KEGG   ENZYME: 1.14.19.77
Entry
EC 1.14.19.77               Enzyme                                 
Name
plasmanylethanolamine desaturase;
TMEM189 (gene name);
2-acyl-1-alkyl-sn-glycero-3-phosphoethanolamine desaturase;
alkylacylglycerophosphoethanolamine desaturase;
alkylacylglycero-phosphorylethanolamine dehydrogenase;
alkyl-acylglycerophosphorylethanolamine dehydrogenase;
1-O-alkyl-2-acyl-sn-glycero-3-phosphorylethanolamine desaturase;
1-O-alkyl 2-acyl-sn-glycero-3-phosphorylethanolamine desaturase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
Sysname
plasmanylethanolamine,ferrocytochrome b5:oxygen oxidoreductase (plasmenylethanolamine-forming)
Reaction(IUBMB)
a plasmanylethanolamine + 2 ferrocytochrome b5 + O2 + 2 H+ = a plasmenylethanolamine + 2 ferricytochrome b5 + 2 H2O [RN:R04571]
Reaction(KEGG)
R04571
Substrate
plasmanylethanolamine [CPD:C04475];
ferrocytochrome b5 [CPD:C00999];
O2 [CPD:C00007];
H+ [CPD:C00080]
Product
plasmenylethanolamine [CPD:C04756];
ferricytochrome b5 [CPD:C00996];
H2O [CPD:C00001]
Comment
The enzyme catalyses the introduction of a double bond at position 1 of the alkyl group attached by an ether bond at the sn-1 position of plasmanylethanolamine, generating a vinyl ether-containing plasmenylethanolamine. The enzyme is found in animals and some bacteria, but not in plants, fungi, or most aerobic bacteria.
History
EC 1.14.19.77 created 1976 as EC 1.14.99.19, transferred 2020 to EC 1.14.19.77
Pathway
ec00565  Ether lipid metabolism
ec01100  Metabolic pathways
Orthology
K20656  plasmanylethanolamine desaturase
Genes
HSA387521(PEDS1) 387522(PEDS1-UBE2V1)
PTR100538341(TMEM189)
PPS100994664(PEDS1)
GGO101124230(TMEM189)
PON100937144
NLE100594969
MCC702250(TMEM189)
MCF101866901(PEDS1)
MTHB126964390
MNI105470687(TMEM189)
CSAB103244462(TMEM189)
CATY105585397(TMEM189)
PANU101010392(TMEM189)
TGE112632714(TMEM189)
RRO104678546
RBB108539455(TMEM189)
TFN117068909(TMEM189)
PTEH111521037
CANG105502576(TMEM189)
CJC100538343(TMEM189)
SBQ101035169(TMEM189)
MMUR105872283(TMEM189)
LCAT123622714(PEDS1)
PCOQ105818626
OGA100952169
MMU407243(Peds1)
MCAL110284278
MPAH110317661(Tmem189)
RNO362278(Peds1)
MCOC116091429(Tmem189)
MUN110548943
CGE100760484
MAUA101832721(Peds1)
PLEU114692668
MORG121460120
MFOT126487394
AAMP119814411
NGI103735785
HGL101698415
CPOC100727302
CCAN109692606(Tmem189)
DORD105991639
DSP122102251
NCAR124975255
OPI105941521
TUP102495771(TMEM189)
GVR103589806
CFA611401
CLUD112674108(PEDS1)
VVP112931947(TMEM189)
VLG121478010
AML100465807
UMR103669669
UAH113258709(TMEM189)
UAR123775921
ELK111141411
LLV125109639
MPUF101670792
NVS122915980
ORO101379558
EJU114225507
ZCA113937342
MLX118023964
NSU110576694
LWW102726182
FCA101081283(TMEM189)
PYU121019937(PEDS1)
PBG122467279
LRUF124502885
PTG102966132(TMEM189)
PPAD109272284(TMEM189)
AJU106986028(TMEM189)
HHV120230415
BTA507694(PEDS1)
BOM102278448(TMEM189)
BIU109567543
BBUB102400490(PEDS1)
BBIS104985113(TMEM189)
CHX102173207
OAS101117690
ODA120869090(PEDS1)
CCAD122448812
SSC100513322(TMEM189)
CFR102516656
CBAI105071854
CDK105087876
VPC102534999
BACU102998454(TMEM189)
LVE103069487(TMEM189)
OOR101287086
DLE111186630
PCAD102976124(TMEM189)
PSIU116739922
ECB100071459(TMEM189)
EPZ103560083
EAI106825706
