KEGG   ENZYME: 1.16.1.9
Entry
EC 1.16.1.9                 Enzyme                                 
Name
ferric-chelate reductase (NADPH);
ferric chelate reductase (ambiguous);
iron chelate reductase (ambiguous);
NADPH:Fe3+-EDTA reductase;
NADPH-dependent ferric reductase;
yqjH (gene name);
Fe(II):NADP+ oxidoreductase
Class
Oxidoreductases;
Oxidizing metal ions;
With NAD+ or NADP+ as acceptor
Sysname
Fe(II)-siderophore:NADP+ oxidoreductase
Reaction(IUBMB)
2 Fe(II)-siderophore + NADP+ + H+ = 2 Fe(III)-siderophore + NADPH [RN:R09541]
Reaction(KEGG)
R09541
Substrate
Fe(II)-siderophore;
NADP+ [CPD:C00006];
H+ [CPD:C00080]
Product
Fe(III)-siderophore;
NADPH [CPD:C00005]
Comment
Contains FAD. The enzyme, which is widespread among bacteria, catalyses the reduction of ferric iron bound to a variety of iron chelators (siderophores), including ferric triscatecholates and ferric dicitrate, resulting in the release of ferrous iron. The enzyme from the bacterium Escherichia coli has the highest efficiency with the hydrolysed ferric enterobactin complex ferric N-(2,3-dihydroxybenzoyl)-L-serine [3]. cf. EC 1.16.1.7, ferric-chelate reductase (NADH) and EC 1.16.1.10, ferric-chelate reductase [NAD(P)H].
History
EC 1.16.1.9 created 1992 as EC 1.6.99.13, transferred 2002 to EC 1.16.1.7, transferred 2011 to EC 1.16.1.9, modified 2012, modified 2014
Orthology
K07229  ferric-chelate reductase (NADPH)
Genes
ECOb3070(nfeF)
ECJJW3041(yqjH)
ECDECDH10B_3245(yqjH)
EBWBWG_2780(yqjH)
ECOKECMDS42_2539(yqjH)
ECEZ4423(yqjH)
ECSECs_3952(yqjH)
ECFECH74115_4383
ETWECSP_4044(yqjH)
ELXCDCO157_3693
EOIECO111_3892(yqjH)
EOJECO26_4171(yqjH)
EOHECO103_3815(yqjH)
ECOOECRM13514_4030(yqjH)
ECOHECRM13516_3833(yqjH)
ESLO3K_03605
ESOO3O_22040
ESMO3M_03645
ECKEC55989_3484(yqjH)
ECGE2348C_3363(yqjH)
EOKG2583_3794(yqjH)
ELRECO55CA74_18080
ELHETEC_3340
ECWEcE24377A_3535
EUNUMNK88_3823
ECPECP_3160
ENAECNA114_3162(ygjH1)
ECOSEC958_3475(yqjH)
ECVAPECO1_3346(yqjH)
ECOAAPECO78_19155
ECXEcHS_A3251
ECMEcSMS35_3364
ECYECSE_3351
ECRECIAI1_3217(yqjH)
ECQECED1_3738(yqjH)
EUMECUMN_3553(yqjH)
ECTECIAI39_3566(yqjH)
EOCCE10_3600(yqjH)
EBRECB_02939(yqjH)
EBLECD_02939(yqjH)
EBEB21_02889(yqjH)
EBDECBD_0672
ECIUTI89_C3508(yqjH)
EIHECOK1_3502
ECZECS88_3467(yqjH)
ECCc3823(yqjH)
ELOEC042_3363
ELNNRG857_15285
ESEECSF_2913
ECLEcolC_0630
EKOEKO11_0649
EKFKO11_07370(yqjH)
EABECABU_c34900(yqjH)
EDHEcDH1_0631
EDJECDH1ME8569_2965(yqjH)
ELUUM146_00955
ELWECW_m3337(yqjH)
ELLWFL_16305(yqjH)
ELCi14_3517(yqjH)
ELDi02_3517(yqjH)
ELPP12B_c3187
ELFLF82_3675(yqjH)
ECOLLY180_15845
ECOIECOPMV1_03388(yqjH)
ECOJP423_17345
EFEEFER_3022(yqjH)
EALEAKF1_ch2859
EMAC1192_19735
ESZFEM44_06405(nfeF)
STYSTY3392
STTt3134
SEXSTBHUCCB_33110
SENTTY21A_15865
STMSTM3214(yqjH)
SEOSTM14_3891(yqjH)
SEVSTMMW_32151
SEYSL1344_3187(yqjH)
SEMSTMDT12_C32720
SEJSTMUK_3203(yqjH)
SEBSTM474_3368(yqjH)
SEFUMN798_3496
SETUSTU288_16280
SETCCFSAN001921_00935
