Entry
Name
gamma-glutamyl hercynylcysteine S-oxide synthase;
EgtB
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
Miscellaneous
BRITE hierarchy
Sysname
hercynine,gamma-L-glutamyl-L-cysteine:oxygen oxidoreductase [gamma-L-glutamyl-S-(hercyn-2-yl)-L-cysteine S-oxide-forming]
Reaction(IUBMB)
hercynine + gamma-L-glutamyl-L-cysteine + O2 = gamma-L-glutamyl-S-(hercyn-2-yl)-L-cysteine S-oxide + H2O [RN:
R11013 ]
Reaction(KEGG)
Substrate
Product
gamma-L-glutamyl-S-(hercyn-2-yl)-L-cysteine S-oxide [CPD:
C20995 ];
H2O [CPD:
C00001 ]
Comment
Requires Fe2+ for activity. The enzyme, found in bacteria, is specific for both hercynine and gamma-L-glutamyl-L-cysteine. It is part of the biosynthesis pathway of ergothioneine.
History
EC 1.14.99.50 created 2015
Pathway
Orthology
K18912 gamma-glutamyl hercynylcysteine S-oxide synthase
Genes
REH : H16_B0297(h16_B0297)
LIMN : HKT17_09865(egtB) HKT17_14765
RHF : EUB48_06585(egtB) EUB48_07140(egtB)
VAP : Vapar_1575 Vapar_2054
VPD : VAPA_1c16700 VAPA_1c22060
VAA : AX767_04815 AX767_15715
LIH : L63ED372_02889(egtB)
DUG : HH213_21580(egtB) HH213_22600
NOK : FAY22_04775(egtB) FAY22_08215(egtB)
URU : DSM104443_04037(egtB_2)
UPL : DSM104440_01406(egtB_2)
VIN : AKJ08_0461 AKJ08_3637
MBAI : MB901379_04624(egtB)
MHEK : JMUB5695_00320(egtB_1)
MPHL : MPHLCCUG_00352(egtB)
MTHN : 4412656_04308(egtB)
MAUU : NCTC10437_05230(egtB)
MFLV : NCTC10271_00325(egtB)
MSAL : DSM43276_00320(egtB)
MTER : 4434518_03930(egtB)
NFR : ERS450000_05023(egtB)
NAD : NCTC11293_06260(egtB)
NWL : NWFMUON74_10230(egtB)
RCR : NCTC10994_01625(egtB)
SAMB : SAM23877_6629(egtB)
SCX : AS200_01260 AS200_01270 AS200_07585
SLE : sle_06840(sle_06840)
SCLF : BB341_01705 BB341_28215
SGM : GCM10017557_08710(egtB)
SPAC : B1H29_00680 B1H29_00690 B1H29_03970 B1H29_36370 B1H29_36380
STUI : GCM10017668_06260(egtB)
SGOB : test1122_11460(egtB)
NAQU : ENKNEFLB_01973(egtB)
AGRA : AGRA3207_000993(egtB) AGRA3207_006136
MSAG : GCM10017556_54340(egtB)
RUB : GBA63_13755(egtB) GBA63_15135(egtB)
RMAR : GBA65_13020(egtB) GBA65_19945(egtB)
SYY : SYNGTS_0280(slr1303)
SYT : SYNGTI_0280(slr1303)
SYS : SYNPCCN_0280(slr1303)
SYQ : SYNPCCP_0280(slr1303)
LCRE : Pla8534_10940(pkn1_8)
AAGG : ETAA8_47760(pkn1_10)
AMUC : Pan181_50170(pkn1_4)
PND : Pla175_00970(egtB_1)
PFER : IRI77_13450(egtB) IRI77_36140
NLI : G3M70_02210 G3M70_02245
» show all
Taxonomy
Reference
Authors
Seebeck FP
Title
In vitro reconstitution of Mycobacterial ergothioneine biosynthesis.
Journal
Sequence
Reference
Authors
Pluskal T, Ueno M, Yanagida M
Title
Genetic and metabolomic dissection of the ergothioneine and selenoneine biosynthetic pathway in the fission yeast, S. pombe, and construction of an overproduction system.
Journal
Other DBs