCH102046275
AROW112976664
ASN102375758
AMJ102575737(CYP11B1)
CPOO109310774
CMY102933677
CPIC101950678
TST117873891
CABI116833743
MRV120396417
ACS100560890
PVT110084842
SUND121929727
PBI103058342
PMUR107300041
CTIG120298053
TSR106545562
PGUT117666942
VKO123035256
PMUA114600140
ZVI118089700
GJA107116366
STOW125425154
XLA108718624
XTR101731070
RTEM120921857
BBUF121001585
BGAR122938238
DRE791124(cyp11c1)
SRX107745157
SANH107698185
SGH107570796
CCAR109110857
CAUA113059430
PPRM120491104
MAMB125243223
IPU108263488
PHYP113525473
SMEO124384380
TFD113647799
AMEX103026652
EEE113574779
TRU101075863
TNGGSTEN00015374G001
LCO104920541
NCC104944920
CGOB115021232
ELY117265363
EFO125893014
PLEP121945728
SLUC116049596
ECRA117946724
ESP116691100
PFLV114556971
GAT120810783
PPUG119198098
MSAM119897544
CUD121514148
ALAT119006071
MZE101463871
ONL100533461(cyp11b)
OAU116320943
OLA100125822(cyp11b)
OML112143274
XMA102236274
XCO114139300
XHE116715552
PRET103478110
PFOR103136813
PLAI106957061
PMEI106922010
GAF122830567
CVG107088793
CTUL119783082
GMU124865602
NFU107379700
KMR108235361
ALIM106515094
NWH119410002
AOCE111567446 111575932
MCEP125015727
CSEM103388284
POV109633048
SSEN122774868
HHIP117777191
HSP118113534
LCF108885901
SDU111230014
SLAL111652162
XGL120784322
HCQ109522775
BPEC110163163
MALB109970182
BSPL114842551
SASA100136945
OTW121840636
OMY100135891(cyp11b) 110534298
OGO123998350 124004644
ONE115122985
SALP112074060
SNH120047273
CCLU121543144 123481512
ELS105018961
SFM108925533
PKI111853322
AANG118210794
LOC102683152
PSPA121306922
ARUT117395226 117969833
LCM102345423
 » show all
Reference
1  [PMID:13276417]
  Authors
GRANT JK, BROWNIE AC.
  Title
The role of fumarate and TPN in steroid enzymic 11beta-hydroxylation.
  Journal
Biochim Biophys Acta 18:433-4 (1955)
DOI:10.1016/0006-3002(55)90111-6
Reference
2  [PMID:13211659]
  Authors
HAYANO M, DORFMAN RI.
  Title
On the mechanism of the C11 beta-hydroxylation of steroids.
  Journal
J Biol Chem 211:227-35 (1954)
Reference
3  [PMID:13426185]
  Authors
TOMKINS GM, MICHAEL PJ, CURRAN JF.
  Title
Studies on the nature of steroid 11-beta hydroxylation.
  Journal
Biochim Biophys Acta 23:655-6 (1957)
DOI:10.1016/0006-3002(57)90396-7
Reference
4  [PMID:3485096]
  Authors
Yanagibashi K, Haniu M, Shively JE, Shen WH, Hall P
  Title
The synthesis of aldosterone by the adrenal cortex. Two zones (fasciculata and glomerulosa) possess one enzyme for 11 beta-, 18-hydroxylation, and aldehyde synthesis.
  Journal
J Biol Chem 261:3556-62 (1986)
Reference
5  [PMID:4967077]
  Authors
Zuidweg MH.
  Title
Hydroxylation of Reichstein's compound S with cell-free preparations from Curvularia lunata.
  Journal
Biochim Biophys Acta 152:144-58 (1968)
DOI:10.1016/0005-2760(68)90016-7
Other DBs
ExplorEnz - The Enzyme Database: 1.14.15.4
IUBMB Enzyme Nomenclature: 1.14.15.4
ExPASy - ENZYME nomenclature database: 1.14.15.4
BRENDA, the Enzyme Database: 1.14.15.4
CAS: 9029-66-7

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