KEGG   ENZYME: 1.2.1.87
Entry
EC 1.2.1.87                 Enzyme                                 
Name
propanal dehydrogenase (CoA-propanoylating);
BphJ
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
Sysname
propanal:NAD+ oxidoreductase (CoA-propanoylating)
Reaction(IUBMB)
propanal + CoA + NAD+ = propanoyl-CoA + NADH + H+ [RN:R09097]
Reaction(KEGG)
R09097;
(other) R01172
Substrate
propanal [CPD:C00479];
CoA [CPD:C00010];
NAD+ [CPD:C00003]
Product
propanoyl-CoA [CPD:C00100];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme forms a bifunctional complex with EC 4.1.3.43, 4-hydroxy-2-oxohexanoate aldolase, with a tight channel connecting the two subunits [1,2,3]. Also acts, more slowly, on glycolaldehyde and butanal. In Pseudomonas species the enzyme forms a bifunctional complex with EC 4.1.3.39, 4-hydroxy-2-oxovalerate aldolase. The enzymes from the bacteria Burkholderia xenovorans and Thermus thermophilus also perform the reaction of EC 1.2.1.10, acetaldehyde dehydrogenase (acetylating). NADP+ can replace NAD+ with a much slower rate [3].
History
EC 1.2.1.87 created 2013
Pathway
ec00622  Xylene degradation
ec00640  Propanoate metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K13922  propionaldehyde dehydrogenase
K18366  acetaldehyde/propanal dehydrogenase
Genes
ECGE2348C_2143(pduP)
ECWEcE24377A_2292(pduP)
ECVAPECO1_2291(eutE)
ECQECED1_3458
EUMECUMN_2347
ECZECS88_4675
ECCc4534
ELNNRG857_10215
ELFLF82_343
EFEEFER_2021
EMAC1192_01885
ESZFEM44_24955(pduP)
STYSTY2256(pduP)
STTt0823(pduP)
SEXSTBHUCCB_8780
SENTTY21A_04180
STMSTM2051(pduP)
SEOSTM14_2540(pduP)
SEVSTMMW_20811
SEYSL1344_2027(pduP)
SEMSTMDT12_C20730
SEJSTMUK_2081(pduP)
SEBSTM474_2136(pduP)
SEFUMN798_2216(pduP)
SETUSTU288_06645
SETCCFSAN001921_06530
SENRSTMDT2_20241(pduP)
SENDDT104_21081(pduP)
SENICY43_11070
SEENSE451236_16465
SPTSPA0820(pduP)
SEKSSPA0767
SPQSPAB_01053
SEISPC_1663(pduP)
SECSCH_2059(pduP)
SEHSeHA_C2274
SHBSU5_02645
SENHCFSAN002069_21565
SEEHSEEH1578_19535
SEESNSL254_A2228
SENNSN31241_31520
SEWSeSA_A2221
SEASeAg_B2174
SENSQ786_10125
SEDSeD_A2387
SEGSG2080(pduP)
SELSPUL_0849(pduP)
SEGASPUCDC_0849(pduP)
SETSEN2049(pduP)
SENAAU38_10340
SENOAU37_10350
SENVAU39_10350
SENQAU40_11595
SENLIY59_10635
SENJCFSAN001992_01180
SEECCFSAN002050_17215
SEEBSEEB0189_009210
SEEPI137_03830
SENBBN855_21360
