Entry
Name
protoporphyrinogen IX dehydrogenase (quinone);
HemG;
protoporphyrinogen IX dehydrogenase (menaquinone)
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With a quinone or related compound as acceptor
BRITE hierarchy
Sysname
protoporphyrinogen IX:quinone oxidoreductase
Reaction(IUBMB)
protoporphyrinogen IX + 3 quinone = protoporphyrin IX + 3 quinol [RN:
R09489 ]
Reaction(KEGG)
Substrate
Product
Comment
Contains FMN. The enzyme participates in heme b biosynthesis. In the bacterium Escherichia coli it interacts with either ubiquinone or menaquinone, depending on whether the organism grows aerobically or anaerobically.
History
EC 1.3.5.3 created 2010, modified 2020
Pathway
ec01110 Biosynthesis of secondary metabolites
Orthology
K00230 menaquinone-dependent protoporphyrinogen oxidase
Genes
ECOO : ECRM13514_4921(hemG)
ECOH : ECRM13516_4701(hemG)
ELR : ECO55CA74_22285(hemG)
ECW : EcE24377A_4369(hemG)
EDJ : ECDH1ME8569_3727(hemG)
ECOI : ECOPMV1_04208(hemG)
SEM : STMDT12_C41370(hemG)
SETC : CFSAN001921_20495(hemG)
SEEN : SE451236_00965(hemG)
SENH : CFSAN002069_12125(hemG)
SEEH : SEEH1578_06015(hemG)
SENJ : CFSAN001992_13750(hemG)
SEEC : CFSAN002050_02815(hemG)
SEEB : SEEB0189_022410(hemG)
SENC : SEET0819_03770(hemG)
RTG : NCTC13098_06968(hemG)
REE : electrica_04845(hemG)
CLAP : NCTC11466_04379(hemG)
KIE : NCTC12125_03546(hemG)
BAGE : BADSM9389_39510(hemG)
METY : MRY16398_53920(hemG)
AHN : NCTC12129_04702(hemG)
PTF : PROFFT_A_06710(hemG)
PSHI : SAMEA2665130_3044(hemG)
YPG : YpAngola_A1916(hemG)
YPI : YpsIP31758_0287(hemG)
SMW : SMWW4_v1c02680(hemG)
SERS : SERRSCBI_01195(hemG)
SFJ : SAMEA4384070_0240(hemG)
SOF : NCTC11214_02061(hemG)
PAQU : DMB82_0018105(hemG)
DIC : Dpoa569_003715(hemG)
EHD : ERCIPSTX3056_370(hemG)
TPTY : NCTC11468_03458(hemG)
PHEI : NCTC12003_00595(hemG)
PRJ : NCTC6933_00652(hemG)
LRI : NCTC12151_03540(hemG)
HPIT : NCTC13334_00371(fldA_1)
PDAG : 4362423_01817(hemG)
ADP : NCTC12871_00271(hemG)
ALIG : NCTC10568_01950(hemG)
ASEG : NCTC10977_00244(hemG)
AVT : NCTC3438_00571(hemG)
RPNE : NCTC8284_00527(hemG)
PAET : NCTC13378_01747(hemG)
VAU : VANGNB10_cI2691c(hemG)
VSI : MTO69_06285 MTO69_13480(hemG)
VPL : SA104470976_02689(hemG)
EAZ : JHT90_07035(hemG) JHT90_07970(hemG)
SON : SO_0025(hemG) SO_0027(hemG) SO_3720(hemG)
SFR : Sfri_0017 Sfri_0019 Sfri_0813
SAZ : Sama_0036 Sama_0038 Sama_2882
SBL : Sbal_0025 Sbal_0027 Sbal_3400
SBM : Shew185_0020 Shew185_0022 Shew185_0939
SBN : Sbal195_0024 Sbal195_0026 Sbal195_0973
SBP : Sbal223_0024 Sbal223_0026 Sbal223_0962
SBT : Sbal678_0024 Sbal678_0026 Sbal678_1000
SBS : Sbal117_0025 Sbal117_0027 Sbal117_3540
SBB : Sbal175_0024 Sbal175_0026 Sbal175_0966
SLO : Shew_0023 Shew_0025 Shew_0678
SPC : Sputcn32_0017 Sputcn32_0019 Sputcn32_3038
SHP : Sput200_0017 Sput200_0019 Sput200_3147
