KEGG   ENZYME: 1.21.99.4
Entry
EC 1.21.99.4                Enzyme                                 
Name
thyroxine 5'-deiodinase;
diiodothyronine 5'-deiodinase [ambiguous];
iodothyronine 5'-deiodinase;
iodothyronine outer ring monodeiodinase;
type I iodothyronine deiodinase;
type II iodothyronine deiodinase;
thyroxine 5-deiodinase [misleading];
L-thyroxine iodohydrolase (reducing)
Class
Oxidoreductases;
Catalysing the reaction X-H + Y-H = X-Y;
With unknown physiological acceptors
Sysname
3,3',5-triiodo-L-thyronine,iodide:acceptor oxidoreductase (iodinating)
Reaction(IUBMB)
3,3',5-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + reduced acceptor [RN:R03734]
Reaction(KEGG)
R03734
Substrate
3,3',5-triiodo-L-thyronine [CPD:C02465];
iodide [CPD:C00708];
acceptor [CPD:C00028];
H+ [CPD:C00080]
Product
L-thyroxine [CPD:C01829];
reduced acceptor [CPD:C00030]
Comment
The enzyme activity has only been demonstrated in the direction of 5'-deiodination, which renders the thyroid hormone more active. The enzyme consists of type I and type II enzymes, both containing selenocysteine, but with different kinetics. For the type I enzyme the first reaction is a reductive deiodination converting the -Se-H group of the enzyme into an -Se-I group; the reductant then reconverts this into -Se-H, releasing iodide.
History
EC 1.21.99.4 created 1984 as EC 3.8.1.4, transferred 2003 to EC 1.97.1.10, transferred 2015 to EC 1.21.99.4
Orthology
K01562  type I thyroxine 5'-deiodinase
K17904  type II thyroxine 5'-deiodinase
Genes
HSA1733(DIO1) 1734(DIO2)
PTR467521(DIO2) 469331(DIO1)
PPS100972089(DIO2) 100980739(DIO1)
GGO101124806(DIO2) 101154004(DIO1)
PON100440998(DIO1) 100449335(DIO2)
NLE100586423(DIO1) 100606409(DIO2)
MCC707484(DIO2) 714739(DIO1)
MCF102122576(DIO2) 102128623(DIO1)
MTHB126957933 126962453
CSAB103224787(DIO1) 103229434(DIO2)
CATY105590919(DIO2) 105596015(DIO1)
PANU100997384(DIO1) 101016937(DIO2)
TGE112629280(DIO2) 112633267(DIO1)
RRO104669397(DIO1) 104677628(DIO2)
RBB108530802(DIO2) 108531213(DIO1)
TFN117069245(DIO2) 117092556(DIO1)
PTEH111523527(DIO1) 111554703(DIO2)
CJC100385960(DIO1) 100406379(DIO2)
SBQ101030674(DIO1) 101037342(DIO2)
CSYR103261496(DIO2)
MMUR105867863(DIO2) 105877594(DIO1)
LCAT123635626(DIO1) 123640208(DIO2)
OGA100944413(DIO1) 100964445(DIO2)
MMU13370(Dio1) 13371(Dio2)
MCAL110293582(Dio1) 110307002(Dio2)
MPAH110323703(Dio1) 110324869(Dio2)
RNO25430(Dio1) 65162(Dio2)
MCOC116080635(Dio2) 116095481(Dio1)
MUN110551834(Dio2) 110564009(Dio1)
CGE100765192(Dio1) 100774757(Dio2)
MAUA101835104(Dio2) 101839024(Dio1)
PLEU114697681(Dio2) 114707566(Dio1)
MORG121448732(Dio1) 121452546(Dio2)
MFOT126497952 126507778
AAMP119817304(Dio1) 119819662(Dio2)
NGI103732556(Dio2) 103734117(Dio1)
HGL101697296(Dio2) 101704592(Dio1)