SENEIA1_10235
SENCSEET0819_17400
SESSARI_00836
SALZEOS98_08755
SSNSSON_2071(pduP)
KPNKPN_03216(pduP)
KPUKP1_4485(pduP)
KPMKPHS_42790
KPPA79E_0893
KPHKPNIH24_07395
KPZKPNIH27_20735
KPVKPNIH29_21505
KPWKPNIH30_21525
KPYKPNIH31_20790
KPGKPNIH32_22385
KPCKPNIH10_21320
KPQKPR0928_20810
KPTVK055_4309
KPOKPN2242_19030
KPRKPR_1818(pduP)
KPJN559_1023
KPID364_16325
KPAKPNJ1_01028
KPSKPNJ2_01059
KPXPMK1_00697(adhE_2)
KPBFH42_12040
KPNEKU54_005045
KPNULI86_05055
KPNKBN49_0892(pduP)
KVAKvar_0854
KPEKPK_0899(pduP)
KPKA593_06210
KVDKR75_03660
KVQSP68_10205
KOXKOX_01510
KOEA225_4767
KOYJ415_08185
KOMHR38_27645
KOKKONIH1_23950
KOCAB185_12440
KQUAVR78_25830
KQVB8P98_04975
KLLBJF97_23780
KLWDA718_05410(pduP)
KARLGL98_04555(pduP)
KGRJJJ10_05430(pduP)
KPASLUW96_01605(pduP)
RORRORB6_03630
RPLNB1209_10115
RAODSD31_10070
REEelectrica_01995(adhE_2)
CROROD_21371(pduP)
CKOCKO_00785
CFDCFNIH1_21250
CBRAA6J81_01060
CWECO701_07975
CYOCD187_09160
CPOTFOB25_20470(pduP)
CFQC2U38_15370
CSEDJY391_08735(pduP)
CAMAF384_10465
CAFAL524_12215
CIFAL515_09995
CFARCI104_16250
CIRC2U53_26060
CIEAN232_13940
CPARCUC49_05370
CTELGBC03_14230(pduP)
CITZE4Z61_02800(pduP)
CARSE1B03_16780(pduP)
ESCEntcl_1746
KLEAO703_13215
BUFD8682_02430
BFTMNO13_13040
METYMRY16398_18470(pduP)
AHNNCTC12129_00739(eutE)
ASUBNLZ15_18905(grpJ)
KINAB182_08085
PDZHHA33_11210(pduP)
EBCC2U52_18670
EBUCUC76_20230
YENYE2741(pduP)
YEPYE105_C1544
YEYY11_16281
YEWCH47_2090
YETCH48_3140
YEFFORC2_2722
YEEYE5303_31741(pduP)
YALAT01_4022
YFRAW19_708
YINCH53_3356
YKRCH54_954
YAKACZ76_01720
YMADA391_08085
YHID5F51_11565
YCAF0T03_14035
YMOHRD69_13100
YASN0H69_17145
YKIHRD70_18685
RVCJ9880_23725
GQUAWC35_20645
PATREV46_07230
PATOGZ59_14670(nahO)
PWAPecwa_4095
PPARA8F97_21010
PECW5S_4254
PWSA7983_05610
SODSant_2129(eutE)
SLIGGTU79_14960
MINTC7M51_00183(adhE_2)
MTHIC7M52_02536(adhE_2)
HPARAL518_16385
PSDDSC_09370
RGLCS053_01765
RTHLRK53_10285
RBDALSL_0878 ALSL_1081
VEJVEJY3_08440
VSHBSZ05_01030 BSZ05_12300
VAFD1115_22445
VASGT360_18010
VZIG5S32_07725
PREPCA10_13830
PFUWKF707C_12180 KF707C_16060(salG) KF707C_16240(bphX2)
PPIND085(nahO)
PPUTL483_14060
PPUNPP4_27270(mhpF)
PVRPverR02_11590 PverR02_14705
PPUUPputUW4_01661(mhpF)
PKCPKB_4238(nahO)
PFZAV641_10530
PLQAA042_19760
PALKPSAKL28_05970
PPSYAOC04_07830
PFKPFAS1_28770
PSETTHL1_1434
PSILPMA3_11730
PKEDLD99_14745
