KEGG   ENZYME: 1.2.1.106
Entry
EC 1.2.1.106                Enzyme                                 
Name
[amino-group carrier protein]-5-phospho-L-glutamate reductase;
lysY (gene name)
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
Sysname
[amino-group carrier protein]-C-terminal-gamma-(L-glutamate 5-semialdehyde-2-yl)-L-glutamate:NADP+ 5-oxidoreductase (phosphorylating)
Reaction(IUBMB)
an [amino-group carrier protein]-C-terminal-gamma-(L-glutamate 5-semialdehyde-2-yl)-L-glutamate + phosphate + NADP+ = an [amino-group carrier protein]-C-terminal-gamma-(5-phospho-L-glutamyl)-L-glutamate + NADPH + H+ [RN:R10931]
Reaction(KEGG)
R10931
Substrate
[amino-group carrier protein]-C-terminal-gamma-(L-glutamate 5-semialdehyde-2-yl)-L-glutamate [CPD:C20949];
phosphate [CPD:C00009];
NADP+ [CPD:C00006]
Product
[amino-group carrier protein]-C-terminal-gamma-(5-phospho-L-glutamyl)-L-glutamate [CPD:C20950];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme participates in an L-arginine biosynthesis pathway in certain species of archaea and bacteria. In some organisms the enzyme is bifunctional and also catalyses the activity of EC 1.2.1.103, [amino-group carrier protein]-6-phospho-L-2-aminoadipate reductase.
History
EC 1.2.1.106 created 2021
Pathway
ec00220  Arginine biosynthesis
ec01100  Metabolic pathways
Orthology
K05829  LysW-gamma-L-alpha-aminoadipyl-6-phosphate/LysW-L-glutamyl-5-phosphate reductase
Genes
ENFAKI40_3666(argC1)
CARIFNU76_03415(argC)
ADEAdeh_0171
ACPA2cp1_0191
AFWAnae109_0180
ANKAnaeK_0180
MXAMXAN_5110(argC)
MSDMYSTI_01367 MYSTI_05599
MYMA176_001775
MFBMFUL124B02_07590 MFUL124B02_30545
CCXCOCOR_02066(argC) COCOR_02384(argC1)
MFULILAB_33480
MMASMYMAC_004992
SURSTAUR_5875(argC) STAUR_7165
AGEAA314_09030
AVMJQX13_05280(argC) JQX13_36440(argC)
MBDMEBOL_002073
CFUSCYFUS_008834
VINAKJ08_2701
CCROCMC5_013340(argC)
LLUAKJ09_08207
MRMA7982_11144
HOHHoch_4934
PMSKNP414_04936
PMQPM3016_4338
PMWB2K_22475
PIHUB51_14595
PSWUSY83_08900
GEKkuro4_23330(argC)
SGRSGR_3479
SSXSACTE_1738
SFASfla_0120
STRPF750_6904
SFISFUL_3351
SCIB446_19850(lysY)
SLCSL103_03075
SPRISPRI_3643
SCZABE83_19105
SCXAS200_22010
SRWTUE45_06897(argC_2)
SPAVSpa2297_32275
STRTA8713_31070
SALWCP975_34095(argC)
SLAUSLA_3044
SALJSMD11_6707(lysY)
STROSTRMOE7_34015
STIRDDW44_16560(argC)
SNKCP967_01835(argC) CP967_15200(argC)
SFICEIZ62_06085
SSPODDQ41_08070(argC)
SCAVCVT27_15445(argC)
SCYGS1361_31455(argC2)
SGJIAG43_00725(argC)
SDDD9753_06835(argC)
KABB7C62_16030
KITCFP65_3941
AGRAAGRA3207_003395(argC)
SESPBN6_56700
SSYIEKG83_30605
ASEACPL_7490(argC)
ACTSACWT_7360
PLKCIK06_18385(argC)
CAICaci_6304
NAVJQS30_10085(argC)