CPOC100715950(Dio1) 100721073(Dio2)
CCAN109674806(Dio2) 109684245(Dio1)
DORD105984595(Dio2) 105990013(Dio1)
DSP122099113(Dio1) 122118891(Dio2)
NCAR124978289 124991557
OCU100101570(DIO1) 100354221(DIO2)
OPI101519356(DIO2) 101524720(DIO1)
TUP102480600(DIO2) 102482647(DIO1)
CFA403635(DIO1) 490813(DIO2)
CLUD112647057(DIO1) 125752081(DIO2)
VVP112926114(DIO1) 112934900(DIO2)
VLG121493787(DIO2) 121499752(DIO1)
AML100466148(DIO1) 100478833(DIO2)
UMR103670636(DIO2) 103670695(DIO1)
UAH113254643(DIO1) 113270276(DIO2)
UAR123793670(DIO1) 123798929(DIO2)
ELK111143355 111148782
LLV125098953 125103734
MPUF101684270(DIO2) 101687410(DIO1)
ORO101370186(DIO2) 101370991(DIO1)
EJU114201393(DIO2) 114212046(DIO1)
ZCA113910440(DIO2) 113925118(DIO1)
MLX118002570(DIO2) 118019390(DIO1)
NSU110571486(DIO2) 110575062(DIO1)
LWW102740976(DIO2) 102749577(DIO1)
FCA101088170(DIO2) 493798(DIO1)
PYU121027160(DIO1) 121032131(DIO2)
PBG122469402(DIO2) 122480529(DIO1)
LRUF124512219 124516410
PTG102948967(DIO1) 102963335(DIO2)
PPAD109260795(DIO2) 109266846(DIO1)
AJU106975081(DIO1) 106983577(DIO2)
HHV120236285(DIO1) 120248619(DIO2)
BTA494548(DIO2) 782446(DIO1)
BOM102274791(DIO1) 102284841(DIO2)
BIU109556270(DIO1) 109565391(DIO2)
BBUB102398529(DIO1) 102407472(DIO2)
CHX102178591(DIO1) 102179571(DIO2)
OAS100310792(DIO1) 100310793(DIO2)
ODA120853618(DIO2) 120856112(DIO1)
CCAD122436948(DIO1) 122443921(DIO2)
SSC414379(DIO2) 414380(DIO1)
CFR102507259(DIO2) 102518353(DIO1)
CBAI105066431(DIO1) 105069686(DIO2)
CDK105086052(DIO2) 105092845(DIO1)
VPC102534145(DIO1) 102541981(DIO2)
BACU103005103(DIO1) 103007605(DIO2)
LVE103074814 103080109(DIO1)
OOR101275852(DIO1) 101276046(DIO2)
DLE111175838(DIO1) 111176195(DIO2)
PCAD102975485(DIO2) 102991668(DIO1)
PSIU116749423(DIO2) 116752684(DIO1)
ECB100050359(DIO1) 100052547(DIO2)
EPZ103541011(DIO1) 103561958(DIO2)
EAI106833199(DIO1) 106834802(DIO2)
MYB102248197(DIO2) 102261233(DIO1)
MYD102756562(DIO2)
MMYO118658770(DIO2) 118674992(DIO1)
MLF102424378(DIO2) 102435093(DIO1)
MNA107542495(DIO1) 107542686(DIO2)
PKL118714543(DIO2) 118724627(DIO1)
HAI109384683(DIO2) 109395429(DIO1)
DRO112311947(DIO2) 112314579(DIO1)
SHON118976800(DIO2) 118984971(DIO1)
AJM119056394(DIO2) 119061272(DIO1)
PDIC114491345(DIO2) 114497342(DIO1)
PHAS123808645(DIO2) 123830443(DIO1)
MMF118627096(DIO1) 118638365(DIO2)
RFQ117023789(DIO2) 117027433(DIO1)
PALE102879053(DIO2) 102888357(DIO1)
PGIG120619567(DIO2) 120621471(DIO1)
PVP105290106(DIO2) 105298962(DIO1)
RAY107497931(DIO1) 107506706(DIO2)
MJV108394944(DIO2) 108395886(DIO1)
TOD119236623(DIO1) 119239315(DIO2)
SARA101549554(DIO2)
LAV100658761(DIO2) 100675470(DIO1)
TMU101342540 101353539
ETF101650089(DIO2) 101655004(DIO1)
DNM101438480 101440823(DIO2)
MDO100016991(DIO2) 100617416(DIO1)
GAS123237820(DIO2) 123245408(DIO1)
SHR100917546(DIO2) 100923092(DIO1)