PALLUYA_06975 UYA_07055
PUMHGP31_20765
PPSHG5J76_13485
PLALFXN65_06425
PAZEKSS91_19290
PPHABVH74_17965
PTAENCTC10697_02056(bphJ)
PCAVD3880_17510
PPHNHU825_04965 HU825_14760
PIZLAB08_R40960
PSCA458_06515
PSTUUIB01_22745
PBMCL52_14715
SDEGGOM96_01765
AVNAvin_30580(lapF)
AVLAvCA_30580(lapF)
AVDAvCA6_30580(lapF)
HARRHV822_17980
MARJMARI_05450(bphJ)
ALCOTEC02_08815
AEIAOY20_01980
ASJAsACE_CH00351
ADVDJ533_16965
ARJDOM24_01570
AWUBEN71_02685
ACUMC9E88_006010
ALWFOB21_11705
ATNFM020_13985
ACHICDG60_02960
ALJG8D99_13405
AWGGFH30_01710
ASHAG8E00_02250
ATGJ4G44_04385
AVBRYU24_27160
ABOUACBO_27750
ACIUA3K93_01260
SPCSputcn32_0199
SPLSpea_2117
SHWSputw3181_0418
SHLShal_2089
SWDSwoo_1391
COLWA3Q33_18580
CBERB5D82_11265
THTE2K93_11205
PHAPSHAa2142(mhpF)
PTNPTRA_a2595(bphJ)
PNGPNIG_a2789(bphJ)
LALAT746_01295
SALHHMF8227_02731(bphJ)
CJACJA_1528(nahO)
CEGD0C16_06470
TTUTERTU_1282
SPOIIMCC21906_00396 IMCC21906_02715
SNANI6N98_10795
STAWNCG89_14275
ZALAZF00_03865 AZF00_11425 AZF00_17815
HJABST95_09510
HALCEY643_13290
AFUSEYZ66_02680 EYZ66_12970
HMARHVMH_0575(mhpF)
CYQQ91_0509(nahO) Q91_1490
CZACYCME_0970(nahO) CYCME_2102
CYYCPC19_05400 CPC19_10510
BLEPAL038_01295
THISHZT40_10610
AEHMlg_2461
KAKKalk_07860
MMWMmwyl1_3802
MPRIMP3633_3150
MGEOCFI10_00430 CFI10_04965 CFI10_06045
MSECLN244_04510 LN244_04770 LN244_11325
MRZKDW95_00760
NCUF0U83_03050
NJPNEJAP_0672(mhpF)
NIKF5I99_02025 F5I99_10100 F5I99_10515
AJPAMJAP_2525 AMJAP_2998
ASIMFE240_03465
TAUTola_1697
ZDFAN401_14620
SOKD0B54_06195
SINIGT972_14665
FCEJN531_005835
GBIPG2T_09670
TBNTBH_C0929
GPBHDN1F_27080(aphF)
NZOSAMEA4504057_0443(bphJ)
NCINCTC10296_00918(bphJ)
NWDH3L96_04780
NDULVJ88_00575
VFFVITFI_CDS1375
PTESJQU52_04845
USULVJ78_03645
AQLBXU06_16255 BXU06_16880 BXU06_17060
RPIRpic_4618
RPFRpic12D_3542
RINACS15_4355
REHH16_B0596(h16_B0596)
CNCCNE_2c05410
CUHBJN34_24655
RMERmet_1320(mhpF)
CTIRALTA_B0400(mhpF)
CBWRR42_s2314
COXE0W60_08020
CCAXKZ686_10000
BVIBcep1808_7604
BURBcep18194_B1458 Bcep18194_B2960
BCJBCAM1614(mhpF)
BCENDM39_3382 DM39_4833
BCEOI35_5474(mhpF)
BCTGEM_4110 GEM_5402
BCEDDM42_4992 DM42_6344
BCEPAPZ15_31150
BPYRABD05_27815
BCONNL30_04135 NL30_24595
BDFWI26_15990 WI26_21150
BTEIWS51_00565 WS51_05700
BPSLWS57_06040 WS57_12160
BMECWJ16_26795
BSTLBBJ41_10515 BBJ41_21345
BANNJFN94_19130 JFN94_25655
BARINLX30_30180
BUQAC233_11190
