KEGG   ENZYME: 1.14.19.9
Entry
EC 1.14.19.9                Enzyme                                 
Name
tryptophan 7-halogenase;
prnA (gene name);
rebH (gene name);
ktzQ (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
Sysname
L-tryptophan:FADH2 oxidoreductase (7-halogenating)
Reaction(IUBMB)
tryptophan + FADH2 + chloride + O2 + H+ = 7-chloro-L-tryptophan + FAD + 2 H2O [RN:R09570]
Reaction(KEGG)
R09570
Substrate
tryptophan [CPD:C00078];
FADH2 [CPD:C01352];
chloride [CPD:C00698];
O2 [CPD:C00007];
H+ [CPD:C00080]
Product
7-chloro-L-tryptophan [CPD:C19687];
FAD [CPD:C00016];
H2O [CPD:C00001]
Comment
A flavin-dependent halogenase. The enzyme from the bacterium Lechevalieria aerocolonigenes catalyses the initial step in the biosynthesis of rebeccamycin [2]. It utilizes molecular oxygen to oxidize the FADH2 cofactor, giving C4a-hydroperoxyflavin, which then reacts with chloride to produce a hypochlorite ion. The latter reacts with an active site lysine to generate a chloramine, which chlorinates the substrate. Also acts on bromide ion. cf. EC 1.14.19.58, tryptophan 5-halogenase, and EC 1.14.19.59, tryptophan 6-halogenase.
History
EC 1.14.19.9 created 2009 as EC 1.14.14.7, transferred 2014 to EC 1.14.19.9, modified 2018
Pathway
ec00404  Staurosporine biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K14266  tryptophan 7-halogenase
Genes
IZHFEM41_13305
SRRSerAS9_4268
SRLSOD_c40000
SRYM621_21745
SPLYQ5A_021600(prnA)
SRSSerAS12_4269
SRASerAS13_4269
SMAFD781_2597
SRZAXX16_2520
SERMCLM71_13470
SRHZFO014_20195
SFOZ042_23765
LPVHYN51_07845
PRAGEKN56_16625
XCCXCC2825(prnA) XCC3966(prnA) XCC4133(prnA)
XCBXC_1287 XC_4056 XC_4225
XCAxcc-b100_1333 xcc-b100_4156 xcc-b100_4345
XCPXCR_0306 XCR_3200 XCR_4464
XCVXCV3144 XCV4141 XCV4377
XAXXACM_2929 XACM_3918 XACM_4146
XACXAC2995(prnA) XAC4051(prnA) XAC4275(prnA)
XCIXCAW_00251(prnA) XCAW_00399(prnA) XCAW_03274(prnA)
XCTJ151_03180 J151_04227 J151_04455
XCJJ158_03159 J158_04180 J158_04406
XCUJ159_03155 J159_04176 J159_04404
XCNJ169_03178 J169_04224 J169_04452
XCWJ162_03159 J162_04181 J162_04410
XCRJ163_03155 J163_04176 J163_04405
XCMJ164_03155 J164_04177 J164_04405
XCFJ172_03171 J172_04217 J172_04445
XFUXFF4834R_chr16360 XFF4834R_chr39170 XFF4834R_chr41410
XAOXAC29_15230 XAC29_20405
XOMXOO0227(XOO0227) XOO0354(XOO0354) XOO1160(XOO1160)
XOOXOO0248(prnA) XOO0391(prnA) XOO1263(prnA)
XOPPXO_02202 PXO_02802 PXO_03613
XOYAZ54_01210 AZ54_18175 AZ54_23170
XORXOC_1412 XOC_4642
XOZBE73_00300 BE73_16315
XALXALC_0046 XALC_3150
XSASB85_11965 SB85_15250
XTNFD63_00455 FD63_19310
XVEBJD12_05865 BJD12_10970 BJD12_11995
XPEBJD13_01635 BJD13_17590 BJD13_18805
XHRXJ27_05710 XJ27_14105 XJ27_14990
XGABI317_01410 BI317_02405 BI317_11020
