KEGG   ENZYME: 1.3.1.84
Entry
EC 1.3.1.84                 Enzyme                                 
Name
acrylyl-CoA reductase (NADPH)
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
propanoyl-CoA:NADP+ oxidoreductase
Reaction(IUBMB)
propanoyl-CoA + NADP+ = acryloyl-CoA + NADPH + H+ [RN:R00919]
Reaction(KEGG)
R00919
Substrate
propanoyl-CoA [CPD:C00100];
NADP+ [CPD:C00006]
Product
acryloyl-CoA [CPD:C00894];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Catalyses a step in the 3-hydroxypropanoate/4-hydroxybutanoate cycle, an autotrophic CO2 fixation pathway found in some thermoacidophilic archaea [1]. The enzyme from Sulfolobus tokodaii does not act on either NADH or crotonyl-CoA [2]. Different from EC 1.3.1.8, which acts only on enoyl-CoA derivatives of carbon chain length 4 to 16. Contains Zn2+.
History
EC 1.3.1.84 created 2009, modified 2014
Pathway
ec00720  Carbon fixation pathways in prokaryotes
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K14469  acrylyl-CoA reductase (NADPH) / 3-hydroxypropionyl-CoA dehydratase / 3-hydroxypropionyl-CoA synthetase
K15020  acryloyl-coenzyme A reductase
Genes
BNGEH206_02650
TCIA7K98_04000
PCIPCH70_27690
PFSPFLU_2204
PSESPSCI_5565
PVWHU752_019175
PIGEGT29_20960
DOEDENOEST_2465
MXAMXAN_4266
MSDMYSTI_03692
MYMA176_002621
MFBMFUL124B02_26250
CCXCOCOR_03605(adhP)
MFULILAB_29490
MMASMYMAC_004185
SURSTAUR_8160
AGEAA314_03269
AVMJQX13_52660
MBDMEBOL_000911
CFUSCYFUS_007357
LLUAKJ09_03010
NIYFQ775_13560
PALGHFP57_16695
SANDH3309_14800
POQKZX46_11635
GOYGLS_c14560(adhT)
APERA0U91_09345
AEBC6I20_03415
AACDLWP59_17500
PDXPsed_3739
PBROHOP40_32830
RMARGBA65_02000
BSOLFSW04_20500
RRSRoseRS_3202
RCARcas_2930
CAUCaur_0613
CHLChy400_0662
CAGCagg_3394
CTMCabther_B0610
CVLJ8C06_12460
CHLOJ8C02_11660
GGRHKW67_05055
CTSCtha_1050
HAKZJ0X25_09315
NAYHYG81_22555
TACTa0841
TVOTVG0995648(TVG0995648)
PTOPTO1151
FACFACI_IFERC01G0984
FAIFAD_0007
CDIVCPM_0774
STOSTK_04800
SOHD1869_02215
SSOSSO0764(adh-2)
SOLSsol_0305 Ssol_1823
SSOASULA_0298 SULA_1853
SSOLSULB_0300 SULB_1854
SSOFSULC_0298 SULC_1852
SSHIJ5U23_01281 J5U23_02641
SCASSACC_07300 SACC_17810
SAISaci_0911(adh)
SACNSacN8_04415 SacN8_05425
SACRSacRon12I_04405 SacRon12I_05415
SACSSUSAZ_04165 SUSAZ_05205
SISLS215_0315 LS215_1474
SIAM1425_0286 M1425_1378
SIMM1627_0286 M1627_1428
SIDM164_0304 M164_1370
SIYYG5714_0289 YG5714_1372
SINYN1551_1469 YN1551_2895
SIILD85_0292 LD85_1501
SIHSiH_0293 SiH_1323
SIRSiRe_0291 SiRe_1239
SICSiL_0277 SiL_1236
SULABFU36_02155 BFU36_06670
SULEGFS03_02995 GFS03_07700
SULOGFS33_08240 GFS33_13105
SULLEWF20_03740
MSEMsed_1426
MCNMcup_0809
MHKDFR87_11745
MPRUDFR88_11185
MTENGWK48_03460
MJNMjAS7_2497
AHOAhos_2283
AMANB6F84_02680
ABRIDFR85_01205
ASULDFR86_02685
AAMBD1866_06505
ACIHHS5_11830
SACDHS1genome_1083
SAZOD1868_01515
CSTYKN1_18030
STEPIC006_1239
SAHSHS7_00830
PAIPAE1921
PISPisl_1770
PCLPcal_0882
PASPars_2114
PYRP186_0181
POGPogu_2773
TNETneu_0785
PYWPYWP30_00861
CMACmaq_1615
TTNTTX_1731(adhP)
TUZTUZN_1795
VDIVdis_0393
VMOVMUT_1233
 » show all
Reference
1  [PMID:18079405]
  Authors
Berg IA, Kockelkorn D, Buckel W, Fuchs G
  Title
A 3-hydroxypropionate/4-hydroxybutyrate autotrophic carbon dioxide assimilation pathway in Archaea.
  Journal
Science 318:1782-6 (2007)
DOI:10.1126/science.1149976
Reference
2  [PMID:19429610]
  Authors
Teufel R, Kung JW, Kockelkorn D, Alber BE, Fuchs G
  Title
3-hydroxypropionyl-coenzyme A dehydratase and acryloyl-coenzyme A reductase, enzymes of the autotrophic 3-hydroxypropionate/4-hydroxybutyrate cycle in the Sulfolobales.
  Journal
J Bacteriol 191:4572-81 (2009)
DOI:10.1128/JB.00068-09
  Sequence
[sto:STK_04800]
Other DBs
ExplorEnz - The Enzyme Database: 1.3.1.84
IUBMB Enzyme Nomenclature: 1.3.1.84
ExPASy - ENZYME nomenclature database: 1.3.1.84
BRENDA, the Enzyme Database: 1.3.1.84

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