KEGG ENZYME: 1.3.98.1

ENZYME: 1.3.98.1

Entry

EC 1.3.98.1                 Enzyme

Name

dihydroorotate dehydrogenase (fumarate);
DHOdehase (ambiguous);
dihydroorotate dehydrogenase (ambiguous);
dihydoorotic acid dehydrogenase (ambiguous);
DHOD (ambiguous);
DHODase (ambiguous);
dihydroorotate oxidase;
pyr4 (gene name)

Class

Oxidoreductases;
Acting on the CH-CH group of donors;
With other, known, physiological acceptors

Sysname

(S)-dihydroorotate:fumarate oxidoreductase

Reaction(IUBMB)

(S)-dihydroorotate + fumarate = orotate + succinate [RN:R01867]

Reaction(KEGG)

R01867

Substrate

(S)-dihydroorotate [CPD:C00337];
fumarate [CPD:C00122]

Product

orotate [CPD:C00295];
succinate [CPD:C00042]

Comment

Binds FMN. The reaction, which takes place in the cytosol, is the only redox reaction in the de novo biosynthesis of pyrimidine nucleotides. Molecular oxygen can replace fumarate in vitro. Other class 1 dihydroorotate dehydrogenases use either NAD+ (EC 1.3.1.14) or NADP+ (EC 1.3.1.15) as electron acceptor. The membrane bound class 2 dihydroorotate dehydrogenase (EC 1.3.5.2) uses quinone as electron acceptor.

History

EC 1.3.98.1 created 1961 as EC 1.3.3.1, transferred 2011 to EC 1.3.98.1

Pathway

ec00240

Pyrimidine metabolism

ec01100

Metabolic pathways

Orthology

K00226

dihydroorotate dehydrogenase (fumarate)

Genes

SCE:	YKL216W(URA1)

SEUB:

DI49_3169

SPAO:

SPAR_K00080

KLA:	KLLA0_C19360g

KMX:	KLMA_10832(URA1)

LTH:	KLTH0F00308g

ZRO:	ZYRO0D00396g

NCS:	NCAS_0D03520(NCAS0D03520)

NDI:	NDAI_0H00120(NDAI0H00120)

TPF:	TPHA_0K00200(TPHA0K00200)

TBL:	TBLA_0B10140(TBLA0B10140)

TGB:	HG536_0C00200

TDL:	TDEL_0F05620(TDEL0F05620)

KAF:	KAFR_0L00170(KAFR0L00170)

KNG:	KNAG_0K02180(KNAG0K02180)

ZMK:	HG535_0D00200

LEL:	LELG_00532

NCR:

NCU04318

NTE:	NEUTE1DRAFT15063(NEUTE1DRAFT_15063)

SMP:	SMAC_05569

PAN:	PODANSg8855

TTT:	THITE_2039441

MTM:	MYCTH_2302739

CTHR:

CTHT_0063240

MGR:

MGG_07263

PPEI:

PpBr36_01903

TMN:	UCRPA7_6289

SSCK:

SPSK_01211

FGR:	FGSG_03777

FPU:	FPSE_03470

FVR:	FVEG_12862

FOX:	FOXG_16831

NHE:	NECHADRAFT_87157

FFC:	NCS54_01386600

TRE:	TRIREDRAFT_67494

TRR:	M419DRAFT_133060

MAW:

MAC_06929

MAJ:

MAA_00067

PLJ:	VFPFJ_09532

PTKZ:

JDV02_002184(URA1)

VAL:	VDBG_00442

VDA:	VDAG_00052

CFJ:	CFIO01_08503

CLUP:

CLUP02_10599

CHIG:

CH63R_09074

ELA:	UCREL1_10685

PFY:	PFICI_13125

SSL:	SS1G_09113

BFU:	BCIN_16g04110(Bcura1)

PSCO:

LY89DRAFT_779573

GLZ:	GLAREA_12815

PNO:	SNOG_06955

PTE:

PTT_01403

BZE:	COCCADRAFT_36785

BSC:	COCSADRAFT_162941

BOR:	COCMIDRAFT_102290

AALT:

CC77DRAFT_1019245

ZTR:	MYCGRDRAFT_53893

PFJ:	MYCFIDRAFT_100268

FFU:	CLAFUR5_00821

BCOM:

BAUCODRAFT_60865

TML:	GSTUM_00009301001

TASA:

A1Q1_07191

TVS:	TRAVEDRAFT_93176

DSQ:	DICSQDRAFT_36335

PCO:	PHACADRAFT_110318

SHS:	STEHIDRAFT_144014

HIR:	HETIRDRAFT_306992

PSQ:	PUNSTDRAFT_128891

FME:	FOMMEDRAFT_83881

GTR:	GLOTRDRAFT_69333

RSX:	RhiXN_00600

LBC:	LACBIDRAFT_243747

CCI:	CC1G_03745

ABP:	AGABI1DRAFT51017(AGABI1DRAFT_51017)

ABV:	AGABI2DRAFT214748(AGABI2DRAFT_214748)

MRR:	Moror_12976

E1B28_000339

SCM:	SCHCO_02645180(SCHCODRAFT_02645180)

CPUT:

CONPUDRAFT_148446

SLA:	SERLADRAFT_374190

SMIN:

v1.2.031230.t1(symbB.v1.2.031230.t1)

PTI:	PHATRDRAFT_48112

FCY:	FRACYDRAFT_159735

TPS:	THAPSDRAFT_262575

SPAR:

SPRG_07872

EHX:	EMIHUDRAFT_447879 EMIHUDRAFT_454934

TBR:	Tb927.5.3830

TBG:	TbgDal_V5320

TCR:	507091.40 508375.50 511643.20 511923.120

LMA:	LMJF_16_0530(DHODH)

LIF:	LINJ_16_0540(DHODH)

LDO:	LDBPK_160540

LMI:	LMXM_16_0530

LBZ:	LBRM_16_0550(DHODH)

LPAN:

LPMP_160530(DHODH)

SLIG:

GTU79_13620

EAM:

EAMY_0442

EAY:

EAM_2979

PLU:

plu3917

PAKH:

B0X70_19550

PLUI:

CE143_19590

HSO:

HS_0799

HSM:

HSM_1268

MHT:

D648_7350

MHQ:	D650_20270

MHAT:

B824_7980

MHX:	MHH_c13360

MHAE:

F382_11785

MHAM:

J450_10470

MHAO:

J451_11895

MHAL:

N220_03905

MHAQ:

WC39_09975

MHAY:

VK67_09975

MVR:	X781_16500

MVI:

X808_6700

MVG:

X874_6790

MVE:	X875_14030

MBOS:

ICJ55_09750

MANN:

GM695_09135

BTO:

WQG_17660

BTRE:

F542_4910

BTRH:

F543_5590

BTRA:

F544_17520

AVN:	Avin_16810

AVL:	AvCA_16810

AVD:	AvCA6_16810

ACX:	Achr_26260

DCE:	O6P33_10105

MAD:

HP15_3391

MARI:

ACP86_07480

MSQ:	BKP64_16755

MARA:

D0851_10945 D0851_18410

MALL:

PBN92_18370

MSHE:

MAALD49_36130

SVO:	SVI_3253(pyrD-2)

SJA:	SJ2017_0984

SPSW:

Sps_04212

SMAI:

EXU30_18570

SPOL:

FH971_08915

SBK:	SHEWBE_3881(pyrDA)

SAES:

HBH39_14755

SPSH:

FM037_06995

SEUR:

FM038_018380

ASEM:

NNL22_06545

HALC:

EY643_09390

MCA:

MCA0768

METU:

GNH96_04320

MMT:	Metme_2775

MDN:	JT25_001530

MDH:	AYM39_15425

MKO:	MKLM6_3174

METL:

U737_16125

MPAD:

KEF85_07025

MELL:

IVG45_04850

MRP:	NM686_009980

MPSY:

CEK71_06400

MMAI:

sS8_1223

MMOB:

F6R98_04715

MOZ:	MoryE10_08030

MISZ:

MishRS11D_17740

MESL:

KKZ03_21285

ALV:	Alvin_0263

ATEP:

Atep_27990

TVI:	Thivi_3812

TMB:	Thimo_1403

MPUR:

MARPU_05485

TSY:	THSYN_04345

TTP:	E6P07_12915

THIP:

N838_16860

CJAP:

GWK36_01240

THIM:

KFB96_04600

TBOG:

LT988_24185

TTC:	FOKN1_1242

THIC:

TspCOW1_14190

TBN:

TBH_C0805

EPS:	L0Y14_13385

KAK:	Kalk_02580 Kalk_07040

MGEO:

CFI10_15325

MSEC:

LN244_02885

NCU:	F0U83_00185

NIK:	F5I99_05325

ENG:	O2T12_02500

GBI:	PG2T_06905

SEDS:

AAY24_15345

REV:	HUE57_13135

NSI:	A6J88_09380

NMJ:	NM96_03960

NFV:	FAH67_03720

NSF:	FAH66_03810

NSC:	J7445_05750

NPF:	LPB400_06780

NMB:	MON40_06645

KOA:	H3L93_07410

ECOR:

SAMEA4412678_1339(pyrDA)

EEX:	EZJ17_01640

MCER:

MON37_06680

USU:	LVJ78_03140

UTE:	LVJ83_00100

CVI:	CV_3551(pydA)

CVC:	BKX93_08625

CHRI:

DK842_02830

CHRB:

DK843_08315

CRZ:	D1345_16690

CHRM:

FYK34_12210

CHAE:

CH06BL_34350(pyrDA)

AMAH:

DLM_0496

AQS:	DKK66_02525

IOD:	EJO50_06000

IFL:	C1H71_19290

JEU:	BJP62_00695

JES:	JHS3_07590(pyrDA)

DEE:	HQN60_14255

DTK:	K4H28_05370

CHIZ:

HQ393_06550

CFON:

HZU75_00840

CHIC:

N8I74_10660

LHK:

LHK_00854

JAB:	VN23_05145

TBD:

Tbd_2467

DAR:

Daro_2839

DEY:	HYN24_06185

DDEN:

KI615_07115

DECH:

GBK02_08400

QAU:	KI612_11625

FLE:	KI610_14895

THK:	CCZ27_20915

ACOM:

CEW83_02880

BOP:	AXW83_04650

MSL:

Msil_2988

MTUN:

MTUNDRAET4_0045.1 MTUNDRAET4_4084

PZU:

PHZ_p0133

SDO:	SD1155_02675

RCP:	RCAP_rcc01727(pyrD1)

NPP:	PP1Y_AT22953

APT:	APA01_14720

APW:	APA42C_14720

APF:	APA03_14720

APU:	APA07_14720

APG:	APA12_14720

APQ:	APA22_14720

APX:	APA26_14720

APZ:	APA32_14720

APK:	APA386B_337

ASZ:

ASN_2514

ASV:	WG31_07745

APER:

A0U91_00355

APOM:

CPF11_12800

ATO:	CIW82_01015

AASC:

A4S02_05460

ACET:

DS739_07630

AOY:	EOV40_006810

SWF:	E3E12_02125

SKT:	IGS68_25625

SMUC:

JL100_028115

SROE:

JL101_026530

MAG:

amb2359

MAGX:

XM1_3143

MAGN:

WV31_07695

DEX:	HWD60_06700

DVN:	HQ394_06335

MAES:

Ga0123461_1564

MFN:	Ga0123462_0818

SAQT:

GJV85_11300

SKU:	Sulku_1859

SULR:

B649_05420

GSB:	GSUB_01640

DVE:	DESUT3_21070

DES:	DSOUD_1621

DPS:

DP0769

DLM:	DPPLL_37520

DBK:	DGMP_36840

DWD:	DSCW_05980 DSCW_06290

DALK:

DSCA_43100

DML:	Dmul_38520(pyrD2)

DEK:	DSLASN_19100

ADE:

