Entry
Name
methylenetetrahydrofolate dehydrogenase (NAD+);
methylenetetrahydrofolate dehydrogenase (NAD+)
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
5,10-methylenetetrahydrofolate:NAD+ oxidoreductase
Reaction(IUBMB)
5,10-methylenetetrahydrofolate + NAD+ = 5,10-methenyltetrahydrofolate + NADH + H+ [RN:
R01218 ]
Reaction(KEGG)
Substrate
5,10-methylenetetrahydrofolate [CPD:
C00143 ];
NAD+ [CPD:
C00003 ]
Product
History
EC 1.5.1.15 created 1978
Pathway
Orthology
K00295 methylenetetrahydrofolate dehydrogenase (NAD+)
K13403 methylenetetrahydrofolate dehydrogenase(NAD+) / 5,10-methenyltetrahydrofolate cyclohydrolase
Genes
HSA : 10797(MTHFD2) 441024(MTHFD2L)
PTR : 459331(MTHFD2) 461253(MTHFD2L)
PPS : 100974548(MTHFD2L) 100994215(MTHFD2) 117980958
GGO : 101139170(MTHFD2L) 101146472(MTHFD2)
PON : 100442117(MTHFD2) 100445055(MTHFD2L) 100456570
NLE : 100584729(MTHFD2) 100589055(MTHFD2L) 100590349
HMH : 116466952(MTHFD2L) 116480324 116483870(MTHFD2)
MCC : 702907(MTHFD2L) 714974(MTHFD2)
MCF : 102119606(MTHFD2L) 102144180(MTHFD2)
MTHB : 126934050 126954903
MNI : 105465284(MTHFD2) 105477284(MTHFD2L)
CSAB : 103220037(MTHFD2) 103235800(MTHFD2L)
CATY : 105576875(MTHFD2L) 105596885(MTHFD2)
PANU : 101015526(MTHFD2) 101021362(MTHFD2L)
TGE : 112604569(MTHFD2) 112625208(MTHFD2L)
MLEU : 105529093(MTHFD2L) 105540224(MTHFD2)
RRO : 104658885(MTHFD2L) 104674805(MTHFD2)
RBB : 108515812(MTHFD2L) 108520674(MTHFD2) 108532678
TFN : 117062048(MTHFD2) 117078495 117085481(MTHFD2L)
PTEH : 111523403(MTHFD2) 111524570(MTHFD2L)
CANG : 105501299(MTHFD2L) 105514640(MTHFD2) 105523714
CJC : 100389511(MTHFD2L) 100402525(MTHFD2)
SBQ : 101027806(MTHFD2) 101048869(MTHFD2L) 101052018
CIMI : 108289300(MTHFD2) 108292192(MTHFD2L)
CSYR : 103263959(MTHFD2L) 103266737(MTHFD2)
MMUR : 105860225(MTHFD2L) 105884595(MTHFD2)
LCAT : 123624717(MTHFD2L) 123637071(MTHFD2)
PCOQ : 105821496(MTHFD2) 105822837(MTHFD2L)
OGA : 100944415(MTHFD2) 100950521(MTHFD2L)
MMU : 17768(Mthfd2) 665563(Mthfd2l)
MCAL : 110294891(Mthfd2l) 110296265(Mthfd2)
MPAH : 110316109(Mthfd2) 110330651(Mthfd2l)
RNO : 305248(Mthfd2l) 680308(Mthfd2)
MCOC : 116099135(Mthfd2) 116104468(Mthfd2l)
ANU : 117713165(Mthfd2l) 117715560(Mthfd2)
MUN : 110559317 110559321 110560481(Mthfd2l)
CGE : 100760811 100770086(Mthfd2)
MAUA : 101834616(Mthfd2l) 101838681(Mthfd2)
PROB : 127232096(Mthfd2l) 127235701(Mthfd2)
PLEU : 114694412(Mthfd2) 114701739(Mthfd2l)
MORG : 121437483(Mthfd2) 121460790(Mthfd2l)
MFOT : 126506448 126514549 126515370
AAMP : 119807921(Mthfd2) 119815105(Mthfd2l)
NGI : 103727002(Mthfd2) 103742471(Mthfd2l)
HGL : 101703156(Mthfd2l) 101705997(Mthfd2)
CCAN : 109681115(Mthfd2l) 109688133(Mthfd2)
DORD : 105988451(Mthfd2l) 105999581(Mthfd2)
NCAR : 124963210 124986624
OCU : 100342676 100344170 100349062
OPI : 101533756(MTHFD2) 101534502(MTHFD2L)
