KEGG   ENZYME: 1.3.8.9
Entry
EC 1.3.8.9                  Enzyme                                 
Name
very-long-chain acyl-CoA dehydrogenase;
ACADVL (gene name).
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With a flavin as acceptor
Sysname
very-long-chain acyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase
Reaction(IUBMB)
a very-long-chain acyl-CoA + electron-transfer flavoprotein = a very-long-chain trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein
Reaction(KEGG)
(other) R01279 R03990
Substrate
very-long-chain acyl-CoA [CPD:C20876];
electron-transfer flavoprotein [CPD:C04253]
Product
very-long-chain trans-2,3-dehydroacyl-CoA [CPD:C20879];
reduced electron-transfer flavoprotein [CPD:C04570]
Comment
Contains FAD as prosthetic group. One of several enzymes that catalyse the first step in fatty acids beta-oxidation. The enzyme is most active toward long-chain acyl-CoAs such as C14, C16 and C18, but is also active with very-long-chain acyl-CoAs up to 24 carbons. It shows no activity for substrates of less than 12 carbons. Its specific activity towards palmitoyl-CoA is more than 10-fold that of the long-chain acyl-CoA dehydrogenase [1]. cf. EC 1.3.8.1, short-chain acyl-CoA dehydrogenase, EC 1.3.8.7, medium-chain acyl-CoA dehydrogenase, and EC 1.3.8.8, long-chain acyl-CoA dehydrogenase.
History
EC 1.3.8.9 created 1961 as EC 1.3.2.2, transferred 1964 to EC 1.3.99.3, part transferred 2012 to EC 1.3.8.9
Pathway
ec00071  Fatty acid degradation
ec01100  Metabolic pathways
Orthology
K09479  very long chain acyl-CoA dehydrogenase
Genes
HSA37(ACADVL)
PTR455237(ACADVL)
PPS100986379(ACADVL)
GGO101143346(ACADVL)
PON100454381(ACADVL)
NLE100585921(ACADVL)
MCC714326(ACADVL)
MCF101925858(ACADVL)
MTHB126939682
CSAB103242278(ACADVL)
CATY105582769(ACADVL)
PANU101018882(ACADVL)
TGE112608977(ACADVL)
RRO104673335(ACADVL)
RBB108514298(ACADVL)
TFN117067801(ACADVL)
PTEH111521283(ACADVL)
CJC100399197(ACADVL)
SBQ101028298(ACADVL)
CSYR103263239(ACADVL)
MMUR105877978(ACADVL)
LCAT123650853(ACADVL)
OGA100947350(ACADVL)
MMU11370(Acadvl)
MCAL110304163(Acadvl)
MPAH110332221(Acadvl)
RNO25363(Acadvl)
MCOC116079063(Acadvl)
MUN110555097(Acadvl)
CGE100767527(Acadvl)
MAUA101824933(Acadvl)
PLEU114693210(Acadvl)
MORG121456541(Acadvl)
MFOT126513897
AAMP119811176(Acadvl)
NGI103752159(Acadvl)
HGL101707761(Acadvl)
CPOC100713909(Acadvl)
CCAN109674520(Acadvl)
DORD105983460(Acadvl)
DSP122100421(Acadvl)
NCAR124981031
OCU100346654(ACADVL)
OPI101517023(ACADVL)
TUP102486032(ACADVL)
CFA489463(ACADVL)
CLUD112647487(ACADVL)
VVP112924990(ACADVL)
VLG121499762(ACADVL)
AML100472785(ACADVL)
UMR103660348(ACADVL)
UAH113271108(ACADVL)
UAR123792174(ACADVL)
ELK111161073
LLV125087809
MPUF101679496(ACADVL)
ORO101376612(ACADVL)
