KEGG   ENZYME: 1.3.1.94
Entry
EC 1.3.1.94                 Enzyme                                 
Name
polyprenol reductase;
SRD5A3 (gene name);
DFG10 (gene name)
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
ditrans,polycis-dolichol:NADP+ 2,3-oxidoreductase
Reaction(IUBMB)
ditrans,polycis-dolichol + NADP+ = ditrans,polycis-polyprenol + NADPH + H+ [RN:R12299]
Reaction(KEGG)
R12299
Substrate
ditrans,polycis-dolichol [CPD:C00381];
NADP+ [CPD:C00006]
Product
ditrans,polycis-polyprenol [CPD:C06081];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The reaction occurs in the reverse direction with reduction of the terminal double bond next to the alcohol group. Isolated from human fetal brain tissue but present in all eukaryotes. In mammalian cells dolichols are predominantly 18-21 isoprene units in length.
History
EC 1.3.1.94 created 2012
Pathway
ec00510  N-Glycan biosynthesis
ec01100  Metabolic pathways
Orthology
K12345  3-oxo-5-alpha-steroid 4-dehydrogenase 3 / polyprenol reductase
Genes
HSA79644(SRD5A3)
PTR471241(SRD5A3)
PPS100987485(SRD5A3)
GGO101127484(SRD5A3)
PON100461714(SRD5A3)
NLE100604898(SRD5A3)
MCC696381(SRD5A3)
MCF102135568(SRD5A3)
CSAB103235668(SRD5A3)
CATY105591982(SRD5A3)
PANU101018670(SRD5A3)
TGE112625457(SRD5A3)
RRO104662017(SRD5A3)
RBB108531594(SRD5A3)
TFN117085599(SRD5A3)
PTEH111526483(SRD5A3)
CJC100409457(SRD5A3)
SBQ101035698(SRD5A3)
CSYR103249196(SRD5A3)
MMUR105867840(SRD5A3)
LCAT123624848(SRD5A3)
OGA100962186(SRD5A3)
MMU57357(Srd5a3)
MCAL110294824(Srd5a3)
MPAH110330734(Srd5a3)
RNO305291(Srd5a3)
MCOC116071286(Srd5a3)
MUN110556924(Srd5a3)
CGE100770660(Srd5a3)
MAUA101843963(Srd5a3)
PLEU114683326(Srd5a3)
MORG121460946(Srd5a3)
AAMP119817624(Srd5a3)
NGI103734389(Srd5a3)
HGL101726767(Srd5a3)
CPOC100727041(Srd5a3)
CCAN109698967(Srd5a3)
DORD105980241(Srd5a3)
DSP122106914(Srd5a3)
NCAR124995103
OCU100346041(SRD5A3)
OPI101525367(SRD5A3)
TUP102493739(SRD5A3) 106736078
CFA482155(SRD5A3)
CLUD112652140(SRD5A3)
VVP112923679(SRD5A3)
VLG121473600(SRD5A3)
AML100463734(SRD5A3)
UMR103672741(SRD5A3)
UAH113262505(SRD5A3)
UAR123804043(SRD5A3)
ELK111149140
LLV125093733
MPUF101675597(SRD5A3)
ORO101370876(SRD5A3)
EJU114206831(SRD5A3)
ZCA113925732(SRD5A3)
MLX118010518(SRD5A3)
FCA101090010(SRD5A3)
PYU121035507(SRD5A3)
PBG122478868(SRD5A3)
PTG102960215(SRD5A3)
PPAD109278937(SRD5A3)
AJU113598703(SRD5A3)
HHV120243022(SRD5A3)
BTA535834(SRD5A3)
BOM102284607(SRD5A3)
BIU109560479(SRD5A3)
BBUB102412800(SRD5A3)
CHX102180581(SRD5A3)
OAS101106772(SRD5A3)
ODA120862131(SRD5A3)
CCAD122428312(SRD5A3)
SSC100525350