XPHXppCFBP6546_12895(XppCFBP6546P_12895) XppCFBP6546_14225(XppCFBP6546P_14225) XppCFBP6546_20780(XppCFBP6546P_20780)
XVAC7V42_15320 C7V42_20700 C7V42_21795
XANAC801_15025 AC801_20100 AC801_21310
XARXB05_09710 XB05_15350 XB05_16190
XHYFZ025_10295
XCZEBN15_18865
XTHG4Q83_16585
XEUXSP_002911 XSP_003822 XSP_004005
XHDLMG31886_13630(rebH_1) LMG31886_41690(rebH_2) LMG31886_43690(prnA)
XPRMUG10_10905 MUG10_11865 MUG10_16890
SMZSMD_2241
STEKAXG53_00515
SRHBAY15_2027
SINCDAIF1_21520(rebH)
SPAQSTNY_R22560
PSUPsesu_0608
PSUWWQ53_09240 WQ53_11385
PSDDSC_13765
PMEXH4W19_15360
PJPLAG73_06040 LAG73_07150 LAG73_15465 LAG73_15855
PDDMNQ95_07720 MNQ95_09975
LCPLC55x_4850
LGULG3211_3661
LMBC9I47_2713
LYJFKV23_02880 FKV23_16040
LSOLGOY17_08915 GOY17_15330
LAREHIV01_005275 HIV01_011120 HIV01_011135
LUMCNR27_04160 CNR27_08975
TCNH9L16_04410 H9L16_04425
XBCELE36_04695
RHDR2APBS1_3097
RGLCS053_01015 CS053_01640 CS053_15710
RTHLRK53_02435 LRK53_15490
DJICH75_07495
DJAHY57_04760
DTXATSB10_00600 ATSB10_27850 ATSB10_28850 ATSB10_34900 ATSB10_36600
DTLH8F01_11540
DTADYST_03403
LRZBJI69_18130
LPYFIV34_10005 FIV34_20610
XBAC7S18_13195 C7S18_17415
RBDALSL_0860 ALSL_2664
PFLPFL_3604(prnA)
PPRCPFLCHA0_c36450
PPROPPC_3743(prnA)
PCHEY04_18035
PCZPCL1606_28070
PCPJM49_15070
PSEMTO66_16635
PYMAK972_1426
PAGRE2H98_01780 E2H98_18470 E2H98_18485
ACVAMD27_06210
AGYLFPL18_02820
SONSO_3513
SDNSden_2030 Sden_2707
SFRSfri_1309 Sfri_1312 Sfri_1786
SAZSama_0939
SBLSbal_1078 Sbal_1121 Sbal_1124 Sbal_1409
SBMShew185_1138 Shew185_1176 Shew185_1179 Shew185_1400 Shew185_2037
SBNSbal195_1172 Sbal195_1209 Sbal195_1212 Sbal195_1436 Sbal195_2084
SBPSbal223_2301 Sbal223_2945 Sbal223_3178 Sbal223_3181 Sbal223_3217
SBTSbal678_1200 Sbal678_1239 Sbal678_1242 Sbal678_1471 Sbal678_2086
SBSSbal117_1180 Sbal117_1222 Sbal117_1225 Sbal117_1517
SBBSbal175_2927 Sbal175_3149 Sbal175_3152 Sbal175_3194
SLOShew_1113 Shew_2293
SSESsed_1209
SPLSpea_1098
SHEShewmr4_2941
SHMShewmr7_3023
SHNShewana3_3120
SHLShal_1146
SWDSwoo_1140 Swoo_1143 Swoo_1306 Swoo_2208 Swoo_3837 Swoo_3936 Swoo_3937 Swoo_3938
SWPswp_1626 swp_1630
SVOSVI_1019 SVI_1518 SVI_1519
SHFCEQ32_21595
SJASJ2017_1288 SJ2017_1447 SJ2017_1450 SJ2017_2015 SJ2017_2018 SJ2017_2082 SJ2017_2217
SPSWSps_02370
SBJCF168_05240 CF168_09255
SMAVCFF01_13830
SHEWCKQ84_00720 CKQ84_02085
SLJEGC82_00935 EGC82_11095 EGC82_11105 EGC82_12745 EGC82_14765 EGC82_14780
SMAIEXU30_00970 EXU30_15720 EXU30_17345 EXU30_17360
SPOLFH971_08810 FH971_13105 FH971_13120
SKHSTH12_00467(rebH_1) STH12_01336(rebH_2) STH12_03665(rebH_3)
SAESHBH39_09575 HBH39_10720 HBH39_10735 HBH39_12430
SLITJQC75_04470
SPSHFM037_21320
SEURFM038_006245 FM038_015320 FM038_015325
SCYPJYB88_04275 JYB88_09370
SSEMJYB85_04475 JYB85_09585
SGLAFJ709_05095 FJ709_07645 FJ709_10710
SINVK8B83_01875 K8B83_09710 K8B83_09725 K8B83_14180