BURKDM992_32620
BXEBxe_C1188(bphJ)
BXBDR64_8617
BFNOI25_4590
PARBCJU94_37875 CJU94_38120
PCAFDSC91_003290
PMEGFNZ07_21160
PPKU875_01895
PRBX636_07575
CABASBC2_49010(bphJ)
LIMNHKT17_03825
AXYAXYL_04308
CDNBN940_14426
RFRRfer_0455
PNAPnap_4143
AJSAjs_0223
ACIDCBP33_01110
ACIPCBP36_01205
ACINCBP34_01115
ACISCBP35_17745
AMONH9L24_14180
VEIVeis_2782
VBOCKY39_28500
CTTCtCNB1_1352 CtCNB1_3148
CTESO987_07735
COFFOZ74_08310
ADNAlide_0338
ADKAlide2_0283
OTDJ1M35_00050
HYLLPB072_18195
HPSEHPF_01855(bphJ)
HYNF9K07_02770 F9K07_11455
HTNKI616_01950
DIHG7047_09700
SIMPC6571_13620
MELAC6568_07855
MJELVC68_01010
STHMIS481_10545
SAQAOMP39_09125
MPTMpe_A2267 Mpe_A3322
METPC1M51_06445 C1M51_16315
SNNEWH46_19315
IDCLRM40_19580
JAJEKL02_01795 EKL02_13155
MASWAM586_18655
LCHLcho_3341
RBUPG1C_14095
ABREpbN1_20570(mhpF)
DARDaro_0906 Daro_1355 Daro_3783 Daro_3807
DEYHYN24_14115 HYN24_14205
DDENKI615_16875
QAUKI612_15150
FLEKI610_08590 KI610_13430 KI610_15455
AZOazo1856(lapF) azo1973(mhpF) azo2432(nahO)
AOAdqs_2009 dqs_2128 dqs_2576
AZIAzCIB_1508 AzCIB_4410
AZDCDA09_09960 CDA09_10330 CDA09_10455 CDA09_21435
AZRCJ010_12265 CJ010_12840 CJ010_15210
TMZTmz1t_2078 Tmz1t_3106
THUAC731_001815 AC731_008900
THKCCZ27_04600 CCZ27_10755
AZQG3580_00545 G3580_08275
ACOMCEW83_03605
ACIBACBT_0260(dmpF)
AFCAFAEC_1845(dmpF)
AAQIAAQM_0981(dmpF)
ACLOACLO_a0140(dmpF)
ADZADFLV_2552(dmpF)
ARCABLL_2443
ALKALEK_0382(dmpF)
AANAAANAER_1259(dmpF)
DALDalk_4987
BBAEFRD01_01510
SHZshn_33315
RPCRPC_1174
CIDP73_1381
RCPRCAP_rcc02201(adhE)
RSUNHU_00544(adhE)
RHMB5V46_15215
DAAAKL17_3p0138
TECAKL02_008265
PGVSL003B_p0057
NPPPP1Y_AT32733
SGISGRAN_1580(mhpF)
SJPSJA_C1-11900(mhpF)
SINBSIDU_08315
SYBTZ53_09025 TZ53_23470
SHYDCJD35_06510
SUFLFIL70_18990
SBARH5V43_20640
SFLASPHFLASMR4Y_02367(bphJ)
SPHJBSL82_10440
PMASNCF86_10600
TFVIDJ81_04965
RRURru_A0914
RRFF11_04715
TXITH3_21413
HTLHPTL_0048
BSMBSM4216_0948
BDAFSZ17_13230
BACIB1NLA3E_08430 B1NLA3E_09190 B1NLA3E_13975
BACQDOE78_09225
BHKB4U37_13940
CSOALIS82_15920
OCNCUC15_03675
GMCGY4MC1_1873
GJFM493_00040
GTHGeoth_1939
PTLAOT13_13035
PARGPspKH34_15470
LGYT479_19650
LYZDCE79_01750
LYGC1N55_08070
VIGBKP57_09385
VNTOLD84_14185
VIKKFZ58_14505
LAOAOX59_17245
BSJUP17_10520
PFRIL8956_11385
PRDF7984_12030
GRCGI584_15705
RUEDT065_13785 DT065_15200
SALEEPH95_15035
CTHUHUR95_02355
BSEBsel_3117