TUP : 102468110(MTHFD2L) 102477024(MTHFD2)
GVR : 103590264(MTHFD2L) 103605417(MTHFD2)
CFA : 482197(MTHFD2L) 483107(MTHFD2)
CLUD : 112652348(MTHFD2L) 112664237(MTHFD2)
VVP : 112909247(MTHFD2L) 112916728(MTHFD2)
VLG : 121472878(MTHFD2L) 121490573(MTHFD2)
AML : 100463985(MTHFD2L) 100475974(MTHFD2)
UMR : 103665392(MTHFD2L) 103671402(MTHFD2)
UAH : 113243787(MTHFD2) 113263273(MTHFD2L)
UAR : 123786069(MTHFD2) 123787115(MTHFD2L)
MPUF : 101672189(MTHFD2) 101675264(MTHFD2L)
NVS : 122889143(MTHFD2L) 122915000(MTHFD2)
ORO : 101365960(MTHFD2L) 101375555(MTHFD2)
EJU : 114206623(MTHFD2L) 114218947(MTHFD2)
ZCA : 113925939(MTHFD2L) 113937926(MTHFD2)
MLX : 118007960(MTHFD2) 118010451(MTHFD2L)
NSU : 110588813(MTHFD2) 110591451(MTHFD2L)
LWW : 102726104(MTHFD2) 102739556(MTHFD2L)
FCA : 101083836(MTHFD2) 101093354(MTHFD2L)
PYU : 121019233(MTHFD2) 121034386(MTHFD2L)
PBG : 122478796(MTHFD2L) 122497031(MTHFD2)
PTG : 102961104(MTHFD2) 102967232(MTHFD2L)
PPAD : 109263019(MTHFD2) 109277695(MTHFD2L)
AJU : 106982039(MTHFD2L) 106988599(MTHFD2)
HHV : 120231055(MTHFD2L) 120236983(MTHFD2)
BTA : 517539(MTHFD2) 536269(MTHFD2L)
BOM : 102272253(MTHFD2L) 102277964(MTHFD2)
BIU : 109560580(MTHFD2L) 109565920(MTHFD2)
BBUB : 102390419(MTHFD2L) 102394714(MTHFD2)
BBIS : 104980895(MTHFD2) 104987310(MTHFD2L)
CHX : 102179276 102184159(MTHFD2)
OAS : 100137069(MTHFD2) 101104908(MTHFD2L) 101107147 105612852
ODA : 120851246(MTHFD2) 120861441(MTHFD2L)
CCAD : 122428280(MTHFD2L) 122441493(MTHFD2)
SSC : 100525706(MTHFD2L) 100737806(MTHFD2)
CFR : 102506350(MTHFD2) 102507186(MTHFD2L)
CBAI : 105066980(MTHFD2) 105080380(MTHFD2L)
CDK : 105091387(MTHFD2L) 105096568(MTHFD2)
VPC : 102533859(MTHFD2L) 102545702(MTHFD2)
BACU : 102999576(MTHFD2) 103005088(MTHFD2L)
LVE : 103070308(MTHFD2L) 103080041(MTHFD2)
OOR : 101271285(MTHFD2) 101284968(MTHFD2L)
DLE : 111169110(MTHFD2) 111187610(MTHFD2L)
PCAD : 102978086 102982589(MTHFD2L) 112067504
PSIU : 116754589(MTHFD2L) 116764227(MTHFD2)
NASI : 112405685(MTHFD2L) 112413656(MTHFD2)
ECB : 100053990(MTHFD2) 100056425(MTHFD2L)
EPZ : 103564986(MTHFD2) 103565139(MTHFD2L)
EAI : 106823850(MTHFD2) 106846392(MTHFD2L)
MYB : 102241059(MTHFD2L) 102257615(MTHFD2)
MYD : 102754790(MTHFD2) 102755341(MTHFD2L)
MMYO : 118668841(MTHFD2) 118669831(MTHFD2L)
MLF : 102426627(MTHFD2) 102426926(MTHFD2L)
MNA : 107529263(MTHFD2) 107534504(MTHFD2L)
PKL : 118705285(MTHFD2L) 118717559(MTHFD2)
HAI : 109371186(MTHFD2) 109371843(MTHFD2L)
SHON : 118979460(MTHFD2L) 118994505 119000082(MTHFD2)
AJM : 119038407(MTHFD2) 119052831(MTHFD2L)
PDIC : 114492524(MTHFD2L) 114500000(MTHFD2)
PHAS : 123811404(MTHFD2) 123831166(MTHFD2L)
RFQ : 117021907(MTHFD2L) 117032654(MTHFD2)
PALE : 102884965(MTHFD2) 102885905(MTHFD2L)
PGIG : 120588205(MTHFD2L) 120594387(MTHFD2)
PVP : 105290775(MTHFD2) 105292343(MTHFD2L)