SXMMKD32_05290
SVMKDH10_000762 KDH10_001560 KDH10_001563
IDTC5610_03930
CPSCPS_0239 CPS_0992 CPS_1022 CPS_1023 CPS_3699 CPS_3700 CPS_3734
COMCMT41_03740 CMT41_03905 CMT41_12850 CMT41_12890 CMT41_12895
COZA3Q34_13470 A3Q34_13475
COLWA3Q33_00830 A3Q33_15610 A3Q33_17475 A3Q33_17485 A3Q33_17490 A3Q33_17495 A3Q33_17620 A3Q33_17635 A3Q33_17760 A3Q33_17865 A3Q33_18010
COLADBO93_11560
COVEKO29_00275 EKO29_00280 EKO29_08280
CBERB5D82_14365 B5D82_15910 B5D82_17130 B5D82_17135
LSDEMK97_04355 EMK97_07160
THTE2K93_02195 E2K93_02210 E2K93_07980 E2K93_13980
THAPFNC98_03305 FNC98_03320 FNC98_11360 FNC98_12860 FNC98_15960 FNC98_16240
THABLP316_02775 LP316_05615 LP316_09335 LP316_09350
PHAPSHAa1353
PTNPTRA_a1709(prnA)
PATPatl_0807 Patl_1964 Patl_2546 Patl_3276 Patl_3277 Patl_3685 Patl_3817 Patl_4289
PSMPSM_A1379 PSM_A1883
PSEOOM33_09560 OM33_09825 OM33_16010 OM33_20355 OM33_20360
PIAPI2015_1338 PI2015_1821
PPHEPP2015_1295 PP2015_3630
PBWD172_001325 D172_007460 D172_009385 D172_009845 D172_010375 D172_010380
PRRAT705_04675
PLZS4054249_07065 S4054249_08730
PALNB0W48_16180
PPISB1L02_10070
PEAPESP_a0243 PESP_a1356 PESP_a1684(prnA) PESP_a2173(prnA) PESP_a2210(prnA) PESP_a2308 PESP_a2309(prnA)
PSPOPSPO_a1380(prnA) PSPO_a1442(prnA) PSPO_b0274 PSPO_b1267 PSPO_b1268
PARTPARC_a0212 PARC_a1605(prnA) PARC_a1606 PARC_a2186 PARC_a2299(prnA)
PTUPTUN_a1620(prnA) PTUN_a1621(prnA) PTUN_a1624 PTUN_a1625 PTUN_a1728(prnA) PTUN_a1858(prnA)
PNGPNIG_a1798(prnA) PNIG_p0040
PTDPTET_a1596(prnA) PTET_a2158(prnA)
PSENPNC201_06690(rebH1)
PDJD0907_05960 D0907_07245 D0907_09035 D0907_09040 D0907_12865
PAGAPAGA_a0247 PAGA_a1717 PAGA_a2201(prnA)
PCARPC2016_1297 PC2016_1298 PC2016_1401 PC2016_2965
PMAACPA52_01115 CPA52_05300 CPA52_06760 CPA52_06765 CPA52_07285 CPA52_09220
PXIJ5O05_00970 J5O05_00985 J5O05_16795 J5O05_16865 J5O05_16875 J5O05_16880
PVBJ5X90_16530
PSAZPA25_11710 PA25_11720 PA25_12430 PA25_16680
PDVFFU37_05885 FFU37_07935 FFU37_08345 FFU37_08350 FFU37_16425
PFLICTT31_06790
PSYMJ1N51_08225 J1N51_13150
AMCMADE_1009520 MADE_1019530
AMHI633_10290 I633_20160 I633_20735 I633_21345 I633_21350
AMAAamad1_10325 amad1_19215 amad1_19710
AMALI607_09170 I607_18205
AMAEI876_09530 I876_18580
AMAOI634_09610 I634_18345
AMADI636_09925 I636_18360 I636_18845
AMAII635_10320 I635_19205 I635_19700
AMAGI533_09490 I533_18275
AMACMASE_02600 MASE_09130 MASE_18615 MASE_19100 MASE_19660 MASE_19665
AMBAMBAS45_02875 AMBAS45_09685 AMBAS45_18850
AMGAMEC673_02795 AMEC673_09460 AMEC673_18590 AMEC673_19415 AMEC673_19420
AMKAMBLS11_08935 AMBLS11_17850 AMBLS11_18405 AMBLS11_18850 AMBLS11_18855
ALTambt_07620 ambt_17280 ambt_22070 ambt_22075
AALEP13_01165 EP13_09590 EP13_19055
AAUSEP12_01215 EP12_16110 EP12_16115 EP12_16150
ASPAOR13_1413 AOR13_2668 AOR13_3252 AOR13_3556 AOR13_3557
