KEGG   ENZYME: 1.3.1.72
Entry
EC 1.3.1.72                 Enzyme                                 
Name
Delta24-sterol reductase;
lanosterol Delta24-reductase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
sterol:NADP+ Delta24-oxidoreductase
Reaction(IUBMB)
5alpha-cholest-7-en-3beta-ol + NADP+ = 5alpha-cholesta-7,24-dien-3beta-ol + NADPH + H+ [RN:R05703]
Reaction(KEGG)
Substrate
5alpha-cholest-7-en-3beta-ol [CPD:C01189];
NADP+ [CPD:C00006]
Product
5alpha-cholesta-7,24-dien-3beta-ol [CPD:C05439];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Acts on a range of steroids with a 24(25)-double bond, including lanosterol, desmosterol and zymosterol.
History
EC 1.3.1.72 created 2001
Pathway
ec00100  Steroid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K09828  Delta24-sterol reductase
Genes
HSA1718(DHCR24)
PTR456879(DHCR24)
PPS100972820(DHCR24)
GGO101131027(DHCR24)
PON100460563(DHCR24)
NLE100584832(DHCR24)
MCC717022(DHCR24)
MCF102144711(DHCR24)
MTHB126962307
CSAB103224760(DHCR24)
CATY105595994(DHCR24)
PANU101000886(DHCR24)
TGE112611859(DHCR24)
RRO104669609(DHCR24)
RBB108527886(DHCR24)
TFN117091964(DHCR24)
PTEH111523317(DHCR24)
CJC100405876(DHCR24)
SBQ101050483(DHCR24)
CSYR103270278(DHCR24)
MMUR105862976(DHCR24)
LCAT123635605(DHCR24)
OGA100961965(DHCR24)
MMU74754(Dhcr24)
MCAL110293777(Dhcr24)
MPAH110323016(Dhcr24)
RNO298298(Dhcr24)
MCOC116096334(Dhcr24)
MUN110547624(Dhcr24)
CGE100769920(Dhcr24)
MAUA101843861(Dhcr24)
PLEU114705886(Dhcr24)
MORG121448218(Dhcr24)
MFOT126498105
AAMP119816102(Dhcr24)
NGI103734101(Dhcr24)
HGL101703975(Dhcr24)
CPOC100714000(Dhcr24)
CCAN109682111(Dhcr24)
DORD105989945(Dhcr24)
DSP122099114(Dhcr24)
NCAR124961299
OCU100339404(DHCR24)
OPI101528234(DHCR24)
TUP102493621(DHCR24)
CFA489573(DHCR24)
CLUD112647080(DHCR24)
VVP112926100(DHCR24)
VLG121500401(DHCR24)
AML100468564(DHCR24)
UMR103670864(DHCR24)
UAH113254624(DHCR24)
UAR123795391(DHCR24)
ELK111143075
LLV125097788
MPUF101672112(DHCR24)
ORO101377395(DHCR24)
EJU114212110(DHCR24)
ZCA113909333(DHCR24)
MLX118019372(DHCR24)
NSU110575071(DHCR24)
FCA101098730(DHCR24)
PYU121027183(DHCR24)
PBG122480549(DHCR24)
LRUF124515860
PTG102960943(DHCR24)
PPAD109266824(DHCR24)
AJU106975067(DHCR24)
HHV120236003(DHCR24)
BTA533726(DHCR24)
BOM102282216(DHCR24)
BIU109556253(DHCR24)
BBUB102412870(DHCR24)
CHX102172859(DHCR24)
OAS101123162(DHCR24)
ODA120856095(DHCR24)
CCAD122436926(DHCR24)
SSC100628197(DHCR24)
CFR102514059(DHCR24)
CBAI105066413(DHCR24)
CDK105092825(DHCR24)
VPC102538812(DHCR24)
BACU102997333(DHCR24)
LVE103074307(DHCR24)
OOR101270880(DHCR24)
DLE111175853(DHCR24)
PCAD102985159(DHCR24)
PSIU116762463(DHCR24)
ECB100034055(DHCR24)
EPZ103566198(DHCR24)
EAI106833221(DHCR24)
MYB102247409(DHCR24)
MYD102763230(DHCR24)