SENRSTMDT2_31071
SENDDT104_32101
SENICY43_16755
SEENSE451236_22200
SPTSPA3082(yqjH)
SEKSSPA2878
SPQSPAB_04010
SEISPC_3289(yqjH)
SECSCH_3160(yqjH)
SEHSeHA_C3508
SHBSU5_03709
SENHCFSAN002069_16065
SEEHSEEH1578_02210
SEESNSL254_A3474
SENNSN31241_43430
SEWSeSA_A3404
SEASeAg_B3400
SENSQ786_15675
SEDSeD_A3570
SEGSG3110(yqjH)
SELSPUL_3226
SEGASPUCDC_3212
SETSEN3056(yqjH)
SENAAU38_15555
SENOAU37_15755
SENVAU39_15755
SENQAU40_17530
SENLIY59_16160
SENJCFSAN001992_17465
SEECCFSAN002050_23060
SEEBSEEB0189_003795
SEEPI137_15395
SENBBN855_32930
SENEIA1_15545
SENCSEET0819_23080
SESSARI_04415
SBGSBG_2849
SBZA464_3290
SBVN643_14015
SALZEOS98_03220
SFNSFy_4437
SFSSFyv_4514
SFTNCTC1_03370(yqjH_2)
SSNSSON_3208(yqjH)
SBOSBO_2929(yqjH)
SBCSbBS512_E3506
SDYSDY_3254(yqjH)
SDZAsd1617_04341
SHQA0259_19095
ENCECL_04454
ENLA3UG_19740
ECLGEC036_38360
ECLEECNIH2_20185
ECLNECNIH4_03490 ECNIH4_18155
ECLIECNIH5_18765
ECLXLI66_19470
ECLYLI62_21430
ECLZLI64_18610
ECLOENC_33180
EHMAB284_05940
EXFBFV63_18970
ECLAECNIH3_18855
ECLCECR091_18780
EAUDI57_21520
EKBBFV64_20325
ENOECENHK_19165
EECEcWSU1_03884(yqjH)
ELGBH714_20370
ECANCWI88_03080
ERNBFV67_18970
ECLSLI67_020855
ECHGFY206_05660 FY206_21290
ESHC1N69_19845
ENTEnt638_3524
EASEntas_3751
ENRH650_12010
ENXNI40_019255
ENFAKI40_0673
LNICWR52_15730
EBGFAI37_09890
ENDA4308_03830
ENZG0034_19750
ENSHWQ15_04750
ENKLOC22_07475
EHUD5067_0003240
EMORL6Y89_19040
ENBELK40_19615
ESAESA_03485
CSKES15_3444
CSZCSSP291_16180
CSJCSK29544_00465
CCONAFK62_02580
CDMAFK67_02570
CSIP262_05163
CMJAFK66_017450
CUIAFK65_02500
CMWAFK63_16015
CTUCTU_04810(yqjH)
KPNKPN_03499(yqjH)
KPUKP1_4796(yqjH)
KPMKPHS_46310
KPPA79E_0618
KPHKPNIH24_05735
KPZKPNIH27_22115
KPVKPNIH29_23005
KPWKPNIH30_23330
KPYKPNIH31_22515
KPGKPNIH32_24180
KPCKPNIH10_23065
KPQKPR0928_22585
KPTVK055_3969
KPOKPN2242_20590
KPRKPR_4703
KPJN559_0673
KPID364_18030
KPAKPNJ1_00661
KPSKPNJ2_00703
KPXPMK1_01017(yqjH)
KPBFH42_13780
KPNEKU54_003255
KPNULI86_03260
KPNKBN49_0608
KVAKvar_0601
KPEKPK_0613
KPKA593_07745
KVDKR75_05010
KVQSP68_11645
KOXKOX_03200
KOEA225_5090
KOYJ415_06565
KOMHR38_01790
KMIVW41_11500
KOKKONIH1_05845 KONIH1_25745
KOCAB185_10590
KQUAVR78_01335
EAEEAE_03870
EARCCG33218
KQVB8P98_03300
KLLBJF97_25405
KLWDA718_03800
KARLGL98_03160
KGRJJJ10_03360
RORRORB6_21875
RONTE10_24485
RPLNB1209_03150
RAODSD31_03345
RTGNCTC13098_00820(yqjH)
REEelectrica_00599(yqjH)
CROROD_48101
CKOCKO_04480
CFDCFNIH1_02665
CBRAA6J81_20505
CWECO701_01090
CYOCD187_03165
CPOTFOB25_14525
CFQC2U38_22255
CSEDJY391_03345
CAMAF384_24655 F384_24710
CAFAL524_23370
CIFAL515_20290
CFARCI104_03380
CIRC2U53_02015 C2U53_06105
CIEAN232_07830
CPARCUC49_16015
CTELGBC03_01430 GBC03_27565
CITZE4Z61_20170
CARSE1B03_22870
EBTEBL_c04730(yqjH)
CNTJT31_00830
CEMLH23_16825
CENLH86_15805
CLAPNCTC11466_02222(yqjH_1)
PGELG71_00030 LG71_25630
ESCEntcl_0639
KLEAO703_18245
KSAC813_18645
KORAWR26_03110
KRDA3780_21625
