KEGG   ENZYME: 1.2.1.103
Entry
EC 1.2.1.103                Enzyme                                 
Name
[amino-group carrier protein]-6-phospho-L-2-aminoadipate reductase;
lysY (gene name)
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
Sysname
[amino-group carrier protein]-C-terminal-[N-(1-carboxy-5-oxopentyl)-L-glutamine]:NADP+ 5-oxidoreductase (phosphorylating)
Reaction(IUBMB)
an [amino-group carrier protein]-C-terminal-[N-(1-carboxy-5-oxopentyl)-L-glutamine] + phosphate + NADP+ = an [amino-group carrier protein]-C-terminal-[N-(1-carboxy-5-phosphooxy-5-oxopentyl)-L-glutamine] + NADPH + H+ [RN:R09777]
Reaction(KEGG)
R09777
Substrate
[amino-group carrier protein]-C-terminal-[N-(1-carboxy-5-oxopentyl)-L-glutamine];
phosphate [CPD:C00009];
NADP+ [CPD:C00006]
Product
[amino-group carrier protein]-C-terminal-[N-(1-carboxy-5-phosphooxy-5-oxopentyl)-L-glutamine];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme participates in an L-lysine biosynthesis in certain species of archaea and bacteria.
History
EC 1.2.1.103 created 2019
Pathway
ec00300  Lysine biosynthesis
ec01100  Metabolic pathways
Orthology
K05829  LysW-gamma-L-alpha-aminoadipyl-6-phosphate/LysW-L-glutamyl-5-phosphate reductase
Genes
ENFAKI40_3666(argC1)
CARIFNU76_03415(argC)
ADEAdeh_0171
ACPA2cp1_0191
AFWAnae109_0180
ANKAnaeK_0180
MXAMXAN_5110(argC)
MSDMYSTI_01367 MYSTI_05599
MYMA176_001775
MFBMFUL124B02_07590 MFUL124B02_30545
CCXCOCOR_02066(argC) COCOR_02384(argC1)
MFULILAB_33480
MMASMYMAC_004992
SURSTAUR_5875(argC) STAUR_7165
AGEAA314_09030
AVMJQX13_05280(argC) JQX13_36440(argC)
MBDMEBOL_002073
CFUSCYFUS_008834
VINAKJ08_2701
CCROCMC5_013340(argC)
LLUAKJ09_08207
MRMA7982_11144
HOHHoch_4934
PMSKNP414_04936
PMQPM3016_4338
PMWB2K_22475
PIHUB51_14595
PSWUSY83_08900
GEKkuro4_23330(argC)
SGRSGR_3479
SSXSACTE_1738
SFASfla_0120
STRPF750_6904
SFISFUL_3351
SCIB446_19850(lysY)
SLCSL103_03075
SPRISPRI_3643
SCZABE83_19105
SCXAS200_22010
SRWTUE45_06897(argC_2)
SPAVSpa2297_32275
STRTA8713_31070
SALWCP975_34095(argC)
SLAUSLA_3044
SALJSMD11_6707(lysY)
STROSTRMOE7_34015
STIRDDW44_16560(argC)
SNKCP967_01835(argC) CP967_15200(argC)
SFICEIZ62_06085
SSPODDQ41_08070(argC)
SCAVCVT27_15445(argC)
SCYGS1361_31455(argC2)
SGJIAG43_00725(argC)
SDDD9753_06835(argC)
KABB7C62_16030
KITCFP65_3941
AGRAAGRA3207_003395(argC)
SESPBN6_56700
SSYIEKG83_30605
ASEACPL_7490(argC)
ACTSACWT_7360
PLKCIK06_18385(argC)
CAICaci_6304
NAVJQS30_10085(argC)
RRSRoseRS_1060
RCARcas_3468
CAUCaur_0335
CHLChy400_0360
CAGCagg_3596
HAUHaur_3307
TROtrd_1518(argC)
STISthe_0216
ATMANT_12400(argC)
PSUBPelsub_P1479
CAPCLDAP_41080(argC)
KBSEPA93_38765