Adeh_0762

ACP:	A2cp1_0813

AFW:	Anae109_0808

ANK:	AnaeK_0809

AORY:

AMOR_34260

SA2375

SAV:

SAV2589

SAW:

SAHV_2573

SAH:	SaurJH1_2665

SAJ:	SaurJH9_2611

SAM:

MW2509

SAS:

SAS2475

SAR:

SAR2669

SAC:	SACOL2606(pyrD)

SAX:	USA300HOU_2583(pyrD)

SAA:	SAUSA300_2526(pyrD)

SAO:	SAOUHSC_02909

SAE:	NWMN_2488(pyrD)

SAD:	SAAV_2655(pyrD)

SUU:	M013TW_2563

SUV:	SAVC_11825

SUE:

SAOV_2634

SUJ:	SAA6159_02486

SUK:	SAA6008_02648(pyrD)

SUC:	ECTR2_2443(pyrD)

SUT:	SAT0131_02823

SUQ:	HMPREF0772_10602(pyrD)

SUZ:	MS7_2595(pyrD)

SUD:	ST398NM01_2639

SUX:	SAEMRSA15_24920

SUW:	SATW20_27300

SUG:	SAPIG2639(pyrD)

SUF:	SARLGA251_23630

SAUA:

SAAG_00409

SAUE:

RSAU_002430(pyrD)

SAUN:

SAKOR_02583

SAUS:

SA40_2343

SAUU:

SA957_2427

SAUG:

SA268_2505

SAUZ:

SAZ172_2709

SAUT:

SAI1T1_2019270

SAUJ:

SAI2T2_1019280

SAUK:

SAI3T3_1019270

SAUQ:

SAI4T8_1019280

SAUV:

SAI7S6_1019270

SAUW:

SAI5S5_1019210

SAUX:

SAI6T6_1019220

SAUY:

SAI8T7_1019250

SAUF:

X998_2573

SAB:

SAB2464

SUY:	SA2981_2527

SAUB:

C248_2650

SAUM:

BN843_26270

SAUC:

CA347_2666(pyrD)

SAUR:

SABB_02002

SAUI:

AZ30_13560

SAUD:

CH52_06060

SAMS:

NI36_12960

SUH:	SAMSHR1132_24040

SER:	SERP2144(pyrD)

SEP:

SE_2132

SEPP:

SEB_02136

SEPS:

DP17_1072(pyrD)

SHA:

SH0471

SHH:	ShL2_00375(pyrD)

SSP:

SSP0278

SLG:	SLGD_00405

SLN:	SLUG_04010

SWA:	A284_01580

SPAS:

STP1_1082

SXY:	BE24_10565

SXL:	SXYLSMQ121_0306

SXO:	SXYL_00310(pyrD)

SCAP:

AYP1020_1752(pyrD)

SEQO:

SE1039_22680

SPET:

CEP67_06915

SCOH:

BZ166_06040

SNL:	BJD96_01840

SKL:	C7J89_03360

SHOM:

EGX58_05985

SCAR:

DWB96_01845

SARL:

SAP2_04040

SSH:	NCTC13712_02544(pyrD)

SSIM:

SAMEA4384339_2389(pyrD)

SLLO:

ISP08_02110

SAUL:

I6G39_10075

SSAC:

I6I31_02655

SPSD:

JMB28_02050

STAS:

HYI43_02165

SURY:

MUA21_11220

SEDA:

MNY58_01610

SCAQ:

QMO72_01675

SDEV:

Q2T90_05295

MBOC:

QSV55_00170

GOT:	AXE85_02950

GMO:	NCTC11323_00512(pyrDA)

GEQ:	CG018_05105

GSA:	FOC50_01420

GHA:	NCTC10459_00606(pyrDA)

LLA:	L192589(pydA)

LLK:	LLKF_1674(pydA)

LLT:	CVCAS_1457(pydA)

LLS:	lilo_1474(pydA)

LLD:	P620_08460

LLX:	NCDO2118_1571(pyrDA)

LLJ:	LG36_1498(pydA)

LLM:	llmg_0952(pyrDA)

LLC:

LACR_1644

LLR:

llh_4795

LLN:	LLNZ_04890

LLI:	uc509_1504(pyrDA)

LLW:

kw2_1506

LGR:

LCGT_1508

LGV:

LCGL_1530

LPK:	LACPI_0826

LRN:	CMV25_01670

LTI:	JW886_07030

LCAR:

BHS00_06855

LPAA:

BHS01_07430

LPET:

lgb_01514(pyrDA)

LFO:	LMK00_08890

SPY:	SPy_1432(pyrD)

SPZ:	M5005_Spy1165(pyrD)

SPYM:

M1GAS476_1227(pyrD)

SPYA:

A20_1200(pyrD)

SPM:	spyM18_1441

SPG:	SpyM3_1091(pyrD)

SPS:

SPs0774

SPH:	MGAS10270_Spy1236(pyrD)

SPI:	MGAS10750_Spy1273(pyrD)

SPJ:	MGAS2096_Spy1237(pyrD)

SPK:	MGAS9429_Spy1214(pyrD)

SPF:	SpyM50695(pyrD)

SPA:	M6_Spy1191

SPB:	M28_Spy1159(pyrD)

STG:	MGAS15252_1104(pyrD)

STX:	MGAS1882_1099(pyrD)

SOZ:	Spy49_1144(pyrD)

STZ:	SPYALAB49_001164(pyrD)

SPYH:

L897_05790

SPYO:

STAB901_06095

SPN:	SP_0764(pyrDA)

SPD:	SPD_0665(pyrDa)

SPR:	spr0672(pyrDA)

SPW:

SPCG_0713

SJJ:

SPJ_0701

SNV:	SPNINV200_06750(pyrD)

SPX:

SPG_0695

SNT:

SPT_0777

SND:

MYY_0796

SPNN:

T308_03565

SNE:	SPN23F06860(pyrD)

SPV:

SPH_0863

SNC:	HMPREF0837_11046

SNM:	SP70585_0807

SPP:

SPP_0773

SNI:	INV104_06350(pyrD)

