KEGG   ENZYME: 1.18.1.1
Entry
EC 1.18.1.1                 Enzyme                                 
Name
rubredoxin---NAD+ reductase;
rubredoxin reductase;
rubredoxin-nicotinamide adenine dinucleotide reductase;
dihydronicotinamide adenine dinucleotide-rubredoxin reductase;
reduced nicotinamide adenine dinucleotide-rubredoxin reductase;
NADH-rubredoxin reductase;
rubredoxin-NAD reductase;
NADH: rubredoxin oxidoreductase;
DPNH-rubredoxin reductase;
NADH-rubredoxin oxidoreductase
Class
Oxidoreductases;
Acting on iron-sulfur proteins as donors;
With NAD+ or NADP+ as acceptor
Sysname
rubredoxin:NAD+ oxidoreductase
Reaction(IUBMB)
2 reduced rubredoxin + NAD+ + H+ = 2 oxidized rubredoxin + NADH [RN:R02000]
Reaction(KEGG)
R02000
Substrate
reduced rubredoxin [CPD:C00340];
NAD+ [CPD:C00003];
H+ [CPD:C00080]
Product
oxidized rubredoxin [CPD:C00435];
NADH [CPD:C00004]
Comment
Requires FAD. The enzyme from Clostridium acetobutylicum reduces rubredoxin, ferricyanide and dichlorophenolindophenol, but not ferredoxin or flavodoxin. The reaction does not occur when NADPH is substituted for NADH. Contains iron at the redox centre.
History
EC 1.18.1.1 created 1972 as EC 1.6.7.2, transferred 1978 to EC 1.18.1.1, modified 2001
Pathway
ec00071  Fatty acid degradation
Orthology
K05297  rubredoxin---NAD+ reductase
K21738  rubredoxin---NAD+ reductase
K22567  rubredoxin---NAD+ reductase
Genes
XBAC7S18_09175
VAGN646_3145
VEXVEA_001294
VDBAL552_01515
VNAPN96_15080
VEJVEJY3_23206
VNLD3H41_24160
VJPNP165_19640
PGHFH974_08085
SKSFCN78_06135 FCN78_12245
PAEPA5349
PAEVN297_5529(alkT)
PAEIN296_5529(alkT)
PAUPA14_70620(rubB)
PAPPSPA7_6126
PAGPLES_57441
PAFPAM18_5469
PNCNCGM2_6116(rubB)
PAEBNCGM1900_6194(rubB)
PDKPADK2_28480
PSGG655_28145
PRPM062_28170
PAEPPA1S_28900
PAERPA1R_gp3281
PAEMU769_29400
PAELT223_29360
PAESSCV20265_6077
PAEUBN889_05937
PAEGAI22_05090
PAECM802_5527(alkT)
PAEOM801_5394(alkT)
PMYPmen_0430 Pmen_4402
PMKMDS_4734
PREPCA10_34400 PCA10_55500(rubB)
PPSEBN5_4231(rubB)
PFUWKF707C_29950 KF707C_55940
PCQPcP3B5_60770(alkT)
PMUIG4G71_03845
PPUPP_5314(alkT) PP_5371
PPFPput_5223
PPGPputGB1_5362
PPWPputW619_0159
PPTPPS_5163
PPBPPUBIRD1_5107(rubB)
PPIYSA_04864
PPXT1E_3940(rubB) T1E_3999
PPUHB479_26305
PPUTL483_31710
PPUNPP4_53750(rubB)
PPUDDW66_5733
PFVPsefu_0279
PMONX969_25520
PMOTX970_25155