THUGKNN16_06515(argC)
TTRTter_0319
PMETG4Y79_18400
DRADR_0963(argC)
DGEDgeo_0685
DDRDeide_10350
DMRDeima_1349
DGODGo_CA1602(argC)
DPDDeipe_2758
DSWQR90_11525
DCHSY84_01780
DABAUC44_08830
DPUSU48_07465
DEZDKM44_07625
DWUDVJ83_06415
DFCDFI_07605
DEINDAAJ005_07915
DGADEGR_14640(argC1)
DPHEHF33_04575
DRDLMT64_04455
TRATrad_1395
TTHTT_C1542
TTJTTHA1904(TTHA1904)
TTSThthe16_1906
TTLTtJL18_1988
TSCTSC_c01930(argC1)
THCTCCBUS3UF1_21020
TOSTheos_1932
TAQTO73_0099
TPARAV541_01265
TBCA0O31_00869(argC_1)
TANTKNN15_05135(argC)
MRBMrub_2723
MREK649_08920(argC)
MSVMesil_0436
MTAIMtai_v1c23220
OPROcepr_1788
MHDMarky_0667
UAMUABAM_02297
CTMCabther_B0218
CVLJ8C06_12705(argC)
CHLOJ8C02_13760(argC)
SCORJ3U87_02880
TAITaci_0448
TLITlie_1470
AMOAnamo_0989
CPORBED41_13055
RMRRmar_0948
RMGRhom172_1918
RBARAWN76_002230
MROMROS_0164
CABYCabys_3149(argC)
PFUPF1683
PFIPFC_10190(argC)
PHOPH1720(PH1720)
PABPAB0291(argC)
PYNPNA2_0328
PYSPy04_1635
TKOTK0277
THSTES1_0508
THVADU37_CDS10060
TCHCHITON_1978
HDLHALDL1_01650
HHBHhub_3649(argC)
HNOLT974_00085(argC)
HLULT972_14175(argC)
HJEHacjB3_00985(argC)
HALHHTSR_0665(argC)
HHSRHSR6_0691(argC)
HSUHLASF_2138(argC)
HSFHLASA_2172(argC)
SALRFQU85_04730
HALREFA46_004290
HARAAArcS_3062(argC)
HAADMW046_06600(argC)
HALXM0R89_05930(argC)
HMArrnAC2678(argC)
HHIHAH_3082(argC)
HHNHISP_15690
HABSG26_07785
HTABVU17_15000
HALJG9465_02500
HSINKDQ40_13800
NPHNP_5260A(argC)
NMONmlp_1242(argC)
NHOHWV23_08505
NSALHWV07_10860
HUTHuta_1501
HTIHTIA_1540
HALAHrd1104_12290
HMUHmuk_0773
HALZE5139_07050
HALLLC1Hm_3289(argC)
HAZPGBQ70_07045
HALIBV210_07080
HSNDV733_03390
HDSHSR122_1704(argC)
HRRHZS55_04380
HPELHZS54_04330
HLTI7X12_08370
HARCHARCEL1_01520
HDOMUK72_02360(argC)
HWAHQ_3715A(argC)
HWCHqrw_4130(argC)
HVOHVO_0045(argC)
HMEHFX_0045(argC)
HGIABY42_00215
HALEG3A49_00605
HBOHbor_01740
HAQDU484_03080
HAJDU500_03520
HAERDU502_01265
HRAEI982_12720
HLMDV707_00745
HALMFCF25_06930
HLAHlac_2615
HALPDOS48_13130
HALBEKH57_10850
HEZZEO776_15100
HALQHrr1229_007370
HSSJ7656_01820
HSAIHPS36_07355
HAZZKI388_13085(argC)
HAEhalTADL_1874
HALNB4589_001580
HALGHUG10_12790
HALUHUG12_02035
HMPK6T50_10110(argC)
HREK6T36_09875(argC)
HRMK6T25_06295(argC)
HACBHbl1158_01730(argC)
HDFAArcSl_0042(argC)
HAHHalar_1203
HTUHtur_0327
HDABB347_12545
HJTDVR14_08505
HALYHYG82_14940
HSALJMJ58_07540
HLOJ0X27_11125
HAKZJ0X25_08130(argC)
NMGNmag_1760(argC)
HXAHalxa_1379
NATNJ7G_0262
NPENatpe_3685
NVRFEJ81_17600
NPLFGF80_16425
NAYHYG81_11425(argC)
NGENatgr_1613
HRUHalru_0400
NOUNatoc_0149
SALIL593_07890(argC)
SAIMK0C01_05790(argC)
HLRHALLA_05495
HLCCHINAEXTREME04210
NAJB1756_08245
NAGAArcMg_3555
NANAArc1_3499
NBGDV706_07695