PCW110200922(DIO2) 110209375(DIO1)
OAA100073387(DIO2) 100088984(DIO1)
GGA373903(DIO2) 395940(DIO1)
PCOC116228787(DIO2) 116235010(DIO1)
MGP100546412(DIO1) 100547728(DIO2)
CJO107315160(DIO2) 107317722(DIO1)
NMEL110401421(DIO2) 110402385(DIO1)
APLA101798258(DIO1) 101798494(DIO2)
ACYG106033047(DIO1) 106044546(DIO2)
AFUL116489880(DIO2) 116492025(DIO1)
TGU100224791(DIO2) 100231867(DIO1)
LSR110470209(DIO1) 110477260(DIO2)
SCAN103815040(DIO1) 103826496(DIO2)
PMOA120500423(DIO2) 120503156(DIO1)
OTC121333794(DIO2) 121345137(DIO1)
PRUF121356005(DIO2) 121362099(DIO1)
GFR102037547(DIO1) 102042772(DIO2)
FAB101808928(DIO1) 101813353(DIO2)
PHI102107712(DIO1) 102112539(DIO2)
PMAJ107206229(DIO2) 107208501(DIO1)
CCAE111929932(DIO2) 111933026(DIO1)
CCW104685655(DIO2) 104695177(DIO1)
CBRC103615045(DIO1) 103621129(DIO2)
ETL114055206(DIO1) 114065458(DIO2)
ZAB102062222(DIO1) 102075444(DIO2)
ACHL103797289(DIO2) 103810651(DIO1)
FPG101918266(DIO1) 101920459(DIO2)
FCH102050452(DIO2) 102054399(DIO1)
CLV102088777(DIO1) 102092044(DIO2)
EGZ104131488(DIO1) 104133264(DIO2)
NNI104009277(DIO1) 104023416(DIO2)
PLET104616823(DIO2) 104622521(DIO1)
PCRI104028932(DIO1) 104038662(DIO2)
PCAO104040845(DIO2) 104040868(DIO1)
ACUN113480623(DIO2) 113482767(DIO1)
TALA104356820(DIO1) 104360359(DIO2)
PADL103912981(DIO2) 103913306(DIO1)
AFOR103900139(DIO2) 103905645(DIO1)
ACHC115349079(DIO1) 115352985(DIO2)
HALD104312814(DIO1) 104317655(DIO2)
HLE104841004(DIO1) 104841842(DIO2)
AGEN126042313 126049347
GCL127017238 127019379
CCRI104159933(DIO2) 104162981(DIO1)
CSTI104554433(DIO2) 104558222(DIO1)
EHS104505543(DIO1) 104506227(DIO2)
CMAC104475523(DIO1) 104484983(DIO2)
MUI104538131 104541817
FGA104072360(DIO1) 104074990(DIO2)
GSTE104253187(DIO1) 104254531(DIO2)
LDI104342168(DIO1) 104353366(DIO2)
MNB103769953(DIO1) 103778292(DIO2)
OHA104332867(DIO2) 104334157(DIO1)
NNT104405298(DIO1) 104407934(DIO2)
DPUB104304531(DIO2) 104307013(DIO1)
PGUU104460751(DIO2) 104467727(DIO1)
ACAR104526232 104532027(DIO1)
CPEA104385151(DIO1) 104385455(DIO2)
AVIT104269864(DIO1) 104274342(DIO2)
CVF104286063(DIO1) 104296067(DIO2)
CUCA104059074(DIO1) 104064447(DIO2)
TEO104371532(DIO1) 104376719(DIO2)
BRHI104496101(DIO1) 104496635(DIO2)
AAM106483152(DIO2) 106497641(DIO1)
AROW112974809(DIO2) 112976019(DIO1)
NPD112943354(DIO1) 112955018(DIO2)
TGT104566351(DIO1) 104570308(DIO2)
DNE112986483(DIO1) 112990013(DIO2)
SCAM104141269(DIO2) 104149593(DIO1)
ASN102372564(DIO1) 102378920(DIO2)
AMJ102566890(DIO1) 102570384(DIO2)
CPOO109307499(DIO1) 109321489(DIO2)
GGN109286631(DIO1) 109298562(DIO2)
PSS102445607(DIO1) 102449273(DIO2)
CMY102936687(DIO2) 102946702(DIO1)
CPIC101940661(DIO2) 101942692(DIO1)
TST117876675(DIO2) 117881410(DIO1)
CABI116817135(DIO1) 116837495(DIO2)
MRV120370494(DIO1) 120403550(DIO2)