PMOSO165_022730
PPJRK21_04949
PMOLCLJ08_13370
PSTPSPTO_5473(rubB)
PSBPsyr_5028
PSYRN018_25385
PSPPSPPH_5110(rubB)
PSAVPSA3335_00955
PAMGBKM19_029100
PCIPCH70_50780
PAVLBKM03_29340
PVDCFBP1590__5340(alkT)
PCABJGS08_26175
PCOFPOR16_24730
PTREI9H09_00720
PSYIMME58_25730
PASTN015_01305
PFLPFL_6103(rubB)
PPRCPFLCHA0_c60620(alkT)
PPROPPC_6056
PFEPSF113_0127(rubB)
PFNHZ99_17075
PFOPfl01_5601(norW)
PFSPFLU_6033
PFCPflA506_5316(rubB)
PPZH045_20525
PFBVO64_2925
PMANOU5_0014 OU5_3562
PTVAA957_14975
PCGAXG94_14840
PVRPverR02_30860
PAZOAYR47_06325
POIBOP93_25835
PRXHRH33_00370
PMEDE3Z27_27880
PFWPF1751_v1c54440(rubB)
PFFPFLUOLIPICF708775
PFXA7318_26865
PENPSEEN5459(rubB)
PLULFOB45_24075
PBAPSEBR_a133
PBCCD58_29280
PPUUPputUW4_05349
PDRH681_24300
PSVPVLB_25165
PSKU771_31185
PKCPKB_5680(alkT)
PCHEY04_30105
PCZPCL1606_01050
PCPJM49_00810
PFZAV641_00595
PLQAA042_09715
PALKPSAKL28_51800
PRHLT40_07120 LT40_07165
PPVNJ69_19510
PSEMTO66_31050
PSECCCOS191_5209(alkT)
PPSYAOC04_20770
PSOSPOS17_6064
PKRAYO71_00595
PFKPFAS1_11625
PANRA7J50_5768
PSETTHL1_5641
PSILPMA3_29615
PYMAK972_6044
PKEDLD99_12320 DLD99_28440
PALLUYA_14270 UYA_23590
PUMHGP31_00235 HGP31_12865
POJPtoMrB4_01360(alkT)
PGGFX982_01593
PPSHG5J76_03830
PGYAWU82_06970
PLALFXN65_27290
PSEJHNQ25_02610 HNQ25_11295
PVKEPZ47_29380
PEZHWQ56_28230
PBZGN234_17540
PKHJLK41_24180
PTYJWV26_09015 JWV26_11725
PMAOPMYSY11_2129 PMYSY11_4365(alkT)
PATAJWU58_01130
PDWBV82_2204
PZEHU754_000465
PMOEHV782_000465
PSEPC4K39_3558
PVWHU752_000445
PTRTHU722_0000355
PXAKSS93_02420
PSAMHU731_015475
PTZHU718_000460
PQIKH389_26700
PSHHHU773_000385
PXNHU772_024485
PHVHU739_018255
PPRGHU725_022420
PNNKEM63_16445
PANHHU763_024160
PASGKSS96_00365
PFAKKSS94_23085 KSS94_26660
PMUYKSS95_03505
PMAMKSS90_25035
PAZEKSS91_00225
PALVKSS97_00410
PPHABVH74_05160
PORYEJA05_27650
PWZJ7655_00040 J7655_09485 J7655_20695
PTKEXN22_01055
PTWTUM18999_01360(alkT)
PZAHU749_001555
PIEHU724_000460
PWYHU734_001290
PTAENCTC10697_00117(alkT_1) NCTC10697_02146(alkT_2)
PGFJ0G10_00420
PCAVD3880_21885
PJUL1P09_24800
PHFNLY38_24255
PPHNHU825_03005
PIZLAB08_R20720 LAB08_R59490
PPEGKUA23_29510
PSIINF676_27000
PSIHLOY51_26455
PSAPST_0438(rubB)
PSZPSTAB_0469(rubB)
PSRPSTAA_0491(rubB)
PSCA458_19190
PSJPSJM300_17460
PSHPsest_3834
PSTUUIB01_19410
PSTTCH92_01830
PSEDDM292_16510