MMYO118676168(DHCR24)
MLF102435870(DHCR24)
MNA107530654(DHCR24)
PKL118723578(DHCR24)
HAI109372611(DHCR24)
DRO112314620(DHCR24)
SHON118984954(DHCR24)
AJM119061043(DHCR24)
PDIC114496704(DHCR24)
PHAS123831206(DHCR24)
MMF118627006(DHCR24)
RFQ117027025(DHCR24)
PALE102893105(DHCR24)
PGIG120621680(DHCR24)
PVP105298949(DHCR24)
RAY107497957(DHCR24)
MJV108394011(DHCR24)
TOD119235114(DHCR24)
SARA101537548(DHCR24)
LAV100672619(DHCR24)
TMU101350369
DNM101430291(DHCR24)
MDO100032491(DHCR24)
GAS123245793(DHCR24)
SHR100923525(DHCR24)
PCW110201325(DHCR24)
OAA100088141(DHCR24)
GGA424661(DHCR24)
PCOC116235101(DHCR24)
MGP100546716(DHCR24)
CJO107317761(DHCR24)
NMEL110402600(DHCR24)
APLA101802248(DHCR24)
ACYG106033080(DHCR24)
AFUL116491795(DHCR24)
TGU100220338(DHCR24)
LSR110476800(DHCR24)
SCAN103815202(DHCR24)
PMOA120503259(DHCR24)
OTC121345091(DHCR24)
PRUF121362175(DHCR24)
GFR102045301(DHCR24)
FAB101811656(DHCR24)
PHI102110388(DHCR24)
PMAJ107208468(DHCR24)
CCAE111933015(DHCR24)
CCW104695172(DHCR24)
CBRC103615101(DHCR24)
ETL114055196(DHCR24)
ZAB102063290(DHCR24)
ACHL103805095(DHCR24)
FPG101919816(DHCR24)
FCH102048838(DHCR24)
CLV102090331(DHCR24)
EGZ104123952(DHCR24)
NNI104009270(DHCR24)
PLET104627324(DHCR24)
PCRI104025109(DHCR24)
ACUN113483026(DHCR24)
TALA104367195(DHCR24)
PADL103913312(DHCR24)
AFOR103905749(DHCR24)
ACHC115349388(DHCR24)
HALD104311120(DHCR24)
CCRI104155673(DHCR24)
CSTI104550808(DHCR24)
EHS104508877(DHCR24)
CMAC104483359(DHCR24)
MUI104541177(DHCR24)
FGA104074979(DHCR24)
GSTE104253659(DHCR24)
LDI104340848(DHCR24)
MNB103772068(DHCR24)
OHA104328021(DHCR24)
NNT104400121(DHCR24)
DPUB104301758(DHCR24)
PGUU104458852(DHCR24)
ACAR104533087(DHCR24)
AVIT104270577(DHCR24)
CVF104286053(DHCR24)
AAM106496004(DHCR24)
AROW112972830(DHCR24)
NPD112943439(DHCR24)
TGT104568529(DHCR24)
DNE112986114(DHCR24)
SCAM104149603(DHCR24)
ASN102381399(DHCR24)
AMJ102561682(DHCR24)
CPOO109307516(DHCR24)
GGN109286611(DHCR24)
PSS102450985(DHCR24)
CMY102929398(DHCR24)
CPIC101948257(DHCR24)
TST117881797(DHCR24)
CABI116817128(DHCR24)
MRV120370794(DHCR24)
ACS100552326(dhcr24)
PVT110082238(DHCR24)
SUND121929555(DHCR24)
PBI103056795(DHCR24)
PMUR107294417(DHCR24)
CTIG120297367(DHCR24)
TSR106544743(DHCR24)
PGUT117664273(DHCR24)
VKO123023491(DHCR24)
PMUA114598950(DHCR24)
ZVI118088986(DHCR24)
GJA107123068(DHCR24)
STOW125433474(DHCR24)
XLA444688(dhcr24.L) 447786(dhcr24.S)
XTR549554(dhcr24)
NPR108793059(DHCR24)
RTEM120945872(DHCR24)
BBUF120978944(DHCR24)
BGAR122943331(DHCR24)
DRE494102(dhcr24)
SRX107716558(dhcr24)
SANH107687183
SGH107566150 107581458
CCAR109050207 109056147
CAUA113062768 113079864 113121083
PPRM120494159(dhcr24)
MAMB125279115(dhcr24)
IPU108257922(dhcr24)
PHYP113545170(dhcr24)
SMEO124376951(dhcr24)
TFD113664011(dhcr24)