SSE : Ssed_0027 Ssed_0029 Ssed_3790
SPL : Spea_0022 Spea_0026 Spea_0673
SHE : Shewmr4_0022 Shewmr4_0024 Shewmr4_3066
SHM : Shewmr7_0020 Shewmr7_0022 Shewmr7_0906
SHN : Shewana3_0028 Shewana3_0030 Shewana3_0871
SHW : Sputw3181_0017 Sputw3181_0019 Sputw3181_0907
SHL : Shal_0020 Shal_0022 Shal_3525
SWD : Swoo_0025 Swoo_0027 Swoo_0793
SWP : swp_0049 swp_0051 swp_4046
SHF : CEQ32_16350 CEQ32_16360 CEQ32_20820
SJA : SJ2017_0018 SJ2017_0020 SJ2017_3313
SPSW : Sps_00060 Sps_00062 Sps_02782
SBJ : CF168_00145 CF168_00155(hemG) CF168_16435
SMAV : CFF01_00120 CFF01_00130(hemG) CFF01_03250
SHEW : CKQ84_07845 CKQ84_07855 CKQ84_12780
SALG : BS332_07170(hemG) BS332_07180 BS332_11735
SLJ : EGC82_01200 EGC82_01210 EGC82_05730
SMAI : EXU30_06050 EXU30_10455
SPOL : FH971_00085(hemG) FH971_00095(hemG) FH971_15915(hemG)
SBK : SHEWBE_0601(hemG) SHEWBE_0603 SHEWBE_4279
SKH : STH12_02758(hemG_1) STH12_03688(hemG_2) STH12_03690(hemG_3)
SAES : HBH39_00085(hemG) HBH39_00095(hemG) HBH39_03665(hemG)
SLIT : JQC75_00130(hemG) JQC75_00140(hemG) JQC75_14870(hemG)
SDK : KHX94_08560(hemG) KHX94_08570(hemG)
SCAA : TUM17387_00180(hemG_1) TUM17387_00210(hemG_2) TUM17387_31140(hemG_3)
SPSH : FM037_00135(hemG) FM037_00155(hemG)
SEUR : FM038_000115(hemG) FM038_000140(hemG) FM038_020585(hemG)
SYK : KDN34_00075(hemG) KDN34_00085(hemG) KDN34_03340(hemG)
SAVI : JYB87_00065(hemG) JYB87_00075(hemG) JYB87_03815(hemG)
SGLA : FJ709_00100(hemG) FJ709_00110(hemG) FJ709_03795(hemG)
SINV : K8B83_02265(hemG) K8B83_02275(hemG) K8B83_06675(hemG)
SXM : MKD32_00090(hemG) MKD32_00100(hemG) MKD32_04555(hemG)
SVM : KDH10_002202(hemG) KDH10_003032(hemG) KDH10_003034(hemG)
SHEJ : MZ182_00085(hemG) MZ182_00095(hemG) MZ182_16225(hemG)
SSEH : N7V09_02440(hemG) N7V09_19030(hemG)
SCHK : GII14_00090(hemG) GII14_00100(hemG) GII14_17195(hemG)
FBL : Fbal_0016 Fbal_0018 Fbal_1684
FES : HER31_15625(hemG) HER31_15635(hemG)
MISZ : MishRS11D_01600(hemG)
AEL : NCTC12917_04133(hemG)
CDIZ : CEDIAZO_00182(hemG)
NANI : NCTC12227_00017(hemG)
UPL : DSM104440_01023(hemG)
PBD : PBOR_19385 PBOR_19950 PBOR_22275
POD : PODO_16560 PODO_19330
PAEN : P40081_19710 P40081_20290 P40081_22675
PAEF : R50345_16725 R50345_19580
PAEQ : R50912_18020 R50912_18585
PAEH : H70357_19840 H70357_25705
PAEJ : H70737_16480 H70737_19840
ACEL : acsn021_22900 acsn021_38960
VGU : HYG85_02500 HYG85_02505 HYG85_12490 HYG85_12785
VPY : HZI73_07560 HZI73_09520 HZI73_14475 HZI73_25650
CIU : G4D55_02785 G4D55_13310
AAXA : NCTC10138_00834(hemG)
CCYC : SCMU_10500(hemG_1) SCMU_10520(hemG_2) SCMU_35450
NBR : O3I_010705 O3I_018085
NNO : NONO_c35320 NONO_c48910
NSR : NS506_03685(hemG) NS506_04302 NS506_04335 NS506_04673 NS506_06213 NS506_07042
NOZ : DMB37_39855 DMB37_40005
NOD : FOH10_14900 FOH10_14980 FOH10_15090
NAD : NCTC11293_03781(hemG)
