KEGG   ENZYME: 1.2.1.85
Entry
EC 1.2.1.85                 Enzyme                                 
Name
2-hydroxymuconate-6-semialdehyde dehydrogenase;
xylG (gene name);
praB (gene name)
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
Sysname
2-hydroxymuconate-6-semialdehyde:NAD+ oxidoreductase
Reaction(IUBMB)
2-hydroxymuconate-6-semialdehyde + NAD+ + H2O = (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + NADH + 2 H+ [RN:R02762]
Reaction(KEGG)
R02762;
(other) R05353
Substrate
2-hydroxymuconate-6-semialdehyde [CPD:C00682];
NAD+ [CPD:C00003];
H2O [CPD:C00001]
Product
(2Z,4E)-2-hydroxyhexa-2,4-dienedioate;
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
This substrate for this enzyme is formed by meta ring cleavage of catechol (EC 1.13.11.2, catechol 2,3-dioxygenase), and is an intermediate in the bacterial degradation of several aromatic compounds. Has lower activity with benzaldehyde [1]. Activity with NAD+ is more than 10-fold higher than with NADP+ [3]. cf. EC 1.2.1.32, aminomuconate-semialdehyde dehydrogenase.
History
EC 1.2.1.85 created 2012
Pathway
ec00362  Benzoate degradation
ec00622  Xylene degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K10217  aminomuconate-semialdehyde/2-hydroxymuconate-6-semialdehyde dehydrogenase
Genes
PGELG71_12245
SLQM495_05225
PSDDSC_09155
PMEXH4W19_03340
PJPLAG73_06440
LABLA76x_2548(aldH8A1)
LAQGLA29479_1093
LCPLC55x_2794(aldH8A1)
LGULG3211_2666(aldh8a1)
LEZGLE_2672
LEMLEN_2363
LMBC9I47_1501
LYTDWG18_05815
LUEDCD74_03960
LYJFKV23_07545
LSOLGOY17_11460
LSXH8B22_00640
LAREHIV01_004055
LHXLYSHEL_29980(hpaE)
LCASLYSCAS_29950(hpaE)
LCICINQ41_07790
LAVIINQ42_07225
LUMCNR27_08240
LUSE5843_08240
LUGFPZ22_13395
THESFHQ07_01245
THEHG7079_08025
TCNH9L16_12765
TBVH9L17_01795
XBCELE36_12500
RHDR2APBS1_1171
RGLCS053_06000
RTHLRK53_07370 LRK53_10265
DJICH75_03340
DJAHY57_09330
DYEEO087_08395
DCSISN74_04660
DTLH8F01_15810
DKOI596_481
LRZBJI69_00885
LPYFIV34_14505
XBAC7S18_00575
RBDALSL_0880
PPSEBN5_3621(xylG)
PFUWKF707C_15540(bzaD) KF707C_16090(salD)
PCQPcP3B5_23470(amnC)
PPWPputW619_2012
PPIND088(nahI)
PPJRK21_04239
PVRPverR02_14685
PSCA458_06530
PSTUUIB01_22730
PBMCL52_14700
PKCPKB_3261(amnc1) PKB_3609(amnc3)
PALKPSAKL28_05930
PSOSPOS17_2264
PFKPFAS1_28785
PSETTHL1_493
PALLUYA_06710 UYA_06990 UYA_20165
PSEPC4K39_5740
PTRTHU722_0014995
PPHABVH74_06145
PTAENCTC10697_02312(amnC)
AVNAvin_08730(xylG) Avin_30620(lapC)
AVLAvCA_08730(xylG) AvCA_30620(lapC)
AVDAvCA6_08730(xylG) AvCA6_30620(lapC)
ACXAchr_32710(xylG)
PAGRE2H98_06030
HPEGEAO82_00565 EAO82_09415
HAESLO767_17660
MADHP15_1111(betB) HP15_4032(betB)
MSRAU15_09320 AU15_22425
MLQASQ50_09225
MSQBKP64_13860
MARJMARI_05430(xylG)
