carboxylate reductase (NADP+);
aromatic acid reductase;
aryl-aldehyde dehydrogenase (NADP+)
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
aryl-aldehyde:NADP+ oxidoreductase (ATP-forming)
an aromatic aldehyde + NADP+ + AMP + diphosphate = an aromatic acid + NADPH + H+ + ATP [RN:
The enzyme contains an adenylation domain, a phosphopantetheinyl binding domain, and a reductase domain, and requires activation by attachment of a phosphopantetheinyl group. The enzyme activates its substrate to an adenylate form, followed by a transfer to the phosphopantetheinyl binding domain. The resulting thioester is subsequently transferred to the reductase domain, where it is reduced to an aldehyde and released.
EC 126.96.36.199 created 1972, modified 2019
Gross GG, Zenk MH.
[Reduction of aromatic acids to aldehydes and alcohols in the cell-free system. 1. Purification and properties of aryl-aldehyde: NADP-oxidoreductase from Neurospora crassa]
Formation and reduction of intermediate acyladenylate by aryl-aldehyde. NADP oxidoreductase from Neurospora crassa.
Venkitasubramanian P, Daniels L, Rosazza JP
Reduction of carboxylic acids by Nocardia aldehyde oxidoreductase requires a phosphopantetheinylated enzyme.
Stolterfoht H, Schwendenwein D, Sensen CW, Rudroff F, Winkler M
Four distinct types of E.C. 188.8.131.52 enzymes can catalyze the reduction of carboxylic acids to aldehydes.
ExplorEnz - The Enzyme Database: 184.108.40.206
ExPASy - ENZYME nomenclature database: 220.127.116.11