ACS100553484(dio2) 100561694(dio1)
PVT110079367(DIO2) 110082244(DIO1)
SUND121929412(DIO1) 121931250(DIO2)
PBI103054347(DIO1) 103061704(DIO2)
PMUR107283018(DIO1) 107283948(DIO2)
CTIG120297356(DIO1) 120311723(DIO2)
TSR106540457(DIO1) 106547214(DIO2)
PGUT117664259(DIO1) 117665881(DIO2)
VKO123023516(DIO1) 123026794(DIO2)
PMUA114591388(DIO2) 114598972(DIO1)
ZVI118081379(DIO2) 118088763(DIO1)
GJA107123704(DIO2) 107124276(DIO1)
STOW125426841(DIO2) 125432437(DIO1)
XLA108699835(dio2.S) 373842(dio2.L) 733447(dio1.L)
XTR100036737(dio2) 100497874(dio1)
NPR108793077(DIO1) 108802676(DIO2)
RTEM120921138(DIO2) 120945892
BBUF120979317(DIO1) 120982052(DIO2)
BGAR122921559 122943044(DIO1)
DRE352937(dio2) 799937(dio1)
SRX107751736
SANH107680786 107700640
SGH107577812 107585920(dio1) 107588276
CCAR109070220 109076656
PPRM120479019(dio2) 120482267(dio1)
MAMB125268512(dio2) 125279278(dio1)
IPU108270487(dio2)
PHYP113533701(dio2)
SMEO124390526(dio2)
TFD113649323(dio2)
AMEX103026954(dio1) 103034785(dio2)
EEE113572165(dio2) 113586860(dio1)
TRU100191067(dio1) 100191068(dio2)
TNGGSTEN00020212G001
LCO104918439(dio1) 104922564(dio2)
NCC104953535(dio2) 104955483 104965519(dio1)
CGOB115007479(dio1) 115027761(dio2)
ELY117253550(dio1)
EFO125895389(dio1)
PLEP121941229(dio1)
SLUC116036769(dio2) 116063484(dio1)
ECRA117935962(dio2) 117950951(dio1)
ESP116670625(dio2) 116696104(dio1)
PFLV114547023(dio2) 114561570(dio1)
GAT120824453(dio1) 120833313(dio2)
PPUG119216338(dio1) 119227296(dio2)
MSAM119900835 119909973(dio2) 119918671
CUD121512862(dio1) 121526461(dio2)
ALAT119028180(dio1) 119034237(dio2)
MZE101482729(dio1) 101487411(dio2)
ONL100534571(dio1) 100694978(dio2)
OAU116318063(dio2) 116333327(dio1)
OLA100192348(dio2) 101160798(dio1)
OML112136905(dio1) 112147170(dio2)
XMA102232010(dio2) 102232075(dio1)
XCO114134239(dio2) 114150762(dio1)
XHE116709155(dio2) 116725429(dio1)
PRET103458987(dio2) 103463606(dio1)
PFOR103138738 103138740 103142552(dio1)
PLAI106935489(dio2) 106963564(dio1)
PMEI106925908(dio1) 106926081 106932062(dio2)
GAF122838228(dio1) 122846658(dio2)
CVG107081946(dio1) 107096556(dio2)
CTUL119772964(dio1) 119787038(dio2)
GMU124855266(dio2) 124873849(dio1)
NFU107391683(dio2) 107393250(dio1)
KMR108230578(dio1) 108244999(dio2)
ALIM106513875(dio1) 106519991(dio2)
NWH119427800(dio2)
AOCE111563633(dio2) 111583913(dio1)
MCEP125009014(dio1) 125023122(dio2)
CSEM103383367(dio2)
POV109625310(dio1) 109627784(dio2)
SSEN122780710(dio1) 122783269(dio2)
HHIP117755784(dio2) 117759728(dio1)
HSP118116908(dio2) 124854833(dio1)
LCF108877349 108897919
SDU111225744(dio2) 111232163(dio1)
SLAL111656316(dio1) 111667262(dio2)
XGL120791201(dio1) 120795388(dio2)
HCQ109524400(dio2) 109532358(dio1)
BPEC110167782(dio1)
MALB109964010(dio1)
BSPL114848503(dio2) 114853908(dio1)
SASA106603085 106613537(dio1)