SWDSwoo_1410
SEURFM038_016485
COZA3Q34_02635
COLWA3Q33_02670
COVEKO29_05100
CBERB5D82_03525
THTE2K93_11185
LALAT746_01255
SALHHMF8227_02739(dmpC)
AFUSEYZ66_02610 EYZ66_02675
MMAIsS8_3506
CYQQ91_0507(xylG) Q91_1784(lapC)
CZACYCME_0670 CYCME_2104
CYYCPC19_03895 CPC19_10520
BLEPAL038_01305
THISHZT40_10600
WMAWM2015_1463
HCSFF32_08345
HALKCUU95_03835
HVNEI420_02095
APACS7S_06985
MGEOCFI10_04950
MSECLN244_11335
NCUF0U83_03040
NJPNEJAP_0670
NIKF5I99_10115 F5I99_10525
AJPAMJAP_3000(dmpC)
ASIMFE240_03495
ZDFAN401_14590
KKOKkor_0387
KGETQ33_1983
KSDKS2013_2033
KPDCW740_01675
SINIGT972_13720
GBIPG2T_02235
TBNTBH_C0927
NZOSAMEA4504057_0449(aldA_1)
NCINCTC10296_00912(aldA_2)
NWDH3L96_04750
NDULVJ88_00605
VFFVITFI_CDS1391
PTESJQU52_04875
USULVJ78_03675
CHROCXB49_03835
CRZD1345_11535
CHAECH06BL_23640
AQLBXU06_16865
AQSDKK66_07230
RSORSp0890(dmpC)
RSMCMR15_mp10874
RSEF504_4327
RPIRpic_4622
RPFRpic12D_3546
RPJN234_08145(gabD) N234_12220
RINACS15_4686
RPUCDC45_22065
REHH16_B0547(h16_B0547)
CNCCNE_2c04930(dmpC) CNE_BB1p12000(dmpC1) CNE_BB1p13290(dmpC2)
REUReut_B5498 Reut_B5689
RMERmet_1322(dmpC) Rmet_5206(amnC)
CBWRR42_m1056 RR42_s2485
CCUPBKK81_23305 BKK81_27085
CUPBKK80_29235 BKK80_33010
CUUBKK79_23895 BKK79_35185
COXE0W60_03770 E0W60_07770
BVIBcep1808_7602
BURBcep18194_B2962 Bcep18194_C7647
BCJBCAM2132(nbaE)
BCENDM39_4835
BCEOI35_6014(nbaE)
BMULNP80_3862
BCTGEM_5404
BCEDDM42_4994
BCONNL30_24605
BDFWI26_15980
BTEIWS51_00555
BPSLWS57_12170
BSTLBBJ41_10505 BBJ41_33975
BANNJFN94_19120
BUGBC1001_3834
BUQAC233_11200
BXEBxe_A1147(amnC)
BXBDR64_3306
BPXBUPH_00408
BPYBphyt_1465
BFNOI25_258
PARBCJU94_37865 CJU94_38110
PTERC2L65_38870
BRHRBRH_03003
PPKU875_01905 U875_06935 U875_20575
PPNODA70_13265 DA70_24010
PPNMLV28_06695 LV28_17435
PRBX636_02635 X636_07565 X636_13600
PPULRO07_00735 RO07_11540
PSPUNA29_07455 NA29_10890
PAPISG18_00950 SG18_11865
PVEUC34_03315 UC34_17030
POXMB84_07750 MB84_21810
PFGAB870_04075 AB870_14465
PNRAT302_11495 AT302_15075
PANDDRB87_15740
PFIBPI93_002965 PI93_010955
LIMNHKT17_03810
BAVBAV0552(amnC)
BHZACR54_00824(amnC_1)
BOJCBF45_01495 CBF45_04520 CBF45_17005
AXYAXYL_02527 AXYL_05539
AXONH44784_030391
AXNAX27061_5279
AXXERS451415_05308(amnC)
ADTAPT56_24280
AISBUW96_02880 BUW96_16325
ASWCVS48_11355
ACHRC2U31_27050
ACHBDVB37_23455
ADYHLG70_11220 HLG70_26345
PUTPT7_3613
PUDG9Q38_13475
CDNBN940_01146 BN940_04321
PIGEGT29_02070 EGT29_19220 EGT29_19355
KGYEHF36_01680 EHF36_16945
PARKLSG25_19445
POLBpro_5132
AJSAjs_0220
AAAAcav_3012
ACIDCBP33_01090
ACIPCBP36_01190
ACINCBP34_01100
ACISCBP35_17760
VEIVeis_2787
VPDVAPA_1c22810
VBOCKY39_28515
CTTCtCNB1_3151
COFFOZ74_08295
ADNAlide_0335
ADKAlide2_0280
OTDJ1M35_00060