MYB102248038(TMEM189)
MYD102771511(TMEM189)
MMYO118663824(PEDS1)
MLF102419117(TMEM189)
MNA107540607
PKL118707452(PEDS1)
HAI109381859(TMEM189)
DRO112303773
SHON118996485
AJM119065260
PDIC114506316
PHAS123814734
MMF118618297(PEDS1)
RFQ117015780(TMEM189)
PALE102896379
PGIG120603799(PEDS1)
PVP105296049(TMEM189)
RAY107510336
MJV108391990
TOD119236437
SARA101553201
LAV100660912(TMEM189)
TMU101358899
ETF101643035
DNM105746476(TMEM189)
MDO100538345(TMEM189)
GAS123237134
SHR100934390
PCW110206649(TMEM189)
OAA100076895(TMEM189)
GGA100538348(TMEM189)
PCOC116242999(TMEM189)
MGP100543540
CJO107323104
NMEL110408011
APLA101798375(TMEM189)
ACYG106041442(PEDS1)
AFUL116495729(TMEM189)
TGU100190093(TMEM189)
LSR110475234
SCAN103818896
PMOA120506992
OTC121342985
PRUF121359463
GFR102031723(TMEM189)
FAB101814305(TMEM189)
PHI102110647
PMAJ107213107
CCAE111938394
CCW104687590
CBRC103618193
ETL114067287
ZAB102065063
ACHL103798359(TMEM189)
FPG101917808(TMEM189)
FCH102048394
CLV102095565
EGZ104132157
NNI104013103(TMEM189)
PLET104616705(TMEM189)
PCRI104037937(TMEM189)
PCAO104052920(TMEM189)
ACUN113487638(TMEM189)
TALA104367064
PADL103919351(TMEM189)
AFOR103894668
ACHC115338769
HLE104833211
AGEN126045297
GCL127023127
CCRI104164280(TMEM189)
CSTI104554134(TMEM189)
EHS104515359(TMEM189)
CMAC104474472(TMEM189)
MUI104547792(TMEM189)
FGA104071417(TMEM189)
GSTE104252508(TMEM189)
LDI104351356(TMEM189)
MNB103782517(TMEM189)
OHA104328844
NNT104413564(TMEM189)
DPUB104302698
PGUU104462006(TMEM189)
ACAR104523481(TMEM189)
CPEA104389641(TMEM189)
AVIT104278359(TMEM189)
CVF104293932(TMEM189)
CUCA104057401(TMEM189)
TEO104382339(TMEM189)
BRHI104493450(TMEM189)
AAM106486457
AROW112960775
DNE112982896
SCAM104150059
ASN102381373(TMEM189)
AMJ102566693(TMEM189)
CPOO109318701
GGN109292380
PSS102450275 102453654
CMY102929896 102930562
CPIC101931926 101952652
TST117885688 117886829
CABI116828653 116838672
MRV120380558 120384194
ACS100566872(tmem189)
PVT110071799
SUND121927916
PBI103064187
PMUR107289376
CTIG120308776
TSR106552877
PGUT117663561
VKO123028509
PMUA114599632
ZVI118088266(PEDS1)
GJA107107785
STOW125432518(PEDS1)
XLA733375
XTR100551495(tmem189)
NPR108800142(UBE2V1)
RTEM120919140
BBUF121005845
BGAR122941547
DRE450031(peds1) 492735(si:ch211-212o1.2)
SRX107711858 107738740 107740306 107751443
SANH107669672 107672277 107679882 107686280 107686334
SGH107549643 107556313 107583780 107594514
CCAR109072739 109083335 109094798
CAUA113061476 113072099 113107526 113107549 113118339
PPRM120484235(peds1) 120493902(si:ch211-212o1.2)
MAMB125253853(si:ch211-212o1.2) 125279730(peds1)
IPU100528160(peds1) 108264382(si:ch211-212o1.2) 124627979
PHYP113528134 113534524
SMEO124395820(si:ch211-212o1.2) 124399753(peds1)
TFD113652612(si:ch211-212o1.2) 113655710(peds1)
AMEX103028470 103038667
EEE113589790 113591012
TRU101074695(tmem189)
TNGGSTEN00023467G001
LCO104919928 104931465
CGOB115010277(tmem189)
ELY117258150(tmem189) 117262447(si:ch211-212o1.2)
EFO125887319(si:ch211-212o1.2) 125891910(peds1)
PLEP121947283(peds1) 121950077(si:ch211-212o1.2)
SLUC116043606(peds1) 116046469(si:ch211-212o1.2)
ECRA117947032(tmem189) 117948510(si:ch211-212o1.2)
ESP116692083 116694433
PFLV114558639 114560362
GAT120828834(peds1)
PPUG119206802 119222094(peds1)