CFR102523042(SRD5A3)
CBAI105077674(SRD5A3)
CDK105091542(SRD5A3)
VPC102537511(SRD5A3)
BACU103012155(SRD5A3)
LVE103087526(SRD5A3)
OOR101276021 101290031(SRD5A3)
DLE111169636(SRD5A3)
PCAD102987064(SRD5A3)
PSIU116749364 116754344(SRD5A3)
ECB100059582(SRD5A3)
EPZ103554975(SRD5A3)
EAI106836922(SRD5A3)
MYB102257134(SRD5A3)
MYD102771502(SRD5A3)
MMYO118668902(SRD5A3)
MLF102442157(SRD5A3)
MNA107532791(SRD5A3)
PKL118706564(SRD5A3)
HAI109381825(SRD5A3)
DRO112316781(SRD5A3)
SHON118978619(SRD5A3)
AJM119044892(SRD5A3)
PHAS123815907(SRD5A3)
MMF118635260(SRD5A3)
RFQ117022239(SRD5A3)
PALE102896891(SRD5A3)
PGIG120588089(SRD5A3)
PVP105293769(SRD5A3)
RAY107520901(SRD5A3)
MJV108400780(SRD5A3)
TOD119260781(SRD5A3)
SARA101539064(SRD5A3)
LAV100671020(SRD5A3)
TMU101348372
DNM101426407(SRD5A3)
MDO100017228(SRD5A3)
GAS123251476(SRD5A3)
SHR100928836(SRD5A3)
PCW110200149(SRD5A3)
OAA100075423(SRD5A3)
GGA422750(SRD5A3)
PCOC116225919(SRD5A3)
MGP100541554(SRD5A3)
CJO107313729(SRD5A3)
NMEL110398188(SRD5A3)
APLA101796282(SRD5A3)
ACYG106030826(SRD5A3)
AFUL116488841(SRD5A3)
TGU100224163(SRD5A3)
LSR110484867(SRD5A3)
SCAN103826189(SRD5A3)
PMOA120497508(SRD5A3)
OTC121335219(SRD5A3)
PRUF121348803(SRD5A3)
GFR102042544(SRD5A3)
FAB101812956(SRD5A3)
PHI102113098(SRD5A3)
PMAJ107202960(SRD5A3)
CCAE111928443(SRD5A3)
CCW104690628(SRD5A3)
CBRC103622554(SRD5A3)
ETL114058307(SRD5A3)
ZAB102071936(SRD5A3)
FPG101920408(SRD5A3)
FCH102059273(SRD5A3)
CLV102095131(SRD5A3)
EGZ104129459(SRD5A3)
NNI104020822(SRD5A3)
PLET104615121(SRD5A3)
PCRI104026375(SRD5A3)
ACUN113479224(SRD5A3)
TALA104360948(SRD5A3)
PADL103926347(SRD5A3)
ACHC115347095(SRD5A3)
HALD104310495(SRD5A3)
CCRI104154944(SRD5A3)
CSTI104551479(SRD5A3)
EHS104502937(SRD5A3)
CMAC104474499(SRD5A3)
FGA104069440(SRD5A3)
GSTE104251972(SRD5A3)
LDI104341202(SRD5A3)
MNB103771301(SRD5A3)
OHA104334923(SRD5A3)
AAM106490085(SRD5A3)
AROW112975832(SRD5A3)
NPD112942655(SRD5A3)
DNE112979429(TMEM165)
ASN102379264 102384757
AMJ102567202(SRD5A3)
CPOO109322191(SRD5A3)
GGN109303658(SRD5A3)
PSS102444263(SRD5A3)
CMY102936322(SRD5A3)
CPIC101937467(SRD5A3)
TST117878354(SRD5A3)
CABI116826032(SRD5A3)
MRV120406924(SRD5A3)
ACS100551938(srd5a3) 103282902
PVT110078425(SRD5A3)
SUND121932100(SRD5A3)
PBI103063410(SRD5A3)
PMUR107292123(SRD5A3)
PGUT117662094(SRD5A3)
VKO123017059(SRD5A3)
PMUA114603835(SRD5A3)
ZVI118083326(SRD5A3)
GJA107106033(SRD5A3)
STOW125439607 125439612(SRD5A3)
XLA108698470(srd5a3.L) 379123(srd5a3.S)
XTR779994(srd5a3)
NPR108804033(SRD5A3)
RTEM120922855(SRD5A3)
BBUF120990206(SRD5A3)
BGAR122941791(SRD5A3)