HYLLPB072_18170
HPSEHPF_01880(xylG1)
HYNF9K07_02745
HTNKI616_01975
DIHG7047_01680 G7047_06960
DRGH9K76_11635 H9K76_22935
SIMPC6571_13610
MELAC6568_07865
MJELVC68_00995
STHMIS481_10520
MPTMpe_A2275 Mpe_A3326
METPC1M51_06465 C1M51_15410
JAGGJA_237
HEEhmeg3_19545
LCHLcho_3354
SNNEWH46_19330
IDCLRM40_19560
RBUPG1C_09710
DARDaro_2775 Daro_3787 Daro_3806
DEYHYN24_14135 HYN24_14225
FLEKI610_08570 KI610_13415 KI610_15475
AZOazo1852(lapC) azo2435(nahI)
AOAdqs_2005 dqs_2579
AZDCDA09_10315 CDA09_10435
AZRCJ010_12245 CJ010_15225
TMZTmz1t_3092
THUAC731_001805
THKCCZ27_10700 CCZ27_10775 CCZ27_16270
AZQG3580_00530 G3580_08260
ACIBACBT_0262(dmpC)
AFCAFAEC_1847(dmpC)
AAQIAAQM_0979(dmpC)
ACLOACLO_a0142(dmpC)
ADZADFLV_2554(dmpC)
ALKALEK_0380(dmpC)
AANAAANAER_1257(dmpC)
ARCABLL_2445
MXAMXAN_0921
MSDMYSTI_00939
MYMA176_006058
MFBMFUL124B02_05280
CCXCOCOR_00871(amnC)
MFULILAB_04105
MMASMYMAC_000943
SURSTAUR_2723
AGEAA314_01332
AVMJQX13_18945
MBDMEBOL_007655
PCAYFRD00_12790
BBAEFRD01_09595
PLAPlav_1786
ARAArad_7263(betB)
BSEPHAP48_0048685
BOIBLM15_28155
XDIEZH22_00770
MSLMsil_1476
MTUNMTUNDRAET4_3895(dmpC)
CHELAL346_10040
MAADAZF01_08290
MLUTJET14_11050
PSTGE8M01_24785
JANJann_3775
OCTFTO60_10575
CEHCEW89_11430
OCDFHY55_16240
TECAKL02_008250
CACTHZ995_11525
THASC6Y53_10940
GAKX907_0751
NARSaro_3855
NPPPP1Y_AT15685 PP1Y_AT31595
NPNJI59_24625
NOTC7W88_16330
NOGGKE62_05100
SMAGAN936_00735
SMAZLH19_00745
STERAOA14_03900
SGISGRAN_3552(amnC)
SPHOC3E99_12575
SWISwit_3519
SPHDHY78_06685
SPKCKC8_11570
SJPSJA_C1-11860(hpaE_xylG)
SINBSIDU_08335
SYBTZ53_09005 TZ53_23450
SHYDCJD35_06485
SUFLFIL70_19010
SBARH5V43_20660 H5V43_22325
SPPHKFK14_16495
SPHYCHN51_06960
SPHJBSL82_10460
CNAAB433_18135
ERYCP97_14215
KSCCD178_01493(amnC)
NCBC0V82_23395
TMOTMO_b0431(dmpC)
HTQFRZ44_17510(hpcC)
HADHFRZ61_29630
MAGQMGMAQ_0648
BBATBdt_0556
BBACEP01_17230
BDQCIK05_11245
BDCDOE51_02900
BDZDOM22_02555
HTLHPTL_0058
BLIBL03906
BLDBLi03994(dmpC)
BLHBaLi_c40080
BSONS101395_00391(dmpC)
BCABCE_2154
BCXBCA_2152
BCFbcf_10200
BCERBCK_24235
BCEFBcrFT9_01687
BTLBALH_1841
BMYCDJ92_4635
BTROFJR70_09235
BNTGSN03_10135
BACIB1NLA3E_08450 B1NLA3E_09290
GSTHW35_13035
BACOOXB_2507
BSMBSM4216_0945
BGYBGLY_4398
BACQDOE78_09215
BFDNCTC4823_00790(aldA)
BHKB4U37_13950
BMQBMQ_3590
BMDBMD_3575
BMEGBG04_464
BPFBpOF4_12595
OCNCUC15_03665
OCBCV093_03765
GTNGTNG_3154(nbaE)
GYCGYMC61_2295
GYAGYMC52_1423
GCTGC56T3_2058
GMCGY4MC1_1599
GGHGHH_c14810(dmpC)
GJFM493_17930
GZAIC807_03350
GTHGeoth_1682
PTLAOT13_14425
PCALBV455_00224(xylG)
ASEDIRT44_17635
LGYT479_19630
LYBC3943_22660
LYZDCE79_01740
LPAKGDS87_20215
VIGBKP57_09395
LAOAOX59_17235
FPNABE65_004725
FARABE41_004870
APAKAP3564_06575
BSJUP17_10510