RAY : 107502906(MTHFD2) 107515314(MTHFD2L)
MJV : 108397674(MTHFD2L) 108402265(MTHFD2)
TOD : 119259086(MTHFD2) 119260206(MTHFD2L)
SARA : 101544729(MTHFD2L) 101545103(MTHFD2)
LAV : 100656025(MTHFD2) 100662679(MTHFD2L)
ETF : 101638367(MTHFD2L) 101655590(MTHFD2) 101658878 105978978
DNM : 101424312 101437636 101445213
MDO : 100023851(MTHFD2L) 100024210(MTHFD2)
GAS : 123233069(MTHFD2) 123251355(MTHFD2L)
SHR : 100915702(MTHFD2L) 100917387(MTHFD2)
PCW : 110209788(MTHFD2L) 110222642(MTHFD2)
GGA : 426126(MTHFD2) 770327(MTHFD2L)
PCOC : 116231077(MTHFD2L) 116234498(MTHFD2)
MGP : 100538988(MTHFD2) 100551458(MTHFD2L)
CJO : 107313487(MTHFD2L) 107323669(MTHFD2)
NMEL : 110387225(MTHFD2) 110397997(MTHFD2L)
ACYG : 106041914(MTHFD2L) 106047654(MTHFD2)
AFUL : 116489151(MTHFD2L) 116499426(MTHFD2)
TGU : 100222836(MTHFD2) 100224318
LSR : 110470132 110480183(MTHFD2)
SCAN : 103823444 103824667(MTHFD2)
PMOA : 120498781 120499127(MTHFD2)
OTC : 121336009(MTHFD2) 121348048
PRUF : 121349320 121355610(MTHFD2)
GFR : 102034978(MTHFD2) 102038192(EPGN)
FAB : 101805811(MTHFD2) 101808409(MTHFD2L)
PHI : 102104850(MTHFD2) 102107685(MTHFD2L)
CCAE : 111929467 111938875(MTHFD2)
CBRC : 103622619(MTHFD2) 103624977
ETL : 114068642(EPGN) 114071513(MTHFD2)
ACHL : 103800026(MTHFD2L) 103802746(MTHFD2)
SVG : 106858290 106862868(MTHFD2)
FPG : 101913929(MTHFD2) 101919106(MTHFD2L)
FCH : 102045855(MTHFD2) 102057455(MTHFD2L)
CLV : 102087519(MTHFD2) 102090092
EGZ : 104130378(MTHFD2) 104131554(MTHFD2L)
NNI : 104015875(MTHFD2L) 104019251(MTHFD2)
PLET : 104614772(MTHFD2) 104617764(MTHFD2L)
PCRI : 104025022(MTHFD2) 104031754(MTHFD2L)
PCAO : 104042290(MTHFD2) 104045807(MTHFD2L)
ACUN : 113479567 113488027(MTHFD2)
TALA : 104358962(MTHFD2) 104361426(MTHFD2L)
PADL : 103917169(MTHFD2) 103917712(MTHFD2L)
AFOR : 103898942(MTHFD2L) 103903705(MTHFD2)
ACHC : 115340186 115350463(MTHFD2)
HALD : 104311299(MTHFD2) 104317828(MTHFD2L)
HLE : 104828875(MTHFD2) 104836830(MTHFD2L)
AGEN : 126044745 126051739
CCRI : 104158124(MTHFD2) 104165985(MTHFD2L)
CSTI : 104555931(MTHFD2L) 104561088
EHS : 104512980(MTHFD2) 104513800(MTHFD2L)
CMAC : 104484776(MTHFD2) 104486158(MTHFD2L)
MUI : 104534419(MTHFD2) 104547918(MTHFD2L)
FGA : 104073281(MTHFD2) 104078159(MTHFD2L)
GSTE : 104255438(MTHFD2) 104264846(MTHFD2L)
LDI : 104340776(MTHFD2) 104354133(MTHFD2L)
MNB : 103777742(MTHFD2) 103781409
OHA : 104331902(MTHFD2L) 104338078(MTHFD2)
NNT : 104400179(MTHFD2) 104406440(MTHFD2L)
SHAB : 115604704 115618521(MTHFD2)
DPUB : 104297138(MTHFD2L) 104297832(MTHFD2)
PGUU : 104468149(MTHFD2L) 104471166
ACAR : 104518821 104526815(MTHFD2L)
CPEA : 104394088(MTHFD2L) 104394352(MTHFD2)
AVIT : 104267817(MTHFD2) 104279179(MTHFD2L)
CVF : 104281773(MTHFD2) 104288017(MTHFD2L)
CUCA : 104065439(MTHFD2) 104067484(MTHFD2L)
TEO : 104370029(MTHFD2) 104375962(MTHFD2L)