PCHLLLJ08_18425
PBMCL52_02025
PKGLW136_20055
SDEGGOM96_08385
PBBAKN87_09625
HPEGEAO82_00380 EAO82_02465
HAESLO767_16015
MAQMaqu_0442 Maqu_3591
MHCMARHY2849(alkT) MARHY3494(rubB)
MADHP15_3349
MBSMRBBS_3587(alkT)
MSRAU15_01845 AU15_22050
MSXAU14_08110
MPQABA45_16830
MARIACP86_07285 ACP86_20395
MLQASQ50_08875 ASQ50_10975 ASQ50_12490
MSQBKP64_16950
MARAD0851_01590 D0851_10745
MARJMARI_17880(alkT_1) MARI_30590(alkT_2)
PRWPsycPRwf_2061
PALIA3K91_2007
PSYYDLE54_09830
PSYPE5677_03375
ACBA1S_0994
ABMABSDF2404(rubB)
ABYABAYE1067 ABAYE2799(rubB)
ABCACICU_00955 ACICU_02608
ABNAB57_1073 AB57_2839
ABBABBFA_02593(rubB)
ABXABK1_0980 ABK1_2728
ABZABZJ_01098 ABZJ_02802
ABRABTJ_01105 ABTJ_02817
ABDABTW07_1084 ABTW07_2856
ABHM3Q_1292 M3Q_2875
ABADABD1_09470(rubB)
ABJBJAB07104_01092 BJAB07104_02766
ABABBJAB0715_01106
ABAJBJAB0868_01106 BJAB0868_02648
ABAZP795_12740
ABKLX00_05015
ABAUIX87_00560
ABAAIX88_06985
ABWBL01_04850 BL01_11680
ABALABLAC_17630
ACCBDGL_000275(rubB)
ANORR32_13185
ALCOTEC02_13900
ACALBUM88_04805
ASEII8T81_14050
ACDAOLE_14370
ACIACIAD1065(rubB)
ATTAMQ28_03830
AEIAOY20_14255
AJORZ95_11825
ACWA0J50_12465
ACVAMD27_04170
AHLAHTJS_05070
AJNBVL33_07215
ASOLBEN76_08380
ALABFG52_04590
ASJAsACE_CH00799(rubB)
AIDCTZ23_04340
ADVDJ533_13635
ARJDOM24_10215
AWUBEN71_13890
ACUMC9E88_008150
AGUAS4_32640(rubB)
AUGURS_2062
ALWFOB21_14340
ADSFPL17_01335
ABERBSR55_15775
ATNFM020_04025 FM020_10750
ACHICDG60_13200
ALJG8D99_11510
AWGGFH30_03760
ASHAG8E00_04535
ATGJ4G44_06275
AVBRYU24_22120(rubB)
ABOUACBO_23310(rubB)
AGYLFPL18_12830 FPL18_15235
ACIUA3K93_03400
AVZHWI77_11430
MCTMCR_0041
MCSDR90_38
MCATMC25239_00086(norW)
MOIMOVS_09940
MOSAXE82_01245
MBLAAX09_09510
MBOIDQF64_13375
MCUNNCTC10297_00560(norW)
MNNI6G26_02565
MBAHHYN46_07845
SDNSden_3466
SINVK8B83_21315
THTE2K93_08950
PARTPARC_a1586
HMIsoil367_16035
ALKMNKI27_00235 NKI27_16700
CELLCBR65_18765
SAGAM5M_15220
ZALAZF00_18220
OSGBST96_07165
MTHDA3224_04565
MICCAUP74_00095(rubB_1) AUP74_02936(rubB_2)
MAGAMag101_09900 Mag101_11295 Mag101_12995
MIIBTJ40_17590
MICTFIU95_16400(rubB)
MHYDGTQ55_10320 GTQ55_12815
MCELLPW13_10270
MICZGL2_22400
HJABST95_03215
HALCEY643_19265
KIMG3T16_09300
AFUSEYZ66_14005
CBUCBU_0276
CBSCOXBURSA331_A0379
CBDCBUD_1816
CBGCbuG_1731
CBCCbuK_0471
CEYCleRT_13210
TCXTcr_0037
HTREPV75_00365 EPV75_09705
TAOTHIAE_07020
