KEGG   ENZYME: 1.4.1.12
Entry
EC 1.4.1.12                 Enzyme                                 
Name
2,4-diaminopentanoate dehydrogenase;
2,4-diaminopentanoic acid C4 dehydrogenase
Class
Oxidoreductases;
Acting on the CH-NH2 group of donors;
With NAD+ or NADP+ as acceptor
Sysname
(2R,4S)-2,4-diaminopentanoate:NAD(P)+ oxidoreductase (deaminating)
Reaction(IUBMB)
(2R,4S)-2,4-diaminopentanoate + H2O + NAD(P)+ = (2R)-2-amino-4-oxopentanoate + NH3 + NAD(P)H + H+ [RN:R04200 R04201]
Reaction(KEGG)
Substrate
(2R,4S)-2,4-diaminopentanoate [CPD:C03943];
H2O [CPD:C00001];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
(2R)-2-amino-4-oxopentanoate [CPD:C03341];
NH3 [CPD:C00014];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Also acts, more slowly, on 2,5-diaminohexanoate forming 2-amino-5-oxohexanoate, which then cyclizes non-enzymically to 1-pyrroline-2-methyl-5-carboxylate. It has equal activity with NAD+ and NADP+ [cf. EC 1.4.1.26, 2,4-diaminopentanoate dehydrogenase (NAD+)].
History
EC 1.4.1.12 created 1976, modified 2017
Pathway
ec00310  Lysine degradation
ec00330  Arginine and proline metabolism
ec00470  D-Amino acid metabolism
ec01100  Metabolic pathways
Orthology
K21672  2,4-diaminopentanoate dehydrogenase
Genes
CEHCEW89_15600
EAVEH197_05050
VCPH9L18_06400
VHYG7082_14535
CSQCSCA_0127
CACECACET_c17480(dapB2)
CEUA7L45_16560
CFMBJL90_14515
CARGRSJ17_08675
CDRKB9W14_17905
CTAGLL095_13645 LL095_13650
AMTAmet_2367
AOEClos_1699
GFEGferi_26730
CALEFDN13_03020
CRSFQB35_06685
CPRFK7H06_09005
CRASKVH43_11400
FPLAA4U99_15095
CDFCD630_04420(ord)
PDCCDIF630_00570(ord)
CDCCD196_0399
CDLCDR20291_0385
PDFCD630DERM_04420(ord)
CSTCLOST_1294(ord)
TEMJW646_03950
TGCL0P85_04325(ord)
TEBT8CH_0873(ord)
DAIDesaci_1873
AACXDEACI_0846
VGUHYG85_19050
VPYHZI73_17680
ACAEHYG86_08075
AMIJEQM06_12600
AMICAmi3637_07690
ABUTAmi103574_00595
ETMCE91St48_39740(ord)
EUUADJ67_00765
TTETTE1234
TEXTeth514_1477
THXThet_1426
TPDTeth39_1040
TBOThebr_1067
TWIThewi_1184
TOCToce_1489
NTHNther_1166
NCDACONDI_00602(ord)
HORHore_21120
AFTBBF96_13560
KMEH0A61_00511(ord)
SPOAEQM13_10965
KPARJL105_07140
CAZOG3A45_03845
SEDZJYG23_00910
PFTJBW_01651
MANRMPAN_008560(ord)
MBJKQ51_00248
XCLG4Z02_05170
TBMBK010_05560
TBZBK011_05600
TBKHF295_00050
ARSADJ73_08360
PACPPA2276
PAKHMPREF0675_5353
PAVTIA2EST22_11160
PAXTIA2EST36_11135
PAZTIA2EST2_11080
PAWPAZ_c23740(dapB2)
PADTIIST44_04200
PCNTIB1ST10_11600
PACCPAC1_11610
PACHPAGK_2185
PACNTIA1EST1_11230
CACNRN83_00010
PRLBCB70_06960
CGRN4412665_00379
PAUSNCTC13651_02412
PPCHMPREF9154_0892
ARUBJ5A65_10535
ABATCFX1CAM_0745
TPITREPR_1364
SLRL21SP2_1023
FHWRN87_08680
FPDCTM68_09160
FCII6I83_05765
SBRSY1_03600
TMETmel_0905
TAFTHA_1160
THPBG95_05265
THERY592_05345
TFEJYK00_04200
FNOFnod_1646
FPEFerpe_1990
FIANA23_09975(ord)
FRRIB67_00430
OCYOSSY52_03900(ord)
PMOPmob_1166
MPZMarpi_1533
MARNLN42_08170
DTNDTL3_0759
OCSOF820_08020(ord)
KOLKole_0356
KPFIX53_10190
MPGTheba_1251
MINFMESINF_2284
ASACATHSA_0997
 » show all
Reference
1  [PMID:4684685]
  Authors
Somack R, Costilow RN
  Title
2,4-diaminopentanoic acid C 4 dehydrogenase. Purification and properties of the protein.
  Journal
J Biol Chem 248:385-8 (1973)
  Sequence
Reference
2
  Authors
Stadtman, T.C.
  Title
Lysine metabolism by clostridia. XIIB 2,4-Diaminohexanoate dehydrogenase (2,4-diaminopentanoate dehydrogenase).
  Journal
Adv Enzymol Relat Areas Mol Biol 38:441-445 (1973)
Reference
3  [PMID:4394942]
  Authors
Tsuda Y, Friedmann HC.
  Title
Ornithine metabolism by Clostridium sticklandii. Oxidation of ornithine to 2-amino-4-ketopentanoic acid via 2,4-diaminopentanoic acid; participation of B12 coenzyme, pyridoxal phosphate, and pyridine nucleotide.
  Journal
J Biol Chem 245:5914-26 (1970)
Other DBs
ExplorEnz - The Enzyme Database: 1.4.1.12
IUBMB Enzyme Nomenclature: 1.4.1.12
ExPASy - ENZYME nomenclature database: 1.4.1.12
BRENDA, the Enzyme Database: 1.4.1.12
CAS: 39346-26-4

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