KEGG   ENZYME: 1.14.19.77
Entry
EC 1.14.19.77               Enzyme                                 

Name
plasmanylethanolamine desaturase;
TMEM189 (gene name);
2-acyl-1-alkyl-sn-glycero-3-phosphoethanolamine desaturase;
alkylacylglycerophosphoethanolamine desaturase;
alkylacylglycero-phosphorylethanolamine dehydrogenase;
alkyl-acylglycerophosphorylethanolamine dehydrogenase;
1-O-alkyl-2-acyl-sn-glycero-3-phosphorylethanolamine desaturase;
1-O-alkyl 2-acyl-sn-glycero-3-phosphorylethanolamine desaturase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
Sysname
plasmanylethanolamine,ferrocytochrome b5:oxygen oxidoreductase (plasmenylethanolamine-forming)
Reaction(IUBMB)
a plasmanylethanolamine + 2 ferrocytochrome b5 + O2 + 2 H+ = a plasmenylethanolamine + 2 ferricytochrome b5 + 2 H2O [RN:R04571]
Reaction(KEGG)
R04571
Substrate
plasmanylethanolamine [CPD:C04475];
ferrocytochrome b5 [CPD:C00999];
O2 [CPD:C00007];
H+ [CPD:C00080]
Product
plasmenylethanolamine [CPD:C04756];
ferricytochrome b5 [CPD:C00996];
H2O [CPD:C00001]
Comment
The enzyme catalyses the introduction of a double bond at position 1 of the alkyl group attached by an ether bond at the sn-1 position of plasmanylethanolamine, generating a vinyl ether-containing plasmenylethanolamine. The enzyme is found in animals and some bacteria, but not in plants, fungi, or most aerobic bacteria.
History
EC 1.14.19.77 created 1976 as EC 1.14.99.19, transferred 2020 to EC 1.14.19.77
Pathway
ec00565  Ether lipid metabolism
ec01100  Metabolic pathways
Orthology
K20656  plasmanylethanolamine desaturase
Genes
HSA: 387521(PEDS1) 387522(PEDS1-UBE2V1)
PTR: 100538341(TMEM189)
PPS: 100994664(TMEM189)
GGO: 101124230(TMEM189)
PON: 100937144
NLE: 100594969
MCC: 702250(TMEM189)
MCF: 101866901(TMEM189)
CSAB: 103244462(TMEM189)
CATY: 105585397(TMEM189)
PANU: 101010392(TMEM189)
RRO: 104678546
RBB: 108539455(TMEM189)
TFN: 117068909(TMEM189)
PTEH: 111521037
CJC: 100538343(TMEM189)
SBQ: 101035169(TMEM189)
MMUR: 105872283(TMEM189)
MMU: 407243(Peds1)
MCAL: 110284278
MPAH: 110317661(Tmem189)
RNO: 362278(Peds1)
MCOC: 116091429(Tmem189)
MUN: 110548943
CGE: 100760484
PLEU: 114692668
NGI: 103735785
HGL: 101698415
CCAN: 109692606(Tmem189)
OCU: 103347491(TMEM189)
OPI: 105941521
TUP: 102495771(TMEM189)
CFA: 611401
VVP: 112931947(TMEM189)
VLG: 121478010
AML: 100465807
UMR: 103669669
UAH: 113258709(TMEM189)
ORO: 101379558
ELK: 111141411
MPUF: 101670792
EJU: 114225507
MLX: 118023964
FCA: 101081283(TMEM189)
PYU: 121019937(PEDS1)
PBG: 122467279
PTG: 102966132(TMEM189)
PPAD: 109272284(TMEM189)
AJU: 106986028(TMEM189)
HHV: 120230415
BTA: 507694(TMEM189)
BOM: 102278448(TMEM189)
BIU: 109567543
BBUB: 102400490(TMEM189)
CHX: 102173207(TMEM189)
OAS: 101117690
ODA: 120869090(PEDS1)
CCAD: 122448812
SSC: 100513322(TMEM189)
CFR: 102516656
CBAI: 105071854
CDK: 105087876
BACU: 102998454(TMEM189)
LVE: 103069487(TMEM189)
OOR: 101287086
DLE: 111186630
PCAD: 102976124(TMEM189)
ECB: 100071459(TMEM189)
EPZ: 103560083
EAI: 106825706
MYB: 102248038(TMEM189)
MYD: 102771511(TMEM189)
MMYO: 118663824(PEDS1)
