KEGG   ENZYME: 1.2.1.107
Entry
EC 1.2.1.107                Enzyme                                 

Name
glyceraldehyde-3-phosphate dehydrogenase (arsenate-transferring)
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
Sysname
D-glyceraldehyde-3-phosphate:NAD+ oxidoreductase (arsenate-transferring)
Reaction(IUBMB)
D-glyceraldehyde 3-phosphate + arsenate + NAD+ = 1-arsono-3-phospho-D-glycerate + NADH + H+ [RN:R12785]
Reaction(KEGG)
R12785
Substrate
D-glyceraldehyde 3-phosphate [CPD:C00118];
arsenate [CPD:C11215];
NAD+ [CPD:C00003]
Product
1-arsono-3-phospho-D-glycerate [CPD:C22393];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme, discovered in bacteria, is very similar to EC 1.2.1.12, glyceraldehyde-3-phosphate dehydrogenase (phosphorylating). However, the gene encoding it is located in arsenic resistance islands in the chromosome, next to a gene (arsJ) that encodes a transporter that removes the product, 1-arsono-3-phosphoglycerate, from the cell. Together the two proteins form an arsenic detoxification system.
History
EC 1.2.1.107 created 2021
Orthology
K25224  glyceraldehyde-3-phosphate dehydrogenase (arsenate-transferring)
Genes
PMEX: H4W19_14340
LYJ: FKV23_06175
VCH: VC_1069
VCF: IR04_10685
VCS: MS6_0861
VCE: Vch1786_I0573(gap)
VCQ: EN18_08680
VCJ: VCD_003271
VCI: O3Y_04975
VCO: VC0395_A0587(gap)
VCR: VC395_1084(gap)
VCM: VCM66_1025(gap)
VCX: VAA049_2667(gap)
VCZ: VAB027_1753(gap)
VVU: VV1_1141(gap)
VVY: VV0100
VPA: VP2970
VPB: VPBB_2807
VAG: N646_2065
VDB: AL552_23895(gap)
VHR: AL538_09055(gap)
VSP: VS_3033
VNI: VIBNI_A3753(gap3)
VAN: VAA_00950
VFL: AL536_20840(gap)
VMI: AL543_14595(gap)
VSC: VSVS12_00027(gapA)
VQI: CCZ37_14565(gap)
VTA: A3390(gap)
VAQ: FIV01_13870(gap1)
VFI: VF_2360(gapA2)
VFM: VFMJ11_2481(gap_2)
VSA: VSAL_I2818(gap)
AWD: AWOD_I_0238(gap)
PPR: PBPRA2208(PRO1577)
GHO: AL542_02630(gap)
PMY: Pmen_1522
PRE: PCA10_35760(gap)
PPSE: BN5_2711
PPI: YSA_00655
PPUH: B479_11705
PPUT: L483_15980(gapA)
PPUD: DW66_2537
PMON: X969_09735
PMOT: X970_09395
PMAN: OU5_5709
PSA: PST_2100
PSTT: CH92_11005
PKC: PKB_2804(gap3)
PSEM: TO66_30585
PSET: THL1_2592
PALL: UYA_22530
AVN: Avin_25890(gapA)
AVL: AvCA_25890(gapA)
AVD: AvCA6_25890(gapA)
ACX: Achr_21250(gapA)
MAQ: Maqu_3637
MHC: MARHY3543(gapA)
MAD: HP15_3399
MARJ: MARI_30250(gap3)
SON: SO_0538(gapA)
SDN: Sden_3551
SFR: Sfri_4002
SAZ: Sama_0494
SBL: Sbal_0494
SLO: Shew_0419
SSE: Ssed_0576
SPL: Spea_3736
SHL: Shal_3821
SWD: Swoo_4385
SWP: swp_0526
SVO: SVI_0320(gapA-1)
SPSW: Sps_05321
SBJ: CF168_18175(gap)
SMAV: CFF01_02060(gap)
SHEW: CKQ84_05925(gap)
SBK: SHEWBE_0970(gap)
SKH: STH12_03076(gap3)
SCAA: TUM17387_05290(gapA_1)
ILO: IL2126
IPI: CEW91_02520(gap)
IDI: CWC33_08020(gap)
CPS: CPS_3355(gap3)
CBER: B5D82_14455(gap)
PHA: PSHAb0182(gapB)
PTN: PTRA_b0254(gapA)
PSM: PSM_B0195(gapB)
PSEO: OM33_14525
PPIS: B1L02_19625(gap)
PEA: PESP_b0312(gapA)
PSPO: PSPO_a2458(gapA)
PART: PARC_b0223(gapA)
PTU: PTUN_a0478(gapA)
PNG: PNIG_b0268(gapA)
PTD: PTET_a2754(gapA) PTET_b0264(gapA)
PSEN: PNC201_18440(gap3)
PAGA: PAGA_b0289(gapA)
PIN: Ping_3636
FBL: Fbal_0390
MVS: MVIS_2897
MYA: MORIYA_1495(gap)
SAGA: M5M_16345
MICC: AUP74_02497(gap3)
MICT: FIU95_10310(gap2)
HTR: EPV75_10325(gap)
HMAR: HVMH_1993(gapA)
MEJ: Q7A_2139(gap)