NWL : NWFMUON74_38060 NWFMUON74_38310
NTC : KHQ06_22675 KHQ06_22715 KHQ06_23735 KHQ06_26995 KHQ06_27650
NHU : H0264_24740 H0264_24985 H0264_25060
RPY : Y013_05150 Y013_20215
RBY : CEJ39_06715 CEJ39_15815
RAV : AAT18_05815 AAT18_08970 AAT18_08980
RHS : A3Q41_02221 A3Q41_02227
RRZ : CS378_21050 CS378_23925 CS378_23935
RCR : NCTC10994_01500(hemG) NCTC10994_01867 NCTC10994_02433
RGOR : NMQ04_03705 NMQ04_12025
STRM : M444_02170 M444_33675
SCX : AS200_03740 AS200_40125
SRN : A4G23_05169 A4G23_05177
SLK : SLUN_02165 SLUN_03270 SLUN_37665
SCYA : EJ357_43665 EJ357_43810 EJ357_44880
SGZ : C0216_12945 C0216_13010
SAQU : EJC51_04560 EJC51_04660
SRIM : CP984_01510 CP984_01560
SFUG : CNQ36_31575 CNQ36_33480
SGX : H4W23_04300 H4W23_34530 H4W23_34730
SFEU : IM697_26335 IM697_26445
SFB : CP974_27570 CP974_27610
SPEU : CGZ69_02600 CGZ69_02650
SROI : IAG44_01500 IAG44_01620
SYAN : NRK68_01805 NRK68_01895
PSIC : J4E96_04090 J4E96_13595
CART : PA27867_1307 PA27867_2133
PSEV : USB125703_00831 USB125703_01480
ART : Arth_1632 Arth_3245 Arth_3601
ARU : ASPU41_11530 ASPU41_17465
ARTP : E5206_11165 E5206_17045
APN : Asphe3_12740 Asphe3_21050 Asphe3_34390
SATK : SA2016_1230 SA2016_1242 SA2016_3490 SA2016_3752
CGA : Celgi_1042 Celgi_1392
CEZ : CBP52_06250 CBP52_08235
CELZ : E5225_05590 E5225_07210
CEJ : GC089_05850 GC089_07465
CELH : GXP71_07960 GXP71_09960
CIRA : LFM56_06015 LFM56_07430
CPAL : F1D97_12980 F1D97_14890
NMES : H9L09_13700 H9L09_14905
AMAZ : LUW76_05625 LUW76_09615
AOI : AORI_4637(hemG) AORI_5273(hemG)
APRT : MUY14_08355 MUY14_18085
AIR : NCTC12972_00647(hemG)
ASLA : NCTC11923_02145(hemG)
PSUB : Pelsub_P1818 Pelsub_P2907
PMET : G4Y79_12345 G4Y79_12350
TRA : Trad_1480 Trad_1634 Trad_1780 Trad_1785 Trad_1798
SFC : Spiaf_0394 Spiaf_1022
MINF : MESINF_0631 MESINF_2791
DAP : Dacet_0824 Dacet_1035
MBG : BN140_0569 BN140_1999
MEMA : MMAB1_0733 MMAB1_2592
SALI : L593_02010 L593_10680
HLT : I7X12_00850 I7X12_16905 I7X12_18635
SSAI : N0B31_10040 N0B31_19545
HXA : Halxa_0149 Halxa_0493
HRU : Halru_0890 Halru_2443
NAS : GCU68_07685 GCU68_08545
SAWL : NGM29_02755 NGM29_09730
MEAR : Mpt1_c04600 Mpt1_c08120
MARC : AR505_0825 AR505_0978
PSYT : DSAG12_02325 DSAG12_02579
» show all
Taxonomy
Reference
Authors
Boynton TO, Daugherty LE, Dailey TA, Dailey HA
Title
Identification of Escherichia coli HemG as a novel, menadione-dependent flavodoxin with protoporphyrinogen oxidase activity.
Journal
Reference
Authors
Mobius K, Arias-Cartin R, Breckau D, Hannig AL, Riedmann K, Biedendieck R, Schroder S, Becher D, Magalon A, Moser J, Jahn M, Jahn D
Title
Heme biosynthesis is coupled to electron transport chains for energy generation.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 1.3.5.3
ExPASy - ENZYME nomenclature database: 1.3.5.3
BRENDA, the Enzyme Database: 1.3.5.3