DRE560717(srd5a3)
SRX107718431(srd5a3) 107755245
SANH107665336 107683999
SGH107573990(srd5a3) 107576144 107601910
CCAR109066982(srd5a3)
CAUA113062754 113120990(srd5a3)
PPRM120493381(srd5a3)
MAMB125277994(srd5a3)
IPU108258126(srd5a3)
PHYP113546831(srd5a3)
SMEO124377361(srd5a3)
TFD113653665(srd5a3)
AMEX103045498(srd5a3)
EEE113586386(srd5a3)
TRU105417901(srd5a3)
TNGGSTEN00032760G001
LCO104919092(srd5a3)
NCC104947078(srd5a3)
CGOB115007066(srd5a3)
ELY117253571(srd5a3)
EFO125896382(srd5a3)
PLEP121941200(srd5a3) 121966138
SLUC116058786(srd5a3)
ECRA117950168(srd5a3)
PFLV114561858(srd5a3)
GAT120824159(srd5a3)
PPUG119217210(srd5a3)
MSAM119894691(srd5a3)
CUD121512392(srd5a3)
ALAT119028120(srd5a3)
MZE101473345(srd5a3)
ONL100691782(srd5a3)
OAU116331154(srd5a3)
OLA101156806(srd5a3)
OML112136777(srd5a3)
XMA102237479(srd5a3)
XCO114150660(srd5a3)
XHE116725928(srd5a3)
PRET103463835(srd5a3)
PFOR103137113(srd5a3)
PLAI106963447(srd5a3)
PMEI106924151(srd5a3)
GAF122838027(srd5a3)
CVG107091557(srd5a3)
CTUL119780609(srd5a3)
GMU124874145(srd5a3)
NFU107393391(srd5a3)
KMR108243377(srd5a3)
ALIM106537178(srd5a3)
NWH119407566(srd5a3)
AOCE111569622(srd5a3)
MCEP125009420(srd5a3)
CSEM103376703(srd5a3)
POV109625709(srd5a3)
SSEN122780962(srd5a3)
HHIP117759684(srd5a3)
HSP118120641(srd5a3)
LCF108879013(srd5a3)
SDU111226375(srd5a3)
SLAL111644347(srd5a3)
XGL120790351(srd5a3)
HCQ109532109(srd5a3)
BPEC110154923(srd5a3)
MALB109962082(srd5a3)
BSPL114852942(srd5a3)
SASA106584121(srd5a3)
OTW112249150(srd5a3)
OMY110521674(srd5a3)
OGO124037860(srd5a3)
ONE115145132(srd5a3)
SALP111972319(srd5a3)
SNH120052585(srd5a3)
CCLU121539807(srd5a3)
ELS105011840(srd5a3)
PKI111850121(srd5a3)
AANG118225804(srd5a3)
LOC102697358(srd5a3)
PSPA121320069(srd5a3)
ARUT117421513(srd5a3)
LCM102363132(SRD5A3)
CMK103178169(srd5a3)
RTP109934780(srd5a3)
BFO118419203
BBEL109487727
CIN100181505
SCLV120341137 120341138
SPU115922155 579990
APLC110989371
DMEDmel_CG7840(CG7840)
DER6543492
DSE6611652
DSIDsimw501_GD23520(Dsim_GD23520)
DYADyak_GE18750
DAN6497453
DSR110177042
DPO4817473
DPE6588751
DMN108161783
DWI6641644
DGR6562746
DMODmoj_GI17156
DAZ108611676
DNV108649913
DHE111596226
DVI6627557
CCAT101462110
BOD106615572
MDE101899650 101900443
SCAC106085989 106086001 106086027
LCQ111686624
LSQ119609976
HIS119649470
AGAAgaP_AGAP007493
ACOZ120953893
AARA120898314
ASTE118512194
AAG110674017 5575734
AALB109622565
CQUCpipJ_CPIJ008625
CPII120424174
CNS116348428
BCOO119071534
AME102656812
ACER107994914
ALAB122714305
BIM100744185
BBIF117215693
BVK117238340
BVAN117164846
BTER100647495
CCAL108631761