RRSRoseRS_1060
RCARcas_3468
CAUCaur_0335
CHLChy400_0360
CAGCagg_3596
HAUHaur_3307
TROtrd_1518(argC)
STISthe_0216
ATMANT_12400(argC)
PSUBPelsub_P1479
CAPCLDAP_41080(argC)
KBSEPA93_38765
THUGKNN16_06515(argC)
TTRTter_0319
PMETG4Y79_18400
DRADR_0963(argC)
DGEDgeo_0685
DDRDeide_10350
DMRDeima_1349
DGODGo_CA1602(argC)
DPDDeipe_2758
DSWQR90_11525
DCHSY84_01780
DABAUC44_08830
DPUSU48_07465
DEZDKM44_07625
DWUDVJ83_06415
DFCDFI_07605
DEINDAAJ005_07915
DGADEGR_14640(argC1)
DPHEHF33_04575
DRDLMT64_04455
TRATrad_1395
TTHTT_C1542
TTJTTHA1904(TTHA1904)
TTSThthe16_1906
TTLTtJL18_1988
TSCTSC_c01930(argC1)
THCTCCBUS3UF1_21020
TOSTheos_1932
TAQTO73_0099
TPARAV541_01265
TBCA0O31_00869(argC_1)
TANTKNN15_05135(argC)
MRBMrub_2723
MREK649_08920(argC)
MSVMesil_0436
MTAIMtai_v1c23220
OPROcepr_1788
MHDMarky_0667
UAMUABAM_02297
CTMCabther_B0218
CVLJ8C06_12705(argC)
CHLOJ8C02_13760(argC)
SCORJ3U87_02880
TAITaci_0448
TLITlie_1470
AMOAnamo_0989
CPORBED41_13055
RMRRmar_0948
RMGRhom172_1918
RBARAWN76_002230
MROMROS_0164
CABYCabys_3149(argC)
PFUPF1683
PFIPFC_10190(argC)
PHOPH1720(PH1720)
PABPAB0291(argC)
PYNPNA2_0328
PYSPy04_1635
TKOTK0277
THSTES1_0508
THVADU37_CDS10060
TCHCHITON_1978
HDLHALDL1_01650
HHBHhub_3649(argC)
HNOLT974_00085(argC)
HLULT972_14175(argC)
HJEHacjB3_00985(argC)
HALHHTSR_0665(argC)
HHSRHSR6_0691(argC)
HSUHLASF_2138(argC)
HSFHLASA_2172(argC)
SALRFQU85_04730
HALREFA46_004290
HARAAArcS_3062(argC)
HAADMW046_06600(argC)
HALXM0R89_05930(argC)
HMArrnAC2678(argC)
HHIHAH_3082(argC)
HHNHISP_15690
HABSG26_07785
HTABVU17_15000
HALJG9465_02500
HSINKDQ40_13800
NPHNP_5260A(argC)
NMONmlp_1242(argC)
NHOHWV23_08505
NSALHWV07_10860
HUTHuta_1501
HTIHTIA_1540
HALAHrd1104_12290
HMUHmuk_0773
HALZE5139_07050
HALLLC1Hm_3289(argC)
HAZPGBQ70_07045
HALIBV210_07080
HSNDV733_03390
HDSHSR122_1704(argC)
HRRHZS55_04380
HPELHZS54_04330
HLTI7X12_08370
HARCHARCEL1_01520
HDOMUK72_02360(argC)
HWAHQ_3715A(argC)
HWCHqrw_4130(argC)
HVOHVO_0045(argC)
HMEHFX_0045(argC)
HGIABY42_00215
HALEG3A49_00605
HBOHbor_01740
HAQDU484_03080
HAJDU500_03520
HAERDU502_01265
HRAEI982_12720
HLMDV707_00745
HALMFCF25_06930
HLAHlac_2615
HALPDOS48_13130
HALBEKH57_10850
HEZZEO776_15100
HALQHrr1229_007370
HSSJ7656_01820
HSAIHPS36_07355
HAZZKI388_13085(argC)
HAEhalTADL_1874
HALNB4589_001580
HALGHUG10_12790
HALUHUG12_02035
HMPK6T50_10110(argC)
HREK6T36_09875(argC)
HRMK6T25_06295(argC)
HACBHbl1158_01730(argC)
HDFAArcSl_0042(argC)
HAHHalar_1203
HTUHtur_0327
HDABB347_12545
HJTDVR14_08505
HALYHYG82_14940
HSALJMJ58_07540
HLOJ0X27_11125
HAKZJ0X25_08130(argC)
NMGNmag_1760(argC)
HXAHalxa_1379
NATNJ7G_0262
NPENatpe_3685
NVRFEJ81_17600
NPLFGF80_16425