EJU114225362(ACADVL)
ZCA113939372(ACADVL)
MLX117999991(ACADVL)
NSU110584452(ACADVL)
FCA101094144(ACADVL)
PYU121016030(ACADVL)
PBG122484852(ACADVL)
LRUF124519482
PTG102968012(ACADVL)
PPAD109245981(ACADVL)
AJU106972414(ACADVL)
HHV120231442(ACADVL)
BTA282130(ACADVL)
BOM102273950
BIU109573934(ACADVL)
BBUB102405745(ACADVL)
CHX102181987(ACADVL)
OAS101117173(ACADVL)
ODA120866080(ACADVL)
CCAD122446217(ACADVL)
SSC100520636(ACADVL)
CFR102516576(ACADVL)
CBAI105077481(ACADVL)
CDK105103048(ACADVL)
VPC102539565(ACADVL)
BACU103000307(ACADVL)
LVE103077095(ACADVL)
OOR101275668(ACADVL)
DLE111185665(ACADVL)
PCAD102973774(ACADVL)
PSIU116745056(ACADVL)
ECB100061583(ACADVL)
EPZ103557744(ACADVL)
EAI106844174(ACADVL)
MYB102257348(ACADVL)
MYD102774563(ACADVL)
MMYO118672042(ACADVL)
MLF102423177(ACADVL)
MNA107544584(ACADVL)
PKL118726931(ACADVL)
HAI109394616(ACADVL)
DRO112308631(ACADVL)
SHON118974685(ACADVL)
AJM119037137(ACADVL)
PDIC114514993(ACADVL)
PHAS123809242(ACADVL)
MMF118633802(ACADVL)
RFQ117012846(ACADVL)
PALE102879612(ACADVL)
PGIG120589632(ACADVL)
PVP105291734(ACADVL)
RAY107509515(ACADVL)
MJV108401220(ACADVL)
TOD119232659(ACADVL)
SARA101545206(ACADVL)
LAV100657276(ACADVL)
TMU101361348
DNM101438130(ACADVL)
MDO100016619(ACADVL) 100032148
GAS123242000 123244462(ACADVL)
SHR100925698 100931501(ACADVL)
PCW110193114 110194404(ACADVL)
OAA100089853(ACADVL)
LSR110482134(ACADVL)
CCAE111922435(ACADVL)
ACHC115338360(ACADVL)
AAM106485823(ACADVL)
AROW112962139(ACADVL) 112963323
NPD112947461(ACADVL)
TGT104573439(ACADVL)
DNE112981697(ACADVL)
SCAM104153221(ACADVL)
ASN102371669 102384902(ACADVL)
AMJ102568802(ACADVL) 102576922
CPOO109308570(ACADVL)
GGN109288127(ACADVL)
PSS102443861(ACADVL) 102456803
CMY102938508(ACADVL)
CPIC101946768 101948805(ACADVL)
TST117883233(ACADVL)
CABI116828964 116839188(ACADVL)
MRV120372442 120381766(ACADVL)
PVT110082312(ACADVL)
SUND121933466(ACADVL)
PBI103051941 103059781(ACADVL)
PMUR107291707 107295343(ACADVL)
CTIG120305692(ACADVL) 120307167
TSR106542417(ACADVL) 106551584
PGUT117656436 117659250 117669843
VKO123016648(ACADVL)
PMUA114581599(ACADVL) 114598214
ZVI118093983 118094793(ACADVL)
GJA107118083(ACADVL) 107125630
STOW125445140(ACADVL)
XLA108711808(acadvl.L)
XTR100216267(acadvl)
RTEM120921798(ACADVL)
BBUF120986711(ACADVL)
BGAR122922346(ACADVL)
DRE573723(acadvl)
SRX107731915 107738021
SANH107675499 107683542(acadvl)
SGH107595296 107597078
CCAR109073618 109092601
CAUA113052224 113105619
PPRM120469949(acadvl)
MAMB125265528(acadvl)
IPU108267840(acadvl)
PHYP113540141(acadvl)
SMEO124387396(acadvl)
TFD113654726(acadvl)
AMEX103045531(acadvl)
EEE113567683(acadvl)
TRU101069830(acadvl)
TNGGSTEN00019248G001
LCO104937817(acadvl)
NCC104942951
CGOB115023469(acadvl)
ELY117246106(acadvl)
EFO125883637(acadvl)