LMOlmo1165
LMNLM5578_1238
LMYLM5923_1191
LMTLMRG_00608
LMOCLMOSLCC5850_1154(pduP)
LMOEBN418_1367
LMOBBN419_1365
LMODLMON_1158
LMOWAX10_14330
LMOQLM6179_1472(eutE)
LMRLMR479A_1186(eutE)
LMOMIJ09_04510
LMFLMOf2365_1173(pduP)
LMCLm4b_01170
LMOGBN389_11840(eutE)
LMPMUO_06020
LMOLLMOL312_1152(pduP)
LMOJLM220_17082
LMOZLM1816_08253
LMOXAX24_03195
LMHLMHCC_1486
LMQLMM7_1171(pduP)
LMLlmo4a_1148(pduP)
LMGLMKG_01769
LMSLMLG_1099
LMJLMOG_00564
LMWLMOSLCC2755_1157(pduP)
LMXLMOSLCC2372_1160(pduP)
LMZLMOSLCC2482_1204(pduP)
LMONLMOSLCC2376_1116(pduP)
LMOSLMOSLCC7179_1132(pduP)
LMOOLMOSLCC2378_1169
LMOYLMOSLCC2479_1161(pduP)
LMOTLMOSLCC2540_1143(pduP)
LMOALMOATCC19117_1165(pduP)
LMOKCQ02_05990
LMVY193_09910
LINlin1129
LWElwe1123(pduP)
LSGlse_1043(pduP)
LIVLIV_1097
LIIJL52_05820
LIWAX25_05925
LIAJL58_05945
LIOJL53_06475
LMARLAX80_005405
BFMBP422_09715
SIVSSIL_0067
SSILSOLI23_18500 SOLI23_19600
SOBCSE16_14635
PLLI858_008615
KZONCTC404_01742(bphJ)
SPOOJ3U78_11180
LRELreu_1735
LRFLAR_1623
LRUHMPREF0538_20921
LNGBSQ50_09370
LBRLVIS_1603
LBKLVISKB_1534
LCYLC20004_04075
LPDAYR62_10165
PCEPECL_1370(pduP)
PACIA4V11_08150
LROSLROSL1_1559
LGNABM34_00615
LGMLG542_00695
EAVEH197_11725
ERAFJ9537_04855
VCPH9L18_05050 H9L18_05435
VHYG7082_00730
CBKCLL_A1748 CLL_A2134
CBTCLH_1846
CBECbei_3832 Cbei_4045 Cbei_4054
CBZCbs_3832 Cbs_4045 Cbs_4054
CBEILF65_04317 LF65_04554 LF65_04563
CSRCspa_c21450(eutE) Cspa_c56880
CSBCLSA_c22740(eutE) CLSA_c33640(ald)
CSQCSCA_5280
CCKCcar_06105 Ccar_14685
CEUA7L45_05685
CTAEBGI42_07385 BGI42_07955
CFMBJL90_19995
CCHVBTM20_07295
CDRKB9W14_18820
CDYF3K33_19585 F3K33_20700 F3K33_20745
CCOHSAMEA4530647_0801(sucD)
CGASJ1C67_05805
CCAAKQH81_03695 KQH81_03720
CMAHC1I91_22750
CNNCNEO_2844(eutE)
GFEGferi_18345 Gferi_26075
CALEFDN13_12855
CPRFK7H06_13890
FPLAA4U99_10740
RUMCK1_20690
OVAOBV_17600
ROBCK5_18240
BLABEYS05_10205
BWXNQ550_05520
CPYCphy_1178
LACYA4V08_01395 A4V08_01420 A4V08_07735
CSOCLS_23700 CLS_23750
LXAOW255_01210 OW255_01230
EHLEHLA_3029
PXVFXF36_06965 FXF36_06995
ACELacsn021_21700
RGNRGna_15045
CBOLCGC65_23885 CGC65_23910
CASPNQ535_20225
WHJH9Q79_16945
CSTCLOST_0674(eutE)
ROCHF520_07510
DCADesca_1928
TFRBR63_18135
FWADCMF_27365
AACXDEACI_1969
TJRTherJR_0630
ELMELI_4072
EMTCPZ25_010665
ELIMB2M23_06190
AWOAwo_c25770(pduP)
AWICHL1_000951
VGUHYG85_06815
ACAEHYG86_04020
IBUIB211_01996c
