KEGG   ENZYME: 1.2.99.10
Entry
EC 1.2.99.10                Enzyme                                 
Name
4,4'-diapolycopenoate synthase;
crtNc;
4,4'-diapolycopenealdehyde oxidase (misleading)
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With unknown physiological acceptors
Sysname
4,4'-diapolycopen-4-al,donor:oxygen oxidoreductase (4,4'-diapolycopen-4-oate-forming)
Reaction(IUBMB)
(1) 4,4'-diapolycopen-4-al + H2O + acceptor = 4,4'-diapolycopen-4-oate + reduced acceptor [RN:R11913];
(2) 4,4'-diapolycopene-4,4'-dial + 2 H2O + 2 acceptor = 4,4'-diapolycopene-4,4'-dioate + 2 reduced acceptor [RN:R11914]
Reaction(KEGG)
R11913 R11914
Substrate
4,4'-diapolycopen-4-al [CPD:C21766];
H2O [CPD:C00001];
acceptor [CPD:C00028];
4,4'-diapolycopene-4,4'-dial [CPD:C19798]
Product
4,4'-diapolycopen-4-oate [CPD:C21768];
reduced acceptor [CPD:C00030];
4,4'-diapolycopene-4,4'-dioate [CPD:C21770]
Comment
The enzyme has been described from the bacteria Methylomonas sp. 16a and Bacillus indicus.
History
EC 1.2.99.10 created 2017
Pathway
ec00906  Carotenoid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K22445  4,4'-diapolycopenoate synthase
K25072  4,4'-diapolycopenoate synthase
Genes
MMTMetme_3773
MDNJT25_002370
MDHAYM39_15935
MKOMKLM6_3291
METLU737_16975
MPADKEF85_14160
MELLIVG45_20690
MPSYCEK71_14810
SDOSD1155_11615
MJOFOF60_07450
SAUSA1736(aldH)
SAVSAV1920(aldH)
SAWSAHV_1905(aldH)
SAHSaurJH1_2010
SAJSaurJH9_1977
SAMMW1861(aldH)
SASSAS1844
SARSAR2013
SACSACOL1984(aldA2)
SAXUSA300HOU_1923(aldH1)
SAASAUSA300_1901(aldA2)
SAOSAOUHSC_02142
SAENWMN_1858
SADSAAV_1988(aldA2)
SUUM013TW_1958
SUVSAVC_08865
SUESAOV_2023
SUJSAA6159_01852
SUKSAA6008_01942(aldH)
SUCECTR2_1793
SUTSAT0131_02050
SUQHMPREF0772_11220
SUZMS7_1956
SUDST398NM01_2015
SUXSAEMRSA15_18300
SUWSATW20_19150
SUGSAPIG2015
SUFSARLGA251_18050
SAUASAAG_02441
SAUERSAU_001807(aldA)
SAUNSAKOR_01884
SAUSSA40_1762
SAUUSA957_1846
SAUGSA268_1918
SAUZSAZ172_1934
SAUTSAI1T1_2014580(aldH)
SAUJSAI2T2_1014590(aldH)
SAUKSAI3T3_1014580(aldH)
SAUQSAI4T8_1014590(aldH)
SAUVSAI7S6_1014590(aldH)
SAUWSAI5S5_1014530(aldH)
SAUXSAI6T6_1014550(aldH)
SAUYSAI8T7_1014570(aldH)
SAUFX998_1976
SABSAB1857
SUYSA2981_1878(aldH)
SAUBC248_1998
SAUMBN843_19610
SAUCCA347_2010
SAURSABB_02345(aldH)
SAUIAZ30_10235
SAUDCH52_09320
SUHSAMSHR1132_17650
SERSERP1456(aldA-1)
SEPSE_1603
SEPPSEB_01590
SEPSDP17_549
SHASH1033(aldH)
SHHShL2_00921(aldH)
SSPSSP0871
SCASCA_1490(aldH)
SLGSLGD_01007
SLNSLUG_10460
SSDSPSINT_1673
SDTSPSE_0822(aldA2)
SDPNCTC12225_00891(aldA2)
SWAA284_04405
SPASSTP1_0437
SXYBE24_07515
SXLSXYLSMQ121_0908
SXOSXYL_00917
SHUSHYC_04225
SCAPAYP1020_1196(alkH)
SSCHLH95_04115
SSCZRN70_04335
SAGQEP23_05765
SEQOSE1039_17070
SSIFAL483_02355
SCVA4G25_12615
SPETCEP67_04025
SLZB5P37_02055
SCOHBZ166_08815
SNLBJD96_04780
SKLC7J89_05895
SFQC7J90_11540
SHOMEGX58_08535
SMUSC7J88_04315
SCARDWB96_04715
SCHRDWB92_04145
SARLSAP2_09350
SPICSAMEA4384060_1031(aldH)
SSHNCTC13712_01941(calB)
SSIMSAMEA4384339_1841(aldH)
SDBCNQ82_09420
SLLOISP08_04560
SRAILN051_03735
SPSDJMB28_05070
STASHYI43_04865
SSCUCEP64_03375
SFFFOB90_03705
SSTESAMEA4384403_0759(aldH)
MLENH3V22_04970
MVTI6J10_07365
MCLMCCL_1656
MCAKMCCS_21160(alkH)
MACRBHM04_00375
MBOEHT586_10310
MARYLAU42_09760
MBRUMGG13_09295
MEPIKFV12_11020
MEQUKFV11_09435
PALRHGI30_08165
SPOOJ3U78_06760
VLUM2919_01510
TEMJW646_16765
TGCL0P85_11025
TBBJ0J69_03605
MANRMPAN_016780
CFILMYF79_02315
SSIYJVX97_14910
FRRIB67_08655
 » show all
Reference
1  [PMID:15933032]
  Authors
Tao L, Schenzle A, Odom JM, Cheng Q
  Title
Novel carotenoid oxidase involved in biosynthesis of 4,4'-diapolycopene dialdehyde.
  Journal
Appl Environ Microbiol 71:3294-301 (2005)
DOI:10.1128/AEM.71.6.3294-3301.2005
  Sequence
Reference
2  [PMID:25326460]
  Authors
Steiger S, Perez-Fons L, Cutting SM, Fraser PD, Sandmann G
  Title
Annotation and functional assignment of the genes for the C30 carotenoid pathways from the genomes of two bacteria: Bacillus indicus and Bacillus firmus.
  Journal
Microbiology 161:194-202 (2015)
DOI:10.1099/mic.0.083519-0
Other DBs
ExplorEnz - The Enzyme Database: 1.2.99.10
IUBMB Enzyme Nomenclature: 1.2.99.10
ExPASy - ENZYME nomenclature database: 1.2.99.10
BRENDA, the Enzyme Database: 1.2.99.10

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