AMEX103030946(dhcr24)
EEE113588646(dhcr24)
TRU101075625(dhcr24)
TNGGSTEN00032709G001
LCO104919121(dhcr24)
NCC104962697(dhcr24)
CGOB115006605(dhcr24)
ELY117253413(dhcr24)
EFO125896163(dhcr24)
PLEP121941327(dhcr24)
SLUC116058899(dhcr24)
ECRA117950157(dhcr24)
ESP116695632(dhcr24)
PFLV114561501(dhcr24)
GAT120814877(dhcr24)
PPUG119217119(dhcr24)
MSAM119901038(dhcr24)
ALAT119028332(dhcr24)
MZE101484424(dhcr24)
ONL100707694(dhcr24)
OAU116331179(dhcr24)
OLA101172722(dhcr24)
OML112136989(dhcr24)
XMA102230615(dhcr24)
XCO114151181(dhcr24)
XHE116725486(dhcr24)
PRET103463795(dhcr24)
PFOR103137075(dhcr24)
PLAI106940322(dhcr24)
PMEI106906394(dhcr24)
GAF122838337(dhcr24)
CVG107099452(dhcr24)
CTUL119772288(dhcr24)
GMU124873351(dhcr24)
NFU107393431(dhcr24)
KMR108243375(dhcr24)
ALIM106536488(dhcr24)
NWH119407482(dhcr24)
AOCE111581125(dhcr24)
MCEP125009518(dhcr24)
CSEM103376648(dhcr24)
POV109625262(dhcr24)
SSEN122781215(dhcr24)
HHIP117759880(dhcr24)
HSP118120790(dhcr24)
LCF108879153
SDU111226415(dhcr24)
SLAL111652519(dhcr24)
XGL120790411(dhcr24)
HCQ109532187(dhcr24)
BPEC110154784(dhcr24)
MALB109961993(dhcr24)
BSPL114854573(dhcr24)
SASA106560235 106584213(dhcr24)
STRU115192413(dhcr24)
OTW112248909(dhcr24)
OMY110521638(dhcr24)
OGO124037829(dhcr24)
ONE115145092(dhcr24)
SALP111972291(dhcr24) 111975975
SNH120052566 120054904
CCLU121540180(dhcr24)
ELS105011791(dhcr24)
SFM108935136(dhcr24)
PKI111847581(dhcr24)
AANG118226457(dhcr24)
LOC102692762(dhcr24)
PSPA121327340(dhcr24) 121330796
ARUT117406452 117416469
LCM102351351(DHCR24)
CMK103182734(dhcr24)
RTP109916910(dhcr24)
BFO118403800 118431751
BBEL109461611 109467065 109476830
CIN100181233 100187505
SCLV120332471 120348047
SPU587262
APLC110985153 110985154
SKO100369348(DHCR24)
AAG5575872
AALB109431506
CQUCpipJ_CPIJ000670
CPII120424150
CNS116345307
BCOO119080541 119083674
NVI100123384
CSOL105363161
LHT122501929
CCIN107273594
TCA100142196 657073
DPA109533804
SOY115875084
ATD109608783
CSET123318655
AGB108909545 111692849
LDC111513845
NVL108565317 108567062
APLN108734397 108738175
OTU111417630 111422661 111425659
BMOR101738979 101746101
BMAN114239636 114249041
MSEX115443827 115444097
DPLKGM_208627 KGM_210521
BANY112044057 112044846
NIQ126774980 126777881
PMAC106716611 106718881
PPOT106102515 106111354
PXU106114375 106123118
PRAP110995529 110995549
ZCE119831877 119837670
HAW110372422 110377926
HZE124638198 124642641
TNL113498100 113501990
SLIU111348435 111364485
OFU114352321 114353545
PXY105383674 105384030
API100163443
DNX107163118
AGS114120652 114128394
RMD113553420 113557349
BTAB109040723
DCI103518884
NLU111043354
FOC113214177 113216750
TPAL117647690 117651694
ZNE110827611
CSEC111872676
FCD110847379 110848960 110850479 110851903 110854895 110855958 110856153 110857708 110857900 110860754 110861125 110861204 110861284