OBB114881675
MGEN117223828
NMEA116428930 116428935
CGIG122405098
SOC105207120 105208040
MPHA105828866 105838316
AEC105149417
ACEP105627262
VEM105567279
DQU106742476
CFO105257288
FEX115238156
LHU105676024 105676052
PGC109851972 109851983
OBO105280101
PCF106788533
PFUC122518064
VPS122628099
NVI100119448
CSOL105365575
TPRE106650373
MDL103569697
CGLO123267885
FAS105267066
DAM107039232
AGIF122854151
CCIN107268154
TCA103312608 103312609
DPA109535507
SOY115884008
ATD109597739
CSET123309311
AGB108917481
LDC111505429
NVL108560909
APLN108745120
PPYR116167952
OTU111413171
BMOR101735516
BMAN114244031
MSEX115441984
DPLKGM_202637
BANY112050560
PMAC106720118 106720211
PPOT106105689 106105704
PXU106113359
PRAP110999351
ZCE119833223
HAW110370980
TNL113506815
SLIU111358405
OFU114364468
PXY105381317
API100167163 103310029
DNX107161937 107171225
AGS114124006
RMD113560747
BTAB109042995
DCI103507725
CLEC106666251
HHAL106682440
NLU111060052
PHUPhum_PHUM087110
FOC113209605
TPAL117647953
ZNE110834339
CSEC111862750
FCD110851178
DPXDAPPUDRAFT_200780
DMK116919090
PVM113825995
PJA122266541
PCHN125042929
HAME121872353
PCLA123747043
PTRU123511647
HAZT108669253
EAF111709087
LSM121123591
PPOI119091273
ISCIscW_ISCW012662
DSV119436748 119437645
RSAN119399081
RMP119161359
VDE111243623
VJA111272032
TUT107360225 107369870
DPTE113793835
DFR124490645
CSCU111620265 111627927
PTEP107442370
SDM118186233
CELCELE_B0024.13(B0024.13)
CBRCBG_09584
LOALOAG_18143
NAINECAME_03041
HROHELRODRAFT_188909 HELRODRAFT_66723
GAE121376284
HRF124146038
HRJ124262871
CRG105321676
MYI110466723
PMAX117329650
MMER123531423 123556234
OSN115218440
LAK106156499 106178503
OVIT265_11435
EGLEGR_04368
NVE5514125
EPA110244800
ATEN116308259
ADF107355083
AMIL114975743
PDAM113684423
SPIS111332317
DGT114530317
XEN124438849
TADTRIADDRAFT_53471
AQU105312044
ATHAT1G72590 AT2G16530
ALY9308832 9322122
CRB17891741
CSAT104747449 104766953 104792193
EUSEUTSA_v10000231mg EUTSA_v10022773mg
BRP103837771 103846037
BNA106347044 106358824 106360734 106409483 106433676 106439839 106443044
BOE106304466 106318133 106333812
RSZ108809075
THJ104807290
CPAP110808172
CIT102619924
CICCICLE_v10028796mg
PVY116143770
MINC123228039
TCC18586049 18607676 18610799
GRA105766738 105778158 105787490
GHI107903719 107907818 107918655 107931746 107936328 107936539
GAB108463048 108464827 108482237
DZI111282724 111293122 111300810
EGR104453389 104456991
GMX100814660
GSJ114377345 114378552
PVUPHAVU_011G038300g
VRA106780535
VAR108324616 108339543
VUN114170560
CCAJ109799194
APRC113864415
MTRMTR_4g072070
