KEGG   ENZYME: 1.21.3.10
Entry
EC 1.21.3.10                Enzyme                                 
Name
hercynylcysteine S-oxide synthase;
Egt1;
Egt-1
Class
Oxidoreductases;
Catalysing the reaction X-H + Y-H = X-Y;
With oxygen as acceptor
Sysname
hercynine,L-cysteine:oxygen [S-(hercyn-2-yl)-L-cysteine S-oxide-forming]
Reaction(IUBMB)
hercynine + L-cysteine + O2 = S-(hercyn-2-yl)-L-cysteine S-oxide + H2O [RN:R11014]
Reaction(KEGG)
R11014
Substrate
hercynine [CPD:C05575];
L-cysteine [CPD:C00097];
O2 [CPD:C00007]
Product
S-(hercyn-2-yl)-L-cysteine S-oxide [CPD:C20994];
H2O [CPD:C00001]
Comment
Requires Fe2+ for activity. The enzyme, found in fungal species, is part of a fusion protein that also has the the activity of EC 2.1.1.44, L-histidine Nalpha-methyltransferase. It is part of the biosynthesis pathway of ergothioneine. The enzyme can also use L-selenocysteine to produce hercynylselenocysteine, which can be converted to selenoneine.
History
EC 1.21.3.10 created 2015 as 1.14.99.51, transferred 2022 to EC 1.21.3.10
Pathway
ec00340  Histidine metabolism
Orthology
K20246  L-histidine Nalpha-methyltransferase / hercynylcysteine S-oxide synthase
Genes
QSU111995461
NCRNCU04343(egt-1)
NTENEUTE1DRAFT145472(NEUTE1DRAFT_145472)
SMPSMAC_01803
MTMMYCTH_2074210
CTHRCTHT_0030600
MGRMGG_00020 MGG_13219
PPEIPpBr36_02899
TMNUCRPA7_3011
SSCKSPSK_08945
FGRFGSG_03421 FGSG_11987 FGSG_12773
FPUFPSE_06241 FPSE_08378 FPSE_11477
FVRFVEG_15947
FOXFOXG_20012
NHENECHADRAFT_70968 NECHADRAFT_97208
TRETRIREDRAFT_81410
TRRM419DRAFT_103267
MAWMAC_09617
MAJMAA_04856
CMTCCM_07351
PLJVFPFJ_01447
VDAVDAG_10242
CFJCFIO01_13296
CHIGCH63R_04852
SAPOSAPIO_CDS7015
PFYPFICI_05616
BFUBCIN_12g04180
MBEMBM_01989
PSCOLY89DRAFT_586353
GLZGLAREA_08265
ANIAN7620.2
AFMAFUA_2G15650
ACTACLA_074540
NFINFIA_090880
AORAO090012000265 AO090023000415
ANGANI_1_792134(An15g05880)
AFVAFLA_001980 AFLA_006763
ALUCAKAW2_60182A
ACHEACHE_10907A ACHE_60451S
APUUAPUU_80300A
PDPPDIP_81160
TMFPMAA_036630
TRGTRUGW13939_05155
CIMCIMG_00276
CPWCPC735_059060
UREUREG_00352
PBLPAAG_03909
PBNPADG_11594
ABEARB_02453
TVETRV_08045
AJEHCAG_01026
BGHBDBG_06484
PNOSNOG_13930(SNOG_13929)
PTEPTT_06791
BZECOCCADRAFT_109454
BSCCOCSADRAFT_32544
BORCOCMIDRAFT_95519
AALTCC77DRAFT_949140
ZTRMYCGRDRAFT_75935
PFJMYCFIDRAFT_56905
FFUCLAFUR5_11164
BCOMBAUCODRAFT_116776
NPAUCRNP2_8392
SPOSPBC1604.01(mug158)
CNECNJ01670
CNBCNBJ1790
CNGCNAG_04737
CGICGB_I2320W
TMSTREMEDRAFT_42626
TASAA1Q1_06211
TVSTRAVEDRAFT_64341
DSQDICSQDRAFT_55495
PCOPHACADRAFT_212229
SHSSTEHIDRAFT_66030
HIRHETIRDRAFT_156207
PSQPUNSTDRAFT_131244
ADLAURDEDRAFT_115403
FMEFOMMEDRAFT_78835
GTRGLOTRDRAFT_139012
LBCLACBIDRAFT_188236
MRRMoror_1006
MOREE1B28_012164
CCICC1G_02949
SCMSCHCODRAFT_67573
ABPAGABI1DRAFT120644(AGABI1DRAFT_120644)
ABVAGABI2DRAFT186400(AGABI2DRAFT_186400)
PCUBJR316_0007212
CPUTCONPUDRAFT_77468 CONPUDRAFT_85801
SLASERLADRAFT_470869
WSEWALSEDRAFT_60925
WICJ056_001286
PGRPGTG_04084
MLRMELLADRAFT_110519
 » show all
Reference
1  [PMID:24828577]
  Authors
Pluskal T, Ueno M, Yanagida M
  Title
Genetic and metabolomic dissection of the ergothioneine and selenoneine biosynthetic pathway in the fission yeast, S. pombe, and construction of an overproduction system.
  Journal
PLoS One 9:e97774 (2014)
DOI:10.1371/journal.pone.0097774
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.21.3.10
IUBMB Enzyme Nomenclature: 1.21.3.10
ExPASy - ENZYME nomenclature database: 1.21.3.10
BRENDA, the Enzyme Database: 1.21.3.10

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