AAM : 106484145(MTHFD2) 106491799
AROW : 112975351(MTHFD2) 112977624(MTHFD2L)
NPD : 112950035(MTHFD2) 112950076
TGT : 104565064(MTHFD2L) 104580416(MTHFD2)
DNE : 112988273 112993857(MTHFD2)
SCAM : 104149937(MTHFD2L) 104150773(MTHFD2)
ASN : 102380151(MTHFD2L) 102387286(MTHFD2)
AMJ : 102568648(MTHFD2L) 102576181(MTHFD2)
CPOO : 109309507(MTHFD2L) 109317357(MTHFD2)
GGN : 109295449(MTHFD2) 109297131(MTHFD2L)
PSS : 102453272(MTHFD2) 102459482(MTHFD2L)
CMY : 102929848(MTHFD2) 102931470(MTHFD2L)
CPIC : 101931359(MTHFD2) 101935770(MTHFD2L)
TST : 117872894(MTHFD2) 117878521(MTHFD2L)
CABI : 116814584(MTHFD2L) 116821198(MTHFD2)
MRV : 120397401(MTHFD2) 120405569(MTHFD2L)
ACS : 100553649(mthfd2l) 100566586(mthfd2)
PVT : 110072089(MTHFD2) 110090462(MTHFD2L)
SUND : 121935088(MTHFD2) 121935318(MTHFD2L)
PBI : 103051980(MTHFD2) 103060626
PMUR : 107283230(MTHFD2) 107302390(MTHFD2L)
CTIG : 120299360(MTHFD2) 120302694(MTHFD2L)
TSR : 106543055(MTHFD2L) 106544036(MTHFD2)
PGUT : 117664798(MTHFD2L) 117673329(MTHFD2)
VKO : 123016797(MTHFD2) 123031875
PMUA : 114581905(MTHFD2L) 114602652(MTHFD2)
ZVI : 118087480(MTHFD2) 118094808(MTHFD2L)
XLA : 108711079 432317(mthfd2.L) 446641(mthfd2l.S)
XTR : 100170462(mthfd2) 100497864(mthfd2l)
NPR : 108784463(MTHFD2L) 108793886(MTHFD2)
RTEM : 120916807(MTHFD2L) 120931047(MTHFD2)
DRE : 100004977(mthfd2) 327496(mthfd2l)
SRX : 107711902 107728122 107738998 107739986
SANH : 107667540 107675952 107686384 107702971
SGH : 107548530 107556039 107565988 107599985
CCAR : 109075210 109080159
CAUA : 113085087 113094248 113096344
CGIB : 127957224 127963046 127990259 128018498
PPRM : 120472104(mthfd2) 120485220(mthfd2l)
MAMB : 125267633(mthfd2) 125279652(mthfd2l)
CIDE : 127513246 127517436
MASI : 127415404 127424384 127435972
AMEX : 103037572(mthfd2) 103042060
TNG : GSTEN00029442G001 GSTEN00029619G001
LCO : 104920303(mthfd2) 104923005(mthfd2l)
NCC : 104962129(mthfd2l) 104962309(mthfd2)
CGOB : 115013691 115014110
ELY : 117252090(mthfd2l) 117252403(mthfd2)
EFO : 125890414 125890501(mthfd2)
PLEP : 121944373 121944563(mthfd2)
SLUC : 116054269(mthfd2l) 116056830(mthfd2)
ECRA : 117944702(mthfd2) 117945331
ESP : 116688844(mthfd2l) 116689877
PFLV : 114555201 114556217
GAT : 120830310 120830612(mthfd2)
PPUG : 119225355(mthfd2) 119225600(mthfd2l)
MSAM : 119891386(mthfd2) 119892515(mthfd2l)
CUD : 121510345(mthfd2l) 121510462(mthfd2)
ALAT : 119019845(mthfd2) 119020100(mthfd2l)
OAU : 116310979(mthfd2l) 116332400(mthfd2)
OLA : 101160170(mthfd2) 101165643
OML : 112148134(mthfd2) 112148901(mthfd2l)
PRET : 103469985 103470271(mthfd2)
PFOR : 103142046(mthfd2l) 103151860(mthfd2)
PLAI : 106961883(mthfd2) 106962024(mthfd2l)
PMEI : 106926065 106929472(mthfd2)
GAF : 122828037(mthfd2l) 122828134(mthfd2)
CVG : 107085299(mthfd2l) 107087259(mthfd2)