KCOBWI95_06930
KOTEH164_02875
KPSEIP581_20115
KOBHF650_20805
KGOCEW81_03370
KIENCTC12125_04545(yqjH)
KASKATP_05990
KLUK7B04_08475
LAXAPT61_03165
LEIC2U54_01555
LEHC3F35_15105
LEEDVA44_03160
LERGNG29_19840
LEAGNG26_19040
LPNUKQ929_02610
LAZA8A57_18245
LEFLJPFL01_3620
LEWDAI21_07820
BUFD8682_03200
BAGEBADSM9389_21150
BFTMNO13_12270
METYMRY16398_06890
AHNNCTC12129_00719(yqjH_1)
ASUBNLZ15_18985
YREHEC60_14860
SGOEA8O29_003730
KINAB182_28955
PDZHHA33_05660
IZHFEM41_02445
PSGCG163CM_42220(yqjH)
SCOLKFZ77_02660
EBFD782_0610
EBCC2U52_11840
EBUCUC76_18810
PSTSE05_39570
RAHRahaq_4833
RACEJHW33_25070
RAQRahaq2_4792
RAAQ7S_24696
ROXBV494_23180
RVCJ9880_23835
GQUAWC35_03415
BGJAWC36_03685
BIZHC231_07685
LBQCKQ53_11060
LPOPI6N93_05960
SODSant_3532
ETAETA_13670(yqjH)
EBIEbC_22530(viuB)
EGEEM595_2950(yqjH)
EPECI789_04250
ERWIGN242_07730
ETPLU633_13065
ERPLJN55_14980
PAMPANA_3242(yqjH)
PLFPANA5342_0831(yqjH)
PAJPAJ_2467(yqjH)
PAQPAGR_g0841
PVAPvag_2587(yqjH)
PAGGAL522_20075
PAOPat9b_3261
KLNLH22_06040
PANTPSNIH1_02685
PANPPSNIH2_01560
PAGCBEE12_03490
PSTWDSJ_21015
PALHB1H58_10795
PANSFCN45_15780
PEYEE896_03585
PDISD8B20_14295
PERLAC65_13230
PGZC2E15_17515
PCDC2E16_17515
MINTC7M51_02686(yqjH)
MTHIC7M52_00168(yqjH)
TCIA7K98_03840
TPTYNCTC11468_00709(yqjH)
PFQQQ39_00210
PACSFAZ98_33585
PPULRO07_20020
CDNBN940_13611
ACKC380_01460
ACIOEAG14_20625
AANTHUK68_18355
DTSBI380_23455
DHKBO996_01410
DLAI6G47_23840
CTESO987_25335
CKEB5M06_03115
DIHG7047_17040
DUGHH213_13150
BOTCIT37_37155
BSYMCIT39_09870
BARHWN72_17920
PGAPGA1_c25930
PGLPGA2_c23980
PGDGal_00838
PHPPhaeoP97_00167
PPICPhaeoP14_02344
PHQD1820_07660
LEJETW24_02770
LAQUR2C4_00495
TPROGa0080559_TMP2424
RMBK529_016275
CMAGCBW24_05500
PMASNCF86_15990
AFSAFR_27425
 » show all
Reference
1  [PMID:18765906]
  Authors
Bamford VA, Armour M, Mitchell SA, Cartron M, Andrews SC, Watson KA
  Title
Preliminary X-ray diffraction analysis of YqjH from Escherichia coli: a putative  cytoplasmic ferri-siderophore reductase.
  Journal
Acta Crystallogr Sect F Struct Biol Cryst Commun 64:792-6 (2008)
DOI:10.1107/S174430910802352X
  Sequence
[eco:b3070]
Reference
2  [PMID:21097627]
  Authors
Wang S, Wu Y, Outten FW
  Title
Fur and the novel regulator YqjI control transcription of the ferric reductase gene yqjH in Escherichia coli.
  Journal
J Bacteriol 193:563-74 (2011)
DOI:10.1128/JB.01062-10
  Sequence
[eco:b3070]
Reference
3  [PMID:22098718]
  Authors
Miethke M, Hou J, Marahiel MA
  Title
The siderophore-interacting protein YqjH acts as a ferric reductase in different iron assimilation pathways of Escherichia coli.
  Journal
Biochemistry 50:10951-64 (2011)
DOI:10.1021/bi201517h
Other DBs
ExplorEnz - The Enzyme Database: 1.16.1.9
IUBMB Enzyme Nomenclature: 1.16.1.9
ExPASy - ENZYME nomenclature database: 1.16.1.9
BRENDA, the Enzyme Database: 1.16.1.9
CAS: 120720-17-4

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