CAM101499200
LJALj3g3v3396900.1(Lj3g3v3396900.1)
ADU107463066 107477024
AIP107613544 107624918 107628182
AHF112726933 112729143 112771455 112789130
LANG109325126
FVE101307862 101308431
RCN112169559 112174812
PPER18766685
PMUM103335594
PAVI110750327
PDUL117637235
MDM103445156 114824768
PXB103966945 103967954
ZJU107426582
MNT21395479
CSV101215230
CMO103488097
BHJ120078230
MCHA111007527
CMAX111469837
CMOS111441221
CPEP111793137
RCU8284384 8286664
JCU105628630
HBR110656001
MESC110613747
POP7463988 7477843
PEU105134491 105141598
PALZ118050615 118058982
JRE108987005 109006543
QSU111997342
QLO115969494
TWL119989253
VVI100243811 100265912
VRI117910871
SLY101261171
SPEN107007858
SOT102597141
SSTN125871471
CANN107840488
NTA107767964 107787404
NSY104249824
NTO104117912
NAU109210501
INI109154703 109154818
ITR116028092
SIND105169751
OEU111410560
EGT105965119
SSPL121775542 121775989 121790496
HAN110911547 110923305
ECAD122579113 122581214
LSV111877104 111877105 111877106 111904331
CCAV112528787
DCR108203137
CSIN114303974 114304018 114319812
BVG104884739
SOE110792437
CQI110705196 110718859
NNU104607497
MING122084962
TSS122660512 122662332
PSOM113288793 113289676
NCOL116261532
OSA4336740 4343281
DOSAOs04t0576800-01(Os04g0576800) Os07t0493400-01(Os07g0493400)
OBR102708235
BDI100834872
ATS109764908
TDC119356001 119365135
TAES123046245 123054115 123190006
TUA125539309
SBI8155280
ZMA100194237 100502028
SITA101786400
SVS117863313 117865725
PVIR120674466 120683720
PHAI112901740
PDA103699632
EGU105043343
MUS103984650
DCT110110583
PEQ110019516
AOF109827724 109848985
ATR18444657
SMOSELMODRAFT_24565 SELMODRAFT_66322
PPP112294840
CRECHLRE_17g720950v5
VCNVOLCADRAFT_103030
CVRCHLNCDRAFT_135620
APROF751_0034
OLUOSTLU_26674
OTAOT_ostta12g00150
BPGBathy16g00230
MISMICPUN_62047
MPPMICPUCDRAFT_40219
CMECYME_CMP066C
GSLGasu_16010
SCEYIL049W(DFG10)
SEUBDI49_2730
SPAOSPAR_I01100
AGOAGOS_ADL073W
ERCEcym_4334
KLAKLLA0_C08261g
KMXKLMA_70185(DFG10)
LTHKLTH0A04312g
VPOKpol_1009p22
ZROZYRO0D16852g
CGRCAGL0L00693g
NCSNCAS_0A13460(NCAS0A13460)
NDINDAI_0A02580(NDAI0A02580)
TPFTPHA_0K00940(TPHA0K00940)
TBLTBLA_0J01440(TBLA0J01440)
TDLTDEL_0H02090(TDEL0H02090)
TGBHG536_0C04850
KAFKAFR_0I01850(KAFR0I01850)
KNGKNAG_0D01650(KNAG0D01650)
ZMKHG535_0F03690
PPAPAS_chr1-4_0673
DHADEHA2B09592g
PICPICST_31592(DFG10)
PGUPGUG_02122
SPAASPAPADRAFT_60183
LELLELG_02555
CALCAALFM_C208970CA(DFG10)
CTPCTRG_01961
COTCORT_0C02710
CDUCD36_23150(DFG10)
CTENCANTEDRAFT_115976
YLIYALI0E07788g
CLUCLUG_04172
CLUSA9F13_04g03520
CAURCJI97_001977
PKZC5L36_0A07450
BBRXBRETT_003964