DPXDAPPUDRAFT_106816 DAPPUDRAFT_213873 DAPPUDRAFT_301658 DAPPUDRAFT_301660
DMK116922850 116931952
PVM113816839 113829565
PJA122245795 122255539
PCHN125041732
HAME121860879 121876287
PCLA123765283 123775183
PTRU123514691 123516012
HAZT108676392 108677143
EAF111702287 111705837 111717698 111718323
LSM121126039 121126078 121126089 121126183
PPOI119089646 119089745 119112376
CSCU111619650
CELCELE_F52H2.6(dhcr-24) CELE_Y7A5A.1(Y7A5A.1)
CBRCBG_02085 CBG_07765
NAINECAME_12948
HROHELRODRAFT_88371
LGILOTGIDRAFT_125011
PCAN112574560
BGT106072886
GAE121375292
HRF124119621
HRJ124270270
CRG105347433
MYI110452558
PMAX117325907
MMER123525352
OSN115228593
LAK106176554
NVE5507671
EPA110235299
ATEN116302753
TADTRIADDRAFT_50623
ATHAT3G19820(DWF1)
ALY9321400
CRB17891784
CSAT104705718 104746381 104765853
EUSEUTSA_v10020412mg
BRP103836950 103869418
BNA106346165 106346367 106347920 106352962 106380474 106404283 106425138
BOE106295235 106299900 106315109
RSZ108812033 108859173 108859174
THJ104804923 104815230
CIT102618829
CICCICLE_v10030984mg
PVY116131702
MINC123214529
TCC18610069
GRA105782452 105795877
GHI107913489 107919941
GAB108463919 108475236
DZI111283131 111317559
EGR104421584
GMX100791799 100814521
GSJ114376142 114378101
PVUPHAVU_011G031700g
VRA106756367
VAR108340606
VUN114169185
CCAJ109798769
APRC113864900
MTR25492834
CAM101507942
LJALj3g3v3511360.1(Lj3g3v3511360.1)
ADU107477170
AIP107628731
AHF112737069 112789026
LANG109325468 109353190 109353192
FVE101295708
RCN112200674
PPER18793320
PMUM103321055
PAVI110754644
PDUL117616106
MDM103403411 103451474
PXB103943196
MNT21398099
CSV101213648 101217570
CMO103499124 103499976
BHJ120070196 120086037
MCHA111019723 111020726
CMAX111488060 111493057 111497787
CMOS111452014 111456086 111460987
CPEP111778854 111787724 111806795
RCU8270547 8286535
JCU105634671
HBR110649201
MESC110611449
POP7460681 7481591
PEU105117570 105119294 105120424
PALZ118043059 118055821
JRE108979238
QSU111994940 112003097 112014456
QLO115981859
TWL119995076 119998734
VVI100258158
VRI117917730
SLY101244831 543937(SlSSR1)
SPEN107011008 107011042
SOT102584296(StSSR2) 102604696(StSSR1)
SSTN125846238 125846322
CANN107858473 107858990 107873381
NTA107776792 107785877 107790238 107795958
NSY104224267 104225586 104247240
NTO104115531 104115748
NAU109212734 109215510
INI109164986
ITR116032587
SIND105175842
OEU111374973
EGT105948810
SSPL121769555 121772618 121777693
HAN110882507 110897396 110911946
ECAD122595527 122601571
LSV111884353 111906636 111914648
CCAV112525197 112528552
DCR108202693 108204637
CSIN114317457
BVG104902610
SOE110787922
CQI110691763 110691979 110702045 110735089
NNU104611785
MING122079369
TSS122664415
