KEGG   ENZYME: 1.3.8.8
Entry
EC 1.3.8.8                  Enzyme                                 
Name
long-chain acyl-CoA dehydrogenase;
palmitoyl-CoA dehydrogenase;
palmitoyl-coenzyme A dehydrogenase;
long-chain acyl-coenzyme A dehydrogenase;
long-chain-acyl-CoA:(acceptor) 2,3-oxidoreductase;
ACADL (gene name).
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With a flavin as acceptor
Sysname
long-chain acyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase
Reaction(IUBMB)
a long-chain acyl-CoA + electron-transfer flavoprotein = a long-chain trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein [RN:R00392]
Reaction(KEGG)
Substrate
long-chain acyl-CoA [CPD:C02843];
electron-transfer flavoprotein [CPD:C04253]
Product
long-chain trans-2,3-dehydroacyl-CoA;
reduced electron-transfer flavoprotein [CPD:C04570]
Comment
Contains FAD as prosthetic group. One of several enzymes that catalyse the first step in fatty acids beta-oxidation. The enzyme from pig liver can accept substrates with acyl chain lengths of 6 to at least 16 carbon atoms. The highest activity was found with C12, and the rates with C8 and C16 were 80 and 70%, respectively [2]. The enzyme from rat can accept substrates with C8-C22. It is most active with C14 and C16, and has no activity with C4, C6 or C24 [4]. cf. EC 1.3.8.1, short-chain acyl-CoA dehydrogenase, EC 1.3.8.8, medium-chain acyl-CoA dehydrogenase, and EC 1.3.8.9, very-long-chain acyl-CoA dehydrogenase.
History
EC 1.3.8.8 created 1989 as EC 1.3.99.13, part transferred 2012 to EC 1.3.8.8
Pathway
ec00071  Fatty acid degradation
ec01100  Metabolic pathways
Orthology
K00255  long-chain-acyl-CoA dehydrogenase
Genes
HSA33(ACADL)
PTR459914(ACADL)
PPS100986924(ACADL)
GGO101127206(ACADL)
PON100440170(ACADL)
NLE100595536(ACADL)
MCC711485(ACADL)
MCF102134056(ACADL)
CSAB103217758(ACADL)
CATY105580137(ACADL)
PANU101024730(ACADL)
TGE112636256(ACADL)
RRO104655498(ACADL)
RBB108540361(ACADL)
TFN117094580(ACADL)
PTEH111545984(ACADL)
CJC100414283(ACADL)
SBQ101034499(ACADL)
CSYR103269625(ACADL)
MMUR105863916(ACADL)
LCAT123643779(ACADL)
OGA100958878(ACADL)
MMU11363(Acadl)
MCAL110291490(Acadl)
MPAH110321743(Acadl)
RNO25287(Acadl)
MCOC116088527(Acadl)
MUN110560007(Acadl)
CGE100759026(Acadl)
MAUA101833241(Acadl)
PLEU114693617(Acadl)
MORG121433522(Acadl)
AAMP119820527(Acadl)
NGI103744464(Acadl)
HGL101698104(Acadl)
CPOC100723012(Acadl)
CCAN109691994(Acadl)
DORD105986229(Acadl)
DSP122107366(Acadl)
NCAR124980410
OCU100358521(ACADL)
OPI101528752(ACADL)
TUP102478785(ACADL)
CFA478895(ACADL)
VVP112922460(ACADL)
VLG121480677(ACADL)
AML100467341(ACADL)
UMR103659964(ACADL)
UAH113250509(ACADL)
UAR123798264(ACADL)
ELK111143314
LLV125095200
MPUF101676763(ACADL)
ORO101385517(ACADL)
EJU114215908(ACADL)
ZCA113919326(ACADL)
MLX118012086(ACADL)
FCA101098884(ACADL)
PYU121031008(ACADL)
PBG122481721(ACADL)
PTG102967046(ACADL)
PPAD109265125(ACADL)
AJU106984776(ACADL)
HHV120243742(ACADL)
BTA614508(ACADL)
BOM102266624(ACADL)
BIU109570336(ACADL)
BBUB102409588(ACADL)
CHX102176568(ACADL)
OAS101123271(ACADL)
ODA120854538(ACADL)
CCAD122426438(ACADL)