PASABAOM_0496(dmpC)
PFRIL8956_11375
RUEDT065_12705 DT065_13775 DT065_15100 DT065_15220
SALEEPH95_15025
NTMBTDUT50_14565
AIAAWH56_018035
BOUI5818_04785
HYIK2M58_09720
GAJMY490_08555
BBEBBR47_29750(dhaS)
BFMBP422_09705
PNPIJ22_00660
ANXACH33_11720
ASOCCB4_02007(amnC_1) CB4_02455(xylG)
ATHEK3F53_07220
COHEAV92_02590
AACAaci_1622
AADTC41_1518(hpaE)
AACOK1I37_06145
BTSBtus_0966
KYRCVV65_10360 CVV65_11305
EFFskT53_33740
SOBCSE16_14645
SPAEE2C16_04445 E2C16_12265
SPOOJ3U78_11190
TMRTmar_1783
SAYTPY_0646(hpaE)
SAPSulac_2993
LPILLIP_2170
MITOCO_14810
MIAOCU_15250
MMANMMAN_42260
MJLMjls_4206
MGOAFA91_00050
MHEVMHEL_01580
CEECENDO_03495(amnC)
NFANFA_30520
NFRERS450000_01013(xylG)
NNONONO_c62070
NTPCRH09_30210
RHARHA1_ro03868
RERRER_04700 RER_59330 RER_59420
REYO5Y_02260
REBXU06_02460
RQIC1M55_02645
ROPROP_37370 ROP_54040
REQREQ_05040(amnC)
RPYY013_12510
RBYCEJ39_23380
RAVAAT18_08160
RRZCS378_23180
RHQIM25_04135
RHODAOT96_13010
RRT4535765_01258(amnC_1) 4535765_01264(amnC_2)
RKOJWS14_41345
RGOKYT97_21975
GBRGbro_0237
GTABCM27_21885
GOCCXX93_11290
GOILK459_10080
GHNMVF96_20940
DIZCT688_01910
TOYFO059_00300
SCBSCAB_15221(amnC)
SSXSACTE_4117
SRCM271_42595
SBHSBI_01538
STRTA8713_24460
SGSAVL59_13460
STSIA4E84_37260
SLSSLINC_8207
SVUB1H20_29100
SGEDWG14_08254(amnC)
SLKSLUN_38545
SCYAEJ357_37720
SNKCP967_06825
SAQUEJC51_43200
SSUBCP968_28075
SFEUIM697_27560
SCALI6J39_28950
SROIIAG44_01300 IAG44_38980
STRYEQG64_09015
SGOBtest1122_23010
SINEKI385_15820
SLFJEQ17_41615
KITCFP65_1239
YIALO772_34525
RPLAA4Z71_05995
MVDAWU67_16670
AGYATC03_02600
AMAUDSM26151_04210(amnC_1)
ASOIMTP13_01900
AMINAUMI_10070
AUMAURMO_01499
AUWAURUGA1_01411(betB_2)
SALAESZ53_13890
LTREVS81_03275
GLNF1C58_04490
ARZAUT26_08855
ACITHPK19_02415
DNIHX89_01500
DAYFV141_00665
XYLET495_01770
ICAIntca_1091
JTEASJ30_00120
JLIEXU32_15345
JMEEEW87_015430
PHWG7075_13150
PEIH9L10_13730
AUSIPK37_11700
RAINRai3103_12630
NAROCFH99_04920
KFLKfla_5493
KQIF1D05_11675
TCUTcur_0539
ACTWF7P10_40020
AGRAAGRA3207_000781 AGRA3207_001815
SROSros_7502 Sros_9116
NOABKM31_47335
NOWGBF35_49965
NCXNocox_25070(amnC1) Nocox_40770(amnC2)
NGNLCN96_27995 LCN96_28035 LCN96_54785
FRIFraEuI1c_1246
ACEAcel_1100
AMYCCU254_17660
AACDLWP59_38190
PDXPsed_2510
PBROHOP40_31850
KALKALB_2083
KPHYAOZ06_35745
ALOCRK56596
STPStrop_3528
SAQSare_3903
MAUMicau_4941
MILML5_3354
MICBMicB006_3973
MTUACSH63_33385
MTEMGCE86_19400
MCABHXZ27_25050
MSAGGCM10017556_52240
VMAVAB18032_17800 VAB18032_28761
MCRAID554_21660 ID554_30910
PLKCIK06_22420
PFLAPflav_027560
PSUUPsuf_068120 Psuf_082380 Psuf_082390
VERHUT12_13575 HUT12_26070
PRYPrubr_10630 Prubr_59220
CATICS0771_01300
NHYJQS43_06600
RMARGBA65_17330
RRSRoseRS_2577