MSAM119893928(si:ch211-212o1.2) 119905214(peds1)
CUD121514918(si:ch211-212o1.2) 121517279(peds1)
ALAT119022220(peds1) 119024883(si:ch211-212o1.2)
MZE101463799 101486284
ONL100694737 100695703
OAU116317188(peds1) 116327365(si:ch211-212o1.2)
OLA101156405(tmem189) 101171992
OML112152183(si:ch211-212o1.2) 112159000(peds1)
XMA102227768 102229207
XCO114140351 114157668
XHE116712948 116731156
PRET103466733 103467757
PFOR103138816 103139104
PLAI106952836 106963665
PMEI106916791 106921426
GAF122836108(si:ch211-212o1.2) 122838757(peds1)
CVG107090722 107090913
CTUL119789137(si:ch211-212o1.2) 119799408(peds1)
GMU124855908(si:ch211-212o1.2) 124867048(peds1)
NFU107388536 107391297
KMR108249565(peds1) 108251456(si:ch211-212o1.2)
ALIM106522954(tmem189)
NWH119417484(peds1)
AOCE111572077 111581635
MCEP125004401(peds1) 125015460(si:ch211-212o1.2)
CSEM103379655 103385608 103385617
POV109640617 109641788
SSEN122777382(peds1)
HHIP117762948(si:ch211-212o1.2) 117764114(tmem189)
HSP118109100(si:ch211-212o1.2) 118111559(peds1)
LCF108890485(peds1) 108901902(si:ch211-212o1.2)
SDU111225244 111235131
SLAL111654944 111661889
XGL120793020(si:ch211-212o1.2) 120804464(peds1)
HCQ109507661 109526876(ube2v1)
BPEC110164595 110169509(tmem189)
MALB109962562 109970305
BSPL114857162(si:ch211-212o1.2) 114858657(peds1)
SASA100195807(tm189) 106560866
STRU115168030 115196842
OTW112218501(si:ch211-212o1.2) 112221864(peds1)
OMY110492131(peds1) 110494576(si:ch211-212o1.2)
OGO124037573(si:ch211-212o1.2) 124045951(peds1)
ONE115102403 115134320
SALP111962343 111976475
SNH120061128(peds1) 120066225(si:ch211-212o1.2)
CCLU121531838(si:ch211-212o1.2) 121545700(peds1)
ELS105022328 105024213
SFM108918954 108939288
PKI111850707 111851842 111855731
AANG118207626(peds1) 118211046 118228211(si:ch211-212o1.2)
LOC102687926 102692916
PSPA121296409(si:ch211-212o1.2) 121297917(peds1) 121326222
ARUT117424038(si:ch211-212o1.2) 117425022 117430609
PSEX120535195(si:ch211-212o1.2)
LCM102354153 102358578
CMK103176074(si:ch211-212o1.2) 103190912
RTP109916056 109928512 109928513
BFO118417046
BBEL109480503
CIN100178755
SCLV120332442
SPU593687
APLC110982200
AJC117122298
SKO102807657
DMEDmel_CG10723(Kua)
DER6548909
DSE6614780
DSIDsimw501_GD24246(Dsim_GD24246)
DYADyak_GE13298
DAN6497274
DSR110185755
DPO4816409
DPE6596530
DMN108162003
DWI6646748
DGR6566544
DMODmoj_GI17412
DAZ108609928
DNV115562797
DHE111600428
DVI6634008
CCAT101451618 111591542
BOD106626460
RZE108361242
MDE101898939
SCAC106083295
LCQ111684330
LSQ119604340
HIS119647404
AGAAgaP_AGAP009703
ACOZ120955020
AARA120903482
ASTE118508960
AAG110677009
AALB109418121
CQUCpipJ_CPIJ005919
CPII120431688
CNS116337252
BCOO119085841
AME413030
ACER107996861
ALAB122716216
BIM100748815
BBIF117204735
BVK117230266
BVAN117163702
BTER100651925
BPYO122571054
CCAL108628197
OBB114878339
MGEN117224439
NMEA116432150
CGIG122396849
SOC105199618
MPHA105830825
AEC105151632
ACEP105617457
PBAR105428449
VEM105559297
HST105189447
DQU106743498
CFO105252349
FEX115233409
LHU105674698
PGC109853476
OBO105286238
PCF106793649
PFUC122516290
VPS122628958
NVI100120491
CSOL105367375
TPRE106657654
MDL103569812
CGLO123259190
FAS105264905
DAM107042830
AGIF122851512
CINS118073938
LHT122502105
CCIN107266129
TCA664259
DPA109539052