NASGCU68_05000
PTOPTO1472
FACFACI_IFERC01G1524
FAIFAD_0505(lysY)
CDIVCPM_0548
APEAPE_1462(lysY)
ACJACAM_0921
IHOIgni_0728
IISEYM_02375
IAGIgag_1754
PFMPyrfu_0758
PDLPyrde_1835
STOSTK_01950(argC_lysY)
SOHD1869_00450
SSOSSO0155(argC)
SOLSsol_1133
SSOASULA_1169
SSOLSULB_1170
SSOFSULC_1168
SSHIJ5U23_00109
SCASSACC_00680
SAISaci_0750(argC)
SACNSacN8_03645(argC)
SACRSacRon12I_03630(argC)
SACSSUSAZ_03360
SISLS215_2149
SIAM1425_1984
SIMM1627_2062
SIDM164_1990
SIYYG5714_2107
SINYN1551_0811
SIILD85_2245
SIHSiH_1928
SIRSiRe_1855
SICSiL_1837
SULABFU36_05160
SULEGFS03_10865
SULLEWF20_01890
MSEMsed_0164
MCNMcup_1909
MHKDFR87_05990
MPRUDFR88_05820
MTENGWK48_06270
MJNMjAS7_0747
AHOAhos_0883
AMANB6F84_08265
ABRIDFR85_06580
ASULDFR86_07280
AAMBD1866_12310
ACIHHS5_22580
SACDHS1genome_0844
SAZOD1868_01595
CSTYKN1_18170
STEPIC006_1902
PAIPAE2881
PISPisl_0276
PCLPcal_0373
PASPars_0966
PYRP186_1636
POGPogu_1380
TNETneu_1837
PYWPYWP30_01976
CMACmaq_1301
TTNTTX_0120(lysY_argC)
TUZTUZN_1285
VDIVdis_0193
VMOVMUT_1533
NMRNmar_1289
NIRNSED_07155(argC)
NKRNKOR_07275(argC)
NIDNPIRD3C_0835(argC)
NINNADRNF5_0667(argC)
NIWNisw_07285
NCLC5F47_06945
NOXC5F49_06955
NUEC5F50_09710
NIPNsoK4_01590
NCTNMSP_0399
NICDSQ20_07910
CSYCENSYa_1203
NGANgar_c29960(argC)
NVNNVIE_016490(argC)
NEVNTE_00734
TAANMY3_02222(argC2)
NFNNFRAN_2984(lysY)
NCVNCAV_1251(lysY)
CSUCSUB_C1303
NBVT478_1044(argC)
TAHSU86_009075
NIUDSQ19_03220
NDVNDEV_1624(argC)
CCAINAS2_0267
KCRKcr_0809
BARBAOA66_0020
 » show all
Reference
1  [PMID:10613839]
  Authors
Nishida H, Nishiyama M, Kobashi N, Kosuge T, Hoshino T, Yamane H.
  Title
A prokaryotic gene cluster involved in synthesis of lysine through the amino adipate pathway: a key to the evolution of amino acid biosynthesis.
  Journal
Genome Res 9:1175-83 (1999)
DOI:10.1101/gr.9.12.1175
Reference
2  [PMID:19620981]
  Authors
Horie A, Tomita T, Saiki A, Kono H, Taka H, Mineki R, Fujimura T, Nishiyama C, Kuzuyama T, Nishiyama M
  Title
Discovery of proteinaceous N-modification in lysine biosynthesis of Thermus thermophilus.
  Journal
Nat Chem Biol 5:673-9 (2009)
DOI:10.1038/nchembio.198
  Sequence
[tth:TT_C1542]
Reference
3  [PMID:26966182]
  Authors
Shimizu T, Tomita T, Kuzuyama T, Nishiyama M
  Title
Crystal Structure of the LysY.LysW Complex from Thermus thermophilus.
  Journal
J Biol Chem 291:9948-59 (2016)
DOI:10.1074/jbc.M115.707034
  Sequence
[tth:TT_C1542]
Other DBs
ExplorEnz - The Enzyme Database: 1.2.1.103
IUBMB Enzyme Nomenclature: 1.2.1.103
ExPASy - ENZYME nomenclature database: 1.2.1.103
BRENDA, the Enzyme Database: 1.2.1.103

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