SLUC116048989(acadvl)
ECRA117934572(acadvl)
ESP116686337(acadvl)
PFLV114545512(acadvl)
GAT120821571(acadvl)
PPUG119222335(acadvl)
MSAM119911752(acadvl)
CUD121504728(acadvl)
ALAT119026810(acadvl)
MZE101472773(acadvl)
ONL100703037(acadvl)
OAU116330727(acadvl)
OLA101165349(acadvl)
OML112156048(acadvl)
XMA102217028(acadvl)
XCO114157390(acadvl)
XHE116732534(acadvl)
PRET103480485(acadvl)
PFOR103137528(acadvl)
PLAI106945534(acadvl)
PMEI106906747(acadvl)
GAF122819841(acadvl)
CVG107087781(acadvl)
CTUL119789781(acadvl)
GMU124880174(acadvl)
NFU107372430(acadvl)
KMR108241814(acadvl)
ALIM106529201(acadvl)
NWH119416326(acadvl)
AOCE111575585(acadvl)
MCEP124997830(acadvl)
CSEM103386901(acadvl)
POV109634887(acadvl)
SSEN122766124(acadvl)
HHIP117752053(acadvl)
HSP118102302(acadvl)
LCF108897054
SDU111232992(acadvl)
SLAL111665745(acadvl)
XGL120797419(acadvl)
HCQ109506947(acadvl)
BPEC110157677(acadvl)
MALB109966474(acadvl)
BSPL114843947(acadvl)
SASA106602820(acadvl)
STRU115155021(acadvl)
OTW112216747(acadvl)
OMY110490130(acadvl)
OGO123994754(acadvl)
ONE115106836(acadvl)
SALP111950426(acadvl)
SNH120057400(acadvl)
CCLU121579727(acadvl)
ELS105010800(acadvl)
SFM108918781(acadvl) 108923151
PKI111860921(acadvl)
AANG118222760(acadvl)
LOC102693936(acadvl)
PSPA121306545(acadvl)
ARUT117404600 117967919
LCM102364546(ACADVL)
RTP109912656 109918899(acadvl)
BFO118427578
BBEL109463957
CIN100183990
SCLV120328435
SPU584710
APLC110981027
SKO100369524
DMEDmel_CG7461(CG7461)
DER6547331
DSE6609917
DSIDsimw501_GD11444(Dsim_GD11444)
DYADyak_GE12038
DAN6506293
DSR110177854
DPO26532094
DPE6602657
DMN117188910
DGR6557587
DMODmoj_GI12099
DAZ108614533
DNV108651701
DHE111592309
DVI6623490
CCAT101461538
BOD106622331
RZE108354643 108361541 108378210
MDE101891231
SCAC106091613
LCQ111683088
LSQ119608560 119608561 119608567
HIS119651165
AGAAgaP_AGAP008769
ACOZ120958362 120958363 120958364 120958365
AARA120901834 120902053 120902103 120904618
ASTE118511710 118511711 118511712 118511713
AAG23687873 5565366 5565367
AALB109400327 109400349 109425168 109425169
CQUCpipJ_CPIJ016451 CpipJ_CPIJ016452 CpipJ_CPIJ016453 CpipJ_CPIJ016454
CPII120417357 120417361 120417378
CNS116336875
BCOO119085955
AME412025
ACER107993296
ALAB122713268
BIM100747671
BBIF117207816
BVK117238208
BVAN117160011
BTER100651720
BPYO122570882
CCAL108632159
OBB114874036
MGEN117225101
NMEA116431343
CGIG122404056
SOC105200554
MPHA105838446
AEC105149521
ACEP105622411
PBAR105429882
VEM105562928
HST105188087
DQU106746266
CFO105251587
FEX115241390
LHU105667331
PGC109854598
OBO105276471
PCF106788263
PFUC122517614
VPS122637938
NVI100116828
CSOL105368265
TPRE106657066
MDL103574466
CGLO123261711
FAS105263418
DAM107047818
AGIF122849565 122855670
LHT122497687
CCIN107274922
TCA659957
