KEGG   ENZYME: 1.3.1.77
Entry
EC 1.3.1.77                 Enzyme                                 
Name
anthocyanidin reductase [(2R,3R)-flavan-3-ol-forming];
ANR (gene name) (ambiguous);
flavan-3-ol:NAD(P)+ oxidoreductase;
anthocyanidin reductase (ambiguous)
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
(2R,3R)-flavan-3-ol:NAD(P)+ 3,4-oxidoreductase
Reaction(IUBMB)
a (2R,3R)-flavan-3-ol + 2 NAD(P)+ = an anthocyanidin with a 3-hydroxy group + 2 NAD(P)H + H+ [RN:R07351 R07352]
Reaction(KEGG)
Substrate
(2R,3R)-flavan-3-ol [CPD:C15598];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
anthocyanidin with a 3-hydroxy group [CPD:C21381];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme participates in the flavonoid biosynthesis pathway found in plants. It catalyses the double reduction of anthocyanidins, producing (2R,3R)-flavan-3-ol monomers required for the formation of proanthocyanidins. While the enzyme from the legume Medicago truncatula (MtANR) can use both NADPH and NADH as reductant, that from the crucifer Arabidopsis thaliana (AtANR) uses only NADPH. Also, while the substrate preference of MtANR is cyanidin>pelargonidin>delphinidin, the reverse preference is found with AtANR. cf. EC 1.3.1.112, anthocyanidin reductase [(2S)-flavan-3-ol-forming].
History
EC 1.3.1.77 created 2004, modified 2016
Pathway
ec00941  Flavonoid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K08695  anthocyanidin reductase
Genes
ATHAT1G61720(BAN)
ALY9322580
CRB17894009
CSAT104703765 104714500 104752826
EUSEUTSA_v10023567mg
BRP103831042 103838541
BNA106352233 106374812 106374840 106395425
BOE106302532 106323258 106341298
RSZ108810876
THJ104809521
CPAP110812199
CIT102618954
CICCICLE_v10017667mg
PVY116105178 116141969
MINC123219441 123219660
TCC18597033(ANR)
GRA105768219
GHI107905961 107938221
GAB108452981
DZI111280787
EGR104441057 104441153
GMX100805127(ANR1) 100817081(ANR2)
GSJ114421336 114422060
PVUPHAVU_002G218600g PHAVU_002G218700g
VRA106766353 106767189 106767332 106773404
VAR108323842 108337959
VUN114176923 114179528
CCAJ109794672 109817877
APRC113858180 113859920
MTR25493251
CAM101494604
PSAT127100664
LJALj4g3v0423090.1(Lj4g3v0423090.1)
ADU107480609
AIP107626250
AHF112728650 112791357
LANG109330732
FVE101297977
RCN112202296
PPER18778549
PMUM103324591
PAVI110768767
PDUL117624652
MDM103434638 114827797
PXB103957769 103957850
ZJU107421422
MNT21397956
RCU8267420
JCU105649408
HBR110658083
MESC110602917
POP7490768 7495295
PEU105110148
PALZ118042818
JRE108979344
QSU111989132
QLO115972793 115992511
TWL119990111 120005016
VRI117923743 117924389
SLY101263493
SPEN107012467
SOT102584577
SSTN125860515
NTA107770662 107829462
NSY104233566
NTO104120432
NAU109243327
CSIN114259095 114297899
BVG104883056
CQI110687076 110693741
NNU104585744 104593362 104604944
MING122062392 122091471
TSS122639738 122647935
PSOM113318553 113348609
NCOL116263884
OSA4337100 4337101 4337102
DOSAOs04t0630100-01(Os04g0630100) Os04t0630300-01(Os04g0630300) Os04t0630400-01(Os04g0630400) Os04t0630600-00(Os04g0630600) Os04t0630800-01(Os04g0630800) Os04t0630900-01(Os04g0630900) Os04t0631000-00(Os04g0631000)
OBR102705034 102716961 102717241
BDI100834459 100834762 100835070
ATS109733882 109736125 109736130 109736133 109738472 109750081 109766837 109778519
TDC119273584 119340433 119343101 119343446 119344362 119344363 119344594 119345496 119348096 119348639 119352459 119356613 119356614 119356615 119356617 119356618 119356619 119356622 119356623 119356625 119356627 119357206 119357207 119358703 119361244 119365826 119365829 119365830 119365831 119365832 119365836 119365837 119366539 119366540 119368461
TAES123040141 123042234 123042237 123042239 123042851 123046886 123046888 123046889 123046890 123046891 123047541 123047542 123050175 123050279 123054723 123054724 123054727 123054732 123054733 123054738 123186210 123186211 123186212 123186651 123186652 123186653 123190564 123190566 123190569 123190572 123190573 123191123 123191124
TUA125527806 125527807 125527876 125527877 125528738 125530497 125533915 125534183 125534191 125534196 125534197 125534569 125539841 125539842 125539844 125539845 125546262
SBI110436259 8066840 8066841 8066842 8066844 8066846
ZMA100191338 100280098 100282500 103652362 118474966
SITA101757899 101758322 101759132 101784129
SVS117863580
PVIR120641879 120641880 120641882 120641883 120644933 120675175 120675466 120675567 120676510 120681344 120681438 120682923 120682924
PHAI112899176 112899177 112899179
PDA103698208
EGU105035639
MUS103994101
AOF109821630
ATR18427888
 » show all
Reference
1  [PMID:12532018]
  Authors
Xie DY, Sharma SB, Paiva NL, Ferreira D, Dixon RA
  Title
Role of anthocyanidin reductase, encoded by BANYULS in plant flavonoid biosynthesis.
  Journal
Science 299:396-9 (2003)
DOI:10.1126/science.1078540
  Sequence
Reference
2  [PMID:14725861]
  Authors
Xie DY, Sharma SB, Dixon RA.
  Title
Anthocyanidin reductases from Medicago truncatula and Arabidopsis thaliana.
  Journal
Arch Biochem Biophys 422:91-102 (2004)
DOI:10.1016/j.abb.2003.12.011
  Sequence
[ath:AT1G61720]
Reference
3  [PMID:23288883]
  Authors
Pang Y, Abeysinghe IS, He J, He X, Huhman D, Mewan KM, Sumner LW, Yun J, Dixon RA
  Title
Functional characterization of proanthocyanidin pathway enzymes from tea and their application for metabolic engineering.
  Journal
Plant Physiol 161:1103-16 (2013)
DOI:10.1104/pp.112.212050
Other DBs
ExplorEnz - The Enzyme Database: 1.3.1.77
IUBMB Enzyme Nomenclature: 1.3.1.77
ExPASy - ENZYME nomenclature database: 1.3.1.77
BRENDA, the Enzyme Database: 1.3.1.77
CAS: 93389-48-1

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