SPNG:

HMPREF1038_00774(pyrDA)

SNB:	SP670_1562

SNP:

SPAP_0737

SNX:	SPNOXC06910(pyrD)

SNU:	SPNA45_01088(pyrD)

SPNE:

SPN034156_17400(pyrD)

SPNU:

SPN034183_06920(pyrD)

SPNM:

SPN994038_06810(pyrD)

SPNO:

SPN994039_06820(pyrD)

SAG:	SAG0507(pyrDA)

SAN:

gbs0553

SAK:	SAK_0657(pyrD)

SGC:	A964_0538(pyrD)

SAGS:

SaSA20_0492(pyrD)

SAGL:

GBS222_0484(pyrD)

SAGM:

BSA_5950

SAGI:

MSA_6100

SAGR:

SAIL_6240

SAGP:

V193_02825

SAGC:

DN94_02825

SAGT:

GBSCOH1_0490

SAGE:

EN72_02920

SAGG:

EN73_02995

SAGN:

W903_0684

SAGJ:

ID870_06735

SMU:	SMU_595(pyrD)

SMC:	SmuNN2025_1383(pyrD)

SMUT:

SMUGS5_02615

SMJ:	SMULJ23_1390(pyrD)

SMUA:

SMUFR_0516(pyrD)

STC:	str1207(pyrDa)

STL:	stu1207(pyrDa)

STE:

STER_1173

STN:

STND_1143

STU:	STH8232_1412(pyrD2)

STW:

Y1U_C1109

STHE:

T303_06890

STHS:

AVT04_08805

SSA:	SSA_0373(pyrDA)

SSB:	SSUBM407_0226(pyrD)

SSU:	SSU05_0253

SSV:	SSU98_0249

SSI:	SSU0235(pyrD)

SSS:	SSUSC84_0224(pyrD)

SSF:	SSUA7_0233

SSW:	SSGZ1_0229

SUP:

YYK_01095

SSUS:

NJAUSS_0246

SST:	SSUST3_0256

SSUY:

YB51_1255

SSK:	SSUD12_0231

SSQ:	SSUD9_0275

SUI:	SSUJS14_0240

SUO:	SSU12_0237

SRP:	SSUST1_0248

SSUT:

TL13_0279(pyrD)

SSUI:

T15_0241(pyrD)

SGO:	SGO_0277(pyrA)

SEZ:

Sez_0633

SEQ:

SZO_13640

SEZO:

SeseC_00765(pyrD)

SEQU:

Q426_06160

SEU:

SEQ_0655

SUB:	SUB1264(pyrD)

SDS:	SDEG_1471(pyrD)

SDG:	SDE12394_07655

SDA:	GGS_1341(pyrD)

SDC:	SDSE_1579(pyrD)

SDQ:	SDSE167_1579(pyrD)

SGA:	GALLO_0639(pyrD)

SGG:	SGGBAA2069_c05820(pyrD)

SGT:	SGGB_0614(pyrD1)

SMB:	smi_0815(pyrD2)

SOR:	SOR_0779(pyrD)

STK:

STP_1098

STB:	SGPB_0508(pyrD.1)

SCP:	HMPREF0833_11208

SCF:	Spaf_1800(pyrD3)

SSR:	SALIVB_1200(pyrD)

STF:	Ssal_01281(pyrD)

STJ:	SALIVA_0882(pyrD)

STRS:

SSAL8618_04675

SSAH:

HSISS4_00782(pyrDa)

STD:	SPPN_03865

SMN:	SMA_0601(pyrD)

SIF:	Sinf_0520(pyrD)

SIE:	SCIM_0207(pyrD)

SIB:	SIR_0264(pyrDa)

SIU:	SII_0247(pyrDa)

SANG:

SAIN_1602(pyrDa)

SANC:

SANR_1834(pyrDa)

SANS:

DK43_01485

SCG:	SCI_0264(pyrDa)

SCON:

SCRE_0244(pyrDa)

SCOS:

SCR2_0244(pyrDa)

SOI:	I872_07830

SIK:

K710_0597

SIQ:	DQ08_02880

SIO:	DW64_02870

SIZ:	SI82_03100

SLU:

KE3_0599

SIG:	N596_05700

SIP:	N597_07540

STV:	V470_03580

SPAT:

A0O21_06580

STRA:

ATM98_05310

STRN:

SNAG_0804(pyrDA)

SSOB:

DK181_07280

SRQ:	SR187_1325

SEQI:

A6J79_07300

SKI:	D7D50_04920

SPEI:

EHW89_07920

SRAT:

FY406_00795

SGW:	D7D53_05105

SPLR:

C0J00_07435

STRG:

SRT_15260(pyrD)

SVB:	NCTC12167_01130(pyrDa)

SMEN:

SAMEA4412692_1637(pyrDA)

SFER:

NCTC12278_00551(pyrD)

SCAI:

NCTC12191_01271(pyrD)

SCHJ:

DDV21_003720

SPAB:

KQ224_08155

SLAT:

J4854_09040

SAUP:

NCTC3168_01081(pyrA)

SURN:

NCTC13766_00581(pyrDa)

SACO:

SAME_01789(pyrDa)

SVF:	NCTC3166_01667(pyrA)

SOS:	INT76_08735

STOY:

STYK_07230(pyrD2)

SRUM:

GPZ88_07245

SACY:

O6R09_02735

LJO:

LJ_1281

LJF:	FI9785_918(pyrD)

LJH:

LJP_0899

LJN:	T285_04430

LAC:	LBA1384(pyrD)

LAD:

LA14_1382

LAF:	SD55_1367(pyrD)

LDB:	Ldb1530(pyrD2) Ldb2114(pyrD1)

LBU:	LBUL_1421 LBUL_1955

LDE:	LDBND_1465(pyrD2)

LDL:	LBU_1312 LBU_1730

LGA:

LGAS_1092

LHE:

lhv_2937

LHL:

LBHH_0706

LHR:	R0052_04255

LHV:

lhe_1366

LHH:

LBH_1217

LHD:

HUO_04845

LCR:	LCRIS_01374(pyrD)

LAM:

LA2_07985

LAI:	LAC30SC_07710

LAY:	LAB52_07030

LKE:

WANG_0334

LAW:	LACWKB8_1177

LAE:

LBAT_0593

LGL:	AO203_10565

LAMY:

B1745_02515

LPW:	LpgJCM5343_08490(pyrD)

LKL:	DKL58_05950

LAPI:

DKL56_04930

LHS:	DLD54_05560

LTA:	H1A07_04175

LUU:	H4B44_04115

LPAI:

GYM71_06600

LID:	GYK47_03885

LIQ:	KBW87_03095

LCA:

LSEI_1732

LCZ:	LCAZH_1724

LCS:

LCBD_1929

LCE:

LC2W_1908

LCW:	BN194_19150(pyrDA)

LCL:	LOCK919_1905

LPQ:	AF91_05220

LPI:	LBPG_01010

LPAP:

LBPC_1652

LCB:	LCABL_19520(pyrDA)

LCX:	LCA12A_0064

LRH:	LGG_01789(pyrD)

LRG:

LRHM_1725

LRL:	LC705_01772(pyrD)

LRA:	LRHK_1764(ura1)

LRO:	LOCK900_1732

LRC:	LOCK908_1825

LCHI:

KG086_07665

LZE:	KG087_08315

LFE:

LAF_1201

LFR:

LC40_0780

LFF:

LBFF_1312

LOR:	AYI71_12915

LVA:	LV515_05160

LFN:	LF145_04870

LGAS:

LG045_03135

LPOR:

PRK60_03655

LSN:	LSA_05870(pyrDA)

LLE:	AYR59_06700

LFV:	LF543_00405

FIX:	M8332_02270

FCLI:

M3M38_02110

FHIN:

M3M39_06470

FMT:	M3M35_00035

FCP:	M3M37_03750

LBH:

Lbuc_0385

LBN:	LBUCD034_0423(pyrD)

LPAR:

FAM21731_00580

LCU:	PL11_003320

LHIL:

G8J22_00338(pyrDA)

LSL:	LSL_0194(pyrD)

LSI:	HN6_00184(pyrD)

LSJ:	LSJ_0237(pyrD)

LRM:

LRC_09270

LAGL:

BEN83_03670

LACA:

LAC1533_1249

LSW:	GTO87_04595

LBT:	AYR52_09035

LKU:	APS55_01755

AAPI:

MOO46_04565

LPD:	AYR62_08915

LSA:

LCA_0446

LCV:	FBA2_02465

LGM:	LG542_07010

LHB:	D1010_09270

OOE:

OEOE_0264

OEN:	DSM07_06855

OSI:	DLJ48_04450

LME:

LEUM_1279

LMM:

MI1_05585

LMK:

LMES_1061

LKI:

LKI_09935

LEC:	LGMK_02480

LCN:	C270_04425

LGS:	LEGAS_1084(pyrDA)

LGE:	C269_05380

LLF:	BCR17_00420

LGC:	A9176_06245

LSU:	A6B45_05980

LPSE:

FGL85_06620

WCE:

WS08_0824

WTR:	KHQ32_04645

WCT:

WS74_0890

WCI:	WS105_0888

WCF:	C6P13_07115

WSO:	WSWS_00901(pyrD)

WDI:	H9L19_08060

WVR:	IE337_05655

WEI:	EQG49_10180

FRU:	M3M36_05880

LBE:	MOO44_07200

EFA:	EF0285(pyrD-1)

EFL:	EF62_0674(pyrD-1)

EFI:	OG1RF_10228(pyrDA)

EFD:	EFD32_0224

EFS:	EFS1_0226(pyrD-1)

EFN:	DENG_00270(pyrD)

EFQ:	DR75_2333(ura1)

EFC:	EFAU004_00893(pyrDA)

EFAU:

EFAU085_01453(pyrDA)

EFU:	HMPREF0351_11431(pyrD2)

EFM:

M7W_1926

EFT:	M395_08605

EHR:

EHR_11760

ECAS:

ECBG_02253

EMU:	EMQU_1428(pyrDA)

EDU:

LIU_08370

EGA:	AL523_12545

ETH:	CK496_06715

ESG:	EsVE80_11910(pyrDA)

ELAC:

I4Q40_07110

EIE:	ENLAB_32560(pyrD_2)

EDS:	PML78_01625

THL:	TEH_14370(pyrD)

TEY:	GLW17_01140

TOO:	C7K38_09730

TKR:	C7K43_03450

AUN:	AWM73_03900

ASAN:

AWM72_08265

ACG:	AWM71_06430

ADC:	FOC79_04410

IRU:	M0R79_01675

CDF:	CD630_20770(pyrD1)

PDC:	CDIF630_02300(preA1)

CDC:	CD196_1941(pyrD)

CDL:	CDR20291_1984(pyrD)

PDF:	CD630DERM_20770(pyrD1)

EAC:	EAL2_c20820

AACX:

DEACI_1684

MAS:	Mahau_0412

ATE:

Athe_2085

COB:	COB47_1861

COW:	Calow_1775

CKN:	Calkro_0546

CCHA:

ELD05_03755

CDIA:

CaldiYA01_05040

MHAP:

JFY71_02310

MMI:

MMAR_3409

MMAE:

MMARE11_33160

MLI:	MULP_03673

MPSE:

MPSD_34850

MSHO:

MSHO_48180

MMC:

Mmcs_4864

MKM:

Mkms_4953

MJL:

Mjls_5232

MKN:	MKAN_03625

MCOO:

MCOO_35610

MSEO:

MSEO_01210

MMAM:

K3U93_06375

MMEH:

M5I08_10365 M5I08_19645

MKY:	IWGMT90018_31380

MVA:

Mvan_4110

MRH:	MycrhN_0031

MFX:	MFAL_33820

MPSC:

MPSYJ_00340

MHEV:

MHEL_40650

MMON:

EWR22_26285

RAV:	AAT18_23505

RRZ:	CS378_13285

SBH:

SBI_02815

SMAO:

CAG99_07290

SYUN:

MOV08_41945

ICA:	Intca_3069

PEI:	H9L10_02520

AUS:	IPK37_15620 IPK37_16900

PAC:

PPA0161

PAK:	HMPREF0675_3201

PAV:	TIA2EST22_00810

PAX:	TIA2EST36_00820

PAZ:	TIA2EST2_00800

PAW:	PAZ_c01720(pyrD1)

PAD:	TIIST44_05455

PCN:	TIB1ST10_00810

PACC:

PAC1_00855

PACH:

PAGK_0189

PACN:

TIA1EST1_00815

CACN:

RN83_01250

PRA:	PALO_09840

PRL:	BCB70_05810

CGRN:

4412665_00536(pyrD)

PFR:	PFREUD_01850 PFREUD_07080

PFRE:

RM25_0187 RM25_0674

PACD:

EGX94_05835 EGX94_10695

PAUS:

NCTC13651_00002(preA_1) NCTC13651_01709(preA_2)

PPC:	HMPREF9154_0752

PBO:	PACID_05160

AACI:

ASQ49_02240

ACIJ:

JS278_02796(preA)

AJI:	C0Z10_11770

TFL:	RPIT_11090

TFA:	BW733_11395

TES:	BW730_11575

TEZ:	BKM78_05110

TDF:	H9L22_11270

TLA:	TLA_TLA_01037(preA)

TEJ:	KDB89_02600

RAIN:

Rai3103_06870

PRV:	G7070_10075

BRT:	J4N02_02810

PROP:

QQ658_02755 QQ658_12810

BROO:

brsh051_11910 brsh051_22910

MGG:	MPLG2_2719

FRA:	Francci3_1185

FRE:	Franean1_5282

FAL:

FRAAL1902

FSY:	FsymDg_0518

FRI:	FraEuI1c_1941

NAKA:

H7F38_18945

DROS:

Drose_34975

BLO:

BL1213

BNM:	BALAC2494_01378

ATQ:	GH723_11475

IAM:	HC251_22430

EUZ:	DVS28_a1305

SYN:

sll0744

SYZ:	MYO_128340

SYY:	SYNGTS_2808(sll0744)

SYT:	SYNGTI_2807(sll0744)

SYS:	SYNPCCN_2806(sll0744)

SYQ:	SYNPCCP_2806(sll0744)

SYJ:	D082_16990

SYO:	C7I86_14670

SYC:

syc1720_c

SYU:	M744_04335

SYF:	Synpcc7942_2385

SYP:	SYNPCC7002_A1442

SYV:	AWQ23_07395

SYL:	AWQ21_07330

SYNC:

CB0101_04305

SYNY:

BM449_12055

CGC:	Cyagr_3414

CYI:	CBM981_1673

AMR:	AM1_D0141(pyrD)

WNA:	KA717_12205

TSZ:	OOK60_00115

LSC:	KIK02_12015

LSK:	J5X98_13180

GLP:	Glo7428_4040

MAR:

MAE_38150

MPK:

VL20_5511

MIQ:	B5D77_24730

MVZ:	myaer102_12990

HAO:	PCC7418_0565

CYT:

cce_3252

CWA:	CwatDRAFT_4407

CYP:	PCC8801_0190

CYH:	Cyan8802_0185

CYC:	PCC7424_1262

CYJ:	Cyan7822_3034

CYN:	Cyan7425_4370

ARP:	NIES39_L04100(pyrD)

PAGH:

NIES204_36800(pyrD_2)

PPSU:

NO713_01710(pyrD)

OXY:	HCG48_06495

LFS:	HFV01_05540

MIC:	Mic7113_3075

GEI:	GEI7407_1922

OAC:	Oscil6304_5924

ONI:	Osc7112_1448

PHOR:

JWS08_08745

PYH:	NEA10_02705

ANA:

alr1912

NOP:	Nos7524_1841

NON:	NOS3756_28200

NOE:	CLI64_07475

AVA:

Ava_3045

ANB:	ANA_C11950(pyrD)

ACY:	Anacy_4208

AWA:	AA650_01570

ANN:	EH233_27265

RSIN:

B6N60_01082

CALN:

NIES2098_53340

FIS:	FIS3754_27360

DOU:	BMF77_00528(preA)

DFS:	HGD76_13390

DHT:	NG743_15560

CCUR:

IAR63_06285

CRK:	L3I90_15325

AFLO:

HEQ12_11585

NCN:	BZZ01_04220

CTHE:

Chro_4406

PLP:	Ple7327_2009

SCS:	Sta7437_4659

STAN:

STA3757_05380(pyrD_1)

RRS:	RoseRS_1785

RCA:

Rcas_2064

CAU:

Caur_2081

CHL:	Chy400_2244

CAG:

Cagg_2635

ATM:

ANT_28310

ABAT:

CFX1CAM_0325

PSUB:

Pelsub_P0691

LEK:	hrd7_11400

CAP:	CLDAP_36880

PBF:	CFX0092_A0455 CFX0092_A0485

THUG:

KNN16_09620

TSC:	TSC_c13100

THC:	TCCBUS3UF1_11810

TOS:	Theos_1517

TBC:	A0O31_00009(pyrD)

TANT:

KNN15_11295

OTE:

Oter_0606

OBG:	Verru16b_00598(preA_1) Verru16b_01854(preA_2)

VBH:	CMV30_18235

CAA:

Caka_1151

RUFI:

K0V07_00720

FPES:

NXS98_11220

MIN:	Minf_1387(pyrD) Minf_2385(pyrD)

MKC:	kam1_1406 kam1_2089

MFH:	MFUM_1664 MFUM_2415

MEAP:

MTHMO_0210

VBA:	IMCC26134_01735

RBA:	RB4738 RB4752(pyrD)

RUL:	UC8_16580(pyrDB) UC8_27550

RML:	FF011L_27520(pyrDB_1) FF011L_29420(pyrDB_2) FF011L_48580

MFF:	MFFC18_02890

AHEL:

