KEGG   ENZYME: 1.3.1.87
Entry
EC 1.3.1.87                 Enzyme                                 
Name
3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate dehydrogenase;
hcaB (gene name);
cis-dihydrodiol dehydrogenase;
2,3-dihydroxy-2,3-dihydro-phenylpropionate dehydrogenase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate:NAD+ oxidoreductase
Reaction(IUBMB)
(1) 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD+ = 3-(2,3-dihydroxyphenyl)propanoate + NADH + H+ [RN:R06784];
(2) (2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate + NAD+ = (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + NADH + H+ [RN:R06785]
Reaction(KEGG)
R06784 R06785
Substrate
3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate [CPD:C11588];
NAD+ [CPD:C00003];
(2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate [CPD:C12622]
Product
3-(2,3-dihydroxyphenyl)propanoate [CPD:C04044];
NADH [CPD:C00004];
H+ [CPD:C00080];
(2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate [CPD:C12623]
Comment
This enzyme catalyses a step in the pathway of phenylpropanoid compounds degradation.
History
EC 1.3.1.87 created 2011
Pathway
ec00360  Phenylalanine metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K05711  2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase
Genes
ECOb2541(hcaB)
ECJJW2525(hcaB)
ECDECDH10B_2708(hcaB)
EBWBWG_2305(hcaB)
ECOKECMDS42_2085(hcaB)
ECEZ3813(hcaB)
ECSECs_3407(hcaB)
ECFECH74115_3773(hcaB)
ETWECSP_3485(hcaB)
ELXCDCO157_3174
EOIECO111_3265(hcaB)
EOJECO26_3588(hcaB)
EOHECO103_3061(hcaB)
ESLO3K_06710
ESOO3O_18940
ESMO3M_06755
ECKEC55989_2827(hcaB)
EOKG2583_3071(hcaB)
ELRECO55CA74_15200
ELHETEC_2698
ECWEcE24377A_2826(hcaB)
EUNUMNK88_3194
ECOAAPECO78_16435
ECXEcHS_A2693(hcaB)
ECMEcSMS35_2694(hcaB)
ECYECSE_2828
ECRECIAI1_2593(hcaB)
EUMECUMN_2861(hcaB)
ECTECIAI39_2742(hcaB)
EOCCE10_2973(hcaB)
EBRECB_02433(hcaB)
EBLECD_02433(hcaB)
EBEB21_02397(hcaB)
EBDECBD_1143
ELOEC042_2745(hcaB)
ECLEcolC_1136
EKOEKO11_1192
EKFKO11_10115(hcaB)
EDHEcDH1_1127
EDJECDH1ME8569_2468(hcaB)
ELWECW_m2767(hcaB)
ELLWFL_13550(hcaB)
ELPP12B_c2641(hcaB)
ECOLLY180_13035
ESZFEM44_02695(hcaB)
SFLSF2588(hcaB)
SFXS2760(hcaB)
SFVSFV_2589(hcaB)
SFESFxv_2844(hcaB)
SFNSFy_3675
SFSSFyv_3752
SFTNCTC1_02844(hcaB)
SSNSSON_2623(hcaB)
SBOSBO_2565(hcaB)
SHQA0259_16430
KPVKPNIH29_19735
REEelectrica_01230(hcaB)
CFDCFNIH1_24140
CWECO701_05125
CYOCD187_06580
CPOTFOB25_17725(hcaB)
CFQC2U38_18475
CIFAL515_17225
CIEAN232_10840
CPARCUC49_13150
CITZE4Z61_23080(hcaB)
CARSE1B03_19725(hcaB)
KASKATP_11280(hcaB)
PSGCG163CM_01180(hcaB)
EBFD782_1128
SFWWN53_15155
SFGAV650_10695
PLUplu2207(hcaB)
PLUMA4R40_11065
PAYPAU_02354(hcaB)
PTTVY86_20025
PAKHB0X70_11380
PLUICE143_11295
LRINCTC12151_03200(hcaB)
VNAPN96_06455
VEJVEJY3_06595
VFUvfu_A01968
ALCOTEC02_08855
AEIAOY20_01935
ASJAsACE_CH00361(hcaB)
ADVDJ533_16915(hcaB)
ARJDOM24_01620
ATNFM020_13940(hcaB)
ACHICDG60_03005
ALJG8D99_13365(hcaB)
AWGGFH30_01750(hcaB)
ASHAG8E00_02290(hcaB)
ATGJ4G44_04430(hcaB)
AVBRYU24_27060(hcaB)
ABOUACBO_27660(hcaB)
ACIUA3K93_01305
GBIPG2T_08585
AQLBXU06_16220
BDFWI26_30265
BANNJFN94_26745(hcaB)
PACPFAZ97_23030(hcaB)
BOJCBF45_10080
AFAUZ73_04225
AFQAFA_13930
AAQUD3M96_14790
AAMMFE795_12885(hcaB)
KGYEHF36_10480
DIHG7047_02075(hcaB)
RBUPG1C_04295
SYBTZ53_25060
SPHTK426_22019
MPAMAP_2736(fabG5)
MSAMycsm_01932 Mycsm_01993
MKMMkms_5615
MGORH0P51_21145
MVAMvan_4412
MABMAB_4365c
CDRCDHC03_1955(hcaB)
CAZCARG_03230
CIICIMIT_11750
CMVCMUST_15100(hcaB)
CRFFRC0190_02113
CLIZG7Y31_11570
COKCOCCU_04445(bphB)
NNONONO_c29070
REQREQ_35110
STSIA4E84_36405
SGMGCM10017557_80200(hcaB)
SPHVF9278_45570
MIOAOA12_18575
ASUNKG104_01765
NAEBHE16_09205
NCANoca_0689
BLAPMVA48_02345
TROtrd_A0926
 » show all
Reference
1  [PMID:9603882]
  Authors
Diaz E, Ferrandez A, Garcia JL.
  Title
Characterization of the hca cluster encoding the dioxygenolytic pathway for initial catabolism of 3-phenylpropionic acid in Escherichia coli K-12.
  Journal
J Bacteriol 180:2915-23 (1998)
DOI:10.1128/JB.180.11.2915-2923.1998
  Sequence
[eco:b2541]
Other DBs
ExplorEnz - The Enzyme Database: 1.3.1.87
IUBMB Enzyme Nomenclature: 1.3.1.87
ExPASy - ENZYME nomenclature database: 1.3.1.87
UM-BBD (Biocatalysis/Biodegradation Database): 1.3.1.87
BRENDA, the Enzyme Database: 1.3.1.87

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