MNA: 107540607
PKL: 118707452(PEDS1)
HAI: 109381859(TMEM189)
DRO: 112303773
SHON: 118996485
AJM: 119065260
MMF: 118618297(PEDS1)
PALE: 102896379
PGIG: 120603799(PEDS1)
RAY: 107510336
MJV: 108391990
TOD: 119236437
LAV: 100660912(TMEM189)
TMU: 101358899
MDO: 100538345(TMEM189)
SHR: 100934390
PCW: 110206649(TMEM189)
OAA: 100076895(TMEM189)
GGA: 100538348(TMEM189)
PCOC: 116242999(TMEM189)
MGP: 100543540
CJO: 107323104
NMEL: 110408011
APLA: 101798375(TMEM189)
ACYG: 106041442
TGU: 100190093(TMEM189)
LSR: 110475234
SCAN: 103818896
PMOA: 120506992
OTC: 121342985
PRUF: 121359463
GFR: 102031723(TMEM189)
FAB: 101814305(TMEM189)
PHI: 102110647(TMEM189)
PMAJ: 107213107
CCAE: 111938394
CCW: 104687590
ETL: 114067287
FPG: 101917808(TMEM189)
FCH: 102048394
CLV: 102095565
EGZ: 104132157
NNI: 104013103(TMEM189)
ACUN: 113487638(TMEM189)
PADL: 103919351(TMEM189)
AAM: 106486457
AROW: 112960775
DNE: 112982896
ASN: 102381373(TMEM189)
AMJ: 102566693(TMEM189)
CPOO: 109318701
GGN: 109292380
ACS: 100566872(tmem189)
PVT: 110071799
PBI: 103064187
PMUR: 107289376
TSR: 106552877
PGUT: 117663561
PMUA: 114599632
ZVI: 118088266(PEDS1)
GJA: 107107785
XLA: 733375
XTR: 100551495(tmem189)
NPR: 108800142(UBE2V1)
DRE: 450031(peds1) 492735(si:ch211-212o1.2)
IPU: 100528160(tmem189) 108264382
TRU: 101074695(tmem189)
CGOB: 115010277(tmem189)
ELY: 117258150(tmem189) 117262447(si:ch211-212o1.2)
PLEP: 121947283(peds1) 121950077(si:ch211-212o1.2)
SLUC: 116043606(peds1) 116046469(si:ch211-212o1.2)
ECRA: 117947032(tmem189) 117948510(si:ch211-212o1.2)
GAT: 120828834(peds1)
PPUG: 119206802 119222094(peds1)
MSAM: 119893928(si:ch211-212o1.2) 119905214(peds1)
CUD: 121514918(si:ch211-212o1.2) 121517279(peds1)
OAU: 116317188(peds1) 116327365(si:ch211-212o1.2)
OLA: 101156405(tmem189) 101171992
OML: 112152183(si:ch211-212o1.2) 112159000(peds1)
CTUL: 119789137(si:ch211-212o1.2) 119799408(peds1)
KMR: 108249565(peds1) 108251456(si:ch211-212o1.2)
ALIM: 106522954(tmem189)
XGL: 120793020(si:ch211-212o1.2) 120804464(peds1)
HCQ: 109507661 109526876(ube2v1)
BPEC: 110164595 110169509(tmem189)
SASA: 100195807(tm189) 106560866
OTW: 112218501(si:ch211-212o1.2) 112221864(peds1)
OMY: 110492131(peds1) 110494576(si:ch211-212o1.2)
SNH: 120061128(peds1) 120066225(si:ch211-212o1.2)
AANG: 118207626(peds1) 118211046 118228211(si:ch211-212o1.2)
PSPA: 121296409(si:ch211-212o1.2) 121297917(peds1) 121326222
ARUT: 117424038(si:ch211-212o1.2) 117425022 117430609
CMK: 103176074(si:ch211-212o1.2) 103190912
BFO: 118417046
BBEL: 109480503
CIN: 100178755
SCLV: 120332442
SPU: 593687
APLC: 110982200
SKO: 102807657
DME: Dmel_CG10723(Kua)
DER: 6548909
DSE: 6614780
DSI: Dsimw501_GD24246(Dsim_GD24246)
DAN: 6497274
DSR: 110185755
DPE: 6596530
DMN: 108162003
DWI: 6646748
DGR: 6566544
DAZ: 108609928
DNV: 115562797
DHE: 111600428
DVI: 6634008
BOD: 106626460
MDE: 101898939
SCAC: 106083295
LCQ: 111684330
ACOZ: 120955020
AARA: 120903482
AAG: 110677009
AALB: 109418121
CPII: 120431688
AME: 413030
ACER: 107996861
BIM: 100748815
BBIF: 117204735
BVK: 117230266
BVAN: 117163702
BTER: 100651925