SSC396931(ACADL)
CFR102511378(ACADL)
CBAI105072946(ACADL)
CDK105101591(ACADL)
VPC102544504(ACADL)
BACU103002780(ACADL)
LVE103080374(ACADL)
OOR101280788(ACADL)
DLE111171787(ACADL)
PCAD102976178(ACADL)
PSIU116756693(ACADL)
ECB100066893(ACADL)
EPZ103564161(ACADL)
EAI106848054(ACADL)
MYB102260528(ACADL)
MYD102757895(ACADL)
MMYO118661430(ACADL)
MLF102435683(ACADL)
MNA107524805(ACADL)
PKL118709024(ACADL)
HAI109390442(ACADL)
DRO112307701(ACADL)
SHON118984235(ACADL)
AJM119064357(ACADL)
PDIC114494528(ACADL)
PHAS123829433(ACADL)
MMF118625400(ACADL)
RFQ117025612(ACADL)
PALE102878971(ACADL)
PGIG120587600(ACADL)
PVP105311371(ACADL)
RAY107517635(ACADL)
MJV108394312(ACADL)
TOD119256165(ACADL)
SARA101547913(ACADL)
LAV100657035(ACADL)
TMU101358665
DNM101437224(ACADL)
MDO100015264(ACADL)
GAS123242721(ACADL)
SHR100914644(ACADL)
PCW110223331(ACADL)
OAA100077024(ACADL)
GGA424005(ACADL)
PCOC116235917(ACADL)
MGP100540388(ACADL)
CJO107316458(ACADL)
NMEL110399290(ACADL)
APLA101801335(ACADL)
ACYG106034509(ACADL)
AFUL116490927(ACADL)
TGU100224317(ACADL)
LSR110471675(ACADL)
SCAN103814572(ACADL)
PMOA120511522(ACADL)
OTC121339719(ACADL)
PRUF121364431(ACADL)
GFR102044703(ACADL)
FAB101817085(ACADL)
PHI102106512(ACADL)
PMAJ107207764(ACADL)
CCAE111922608(ACADL)
CCW104694536(ACADL)
ETL114059418(ACADL)
ZAB102064802(ACADL)
FPG101924862(ACADL)
FCH102047187(ACADL)
CLV102095816(ACADL)
EGZ104124193(ACADL)
NNI104010084(ACADL)
PLET104614895(ACADL)
ACUN113482077(ACADL)
TALA104355843(ACADL)
PADL103921668(ACADL)
ACHC115342988(ACADL)
AAM106492331(ACADL)
AROW112976587(ACADL)
NPD112954273(ACADL)
DNE112994329(ACADL)
ASN102387928(ACADL)
AMJ102565241(ACADL)
CPOO109323024(ACADL)
GGN109301990(ACADL)
PSS102461956(ACADL)
CMY102941001(ACADL)
CPIC101943787(ACADL)
TST117884900(ACADL)
CABI116816106(ACADL)
MRV120374657(ACADL)
ACS100562130(acadl)
PVT110072389(ACADL)
SUND121919027(ACADL)
PBI103062999(ACADL)
PMUR107301928(ACADL)
TSR106550960(ACADL)
PGUT117674289(ACADL)
VKO123024353(ACADL)
PMUA114583593(ACADL)
ZVI118096645(ACADL)
GJA107119083(ACADL)
STOW125426189
XLA446669(acadl.L)
XTR734116(acadl)
NPR108794423(ACADL)
RTEM120943855(ACADL)
BBUF121008271(ACADL)
BGAR122944876(ACADL)
DRE394156(acadl)
SRX107747617(acadl)
SANH107700586(acadl)
SGH107576428
CCAR109108344
CAUA113061868 113118574
PPRM120486038(acadl)
MAMB125254237 125254660
IPU108264529 124627118
PHYP113534576(acadl)
SMEO124396059(acadl)
TFD113658614(acadl)
AMEX111197552(acadl)
EEE113577281(acadl)
TRU101075644(acadl)
TNGGSTEN00015856G001
LCO104929358
NCC104953624(acadl)
CGOB115021000 115021017 115021690(acadl)
ELY117254541(acadl)
PLEP121963024(acadl)
SLUC116044465(acadl)
ECRA117939622(acadl)
PFLV114550941(acadl)
GAT120828883(acadl)
PPUG119223123(acadl)
MSAM119904627(acadl)
CUD121506096(acadl)
ALAT119015640(acadl)
MZE101469415(acadl)
ONL100698696
OAU116332244
OLA101159651(acadl)
OML112156666(acadl)
XMA102229820(acadl) 106700234
XHE116715758(acadl) 116715759
PFOR103139182(acadl)
PLAI106940502(acadl)
PMEI106914875(acadl) 106923423
GAF122827219(acadl)
CVG107084233(acadl)
CTUL119780761(acadl)
GMU124861767(acadl)
NFU107377229(acadl)
