KEGG   ENZYME: 1.23.1.2
Entry
EC 1.23.1.2                 Enzyme                                 
Name
(+)-lariciresinol reductase;
pinoresinol/lariciresinol reductase;
pinoresinol-lariciresinol reductases;
(+)-pinoresinol/(+)-lariciresinol;
(+)-pinoresinol-(+)-lariciresinol reductase;
PLR
Class
Oxidoreductases;
Reducing C-O-C group as acceptor;
With NADH or NADPH as donor
Sysname
(-)-secoisolariciresinol:NADP+ oxidoreductase
Reaction(IUBMB)
(-)-secoisolariciresinol + NADP+ = (+)-lariciresinol + NADPH + H+ [RN:R10226]
Reaction(KEGG)
R10226
Substrate
(-)-secoisolariciresinol [CPD:C18167];
NADP+ [CPD:C00006]
Product
(+)-lariciresinol [CPD:C10646];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The reaction is catalysed in vivo in the opposite direction to that shown. A multifunctional enzyme that also reduces (+)-pinoresinol [EC 1.23.1.1, (+)-pinoresinol reductase]. Isolated from the plants Forsythia intermedia [1,2], Thuja plicata (western red cedar) [3], Linum perenne (perennial flax) [5] and Linum corymbulosum [6].
History
EC 1.23.1.2 created 2013
Pathway
ec00999  Biosynthesis of various plant secondary metabolites
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K21568  pinoresinol/lariciresinol reductase
Genes
ATHAT1G32100(PRR1) AT4G13660(PRR2)
ALY9306436 9329761
CRB17878264 17898640 17899710
CSAT104719089 104723827 104723828 104732343 104741806 104757581 104757582 104777243
EUSEUTSA_v10008239mg EUTSA_v10009995mg EUTSA_v10026944mg
BRP103840191 103868905
BNA106362498 106441553 106443341 106451749 106451753 106453825 111203922
BOE106292815 106294294
RSZ108856438 108856439 108856515
THJ104798498 104814402 104814409
CPAP110826366
CIT102608004 102608287
CICCICLE_v10001909mg CICLE_v10001913mg
PVY116120000 116125874 116126062 116137530 116141105
MINC123195988 123196053 123196855
TCC18606866 18606867
GRA105791865 105791869
GHI107900659 107900663 107929415 107929420
GAB108468897 108468899
DZI111286131 111289303 111304310
EGR104444249 104444250 104444251 104444254
GMX100775382 100780465 100786578
GSJ114367117 114369002 114390881
PVUPHAVU_002G132300g PHAVU_002G132400g PHAVU_003G272900g
VRA106765640 106776909 106777876
VAR108331686 108335043 108335182
VUN114173139 114173523 114175607
CCAJ109791501 109801295 109806363
APRC113858524 113869210 113869519
MTRMTR_5g027240 MTR_5g027290 MTR_8g071130
CAM101492057 101501430
LJALj0g3v0024519.1(Lj0g3v0024519.1) Lj0g3v0067389.1(Lj0g3v0067389.1) Lj0g3v0151959.1(Lj0g3v0151959.1) Lj2g3v1536370.1(Lj2g3v1536370.1)
ADU107475254 107479134 107487050 107487131 107487132
AIP107622394 107624243 107641612 107642385 107642387
AHF112747483 112747484 112747485 112782427 112783546 112798030 112798048 112800088 112800089 112800090
LANG109332970 109349050
FVE101307211 101307794 105351891
RCN112177128 112177129 112177130
PPER18775767 18775835 18776245 18777823 18778052
PMUM103336794 103336795 103336796 103336797
PAVI110761041 110772979 110772980
PDUL117613517 117627184 117627185 117627188 117628069 117628098 117628169 117628285
MDM103453140 103453142
PXB103928035
ZJU107410011 107430985 107434370 107434379
MNT21405631 21405632 21405639
CSV101212644 101218862
CMO103499245 103499247
BHJ120077628 120078251
MCHA111022994 111025718
CMAX111466859 111466861 111466862
CMOS111464117 111464118 111464122
CPEP111776321 111776322 111811889
RCU8284632 8284633
JCU105632658
HBR110640204 110649727
MESC110602482 110604749 110605546
POP18094088 18094089 7465466
PEU105121482 105121485 105128209
PALZ118028664 118038662 118038664
JRE108980191 109014289
QSU112001516 112001517 112001518 112015239 112023934 112023936
QLO115969769 115969770 115970900 115971845 115972164 115972599
TWL119993294 119997790 119997791 119997987
VVI100243193 100248319 100253437(IFRL1) 100259918 100260187 100854593
VRI117905205 117921037 117928281 117928296 117928956 117929200 117929210
SLY101258966 101259550