ASQAVL57_02520 AVL57_05400 AVL57_11580 AVL57_20795 AVL57_20800
AAWAVL56_01270 AVL56_04175 AVL56_10730 AVL56_19725 AVL56_19730
ALRDS731_05125 DS731_05130 DS731_10490 DS731_16505 DS731_16510 DS731_16555 DS731_20230 DS731_20235
ALEAV939_01335 AV939_04470 AV939_10600 AV939_19785 AV939_19790
ALZAV940_01335 AV940_04315 AV940_10370 AV940_19480 AV940_19485
APELCA267_006540 CA267_007625 CA267_007635 CA267_007650 CA267_011290 CA267_018090
SALMD0Y50_03705 D0Y50_11830 D0Y50_11920 D0Y50_15220 D0Y50_17935 D0Y50_18235 D0Y50_18250
SALKFBQ74_00400 FBQ74_01065 FBQ74_01080 FBQ74_03905
SMAAIT774_00685 IT774_03000
GAGGlaag_1076 Glaag_1077 Glaag_1905 Glaag_2305 Glaag_2348 Glaag_3525 Glaag_3676 Glaag_3730 Glaag_4254
GNIGNIT_3223 GNIT_3226
GPSC427_0190 C427_0191 C427_0898 C427_2235 C427_3387 C427_3390
PMESFX988_00215 FX988_00606 FX988_02648 FX988_03093 FX988_03229 FX988_03654 FX988_03655
LALAT746_03955 AT746_09735 AT746_17110 AT746_17125 AT746_17575 AT746_17600 AT746_17605 AT746_17610
CATEC2869_04745 C2869_05055 C2869_16750
SALHHMF8227_00170(prnA) HMF8227_00244 HMF8227_00568 HMF8227_00895 HMF8227_00898 HMF8227_01495 HMF8227_02385
PAEWKIH87_08450 KIH87_09625 KIH87_13405 KIH87_13420
FBLFbal_1097 Fbal_2925
CJACJA_0218 CJA_0354 CJA_1049(rebH) CJA_1070 CJA_1159 CJA_2713 CJA_2881 CJA_3150 CJA_3467 CJA_3630
CEBB0D95_05870 B0D95_07910 B0D95_07915 B0D95_10275 B0D95_10445 B0D95_10690 B0D95_10695 B0D95_10705 B0D95_11360 B0D95_11375 B0D95_11585 B0D95_12915 B0D95_13540 B0D95_16795 B0D95_20010
CELLCBR65_07160 CBR65_07165 CBR65_07525 CBR65_07545 CBR65_10230 CBR65_11890 CBR65_11905 CBR65_12890 CBR65_12905 CBR65_16025 CBR65_16125 CBR65_16130 CBR65_16530 CBR65_16705 CBR65_16710 CBR65_16715 CBR65_16730 CBR65_16735 CBR65_16740 CBR65_17680 CBR65_17790 CBR65_18440 CBR65_19585 CBR65_19605
CEKD0B88_00155 D0B88_00160 D0B88_02145 D0B88_02150 D0B88_02155 D0B88_04320 D0B88_04890 D0B88_05355 D0B88_05690 D0B88_06805 D0B88_07010 D0B88_07015 D0B88_07020 D0B88_07935 D0B88_11510 D0B88_11755 D0B88_13300 D0B88_13305 D0B88_14240 D0B88_16250 D0B88_16255 D0B88_17740 D0B88_18630 D0B88_18655
CEGD0C16_02295 D0C16_02500 D0C16_07190 D0C16_07425 D0C16_10855 D0C16_11325 D0C16_13105 D0C16_14095 D0C16_14100 D0C16_14150 D0C16_14205 D0C16_15215 D0C16_15225 D0C16_16010 D0C16_16015 D0C16_16020 D0C16_18210 D0C16_18930 D0C16_20375 D0C16_20550 D0C16_20555 D0C16_20560 D0C16_20810 D0C16_20815
SDESde_1094 Sde_1096 Sde_1104 Sde_1105 Sde_1262 Sde_1398 Sde_1401 Sde_2391 Sde_2498 Sde_2807 Sde_2828 Sde_3053
TTUTERTU_0510 TERTU_1076 TERTU_1501 TERTU_2325 TERTU_2326
SAGAM5M_04370 M5M_05400 M5M_05405 M5M_05410 M5M_10725 M5M_17000 M5M_18325 M5M_18335
MARQMARGE09_P0515 MARGE09_P0516 MARGE09_P0517 MARGE09_P1182 MARGE09_P1184 MARGE09_P4106
