KEGG   ENZYME: 1.21.1.2
Entry
EC 1.21.1.2                 Enzyme                                 
Name
2,4-dichlorobenzoyl-CoA reductase
Class
Oxidoreductases;
Catalysing the reaction X-H + Y-H = X-Y;
With NAD+ or NADP+ as acceptor
Sysname
4-chlorobenzoyl-CoA:NADP+ oxidoreductase (halogenating)
Reaction(IUBMB)
4-chlorobenzoyl-CoA + NADP+ + chloride = 2,4-dichlorobenzoyl-CoA + NADPH + H+ [RN:R05276]
Reaction(KEGG)
R05276
Substrate
4-chlorobenzoyl-CoA [CPD:C06387];
NADP+ [CPD:C00006];
chloride [CPD:C00698]
Product
2,4-dichlorobenzoyl-CoA [CPD:C06671];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme, characterized from Corynebacterium strains able to grow on 2,4-dichlorobenzoate, forms part of the 2,4-dichlorobenzoate degradation pathway.
History
EC 1.21.1.2 created 2000 as EC 1.3.1.63, modified 2011, transferred 2015 to EC 1.21.1.2
Pathway
ec00364  Fluorobenzoate degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Reference
1  [PMID:8626335]
  Authors
Romanov V, Hausinger RP.
  Title
NADPH-dependent reductive ortho dehalogenation of 2,4-dichlorobenzoic acid in Corynebacterium sepedonicum KZ-4 and Coryneform bacterium strainNTB-1 via 2,4-dichlorobenzoyl coenzyme A.
  Journal
J Bacteriol 178:2656-61 (1996)
DOI:10.1128/JB.178.9.2656-2661.1996
Other DBs
ExplorEnz - The Enzyme Database: 1.21.1.2
IUBMB Enzyme Nomenclature: 1.21.1.2
ExPASy - ENZYME nomenclature database: 1.21.1.2
BRENDA, the Enzyme Database: 1.21.1.2

KEGG   REACTION: R05276
Entry
R05276                      Reaction                               
Name
4-chlorobenzoyl-CoA:NADP+ oxidoreductase (halogenating)
Definition
4-Chlorobenzoyl-CoA + Hydrochloric acid + NADP+ <=> 2,4-Dichlorobenzoyl-CoA + NADPH + H+
Equation
Reaction class
RC00001  C00005_C00006
RC00949  C06387_C06671
Enzyme
Pathway
rn00364  Fluorobenzoate degradation
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
Other DBs
RHEA: 23079

DBGET integrated database retrieval system