DPA109541041
SOY115876810
ATD109601372
CSET123317940
AGB108910959
NVL108562362 108569494
APLN108741828
PPYR116160986
OTU111425163
BMOR101744941
BMAN114241040
MSEX115450554 119192036
DPLKGM_210602
BANY112050744
NIQ126771213
PMAC106710891
PXU106124808
PRAP110996061
ZCE119829410
HAW110380632
HZE124630404
TNL113500974
SLIU111353597
OFU114364297
CFEL113381136
API100162051
DNX107164135
AGS114127836 114127838
RMD113560282
BTAB109036499
DCI103511783
CLEC106668658
HHAL106691567
NLU111057385
PHUPhum_PHUM617730
FOC113203933
ZNE110832869
CSEC111868786
FCD110843829
DPXDAPPUDRAFT_327246
DMK116922047
PVM113813193 113823665
PJA122259512
PCHN125031151
HAME121878582
PCLA123762221
PTRU123513027
HAZT108669783
EAF111695316
LSM121122352 121126155
PPOI119109527
DSV119439895
RSAN119386460
RMP119178100
VDE111251465
VJA111270259
TUT107362076
DPTE113799491
DFR124496042
CSCU111630174
PTEP107450301
SDM118184637 118199840
CELCELE_E04F6.5(acdh-12)
CBRCBG_13088
BMYBM_BM3112(Bma-acdh-12)
LOALOAG_00695
NAINECAME_17750
TSPTsp_10283
HROHELRODRAFT_186034
LGILOTGIDRAFT_177715
PCAN112555772
BGT106055817
GAE121375144
HRF124145143
HRJ124282755
CRG105344745
MYI110463202
PMAX117342228
MMER123553917
OBI106875659
OSN115209819
LAK106158444
OVIT265_06522
NVE5510970
EPA110251159
ATEN116295518
ADF107343075
AMIL114953943
PDAM113681975
SPIS111335626
DGT114521443
XEN124446405
HMG100201063
TADTRIADDRAFT_20833 TRIADDRAFT_23854 TRIADDRAFT_30874 TRIADDRAFT_31731 TRIADDRAFT_31757 TRIADDRAFT_31810 TRIADDRAFT_34622
AQU100638454
GAUGAU_0440
 » show all
Reference
1  [PMID:1730632]
  Authors
Izai K, Uchida Y, Orii T, Yamamoto S, Hashimoto T
  Title
Novel fatty acid beta-oxidation enzymes in rat liver mitochondria. I. Purification and properties of very-long-chain acyl-coenzyme A dehydrogenase.
  Journal
J Biol Chem 267:1027-33 (1992)
  Sequence
[rno:25363]
Reference
2  [PMID:7769092]
  Authors
Aoyama T, Souri M, Ushikubo S, Kamijo T, Yamaguchi S, Kelley RI, Rhead WJ, Uetake K, Tanaka K, Hashimoto T
  Title
Purification of human very-long-chain acyl-coenzyme A dehydrogenase and characterization of its deficiency in seven patients.
  Journal
J Clin Invest 95:2465-73 (1995)
DOI:10.1172/JCI117947
  Sequence
[hsa:37]
Reference
3  [PMID:18227065]
  Authors
McAndrew RP, Wang Y, Mohsen AW, He M, Vockley J, Kim JJ
  Title
Structural basis for substrate fatty acyl chain specificity: crystal structure of human very-long-chain acyl-CoA dehydrogenase.
  Journal
J Biol Chem 283:9435-43 (2008)
DOI:10.1074/jbc.M709135200
  Sequence
[hsa:37]
Other DBs
ExplorEnz - The Enzyme Database: 1.3.8.9
IUBMB Enzyme Nomenclature: 1.3.8.9
ExPASy - ENZYME nomenclature database: 1.3.8.9
BRENDA, the Enzyme Database: 1.3.8.9

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