MEC: Q7C_2108
CYQ: Q91_1343
CZA: CYCME_1125(gapA)
CYY: CPC19_06105(gap)
TEE: Tel_01685
THIP: N838_06715
TGR: Tgr7_1924
TKM: TK90_1347
TVR: TVD_05450
GAI: IMCC3135_14690(gap3)
HCH: HCH_04653(gap4)
CSA: Csal_1482
HEL: HELO_2131(gapA2)
HAM: HALO1895
HCO: LOKO_02572(gap3)
HHH: CLM76_12940(gap)
HBE: BEI_2262
HALK: CUU95_17825(gap)
HOL: HORIV_43390(gapA)
HMD: CTT34_06715(gap)
HAXI: HAALTHF_44610n(gapA)
KAK: Kalk_16070(gap)
MGEO: CFI10_07020(gap)
AMED: B224_4163
OCE: GU3_02295
KGE: TQ33_1171
TBN: TBH_C1974
IFL: C1H71_10990(gap)
BOZ: DBV39_18050(gap)
OTK: C6570_08720(gap)
LIH: L63ED372_02115(gap3)
HYR: BSY239_1570(gap)
MPT: Mpe_A1586(gapA)
SNIV: SFSGTM_17030(gapA_1)
ABAW: D5400_02215(gap)
RPB: RPB_1642
XAU: Xaut_3960
SNO: Snov_1293
CSE: Cseg_2582
SIL: SPO3878(gap-4)
RUA: D1823_15265(gap)
RUT: FIU92_15955(gap2)
RDE: RD1_2398(gap)
RLI: RLO149_c016870(gapA2)
DSH: Dshi_1254
OAT: OAN307_c26680(gapA1)
OAR: OA238_c39200(gapA1)
OTM: OSB_25320(gap3)
CID: P73_3782
CEH: CEW89_18775(gap)
MALG: MALG_02770
YPAC: CEW88_05290(gap)
SPSE: SULPSESMR1_03895(gap3)
SULI: C1J05_17385(gap)
RMM: ROSMUCSMR3_03688(gap3)
ROH: FIU89_01470(gap3)
SAGU: CDO87_17825(gap)
MARU: FIU81_06485(gap3)
ROT: FIV09_03305(gap1)
MALU: KU6B_33300(gapA-1)
RSP: RSP_4211(gapA-1)
RCP: RCAP_rcc02071(gap2) RCAP_rcp00086(gap4)
PYE: A6J80_11150(gap)
PZH: CX676_16540(gap)
PARS: DRW48_14855(gap)
PARR: EOJ32_12445(gap)
PMAU: CP157_01235(gap3)
RHC: RGUI_1997
LVS: LOKVESSMR4R_01967(gap3)
RBG: BG454_04280(gap)
GEH: HYN69_14375(gap)
TAW: EI545_16715(gap)
PALW: PSAL_035130(gap3)
SHUM: STHU_01220
TMO: TMO_a0483(gap3)
TXI: TH3_01475
TII: DY252_20165(gap)
MAGQ: MGMAQ_0092(gap)
MGM: Mmc1_2970
SYC: syc2155_c(gap1)
SYR: SynRCC307_0428(gap3)
SYX: SynWH7803_1460(gap3)
CYA: CYA_2179(gap-3)
CYB: CYB_2306(gap-3)
SYNR: KR49_04380
SYND: KR52_07105
SYH: Syncc8109_0834(gap3)
SYNW: SynWH8103_00910(gap3)
SYW: SYNW0799(gap3)
CYI: CBM981_1542(gap)
PMA: Pro_1577(gap3)
PMM: PMM0713(gap1)
PMT: PMT_1000
PMF: P9303_11051(gap3)
PMG: P9301_12361(gap3)
PME: NATL1_11571(gap3)
PRC: EW14_1292
THN: NK55_06405(gap)
LET: O77CONTIG1_03975(gap3)
LBO: LBWT_7080
PSER: ABRG53_3495(gap3)
CYL: AA637_12150(gapA)
TER: Tery_3274
ANA: alr1095(gap3)
NOE: CLI64_20610(gap)
NSH: GXM_05961
AVA: Ava_3715
ANB: ANA_C13129(gap)
CALH: IJ00_10890
NSP: BMF81_03610(gapA)
DOU: BMF77_03708(gap3)
CTHE: Chro_2847
RCA: Rcas_2314
CAU: Caur_0010
CAG: Cagg_3678
HAU: Haur_3331
OBG: Verru16b_00790(gap3)
VBH: CMV30_05700(gap)
 » show all
Reference
1  [PMID:26991003]
  Authors
Chen J, Yoshinaga M, Garbinski LD, Rosen BP.
  Title
Synergistic interaction of glyceraldehydes-3-phosphate dehydrogenase and ArsJ, a novel organoarsenical efflux permease, confers arsenate resistance.
  Journal
Mol Microbiol 100:945-53 (2016)
DOI:10.1111/mmi.13371
  Sequence
Reference
2  [PMID:29717010]
  Authors
Wu S, Wang L, Gan R, Tong T, Bian H, Li Z, Du S, Deng Z, Chen S
  Title
Signature Arsenic Detoxification Pathways in Halomonas sp. Strain GFAJ-1.
  Journal
mBio 9:e00515-18 (2018)
DOI:10.1128/mBio.00515-18
Other DBs
ExplorEnz - The Enzyme Database: 1.2.1.107
IUBMB Enzyme Nomenclature: 1.2.1.107
ExPASy - ENZYME nomenclature database: 1.2.1.107
BRENDA, the Enzyme Database: 1.2.1.107

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