AMICAmi3637_01490
ABUTAmi103574_07470
ETMCE91St48_36280
TEXTeth514_1942
THXThet_0994
MTHOMOTHE_c17900
MTHZMOTHA_c18730
GEKkuro4_24440 kuro4_26240
TTOThethe_02116
TXYThexy_2095
TSHTsac_0219
MASMahau_0819 Mahau_0828
TOCToce_0560
HASHalsa_0996
IFNGM661_12920
KMEH0A61_00535(sucD)
VDNNCTC11831_01740(sucD)
VNKVEIT17_16000
VRGOKW85_08425
PUFUFO1_1126
PFTJBW_03293
STEDSPTER_02990(bphJ_1) SPTER_36970(bphJ_2)
MMUCC1S78_007400
SPAVSpa2297_32965
PACPPA1741
PAKHMPREF0675_4795
PAVTIA2EST22_08550
PAXTIA2EST36_08535
PAZTIA2EST2_08475
PAWPAZ_c18150(eutE)
PADTIIST44_01525
PCNTIB1ST10_08950
PACCPAC1_08955
PACHPAGK_1670
PACNTIA1EST1_08595
CACNRN83_09030
PRAPALO_02255
PRLBCB70_09670
CGRN4412665_00729(sucD_1)
PFRPFREUD_09130(pduP)
PFRERM25_1259
PACDEGX94_11970
PAUSNCTC13651_01469(adhE_2)
PPCHMPREF9154_2990
ARUBJ5A65_14235
PBOPACID_24580
AACIASQ49_09725
ACIJJS278_01049(adhE)
TEJKDB89_01955
SAQSare_4566
CWOCwoe_4834
LAMBKBB96_07960
SOAG3M56_011840
BIPBint_1611
FUSHMPREF0409_01360
FNEFSDG_02008
FHWRN87_00245
FULC4N20_01445
FCII6I83_03175
IPOIlyop_2358
STRSterm_1037
TLITlie_0209
AMOAnamo_0127
SBRSY1_15720
CPORBED41_08950
 » show all
Reference
1  [PMID:19476337]
  Authors
Baker P, Pan D, Carere J, Rossi A, Wang W, Seah SY
  Title
Characterization of an aldolase-dehydrogenase complex that exhibits substrate channeling in the polychlorinated biphenyls degradation pathway.
  Journal
Biochemistry 48:6551-8 (2009)
DOI:10.1021/bi9006644
  Sequence
[bxe:Bxe_C1188]
Reference
2  [PMID:21838275]
  Authors
Carere J, Baker P, Seah SY
  Title
Investigating the molecular determinants for substrate channeling in BphI-BphJ, an aldolase-dehydrogenase complex from the polychlorinated biphenyls degradation  pathway.
  Journal
Biochemistry 50:8407-16 (2011)
DOI:10.1021/bi200960j
  Sequence
[bxe:Bxe_C1188]
Reference
3  [PMID:22316175]
  Authors
Baker P, Hillis C, Carere J, Seah SY
  Title
Protein-protein interactions and substrate channeling in orthologous and chimeric aldolase-dehydrogenase complexes.
  Journal
Biochemistry 51:1942-52 (2012)
DOI:10.1021/bi201832a
  Sequence
[ttj:TTHB247]
Other DBs
ExplorEnz - The Enzyme Database: 1.2.1.87
IUBMB Enzyme Nomenclature: 1.2.1.87
ExPASy - ENZYME nomenclature database: 1.2.1.87
BRENDA, the Enzyme Database: 1.2.1.87

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