KEGG   ENZYME: 1.14.15.5
Entry
EC 1.14.15.5                Enzyme                                 
Name
corticosterone 18-monooxygenase;
corticosterone 18-hydroxylase;
corticosterone methyl oxidase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
corticosterone,reduced-adrenodoxin:oxygen oxidoreductase (18-hydroxylating)
Reaction(IUBMB)
corticosterone + 2 reduced adrenodoxin + O2 + 2 H+ = 18-hydroxycorticosterone + 2 oxidized adrenodoxin + H2O [RN:R03262]
Reaction(KEGG)
R03262;
(other) R03263
Substrate
corticosterone [CPD:C02140];
reduced adrenodoxin [CPD:C00662];
O2 [CPD:C00007];
H+ [CPD:C00080]
Product
18-hydroxycorticosterone [CPD:C01124];
oxidized adrenodoxin [CPD:C00667];
H2O [CPD:C00001]
History
EC 1.14.15.5 created 1972
Pathway
ec00140  Steroid hormone biosynthesis
ec01100  Metabolic pathways
Orthology
K07433  steroid 11beta-monooxygenase / corticosterone 18-monooxygenase
Genes
HSA1585(CYP11B2)
PTR745937(CYP11B2)
PPS100971238(CYP11B2)
GGO101142418
PON100461139
NLE115830633
MCC695914(CYP11B2)
MCF102137301(CYP11B2)
MTHB126961020 126961026
CSAB103237547(CYP11B2)
CATY105581294
PANU101002842
RRO104679775
RBB108536550
TFN117078861
CJC100415304(CYP11B2)
CSYR103276450
MMUR105867373 105867374
LCAT123644516 123644520
OGA100948396 100958146
HGL101700701
CPOC100379213(Cyp11b2) 100727186
GVR103599088 103604864 103604866
 » show all
Reference
1  [PMID:4381410]
  Authors
Raman PB, Sharma DC, Dorfman RI.
  Title
Studies on aldosterone biosynthesis in vitro.
  Journal
Biochemistry 5:1795-804 (1966)
DOI:10.1021/bi00870a004
Other DBs
ExplorEnz - The Enzyme Database: 1.14.15.5
IUBMB Enzyme Nomenclature: 1.14.15.5
ExPASy - ENZYME nomenclature database: 1.14.15.5
BRENDA, the Enzyme Database: 1.14.15.5
CAS: 37256-75-0

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