STRU115158005 115161951(dio2) 115172204
OTW112250646(dio1) 112261480
OMY100135896(dio2) 110524052(dio1)
OGO123996528(dio1) 124001150(dio2)
ONE115107365(dio1) 115145884
SALP111963588 111968967(dio2) 111975862(dio1) 112080277
SNH120054632(dio1) 120060525(dio2)
CCLU121532767 121539637(dio2)
ELS105006471(dio1) 105015440(dio2)
SFM108919387(dio2)
PKI111852657(dio2)
AANG118210941(dio2) 118224590(dio1) 118229914
LOC102695201(dio2) 102695995(dio1)
PSPA121323980 121326804(dio1) 121330326
ARUT117417108(dio1) 117422569 117424881
PSEX120515002(dio1) 120518765(dio2)
LCM102351745(DIO2) 102358780(DIO1)
CMK103186780(dio2) 103188836(dio1)
RTP109926630(dio2) 109928949(dio1)
BFO118432103
CIN100180523
SPU100893862 105442478 115927913 115928194
SKO102803304
PVM113800196 113807377
HAME121858234
PCLA123765862
EAF111706484
PCAN112567673
CRG105326271
MYI110463568
PMAX117325569 117325570 117325571
MMER123549954 123549955
LAK106151249
NVE5497581 5516446 5521975
ATEN116307432
ADF107327158 107331052 107331106 107333022
AMIL114952550 114969602 114969646 114972854 114974175
PDAM113675601 113679027 113679272 113679273 113686683
SPIS111338827
DGT114516609 114516716 114516753 114534415
XEN124436565 124436954 124454118 124454816 124454890 124454939 124454960
TADTRIADDRAFT_56187 TRIADDRAFT_56198 TRIADDRAFT_58190 TRIADDRAFT_58192 TRIADDRAFT_58193 TRIADDRAFT_58194 TRIADDRAFT_58195
DPPDICPUDRAFT_43625
ACANACA1_046490
 » show all
Reference
1  [PMID:7053997]
  Authors
Chopra IJ, Chua Teco GN.
  Title
Characteristics of inner ring (3 or 5) monodeiodination of 3,5-diiodothyronine in rat liver: evidence suggesting marked similarities of inner and outer ring deiodinases for iodothyronines.
  Journal
Endocrinology 110:89-97 (1982)
DOI:10.1210/endo-110-1-89
Reference
2  [PMID:6176242]
  Authors
Goswami A, Leonard JL, Rosenberg IN.
  Title
Inhibition by coumadin anticoagulants of enzymatic outer ring monodeiodination of iodothyronines.
  Journal
Biochem Biophys Res Commun 104:1231-8 (1982)
DOI:10.1016/0006-291X(82)91382-1
Reference
3  [PMID:7227308]
  Authors
Smallridge RC, Burman KD, Ward KE, Wartofsky L, Dimond RC, Wright FD, Latham KR.
  Title
3',5'-diiodothyronine to 3'-monoiodothyronine conversion in the fed and fasted rat: enzyme characteristics and evidence for two distinct 5'-deiodinases.
  Journal
Endocrinology 108:2336-45 (1981)
DOI:10.1210/endo-108-6-2336
Reference
4  [PMID:11898402]
  Authors
Kohrle J.
  Title
Iodothyronine deiodinases.
  Journal
Methods Enzymol 347:125-67 (2002)
DOI:10.1016/s0076-6879(02)47014-0
Other DBs
ExplorEnz - The Enzyme Database: 1.21.99.4
IUBMB Enzyme Nomenclature: 1.21.99.4
ExPASy - ENZYME nomenclature database: 1.21.99.4
BRENDA, the Enzyme Database: 1.21.99.4
CAS: 70712-46-8

DBGET integrated database retrieval system