PSOM113275275 113282591
NCOL116261058
OSA4348555
DOSAOs10t0397400-01(Os10g0397400)
OBR102708833
BDI100827186 100833467
ATS109760115
TDC119330116 119337318
TAES123149858 123162501 123168911
TUA125522815
SBI110431358 8056247
ZMA542549
SITA101752839 101757042
SVS117838443 117852480 117856981
PVIR120650728 120650753 120657707 120657708 120668926 120704572
PHAI112884546 112884560 112889248
PDA103696177 103698781 103712977 103717097 120105812
EGU105055409 105058937
MUS103982623 103983665 103984843
DCT110097493 110103862
PEQ110030816 110030965
AOF109820542 109837421 109848066
ATR18437615
SMOSELMODRAFT_139528 SELMODRAFT_144134 SELMODRAFT_169026 SELMODRAFT_417880
PPP112284728 112288350
CCPCHC_T00002789001
SMPSMAC_03874
PANPODANSg2962
TTTTHITE_2039507
MTMMYCTH_2306485
MGRMGG_01030 MGG_16834
PPEIPpBr36_03320
TMNUCRPA7_4685
SSCKSPSK_02409
FGRFGSG_03444 FGSG_05921 FGSG_09265
FPUFPSE_03059 FPSE_09657 FPSE_10291
FVRFVEG_03845 FVEG_04514
FOXFOXG_05977 FOXG_07585
NHENECHADRAFT_58588 NECHADRAFT_63808 NECHADRAFT_93941
TRETRIREDRAFT_47420 TRIREDRAFT_57141 TRIREDRAFT_78685
TRRM419DRAFT_109375 M419DRAFT_137163 M419DRAFT_73170
MAWMAC_04040
CMTCCM_05983
PLJVFPFJ_08260 VFPFJ_08331
VALVDBG_08197
VDAVDAG_07125
CFJCFIO01_02649 CFIO01_05044
ELAUCREL1_2151 UCREL1_5958
PFYPFICI_14104
SSLSS1G_02891 SS1G_11755
BFUBCIN_02g09030 BCIN_03g08970 BCIN_06g03380
MBEMBM_00612 MBM_03745
PSCOLY89DRAFT_691453 LY89DRAFT_739068 LY89DRAFT_765866
GLZGLAREA_02291 GLAREA_12936
PCSPc22g00330
TMFPMAA_048950
CIMCIMG_01903
CPWCPC735_046090
UREUREG_04798
PBLPAAG_06636
PBNPADG_01091
AJEHCAG_06436
BGHBDBG_02700
PNOSNOG_00346 SNOG_01070
PTEPTT_10208 PTT_16386
BZECOCCADRAFT_28676 COCCADRAFT_92064
BSCCOCSADRAFT_198537 COCSADRAFT_40410 COCSADRAFT_41567
BORCOCMIDRAFT_24089 COCMIDRAFT_80134
AALTCC77DRAFT_1020870 CC77DRAFT_1055926 CC77DRAFT_924902
ZTRMYCGRDRAFT_66881
PFJMYCFIDRAFT_130471 MYCFIDRAFT_43637
BCOMBAUCODRAFT_460309
NPAUCRNP2_9289
MBRMONBRDRAFT_27834
SREPTSG_00994
FCYFRACYDRAFT_178258
SPARSPRG_04988
EHXEMIHUDRAFT_442513
MCAMCA1404
METUGNH96_11360
MAHMEALZ_3890
MBUREQU24_21070
MMAIsS8_2579
MMOBF6R98_14540
MEINmethR_P2083
MISZMishRS11D_00080
BVRBVIR_1714
BLAGBLTE_05860
SRKFGW37_00270
PUVPUV_14270
CRMK6119_18050
 » show all
Reference
1  [PMID:9291139]
  Authors
Bae SH, Paik YK
  Title
Cholesterol biosynthesis from lanosterol: development of a novel assay method and characterization of rat liver microsomal lanosterol delta 24-reductase.
  Journal
Biochem J 326 ( Pt 2):609-16 (1997)
DOI:10.1042/bj3260609
Other DBs
ExplorEnz - The Enzyme Database: 1.3.1.72
IUBMB Enzyme Nomenclature: 1.3.1.72
ExPASy - ENZYME nomenclature database: 1.3.1.72
BRENDA, the Enzyme Database: 1.3.1.72
CAS: 9033-57-2

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