GILNHM04_00450 NHM04_00455 NHM04_00475 NHM04_02155 NHM04_02160 NHM04_06595 NHM04_09235 NHM04_09470 NHM04_09475 NHM04_09480 NHM04_09490 NHM04_09495 NHM04_09500 NHM04_10390 NHM04_12600 NHM04_12790 NHM04_15560 NHM04_15565
MTHDA3224_00665 A3224_10280 A3224_13185 A3224_13675 A3224_13775 A3224_13780
MICCAUP74_00047(rebH_2) AUP74_00418(rebH_3) AUP74_01694(rebH_5) AUP74_01714(rebH_6) AUP74_01717(rebH_7)
MAGAMag101_04505 Mag101_05020 Mag101_05025 Mag101_05030 Mag101_05845 Mag101_06145 Mag101_15200 Mag101_15440 Mag101_15470 Mag101_15480
MHYDGTQ55_04930 GTQ55_15220 GTQ55_15255 GTQ55_15580 GTQ55_15640 GTQ55_17060
MCELLPW13_00265 LPW13_00270 LPW13_08270 LPW13_12545 LPW13_12580 LPW13_12725 LPW13_12730 LPW13_13080
MICZGL2_26880 GL2_26890
HJABST95_08010
HALCEY643_17645 EY643_17650 EY643_17655
AFUSEYZ66_09500
WEZIC757_02330
OMEOLMES_3770
KKOKkor_1103 Kkor_1104
BPMBURPS1710b_A1115(prnA)
BPLBURPS1106A_A2733
BPDBURPS668_A2885
BPSEBDL_5422(prnA)
BPSMBBQ_4121(prnA)
BPSUBBN_5475(prnA)
BPSDBBX_4589(prnA)
BPQBPC006_II2696
BPKBBK_4751(prnA)
BPSHDR55_5722(prnA)
BPSABBU_3999(prnA)
BPSOX996_5526(prnA)
BUTX994_5084(prnA)
BTZBTL_5470(prnA)
BTHADR62_5270
BOKDM82_6302(prnA)
BUUWS70_23855
BSAVWS86_22620
BURBcep18194_C6706
BCMBcenmc03_6983
BAMBamb_4726
BACBamMC406_5264
BCEPAPZ15_34520
BPYRABD05_31840
BCONNL30_32800
BUBBW23_5778(prnA)
BSEMWJ12_18250
BMECWJ16_17180
BURKDM992_38835
RFRRfer_1114
RHOAHZ993_16770 HZ993_23570
LIML103DPR2_00071(prnA)
DIHG7047_26285
RDPRD2015_4477
MIUABE85_11130 ABE85_25300
MASWAM586_04165 AM586_15695 AM586_15710 AM586_23370
MASSCR152_07710 CR152_20130
MTIMDIR46_12900 DIR46_18415 DIR46_23025
MASYDPH57_20335 DPH57_20350 DPH57_25790
MANCIV454_13655 IV454_27775
MFYHH212_12705 HH212_20435 HH212_20960
MASZC9I28_01550 C9I28_01565 C9I28_23500
MALIEYF70_05430 EYF70_10385 EYF70_29085 EYF70_29100
MUMFCL38_13190 FCL38_20515 FCL38_20530
MFLAGO485_10250 GO485_15755 GO485_15770 GO485_26950
MPLIE1742_10580 E1742_16270 E1742_16285
DUGHH213_05265 HH213_08435 HH213_09760 HH213_14300 HH213_14315 HH213_21195
UPVEJN92_04270
UPIEJG51_007940
LCHLcho_3228
PKTAT984_06420 AT984_21730
MBDMEBOL_008074
MRMA7982_07450
RHINGR_a00820
SINOSS05631_a45620
BAPIBBC0122_019690
MEAMex_1p2407
MEXMext_2404
MPOMpop_2363
MZAB2G69_19640
METAY590_11615
MEEDA075_13115
METDC0214_13460
METSDK389_09215
DSALK1X15_04585
THDBHV28_12250
CCRCC_0787 CC_0971 CC_0972 CC_1002 CC_1529 CC_1755 CC_2288 CC_2805 CC_2807 CC_2808
CCSCCNA_00828 CCNA_01022 CCNA_01023 CCNA_01054 CCNA_01598 CCNA_01831 CCNA_02371 CCNA_02896 CCNA_02898 CCNA_02899
CAKCaul_0296 Caul_0297 Caul_1290 Caul_1839 Caul_1840 Caul_1841 Caul_1842 Caul_1853 Caul_1866 Caul_2064 Caul_2138 Caul_2143 Caul_2144 Caul_2406 Caul_3278 Caul_3561 Caul_4092
CSECseg_1566 Cseg_2005 Cseg_2051 Cseg_2053 Cseg_2054 Cseg_3271 Cseg_3732 Cseg_3733