RCARcas_2406
CAUCaur_1356
CHLChy400_1478
CAGCagg_2038
TTJTTHB240(TTHB240)
TTLTtJL18_2422
TSCTSC_c11600
THCTCCBUS3UF1_13030
TOSTheos_2470
TBCA0O31_00089
TANTKNN15_10830
MFFMFFC18_36440(amnC_2)
GESVT84_03880(amnC)
GMSSOIL9_79350
UAMUABAM_05929
ABAAcid345_0685
CTMCabther_A0029
CVLJ8C06_00145
CHLOJ8C02_00140
SCORJ3U87_19665
PGOFSB84_28995
FLIFleli_4022
HSWHsw_0099
HYMN008_07450
HYDPK28_02600
HYEAM218_13535
HYGAUC43_04980
HYHD3Y59_14235
HYJFHG12_07405
HRSHER32_09595
HBNGUY19_14855
HTSHMJ29_08265
PKOPKOR_07060
PACTCA264_17995
RUFTH63_16330
RTIDC20_06920
RUDTH61_07810
NIBGU926_13605
MTTFtrac_2830
CHKD4L85_06690
FUVJR347_00135
CATCA2559_07430
KDIKrodi_1916
DOKMED134_12911
DDOI597_1376(amnC)
DODDCS32_02250
LANLacal_1456
LVNBWR22_13175
LACICW733_09595
ASLAeqsu_0473
AEVEI546_00335
AICJK629_01360
NDODDD_2048
NOMAAT17_09460
NSDBST91_09375
NOBCW736_01885
POMMED152_12769
POBLPB03_06875
PRNBW723_00735
POLABXQ17_06205
POACW731_07310
PHALH9I45_07180
PLITK8354_01550
PPECH9W90_08155
PBATJL193_14270
WINWPG_2044
WIJBWZ20_05975
TENLPB136_00565
TJETJEJU_1410(dmpC)
TMARMARIT_1046(dmpC)
TMPF9Y86_12505
FORFORMB_05920
FOHFORMA_06690
OLLCW732_07060
OAQDZC78_13415
FEKC1H87_06615
TAJC1A40_02560
AUEC5O00_08945
KOSKORDIASMS9_02221(amnC)
KANIMCC3317_39800(amnC)
MARFCJ739_785
PSYNE9099_03025
OCIFEZ18_11750
MGELG5B37_13135
MESQC7H62_1604
ALTIALE3EI_0273
MARXINR76_01215
SABUMBM09_05730
BIAGMA17_09785
FBEFF125_14715
FTEFluta_1400
FLUCHH17_18090
CRMK6119_14505
OHOOweho_2603
CHYDH4K34_09055
BBAUAEM51_05930
 » show all
Reference
1  [PMID:7868591]
  Authors
Inoue J, Shaw JP, Rekik M, Harayama S
  Title
Overlapping substrate specificities of benzaldehyde dehydrogenase (the xylC gene product) and 2-hydroxymuconic semialdehyde dehydrogenase (the xylG gene product) encoded by TOL plasmid pWW0 of Pseudomonas putida.
  Journal
J Bacteriol 177:1196-201 (1995)
DOI:10.1128/JB.177.5.1196-1201.1995
  Sequence
Reference
2  [PMID:17090920]
  Authors
Orii C, Takenaka S, Murakami S, Aoki K
  Title
Metabolism of 4-amino-3-hydroxybenzoic acid by Bordetella sp. strain 10d: A different modified meta-cleavage pathway for 2-aminophenols.
  Journal
Biosci Biotechnol Biochem 70:2653-61 (2006)
DOI:10.1271/bbb.60264
Reference
3  [PMID:19717587]
  Authors
Kasai D, Fujinami T, Abe T, Mase K, Katayama Y, Fukuda M, Masai E
  Title
Uncovering the protocatechuate 2,3-cleavage pathway genes.
  Journal
J Bacteriol 191:6758-68 (2009)
DOI:10.1128/JB.00840-09
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.2.1.85
IUBMB Enzyme Nomenclature: 1.2.1.85
ExPASy - ENZYME nomenclature database: 1.2.1.85
BRENDA, the Enzyme Database: 1.2.1.85

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