THIOAYJ59_00365
TMHJX580_05455
TXAHQN79_11560
TSETHMIRHAS_04100(rubB)
TZOTHMIRHAT_15060(norW)
TIGTHII_3133
TSBHMY34_01370
TANIJ8380_15820
AEHMlg_0757
HHCM911_00990
EBSECTOBSL9_1078
TGRTgr7_0681
TKMTK90_0972
TVRTVD_08070
SPIUSPICUR_05485
SROSBBH56_03120
SPIZGJ672_05460
NAXHC341_07615 HC341_16180
HNAHneap_2210
HAZA9404_11330
GHLGM160_04545
HCHHCH_00777
HAHEENC22_03160
CSACsal_3250
HELHELO_4414(rubB)
HCSFF32_05815
HAKKO116_00116
HAMHALO0041
HHUAR456_20455
HCOLOKO_02284(alkT)
HSIBOX17_06760 BOX17_07650
HALOBWR19_18640
HHHCLM76_06090
HBEBEI_1545 BEI_3745
HAGBB497_04250
HAFC8233_11455
HALKCUU95_06275
HVNEI420_19945
HOLHORIV_72020(rubB)
HSRHSBAA_65910(alkT)
HMDCTT34_17815
HAXIHAALTHF_10940n
HTTHZS52_04950
HCAMI4484_20475
HPIZGYM47_17425
HSXHNO51_20560
HSVHNO53_21145
HTXEKK97_23065
HPROLMS44_23495
CMAIBFX80_00155
CAMHLCW13_17085
PAURFGL86_04005
ABOABO_0162(rubB)
ADIB5T_02839 B5T_04348(rubB)
APACS7S_17715
ALNAS19_01670
AXEP40_21175
KAKKalk_12615
TOLTOL_0163
TORR615_00815
TWANHUF19_17630
OAIOLEAN_C38720(rubB)
MARSA8C75_00675
MGEOCFI10_04725
BSANCHH28_04755
BMARHF888_00555
VCWGJQ55_00595
BACZKFF03_15760
GSNYC6258_00905
RFOREIFOR_00121
OMEOLMES_3725 OLMES_4764
OCEGU3_07995
ZDFAN401_10800
SOKD0B54_23360
SALNSALB1_1968
SEDSAAY24_18110
PTESJQU52_04805
IODEJO50_07550
IFLC1H71_18115
LHKLHK_03088
JEUBJP62_03405
AQLBXU06_11265
DTKK4H28_08660
CHIZHQ393_07450
CFONHZU75_13670
CHICN8I74_13165
CBWRR42_m0808
BURBcep18194_B0789
BCONNL30_16215
BSTLBBJ41_24250
BUMAXG89_24015 AXG89_28675
PCAFDSC91_006346
PNUPnuc_1378
PDQCL55_00012780
PTRPDCO17_07235
PANIDCO16_07150
PCOSC2747_06545
PTXABW99_20085
PANDDRB87_07250
PLGNCTC10937_05175(alkT)
CABASBC2_52550(norW)
LIMNHKT17_05715
CARIFNU76_22145
AMIMMIM_c34090
RFRRfer_0092
RSBRS694_19990
RHFEUB48_00230
RHGEXZ61_16925
POLBpro_4853 Bpro_4857
ACKC380_02900
VPDVAPA_1c22320
HYRBSY239_3842
HYBQ5W_21975
HTNKI616_01040
HCZG9Q37_17830
MPTMpe_A3669
METPC1M51_08230
HARHEAR0644
MMSmma_0610(rubB)
JAGGJA_3183(alkT) GJA_559(rubB)
JABVN23_07460
CFUCFU_0845(rubB)
CARELT85_0937
CPRACPter91_0986(alkT)
MUMFCL38_01385
UPVEJN92_15700
UPIEJG51_017975
NOKFAY22_12385
GLCJQN73_12535
RGUA4W93_27285
AONDEH84_13885
NEUNE1420
NETNeut_1534
NITNAL212_0762
NIINit79A3_0576
NCOAAW31_15800
NURATY38_02115
NSTNstercoris_01532
NMUNmul_A0171
NLCEBAPG3_001890
NIZNNRS527_00136