SPEN107021294 107021639
SOT102590543 102597564
CANN107869653 107872854 107872855
NTA107767259 107806386 107825620
NSY104220290 104234527
NTO104085289 104092562 104092564
NAU109227228
INI109177381 109177391 109177392
ITR116001368 116001648 116002687 116002701
SIND105172735 105172736
OEU111387338 111387358 111387367 111408132 111408280
EGT105973797
SSPL121778590 121780365 121780799 121781020
HAN110865009 110920952 110930107 110930108 110930109
ECAD122580001 122600817 122600894 122600922 122602236
LSV111887528 111898507 111902652
CCAV112529291 112529297 112529363 112529620
DCR108192976 108193011 108206746
CSIN114262347 114281967 114283576
BVG104893088
SOE110801329
CQI110692822 110732670
NNU104596321 104596322 104596323
MING122060488 122062137 122086245 122086283 122087666
TSS122642691 122664432 122664715
PSOM113322331
NCOL116252548 116252549 116254772 116254791 116255118 116255193
OSA4351925 4351926 4351932
DOSAOs12t0263200-01(Os12g0263200) Os12t0265100-01(Os12g0265100)
OBR102717852 102718130
BDI100842184
ATS109737033 109785841 109785845 109785846
TDC119332686 119337515 119353140 119353141 119353142 119360533 119362236 119362237 119362238 119362239 119362241
TAES123040504 123043537 123043538 123043539 123043540 123051402 123051405 123154222 123159917 123170562 123187358
TUA125523955 125535496 125535498
SBI110429729 110429730
ZMA103650598
SITA101764846 101781583
SVS117847104 117849214
PVIR120665987 120665988 120667037 120699226 120699228 120699229
PHAI112888068
PDA103697428 103698420
EGU105040244 105041891 105060630
MUS103981518
DCT110113106 110116470
PEQ110020110
AOF109827161 109840604
ATR18423509 18443892 18443893 18443896
SMOSELMODRAFT_122655 SELMODRAFT_172293 SELMODRAFT_230858 SELMODRAFT_233106 SELMODRAFT_414671 SELMODRAFT_414678 SELMODRAFT_438560 SELMODRAFT_74219 SELMODRAFT_74385 SELMODRAFT_74402
SSESsed_3603
 » show all
Reference
1  [PMID:8262939]
  Authors
Chu A, Dinkova A, Davin LB, Bedgar DL, Lewis NG
  Title
Stereospecificity of (+)-pinoresinol and (+)-lariciresinol reductases from Forsythia intermedia.
  Journal
J Biol Chem 268:27026-33 (1993)
Reference
2  [PMID:8910615]
  Authors
Dinkova-Kostova AT, Gang DR, Davin LB, Bedgar DL, Chu A, Lewis NG
  Title
(+)-Pinoresinol/(+)-lariciresinol reductase from Forsythia intermedia. Protein purification, cDNA cloning, heterologous expression and comparison to isoflavone reductase.
  Journal
J Biol Chem 271:29473-82 (1996)
DOI:10.1074/jbc.271.46.29473
  Sequence
Reference
3  [PMID:9872995]
  Authors
Fujita M, Gang DR, Davin LB, Lewis NG
  Title
Recombinant pinoresinol-lariciresinol reductases from western red cedar (Thuja plicata) catalyze opposite enantiospecific conversions.
  Journal
J Biol Chem 274:618-27 (1999)
DOI:10.1074/jbc.274.2.618
  Sequence
Reference
4  [PMID:13129921]
  Authors
Min T, Kasahara H, Bedgar DL, Youn B, Lawrence PK, Gang DR, Halls SC, Park H, Hilsenbeck JL, Davin LB, Lewis NG, Kang C
  Title
Crystal structures of pinoresinol-lariciresinol and phenylcoumaran benzylic ether reductases and their relationship to isoflavone reductases.
  Journal
J Biol Chem 278:50714-23 (2003)
DOI:10.1074/jbc.M308493200
  Sequence
Reference
5  [PMID:17257599]
  Authors
Hemmati S, Schmidt TJ, Fuss E
  Title
(+)-Pinoresinol/(-)-lariciresinol reductase from Linum perenne Himmelszelt involved in the biosynthesis of justicidin B.
  Journal
FEBS Lett 581:603-10 (2007)
DOI:10.1016/j.febslet.2007.01.018
Reference
6  [PMID:18489708]
  Authors
Bayindir U, Alfermann AW, Fuss E
  Title
Hinokinin biosynthesis in Linum corymbulosum Reichenb.
  Journal
Plant J 55:810-20 (2008)
DOI:10.1111/j.1365-313X.2008.03558.x
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.23.1.2
IUBMB Enzyme Nomenclature: 1.23.1.2
ExPASy - ENZYME nomenclature database: 1.23.1.2
BRENDA, the Enzyme Database: 1.23.1.2

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