SOY115886294
ATD109605491
CSET123311866
AGB108911368
LDC111509314
NVL108568000
APLN108739801
PPYR116158929 116164489
OTU111423031
BMOR101743272
BMAN114250956
MSEX115440982
DPLKGM_214200
BANY112058569
NIQ126780892
PMAC106710805
PPOT106099852
PXU106127716
PRAP110998651
PBX123711983
PNAP125056391
ZCE119840168
CCRC123706104
HAW110375495
HZE124645726
TNL113501554
SLIU111352405
OFU114355799
PXY105387288
BTAB109041238
DCI103513575
CLEC106666949
HHAL106682068
NLU111054838
FOC113208517
TPAL117642786
ZNE110837508
CSEC111870424
SGRE126325528
FCD110842237
DPXDAPPUDRAFT_218891
DMK116927670 123477487
DPZ124337499
PVM113802465 113807099
PJA122251909 122253431
PCHN125026696
HAME121877625
PCLA123771749
PTRU123507915
HAZT108668296
EAF111714086
PPOI119089501
ISCIscW_ISCW002059
DSV119435984
RSAN119404683
RMP119187489
TUT107364898
CSCU111615989 111616728
PTEP107445327
SDM118190183
CELCELE_Y53C10A.5(tmem-189)
CBRCBG_13650
LOALOAG_05866
NAINECAME_11914
HROHELRODRAFT_111107
LGILOTGIDRAFT_221531
PCAN112576912
BGT106067737
GAE121389420
HRF124143429
HRJ124273801
CRG105329576
MYI110464778
PMAX117337061
MMER123549774
OBI106877806
OSN115226040
LAK106153330
NVE5513341 5513345
EPA110249836
ATEN116300970
ADF107358316
AMIL114961458
PDAM113665905
SPIS111333068
DGT114516762
XEN124437565
HMG100206277
TADTRIADDRAFT_55713
AQU100631800
DDIDDB_G0269724
DPPDICPUDRAFT_52080
DFADFA_02722
ACANACA1_110500
TBRTb10.70.5480
TBGTbgDal_X2720
TCR511367.210
LMALMJF_21_0440
LIFLINJ_21_0500
LDOLDBPK_210500
LMILMXM_21_0440
LBZLBRM_21_0500
LPANLPMP_210470
NGRNAEGRDRAFT_80076
AHELQ31a_51050
 » show all
Reference
1  [PMID:5550967]
  Authors
Stoffel W, LeKim D
  Title
Studies on the biosynthesis of plasmalogens. Precursors in the biosynthesis of plasmalogens: on the stereospecificity of the biochemical dehydrogenation of the  1-O-alkyl glyceryl to the 1-O-alk-1'-enyl glyceryl ether bond.
  Journal
Hoppe Seylers Z Physiol Chem 352:501-11 (1971)
DOI:10.1515/bchm2.1971.352.1.501
Reference
2  [PMID:11946011]
  Authors
Paltauf F
  Title
Biosynthesis of plasmalogens from alkyl- and alkyl-acyl-glycerophosphoryl ethanolamine in the rat brain.
  Journal
FEBS Lett 17:118-120 (1971)
DOI:10.1016/0014-5793(71)80578-1
Reference
3  [PMID:4150797]
  Authors
Paltuaf F, Prough RA, Masters BS, Johnston JM
  Title
Evidence for the participation of cytochrome b5 in plasmalogen biosynthesis.
  Journal
J Biol Chem 249:2661-2 (1974)
Reference
4  [PMID:235322]
  Authors
Wykle RL, Schremmer Lockmiller JM
  Title
The biosynthesis of plasmalogens by rat brain: involvement of the microsomal electron transport system.
  Journal
Biochim Biophys Acta 380:291-8 (1975)
DOI:10.1016/0005-2760(75)90015-6
Reference
5  [PMID:31604315]
  Authors
Gallego-Garcia A, Monera-Girona AJ, Pajares-Martinez E, Bastida-Martinez E, Perez-Castano R, Iniesta AA, Fontes M, Padmanabhan S, Elias-Arnanz M
  Title
A bacterial light response reveals an orphan desaturase for human plasmalogen synthesis.
  Journal
Science 366:128-132 (2019)
DOI:10.1126/science.aay1436
Other DBs
ExplorEnz - The Enzyme Database: 1.14.19.77
IUBMB Enzyme Nomenclature: 1.14.19.77
ExPASy - ENZYME nomenclature database: 1.14.19.77
BRENDA, the Enzyme Database: 1.14.19.77

DBGET integrated database retrieval system