DOEDENOEST_0186(rubB)
TBDTbd_2315
MFAMfla_2173
GCAGalf_2385
FAMOYT1_ch0139
SEMEMIZ01_0210
SDRSCD_n02163
SULFCAP31_00410
SPLBSFPGR_33950(alkT)
SNIVSFSGTM_00780
SLACSKTS_14210(rubB)
AIQAzoinq_07040
EBAebA2965(norW) ebA6036
ABREpbN1_18290 pbN1_36310(rubB)
APETToN1_01030(rubB) ToN1_24900
ATWC0099_01440
AOAdqs_2624
AZAAZKH_0051(norW) AZKH_2404(rubB)
AZIAzCIB_2199
ACOMCEW83_06500 CEW83_14970
AZDCDA09_00240 CDA09_07180
BPRCD521_1162
MEAMex_1p0921
MDIMETDI1722
MEXMext_1149
MCHMchl_1308
MPOMpop_4666
MZAB2G69_13015
MORMOC_5231
METAY590_04930
MPHYMCBMB27_04073
METXA3862_08585
HMCHYPMC_3983
SPSESULPSESMR1_04189(alkT)
MONG8E03_03690
NREBES08_26535
SPKCKC8_06485
SECHB18_09050
SBINSBA_ch2_0580
SYBTZ53_18270
SBDATN00_17680
SPHTK426_24049
SHYDCJD35_15685
SUFLFIL70_06640
SPHYCHN51_00400
BLASBSY18_2508
CMANA9D14_14625
ASZASN_3251
ATOCIW82_15195
MAGamb3427
MAGXXM1_4310(rubB)
MAGNWV31_00580
MAGQMGMAQ_0418(rubB)
MGMMmc1_3270
ECOGFIV45_05045 FIV45_16800
PARHI5S86_01510
CACCA_C2448
CAESMB_G2483
CAYCEA_G2462
CRWCROST_030910(nroR)
CFBCLFE_030830(nroR)
CAUNCLAUR_045420(nroR)
EELEUBELI_20024
 » show all
Reference
1  [PMID:4294330]
  Authors
Peterson JA, Kusunose M, Kusunose E, Coon MJ.
  Title
Enzymatic omega-oxidation. II. Function of rubredoxin as the electron carrier in omega-hydroxylation.
  Journal
J Biol Chem 242:4334-40 (1967)
Reference
2  [PMID:4335861]
  Authors
Enzymatic -oxidation. VI. Isolation of homogeneous reduced diphosphopyridine nucleotide-rubredoxin reductase.
  Title
J Biol Chem 247:2109-16 (1972)
Reference
3  [PMID:4403503]
  Authors
Ueda T, Coon MJ.
  Title
Enzymatic   oxidation. VII. Reduced diphosphopyridine nucleotide-rubredoxin reductase: properties and function as an electron carrier in   hydroxylation.
  Journal
J Biol Chem 247:5010-6 (1972)
Reference
4  [PMID:526302]
  Authors
Petitdemange H, Marczak R, Blusson H, Gay R.
  Title
Isolation and properties of reduced nicotinamide adenine dinucleotiderubredoxin oxidoreductase of Clostridium acetobutylicum.
  Journal
Biochem Biophys Res Commun 91:1258-65 (1979)
DOI:10.1016/0006-291X(79)91202-6
Other DBs
ExplorEnz - The Enzyme Database: 1.18.1.1
IUBMB Enzyme Nomenclature: 1.18.1.1
ExPASy - ENZYME nomenclature database: 1.18.1.1
BRENDA, the Enzyme Database: 1.18.1.1
CAS: 9032-27-3

DBGET integrated database retrieval system