KMR108242184(acadl)
ALIM106530711(acadl)
NWH119428683(acadl)
AOCE111571820(acadl)
POV109643952(acadl)
SSEN122783223(acadl)
HHIP117777854(acadl)
HSP118103182(acadl)
LCF108873043(acadl)
SDU111234061(acadl)
SLAL111665351(acadl)
XGL120798316(acadl)
HCQ109528476(acadl)
BPEC110170900
MALB109968757(acadl)
BSPL114870552(acadl)
SASA106575817(acadl)
OTW112214841(acadl)
OMY110527282 110528748
OGO124018695 124018697
ONE115117891(acadl)
SALP111960779(acadl)
SNH120033335 120039490
ELS105023135(acadl)
SFM108928934(acadl)
PKI111852206(acadl)
AANG118214162(acadl)
LOC102687372(acadl)
PSPA121322451(acadl)
ARUT117426942(acadl)
LCM102362263(ACADL)
CMK103182964(acadl)
BFO118403143 118403144
BBEL109461586 109461619
CIN100180056
SCLV120330792 120330793 120330923 120330926 120331437 120346468
SKO100375371
BCOO119084328
DPXDAPPUDRAFT_110684
DMK116923550
PVM113806064
PJA122247998
PCHN125047101
HAME121853660
PCLA123766734
PTRU123503282
HAZT108678307 108680106 108680240 108681914
EAF111695631 111696514
LSM121122406
PPOI119112010 119112280
HROHELRODRAFT_158178
LGILOTGIDRAFT_158547
PCAN112557703
BGT106051136
GAE121385404
HRF124136786
HRJ124253167
CRG105333437 117687133
MYI110457184
PMAX117319963
MMER123559484
LAK106173170
OVIT265_01445
MBRMONBRDRAFT_35315
SREPTSG_02553
AAFAURANDRAFT_24725
EHXEMIHUDRAFT_360281
ACBA1S_1108 A1S_2279
ACIACIAD1723(hcaD) ACIAD2226
ACIUA3K93_07630
SNANI6N98_02130
FCEJN531_013365
RHARHA1_ro00550 RHA1_ro02715 RHA1_ro08138
RSARSal33209_2142
 » show all
Reference
1  [PMID:13239683]
  Authors
CRANE FL, HAUGE JG, BEINERT H
  Title
Flavoproteins involved in the first oxidative step of the fatty acid cycle.
  Journal
Biochim Biophys Acta 17:292-4 (1955)
DOI:10.1016/0006-3002(55)90374-7
Reference
2  [PMID:13319294]
  Authors
HAUGE JG, CRANE FL, BEINERT H.
  Title
On the mechanism of dehydrogenation of fatty acyl derivatives of coenzyme A.  III.  Palmityl coA dehydrogenase.
  Journal
J Biol Chem 219:727-33 (1956)
Reference
3  [PMID:1015826]
  Authors
Hall CL, Heijkenskjold L, Bartfai T, Ernster L, Kamin H.
  Title
Acyl coenzyme A dehydrogenases and electron-transferring flavoprotein from beef hart mitochondria.
  Journal
Arch Biochem Biophys 177:402-14 (1976)
DOI:10.1016/0003-9861(76)90453-7
Reference
4  [PMID:3968063]
  Authors
Ikeda Y, Okamura-Ikeda K, Tanaka K
  Title
Purification and characterization of short-chain, medium-chain, and long-chain acyl-CoA dehydrogenases from rat liver mitochondria. Isolation of the holo- and apoenzymes and conversion of the apoenzyme to the holoenzyme.
  Journal
J Biol Chem 260:1311-25 (1985)
  Sequence
[rno:25287]
Reference
5  [PMID:8155643]
  Authors
Djordjevic S, Dong Y, Paschke R, Frerman FE, Strauss AW, Kim JJ
  Title
Identification of the catalytic base in long chain acyl-CoA dehydrogenase.
  Journal
Biochemistry 33:4258-64 (1994)
DOI:10.1021/bi00180a021
Other DBs
ExplorEnz - The Enzyme Database: 1.3.8.8
IUBMB Enzyme Nomenclature: 1.3.8.8
ExPASy - ENZYME nomenclature database: 1.3.8.8
BRENDA, the Enzyme Database: 1.3.8.8
CAS: 59536-74-2

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