Q31a_47690(pyrDB_1) Q31a_48380(pyrDB_2)

LCRE:

Pla8534_67880

RLC:	K227x_04690(pyrDB) K227x_04760(pyrD_1)

TTF:

THTE_4057

AMUC:

Pan181_30330(pyrD_1)

PND:	Pla175_23340(pyrD)

AMOB:

HG15A2_35930(pyrD_2)

PLH:	VT85_05270(preA)

FMR:	Fuma_01332(preA)

MRI:	Mal4_54110(preA)

ULI:	ETAA1_62400(preA)

AGV:	OJF2_24280(preA)

PCOR:

KS4_01440(pyrDB_1)

VBL:	L21SP4_00337(pyrD_1)

TAER:

GT409_09410

SSM:	Spirs_2131

STA:	STHERM_c17710

STQ:	Spith_1841

SFC:	Spiaf_0536 Spiaf_0539

SLR:	L21SP2_1672 L21SP2_2986

OCK:	EXM22_04520

SBU:	SpiBuddy_1639

SGP:	SpiGrapes_0130

SASS:

MUG09_09205

SCD:	Spica_1957

ABA:	Acid345_0729

ABAS:

ACPOL_5878

ORP:	MOP44_23915

SUS:

Acid_6995

PFER:

IRI77_26680

ABAC:

LuPra_04112(preA_2)

GEX:	GETHOR_03160

MSIL:

METEAL_29980

MSEA:

METESE_26480

LBA:

Lebu_2234

LEO:	AMK43_11050

LOT:	AXF11_03470

LEQ:	BCB68_05100

LHF:	JCM16775_2172

LSZ:	JCM16776_0398

LHG:	JMUB5056_0280

LTE:	JMUB4039_0312

LWD:	JCM16777_0381

LGO:	JCM16774_0141

ACO:	Amico_0095

ARAM:

KAR29_01620

BTH:

BT_1333

BTHO:

Btheta7330_01888(preA)

BFR:

BF2950

BFS:	BF9343_2739

BFG:	BF638R_2834

BFB:	VU15_12665

BHL:	Bache_1898

BXY:

BXY_43000

BOA:	Bovatus_01352(preA)

BCEL:

BcellWH2_05077(preA)

BCAC:

CGC64_14885

BCAE:

A4V03_10890

BZG:	C4H11_13375

BHF:	C3V43_12950

BIS:	DXK01_014385

BUN:	Bun01g_31230

BEG:	INE88_00153(preA)

BSTE:

K6V31_04520

BFE:	K6V30_19800

BNO:	K8P02_06300

BHUM:

JXR92_014825

BFC:	BacF7301_21290

BSAL:

K6V25_17520

BVU:

BVU_3869

BSA:	Bacsa_0937

BDO:	EL88_12980

BDH:	GV66_20615

PCOP:

I6J50_03520

PGI:

PG_2055

PGN:

PGN_1999

PGT:	PGTDC60_0330

PAH:	Poras_0063

PCRE:

NCTC12858_00853(pyrD_1)

PCAG:

NCTC12856_00153(preA)

PEND:

LA319_08760

PSOE:

CE91St14_03870

PORP:

J4862_08105

PBT:	ING2E5B_1970 ING2E5B_2366

PMUC:

ING2E5A_0046(URA1) ING2E5A_0807(pyrD1) ING2E5A_2689(pyrD5)

PET:	PEIBARAKI_4230 PEIBARAKI_6575

PSAC:

PSM36_0452 PSM36_3125

PROJ:

KDN43_02330

PDI:

BDI_0543

PARC:

CI960_12285

PMER:

INE87_01608(preA)

PGOL:

K6V26_03975

PJO:	LK449_10485

PFAI:

NXY11_13335

TFO:

BFO_0242

TOH:	BCB71_09795

COPR:

Cop2CBH44_28640

CFAS:

Cfast33896_11980

OSP:	Odosp_0627

BUY:	D8S85_03235

BVIR:

I6J59_10440

AFD:

Alfi_1991

AOK:	A3BBH6_07330

ACOU:

A5CBH24_07220

ADA:	A5CPEGH6_08340

AIT:	AI2BBH_23820

APUT:

L6V35_04610

ASEN:

NQ519_04230

AIU:	NQ491_08945

RBC:	BN938_0026

TTZ:	FHG85_06125 FHG85_08615 FHG85_09540

BLQ:	L21SP5_00505(pyrD_2) L21SP5_00918(preA) L21SP5_01040(pyrDA_1) L21SP5_02712(pyrDA_2)

BACC:

BRDCF_p2298

DORI:

FH5T_12270 FH5T_15380

DRC:	G0Q07_05720 G0Q07_13085

MCOS:

GM418_18080 GM418_18895 GM418_19895

ASX:	CDL62_00045 CDL62_02800 CDL62_03795 CDL62_17350

ALKQ:

M9189_03830 M9189_05245 M9189_06755 M9189_09210

MBAS:

ALGA_0168 ALGA_1617 ALGA_2539

FLS:	GLV81_15450

FLP:	LK994_03885

SGN:	SGRA_p0002(pyrD)

AUP:	AsAng_0001900

CLIT:

OQ292_19890

FBU:	UJ101_01334(pyrDI)

ORH:	Ornrh_0688

ORI:	Q785_03965

OHM:	MSHRCOH1_00970

EAO:

BD94_0307

EMN:	M876_00490

EEN:	BBD30_05140

ELB:	VO54_02286(pyrDA)

EMG:	BBD33_01820

EGO:	BBD34_10895

EGM:	AYC65_15670

ELZ:	FCS00_09180

APIB:

G8C43_01380

BBL:	BLBBGE_513

BPI:	BPLAN_127(pyrD)

BMM:	MADAR_234(pyrD)

BCP:	BLBCPU_481(pyrD)

BBG:	BGIGA_124(pyrD)

BBQ:	BLBBOR_510

BLP:	BPAA_124(pyrD)

BLU:

K645_2431

BLCK:

DM815_02555

BPUN:

DM780_02440

SHYR:

LA303_01790 LA303_02695 LA303_05480 LA303_05520 LA303_06845

RBAR:

AWN76_001055

CPB:	Cphamn1_2471

CLI:

Clim_2445

PVI:

Cvib_1724

PLT:

Plut_2084

PAA:

Paes_2219

PROC:

Ptc2401_02228(pyrD_2)

PRS:	B9H02_10925

PROS:

CHL67_11440

CTS:

Ctha_0742

IAL:	IALB_2950(pyrD)

MRO:

MROS_2662

TLE:

Tlet_1878

PHY:	AJ81_02475

TME:

Tmel_0121

DDF:	DEFDS_0411

DAP:	Dacet_2754 Dacet_2941

GTL:	EP073_02415

CNI:	Calni_0761

FSI:	Flexsi_2303

CABY:

Cabys_261

DTH:	DICTH_0323

DTU:

Dtur_0444

NDE:	NIDE1091(pyrD)

NMV:	NITMOv2_0967(pyrD)

NIO:	NITINOP_2763(pyrD)

NJA:	NSJP_2098(pyrDA)

NKF:	Nkreftii_000175 Nkreftii_002103

NIF:	W02_33580(pyrD)

ALAM:

RT761_00819(pyrDB)

NFT:	FBF37_00655(pyrD)

MVL:	KOY49_00795

SCHV:

BRCON_0449

STO:	STK_14770(pyrD)

SOH:	D1869_08300

SSO:	SSO0610(pyrD)

SOL:

Ssol_1674

SSOA:

SULA_1702

SSOL:

SULB_1703

SSOF:

SULC_1701

SSHI:

J5U23_02791

SCAS:

SACC_03670

SAI:	Saci_1592(pyrD)

SACN:

SacN8_07725

SACR:

SacRon12I_07735

SACS:

SUSAZ_07530

SIS:	LS215_1630

SIA:	M1425_1522

SIM:	M1627_1637

SID:

M164_1519

SIY:	YG5714_1526

SIN:	YN1551_1310

SII:

LD85_1729

SIH:

SiH_1488

SIR:

SiRe_1397

SIC:

SiL_1400

SULA:

BFU36_02970

SULE:

GFS03_08675

SULO:

GFS33_00450

SULL:

EWF20_09470

MSE:

Msed_1960

MEMJ:

MJ1HA_2228

MCN:

Mcup_0324

MHK:	DFR87_08705

MPRU:

DFR88_08375

MTEN:

GWK48_03320

MJN:	MjAS7_0261

AHO:

Ahos_1133

AMAN:

B6F84_09750

ABRI:

DFR85_09375

ASUL:

DFR86_08435

AAMB:

D1866_00545

ACIH:

HS5_25290

SACD:

HS1genome_0356

SAZO:

D1868_05340

CSTY:

KN1_26740

STEP:

IC006_1331

SAHS:

HS7_09430

PAI:

PAE3263

PIS:

Pisl_0507

PCL:

Pcal_1778

PAS:

Pars_1692

PYR:

P186_1337

POG:

Pogu_0443

TNE:

Tneu_1590

PYW:	PYWP30_01693

TTN:	TTX_0796(pyrD)

TUZ:

TUZN_0505

VDI:

Vdis_1107

VMO:

VMUT_1972

CLG:	Calag_0598

» show all

Reference

1 [PMID:9405053]

Authors

Bjornberg O, Rowland P, Larsen S, Jensen KF

Title

Active site of dihydroorotate dehydrogenase A from Lactococcus lactis investigated by chemical modification and mutagenesis.

Journal

Biochemistry 36:16197-205 (1997)
DOI:10.1021/bi971628y

Sequence

[llm:llmg_0952]

Reference

2 [PMID:9655329]

Authors

Rowland P, Bjornberg O, Nielsen FS, Jensen KF, Larsen S

Title

The crystal structure of Lactococcus lactis dihydroorotate dehydrogenase A complexed with the enzyme reaction product throws light on its enzymatic function.

Journal

Protein Sci 7:1269-79 (1998)
DOI:10.1002/pro.5560070601

Sequence

[llm:llmg_0952]

Reference

3 [PMID:12732650]

Authors

Norager S, Arent S, Bjornberg O, Ottosen M, Lo Leggio L, Jensen KF, Larsen S

Title

Lactococcus lactis dihydroorotate dehydrogenase A mutants reveal important facets of the enzymatic function.

Journal

J Biol Chem 278:28812-22 (2003)
DOI:10.1074/jbc.M303767200

Sequence

[llm:llmg_0952]

Reference

4 [PMID:17617217]

Authors

Zameitat E, Pierik AJ, Zocher K, Loffler M

Title

Dihydroorotate dehydrogenase from Saccharomyces cerevisiae: spectroscopic investigations with the recombinant enzyme throw light on catalytic properties and metabolism of fumarate analogues.

Journal

FEMS Yeast Res 7:897-904 (2007)
DOI:10.1111/j.1567-1364.2007.00275.x

Sequence

[sce:YKL216W]

Reference

5 [PMID:18808149]

Authors

Inaoka DK, Sakamoto K, Shimizu H, Shiba T, Kurisu G, Nara T, Aoki T, Kita K, Harada S

Title

Structures of Trypanosoma cruzi dihydroorotate dehydrogenase complexed with substrates and products: atomic resolution insights into mechanisms of dihydroorotate oxidation and fumarate reduction.

Journal

Biochemistry 47:10881-91 (2008)
DOI:10.1021/bi800413r

Sequence

[tcr:508375.50]

Reference

6 [PMID:19932077]

Authors

Cheleski J, Wiggers HJ, Citadini AP, da Costa Filho AJ, Nonato MC, Montanari CA

Title

Kinetic mechanism and catalysis of Trypanosoma cruzi dihydroorotate dehydrogenase enzyme evaluated by isothermal titration calorimetry.

Journal

Anal Biochem 399:13-22 (2010)
DOI:10.1016/j.ab.2009.11.018