NAYHYG81_11425(argC)
NGENatgr_1613
HRUHalru_0400
NOUNatoc_0149
SALIL593_07890(argC)
SAIMK0C01_05790(argC)
HLRHALLA_05495
HLCCHINAEXTREME04210
NAJB1756_08245
NAGAArcMg_3555
NANAArc1_3499
NBGDV706_07695
NASGCU68_05000
PTOPTO1472
FACFACI_IFERC01G1524
FAIFAD_0505(lysY)
CDIVCPM_0548
APEAPE_1462(lysY)
ACJACAM_0921
IHOIgni_0728
IISEYM_02375
IAGIgag_1754
PFMPyrfu_0758
PDLPyrde_1835
STOSTK_01950(argC_lysY)
SOHD1869_00450
SSOSSO0155(argC)
SOLSsol_1133
SSOASULA_1169
SSOLSULB_1170
SSOFSULC_1168
SSHIJ5U23_00109
SCASSACC_00680
SAISaci_0750(argC)
SACNSacN8_03645(argC)
SACRSacRon12I_03630(argC)
SACSSUSAZ_03360
SISLS215_2149
SIAM1425_1984
SIMM1627_2062
SIDM164_1990
SIYYG5714_2107
SINYN1551_0811
SIILD85_2245
SIHSiH_1928
SIRSiRe_1855
SICSiL_1837
SULABFU36_05160
SULEGFS03_10865
SULLEWF20_01890
MSEMsed_0164
MCNMcup_1909
MHKDFR87_05990
MPRUDFR88_05820
MTENGWK48_06270
MJNMjAS7_0747
AHOAhos_0883
AMANB6F84_08265
ABRIDFR85_06580
ASULDFR86_07280
AAMBD1866_12310
ACIHHS5_22580
SACDHS1genome_0844
SAZOD1868_01595
CSTYKN1_18170
STEPIC006_1902
PAIPAE2881
PISPisl_0276
PCLPcal_0373
PASPars_0966
PYRP186_1636
POGPogu_1380
TNETneu_1837
PYWPYWP30_01976
CMACmaq_1301
TTNTTX_0120(lysY_argC)
TUZTUZN_1285
VDIVdis_0193
VMOVMUT_1533
NMRNmar_1289
NIRNSED_07155(argC)
NKRNKOR_07275(argC)
NIDNPIRD3C_0835(argC)
NINNADRNF5_0667(argC)
NIWNisw_07285
NCLC5F47_06945
NOXC5F49_06955
NUEC5F50_09710
NIPNsoK4_01590
NCTNMSP_0399
NICDSQ20_07910
CSYCENSYa_1203
NGANgar_c29960(argC)
NVNNVIE_016490(argC)
NEVNTE_00734
TAANMY3_02222(argC2)
NFNNFRAN_2984(lysY)
NCVNCAV_1251(lysY)
CSUCSUB_C1303
NBVT478_1044(argC)
TAHSU86_009075
NIUDSQ19_03220
NDVNDEV_1624(argC)
CCAINAS2_0267
KCRKcr_0809
BARBAOA66_0020
 » show all
Reference
1  [PMID:23434852]
  Authors
Ouchi T, Tomita T, Horie A, Yoshida A, Takahashi K, Nishida H, Lassak K, Taka H, Mineki R, Fujimura T, Kosono S, Nishiyama C, Masui R, Kuramitsu S, Albers SV, Kuzuyama T, Nishiyama M
  Title
Lysine and arginine biosyntheses mediated by a common carrier protein in Sulfolobus.
  Journal
Nat Chem Biol 9:277-83 (2013)
DOI:10.1038/nchembio.1200
  Sequence
[sai:Saci_0750]
Reference
2  [PMID:27566549]
  Authors
Yoshida A, Tomita T, Atomi H, Kuzuyama T, Nishiyama M
  Title
Lysine Biosynthesis of Thermococcus kodakarensis with the Capacity to Function as an Ornithine Biosynthetic System.
  Journal
J Biol Chem 291:21630-21643 (2016)
DOI:10.1074/jbc.M116.743021
  Sequence
[tko:TK0277]
Other DBs
ExplorEnz - The Enzyme Database: 1.2.1.106
IUBMB Enzyme Nomenclature: 1.2.1.106
ExPASy - ENZYME nomenclature database: 1.2.1.106
BRENDA, the Enzyme Database: 1.2.1.106

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