CHQAQ619_03595 AQ619_03800 AQ619_03805 AQ619_03810 AQ619_03815 AQ619_06000 AQ619_11175 AQ619_12815 AQ619_12820 AQ619_13170
CFHC1707_01450 C1707_01455 C1707_07875 C1707_10580 C1707_10585 C1707_12315 C1707_15840 C1707_15845 C1707_15850 C1707_24765
CAUFCSW63_12155 CSW63_17575 CSW63_18125 CSW63_18135 CSW63_18140 CSW63_18270 CSW63_18275
CAULKCG34_03255 KCG34_05880 KCG34_07995 KCG34_10965 KCG34_25110
PZUPHZ_c2922
BSBBresu_2902 Bresu_2932
BRDJL11_06740 JL11_06745 JL11_08895
BRGA4249_01995 A4249_02000
BRLBZG35_05160 BZG35_05185 BZG35_05190 BZG35_05195 BZG35_05515 BZG35_07310 BZG35_16770
BVCCEP68_00870 CEP68_00875 CEP68_00885 CEP68_01695
BREVE7T10_08940 E7T10_13035 E7T10_13040 E7T10_13050
BMEDGYM46_04900 GYM46_11970 GYM46_11975 GYM46_12255
BNDKWG56_10000
BGOEIFJ75_05080 IFJ75_05115 IFJ75_05120
BVITJIP62_01295 JIP62_01300 JIP62_12950 JIP62_13905 JIP62_13920 JIP62_13925
BALBM8231_01080 M8231_01100 M8231_01105 M8231_03180 M8231_08880 M8231_08885 M8231_11720
AEXAstex_0704 Astex_1893 Astex_1894 Astex_1988 Astex_2586 Astex_2721 Astex_3213 Astex_3306 Astex_3307 Astex_3308 Astex_3309 Astex_3326 Astex_3382 Astex_3383 Astex_3384 Astex_3619
MMRMmar10_2721 Mmar10_2722 Mmar10_2723 Mmar10_2724 Mmar10_2733 Mmar10_2734
HYTHXX25_10225 HXX25_10230 HXX25_10235 HXX25_10240
HBAHbal_2451 Hbal_2452 Hbal_2454 Hbal_2461 Hbal_2462 Hbal_2796 Hbal_3201
HBCAEM38_01235 AEM38_03490
NARSaro_1604 Saro_1607 Saro_1882 Saro_1889
NPPPP1Y_AT20776 PP1Y_Mpl911
NPNJI59_18265
NREBES08_00125
NOVTQ38_023725
NOTC7W88_00415 C7W88_00430 C7W88_12285 C7W88_19850
NORFA702_20235
NGFFRF71_02040 FRF71_02055 FRF71_03490 FRF71_08605
NDRHT578_16875
SALSala_0182 Sala_0740 Sala_0915 Sala_0918
SPHKSKP52_06765 SKP52_06780 SKP52_12890
SPHPLH20_00455
SMAGAN936_10600 AN936_10615
SMAZLH19_14975 LH19_14990
STERAOA14_04315
SPHQBWQ93_08360 BWQ93_08365 BWQ93_08370 BWQ93_08540 BWQ93_08555 BWQ93_10655 BWQ93_10725 BWQ93_10730 BWQ93_10745 BWQ93_17780 BWQ93_17785 BWQ93_17865 BWQ93_20150
SPHXE5675_04520 E5675_06795 E5675_06800 E5675_06805 E5675_08080 E5675_08095 E5675_14160 E5675_14165
SPHUSPPYR_0415 SPPYR_0958 SPPYR_0959 SPPYR_0960 SPPYR_2280 SPPYR_2283 SPPYR_2572 SPPYR_2884 SPPYR_2885
SPHMG432_14595 G432_14600 G432_16620
STAXMC45_01225 MC45_01980 MC45_04520 MC45_07120 MC45_07125 MC45_07130 MC45_07135 MC45_09815 MC45_09820 MC45_09825 MC45_12650 MC45_13060 MC45_16000 MC45_16045 MC45_17590
SPHITS85_08030 TS85_10270 TS85_10275 TS85_13100
SSANNX02_07560 NX02_18010
SNJA7E77_04240 A7E77_04310 A7E77_04345 A7E77_15290 A7E77_15295 A7E77_15300 A7E77_15690
SMYBJP26_08645 BJP26_08650 BJP26_08655 BJP26_09050 BJP26_13220 BJP26_13290 BJP26_13325 BJP26_18360
SPANAWL63_09435 AWL63_11695
SKRBRX40_04120 BRX40_06800 BRX40_06915 BRX40_06925 BRX40_07205 BRX40_16900 BRX40_17105 BRX40_17325