NCRNCU00387
NTENEUTE1DRAFT82283(NEUTE1DRAFT_82283)
PANPODANSg4842
TTTTHITE_2119503 THITE_2122302
MTMMYCTH_2079764
CTHRCTHT_0024150
MGRMGG_13163
PPEIPpBr36_05220
SSCKSPSK_02576
FGRFGSG_07239
FPUFPSE_00195
FVRFVEG_05346
FOXFOXG_02178
NHENECHADRAFT_104200
TRETRIREDRAFT_2912
TRRM419DRAFT_127156
MAWMAC_08655
MAJMAA_05987
CMTCCM_01790
PLJVFPFJ_05682
VALVDBG_08774
VDAVDAG_06434
CFJCFIO01_11465
CHIGCH63R_02744
SAPOSAPIO_CDS5846
PFYPFICI_03778
SSLSS1G_06974
BFUBCIN_10g03390
MBEMBM_01200
PSCOLY89DRAFT_424051
GLZGLAREA_05521
ANIAN4071.2
AFMAFUA_1G05470
ACTACLA_029190
NFINFIA_019290
AORAO090009000397
ANGANI_1_570164(An18g04290)
AFVAFLA_010960
ALUCAKAW2_31167S
ACHEACHE_11499S
APUUAPUU_40276S
PCSPc18g02350
PDPPDIP_73410
TMFPMAA_024660
TRGTRUGW13939_03718
CIMCIMG_03924
CPWCPC735_004260
PBLPAAG_08631
ABEARB_05619
TVETRV_07203
BGHBDBG_04981
PNOSNOG_11892
PTEPTT_08450
BZECOCCADRAFT_3232
BSCCOCSADRAFT_40094
BORCOCMIDRAFT_84729
AALTCC77DRAFT_1029182
ZTRMYCGRDRAFT_40170
PFJMYCFIDRAFT_28109
FFUCLAFUR5_01652
BCOMBAUCODRAFT_118870
TMLGSTUM_00003395001
SPOSPAC7D4.09c
SREPTSG_08028
DPPDICPUDRAFT_83663
DFADFA_07066
ACANACA1_096750
PFAPF3D7_1455900
PFHPFHG_00677
PREIPRSY57_1455200
PGABPGSY75_1455900
PYOPY17X_1323400
PCBPCHAS_132290
PBEPBANKA_1319600
PVVPVVCY_1302110
PKNPKNH_1225900
PVXPVX_117670
PCYPCYB_125920
TOTTOT_040000692
BMICBMR1_03g02520
CPVcgd5_1340
CHOChro.50250
TGOTGME49_272180
PIFPITG_09474
PSOJPHYSODRAFT_335266
SPARSPRG_09830
GTTGUITHDRAFT_163089
 » show all
Reference
1  [PMID:8486680]
  Authors
Sagami H, Kurisaki A, Ogura K
  Title
Formation of dolichol from dehydrodolichol is catalyzed by NADPH-dependent reductase localized in microsomes of rat liver.
  Journal
J Biol Chem 268:10109-13 (1993)
  Sequence
[rno:305291]
Reference
2  [PMID:20637498]
  Authors
Cantagrel V, Lefeber DJ, Ng BG, Guan Z, Silhavy JL, Bielas SL, Lehle L, Hombauer H, Adamowicz M, Swiezewska E, De Brouwer AP, Blumel P, Sykut-Cegielska J, Houliston S, Swistun D, Ali BR, Dobyns WB, Babovic-Vuksanovic D, van Bokhoven H, Wevers RA, Raetz CR, Freeze HH, Morava E, Al-Gazali L, Gleeson JG
  Title
SRD5A3 is required for converting polyprenol to dolichol and is mutated in a congenital glycosylation disorder.
  Journal
Cell 142:203-17 (2010)
DOI:10.1016/j.cell.2010.06.001
  Sequence
[hsa:79644] [mmu:57357] [sce:YIL049W]
Other DBs
ExplorEnz - The Enzyme Database: 1.3.1.94
IUBMB Enzyme Nomenclature: 1.3.1.94
ExPASy - ENZYME nomenclature database: 1.3.1.94
BRENDA, the Enzyme Database: 1.3.1.94

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