CCAL: 108628197
OBB: 114878339
MGEN: 117224439
NMEA: 116432150
CGIG: 122396849
SOC: 105199618
MPHA: 105830825
AEC: 105151632
ACEP: 105617457
PBAR: 105428449
VEM: 105559297
HST: 105189447
DQU: 106743498
CFO: 105252349
FEX: 115233409
LHU: 105674698
PGC: 109853476
OBO: 105286238
PCF: 106793649
PFUC: 122516290
NVI: 100120491
CSOL: 105367375
TPRE: 106657654
MDL: 103569812
FAS: 105264905
DAM: 107042830
CCIN: 107266129
TCA: 664259
DPA: 109539052
ATD: 109605491
AGB: 108911368
LDC: 111509314
NVL: 108568000
APLN: 108739801
OTU: 111423031
BMOR: 101743272
BMAN: 114250956
MSEX: 115440982
BANY: 112058569
PMAC: 106710805
PPOT: 106099852
PXU: 106127716
PRAP: 110998651
ZCE: 119840168
HAW: 110375495
TNL: 113501554
PXY: 105387288
BTAB: 109041238
DCI: 103513575
CLEC: 106666949
HHAL: 106682068
NLU: 111054838
FOC: 113208517
ZNE: 110837508
CSEC: 111870424
FCD: 110842237
DMK: 116927670
HAME: 121877625
HAZT: 108668296
EAF: 111714086
DSV: 119435984
RSAN: 119404683
RMP: 119187489
TUT: 107364898
PTEP: 107445327
SDM: 118190183
CEL: CELE_Y53C10A.5(tmem-189)
CBR: CBG13650
PCAN: 112576912
BGT: 106067737
GAE: 121389420
CRG: 105329576
MYI: 110464778
PMAX: 117337061
OBI: 106877806
OSN: 115226040
LAK: 106153330
EPA: 110249836
ATEN: 116300970
ADF: 107358316
AMIL: 114961458
PDAM: 113665905
SPIS: 111333068
DGT: 114516762
HMG: 100206277
AQU: 100631800
DFA: DFA_02722
AHEL: Q31a_51050
 » show all
Reference
1  [PMID:5550967]
  Authors
Stoffel W, LeKim D
  Title
Studies on the biosynthesis of plasmalogens. Precursors in the biosynthesis of plasmalogens: on the stereospecificity of the biochemical dehydrogenation of the  1-O-alkyl glyceryl to the 1-O-alk-1'-enyl glyceryl ether bond.
  Journal
Hoppe Seylers Z Physiol Chem 352:501-11 (1971)
DOI:10.1515/bchm2.1971.352.1.501
Reference
2  [PMID:11946011]
  Authors
Paltauf F
  Title
Biosynthesis of plasmalogens from alkyl- and alkyl-acyl-glycerophosphoryl ethanolamine in the rat brain.
  Journal
FEBS Lett 17:118-120 (1971)
DOI:10.1016/0014-5793(71)80578-1
Reference
3  [PMID:4150797]
  Authors
Paltuaf F, Prough RA, Masters BS, Johnston JM
  Title
Evidence for the participation of cytochrome b5 in plasmalogen biosynthesis.
  Journal
J Biol Chem 249:2661-2 (1974)
Reference
4  [PMID:235322]
  Authors
Wykle RL, Schremmer Lockmiller JM
  Title
The biosynthesis of plasmalogens by rat brain: involvement of the microsomal electron transport system.
  Journal
Biochim Biophys Acta 380:291-8 (1975)
DOI:10.1016/0005-2760(75)90015-6
Reference
5  [PMID:31604315]
  Authors
Gallego-Garcia A, Monera-Girona AJ, Pajares-Martinez E, Bastida-Martinez E, Perez-Castano R, Iniesta AA, Fontes M, Padmanabhan S, Elias-Arnanz M
  Title
A bacterial light response reveals an orphan desaturase for human plasmalogen synthesis.
  Journal
Science 366:128-132 (2019)
DOI:10.1126/science.aay1436
Other DBs
ExplorEnz - The Enzyme Database: 1.14.19.77
IUBMB Enzyme Nomenclature: 1.14.19.77
ExPASy - ENZYME nomenclature database: 1.14.19.77
BRENDA, the Enzyme Database: 1.14.19.77

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