SPLMBXU08_04150 BXU08_06855 BXU08_06860 BXU08_06865 BXU08_07125 BXU08_07215 BXU08_07220 BXU08_08470 BXU08_08475 BXU08_08535 BXU08_08540 BXU08_13370 BXU08_16210 BXU08_16590 BXU08_18105 BXU08_18110
SPLKAV944_00760 AV944_06965 AV944_06970 AV944_06975 AV944_08315 AV944_09340 AV944_10045 AV944_10225 AV944_11935 AV944_13075 AV944_13305
SPHCCVN68_01435 CVN68_02715 CVN68_02720 CVN68_05135 CVN68_09110 CVN68_09115 CVN68_09185 CVN68_09190 CVN68_10685 CVN68_10690 CVN68_20490
SPHFDM480_00205 DM480_08710 DM480_08740 DM480_10120 DM480_12765
SPAUDRN02_000480 DRN02_000485 DRN02_000490 DRN02_000915 DRN02_002165 DRN02_003950 DRN02_005970 DRN02_006165 DRN02_015540
SRHIH9L12_00215 H9L12_00355 H9L12_00360 H9L12_00370 H9L12_00390 H9L12_01575 H9L12_09410 H9L12_10305
SLANGV829_02725 GV829_09180 GV829_10825
SDHH9L15_02145 H9L15_07555 H9L15_12345
SSEDH9L14_09665
SPAPH3Z74_00945 H3Z74_00950 H3Z74_08095 H3Z74_12390 H3Z74_17475 H3Z74_18680 H3Z74_18695
SPAIFPZ24_00095 FPZ24_10555 FPZ24_12845 FPZ24_12850 FPZ24_15795 FPZ24_15810
SPIIG7077_01300 G7077_03100 G7077_03105 G7077_03110 G7077_03115 G7077_03795 G7077_03800 G7077_04360 G7077_05460
SSAUH8M03_06400 H8M03_06415 H8M03_07265 H8M03_07270 H8M03_07275 H8M03_07280 H8M03_07415 H8M03_07500
SCHYGVO57_07985
SSUAFPZ54_00195 FPZ54_02585 FPZ54_02590 FPZ54_11705 FPZ54_11720 FPZ54_11795 FPZ54_11985 FPZ54_15595 FPZ54_17065 FPZ54_17070 FPZ54_17075 FPZ54_18510 FPZ54_18525
SBINSBA_ch2_8040
SAERNEF64_04525 NEF64_04530 NEF64_04540 NEF64_05400 NEF64_05405 NEF64_08130 NEF64_09275 NEF64_09285 NEF64_09290 NEF64_10945 NEF64_11050
SMORLHA26_14170 LHA26_18535 LHA26_18680
SGLCM1K48_06720
SQONMP03_05510 NMP03_05520 NMP03_08260 NMP03_15120 NMP03_15125 NMP03_15165
SJPSJA_C2-02280
SYBTZ53_09660 TZ53_09885
SPHRBSY17_3555 BSY17_3569
SYAA6768_12820 A6768_22480
SBARH5V43_19780 H5V43_20005
SAMISAMIE_1002480 SAMIE_1002490 SAMIE_1002500 SAMIE_1033990
SPPHKFK14_01990
CIJWG74_05320
SFLASPHFLASMR4Y_00642(rebH) SPHFLASMR4Y_00643(rebH)
SPHYCHN51_09120
SPHLLPB140_02500 LPB140_04555 LPB140_05345 LPB140_05350 LPB140_05360 LPB140_05365
SPZRG5C33_10730 G5C33_10735
HGNE6W36_05135
PALGHFP57_01285 HFP57_01290
PARJJ4G78_13615
SPHSETR14_01045 ETR14_01060 ETR14_01435 ETR14_01440 ETR14_06770 ETR14_08050 ETR14_08605 ETR14_09110 ETR14_09525 ETR14_13845 ETR14_16025 ETR14_16030 ETR14_16035 ETR14_16040 ETR14_17390 ETR14_25205
SANDH3309_12395 H3309_12510
POQKZX46_07815 KZX46_22120
PMEAKTC28_03345
AEPAMC99_02455 AMC99_02458
ALHG6N82_04490 G6N82_04505 G6N82_08275
AAYWYH_02200(rebH)
PMASNCF86_01535 NCF86_14410
ANHA6F65_00847(rebH_2) A6F65_02486(prnA)
ADOA6F68_02840(rebH) A6F68_02902(prnA)
CNAAB433_11070 AB433_11085
CMANA9D14_05580 A9D14_07220 A9D14_07225 A9D14_07235 A9D14_07240 A9D14_07250 A9D14_16930 A9D14_18570
EGNBMF35_a0032 BMF35_a1032
EFVCHH26_02865 CHH26_09190 CHH26_09195 CHH26_09355
QCINCF85_08025 NCF85_08030 NCF85_10530 NCF85_10545 NCF85_15875
ELIELI_03165
ERKCD351_14245 CD351_14260 CD351_14295
ERFFIU90_07215(prnA1) FIU90_07230(rebH1) FIU90_14280(rebH2) FIU90_14285(rebH3) FIU90_14290(rebH4) FIU90_14295(rebH5) FIU90_15030(prnA2)
EMVHQR01_14295 HQR01_14505 HQR01_14520
PNSA9D12_00165 A9D12_01475 A9D12_01490
PORLBG023_112350 BG023_112708 BG023_112711
PHZCHX26_12975 CHX26_14675 CHX26_14690
POTE2E27_07150 E2E27_07165 E2E27_07685 E2E27_07690 E2E27_07700 E2E27_07705 E2E27_08165 E2E27_09180
NAOY958_17360 Y958_17370 Y958_19595 Y958_21300 Y958_24910 Y958_27480 Y958_30430 Y958_30445
NCBC0V82_07105 C0V82_15910 C0V82_15915 C0V82_18905 C0V82_18910 C0V82_19485 C0V82_19490 C0V82_21735 C0V82_23630 C0V82_25815 C0V82_25820 C0V82_25825 C0V82_25830 C0V82_26005
ECOGFIV45_02305 FIV45_03215 FIV45_03600 FIV45_12000
BBABd1390(prnA)
BBATBdt_1370(prnA)
BBACEP01_16870
BDZDOM22_11990
BDKHW988_11105
SRWTUE45_04027(rebH_2)
SPEUCGZ69_27150
PSEQAD006_32415
CYPPCC8801_1365
CYHCyan8802_1395
MPROBJP34_00885
NOPNos7524_0707
NOECLI64_06600 CLI64_06605
CSGCylst_4395 Cylst_4396
LUOHHL09_00475 HHL09_03265 HHL09_12810 HHL09_12815 HHL09_13380
FMRFuma_01240(rebH_1) Fuma_01246(rebH_2)
MGINFRZ54_05295
CAMUCA2015_3234
SALIL593_06180
HRRHZS55_06640
HPELHZS54_07190
NAYHYG81_13725
 » show all
Reference
1  [PMID:15272170]
  Authors
Dong C, Kotzsch A, Dorward M, van Pee KH, Naismith JH
  Title
Crystallization and X-ray diffraction of a halogenating enzyme, tryptophan 7-halogenase, from Pseudomonas fluorescens.
  Journal
Acta Crystallogr D Biol Crystallogr 60:1438-40 (2004)
DOI:10.1107/S0907444904012521
  Sequence
Reference
2  [PMID:15743914]
  Authors
Yeh E, Garneau S, Walsh CT
  Title
Robust in vitro activity of RebF and RebH, a two-component reductase/halogenase, generating 7-chlorotryptophan during rebeccamycin biosynthesis.
  Journal
Proc Natl Acad Sci U S A 102:3960-5 (2005)
DOI:10.1073/pnas.0500755102
  Sequence
Reference
3  [PMID:17876823]
  Authors
Bitto E, Huang Y, Bingman CA, Singh S, Thorson JS, Phillips GN Jr
  Title
The structure of flavin-dependent tryptophan 7-halogenase RebH.
  Journal
Proteins 70:289-93 (2008)
DOI:10.1002/prot.21627
  Sequence
Reference
4  [PMID:18828589]
  Authors
Heemstra JR Jr, Walsh CT
  Title
Tandem action of the O2- and FADH2-dependent halogenases KtzQ and KtzR produce 6,7-dichlorotryptophan for kutzneride assembly.
  Journal
J Am Chem Soc 130:14024-5 (2008)
DOI:10.1021/ja806467a
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.14.19.9
IUBMB Enzyme Nomenclature: 1.14.19.9
ExPASy - ENZYME nomenclature database: 1.14.19.9
BRENDA, the Enzyme Database: 1.14.19.9

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