CTUL : 119778181(mthfd2l) 119790120(mthfd2)
GMU : 124877333(mthfd2) 124877468(mthfd2l)
NFU : 107394218(mthfd2) 107394299
KMR : 108233658 108234535(mthfd2)
ALIM : 106519077(mthfd2) 106519891(mthfd2l)
NWH : 119413347(mthfd2) 119413862(mthfd2l)
AOCE : 111576630 111580751
MCEP : 125011688 125012175(mthfd2)
CSEM : 103397081 103397730
POV : 109636983 109638160(mthfd2)
SSEN : 122769097(mthfd2l) 122769932(mthfd2)
HHIP : 117768439(mthfd2l) 117768501(mthfd2)
HSP : 118114510(mthfd2) 118115261(mthfd2l)
LCF : 108878136(mthfd2) 108881269(mthfd2l)
SLAL : 111654888 111658241
XGL : 120805230(mthfd2) 120805348(mthfd2l)
SSCV : 125993813 125994143
BPEC : 110172444(mthfd2) 110175266
MALB : 109956494 109961515(mthfd2)
BSPL : 114862214(mthfd2) 114863001(mthfd2l)
SASA : 106570897 106580352(MTDC) 106585270
STRU : 115164469 115200172 115200615
OTW : 112241023(mthfd2l) 112245933 112262863(mthfd2)
OMY : 110525703 110536073(mthfd2) 110536461(mthfd2l)
OGO : 124033299 124035323 124036343(mthfd2)
SALP : 111957600 111975204
SNH : 120054770 120062825(mthfd2l) 120062996(mthfd2)
CCLU : 121530704(mthfd2l) 121530941(mthfd2) 121584182
ELS : 105014522 105026116(mthfd2)
SFM : 108934776(mthfd2) 108938600
PKI : 111855437 111860038(mthfd2)
AANG : 118206167(mthfd2) 118213034 118237204
LOC : 102682748(mthfd2) 102685233(mthfd2l)
PSPA : 121302341(mthfd2) 121303023 121326791
ARUT : 117397875 117408809 117966071
PSEX : 120527431 120538870(mthfd2)
LCM : 102351616(MTHFD2) 102356358(MTHFD2L)
CMK : 103177682 103191574(mthfd2)
DSI : Dsimw501_GD20823(Dsim_GD20823)
SCAC : 106081765 106081776
AALB : 109401292 109623318 115262812
CQU : CpipJ_CPIJ004709 CpipJ_CPIJ004710
CPII : 120428517 120428518
CFEL : 113365739 113376951
CBR : CBG_16896(Cbr-dao-3)
NCS : NCAS_0A03350(NCAS0A03350)
NDI : NDAI_0A03210(NDAI0A03210)
TPF : TPHA_0H01380(TPHA0H01380)
TBL : TBLA_0A09280(TBLA0A09280)
TDL : TDEL_0B02500(TDEL0B02500)
KAF : KAFR_0H00370(KAFR0H00370)
KNG : KNAG_0C06490(KNAG0C06490)
CAL : CAALFM_C404720WA(CaO19.3810)
NTE : NEUTE1DRAFT90232(NEUTE1DRAFT_90232)
BFU : BCIN_15g01620(Bcmtd1)
AOR : AO090005000616 AO090009000139
ANG : ANI_1_982144(An16g07400)
AFV : AFLA_003423 AFLA_011217
TMS : TREMEDRAFT_30073 TREMEDRAFT_45534
TASA : A1Q1_02350 A1Q1_04812
ABP : AGABI1DRAFT119972(AGABI1DRAFT_119972)
ABV : AGABI2DRAFT188587(AGABI2DRAFT_188587)
SCM : SCHCO_02622514(SCHCODRAFT_02622514)
SMIN : v1.2.027029.t1(symbB.v1.2.027029.t1)
FCY : FRACYDRAFT_159628 FRACYDRAFT_196723
TPS : THAPSDRAFT_27550 THAPSDRAFT_31412
PIF : PITG_14310 PITG_14312 PITG_14315 PITG_14322 PITG_14325 PITG_14344 PITG_14346 PITG_14352 PITG_14777 PITG_17187 PITG_17195 PITG_18225 PITG_18545 PITG_18552 PITG_18553 PITG_19374 PITG_19375 PITG_19379 PITG_19399 PITG_20542 PITG_21582
EHX : EMIHUDRAFT_413904 EMIHUDRAFT_78672
GTT : GUITHDRAFT_117739 GUITHDRAFT_157912
» show all
Taxonomy
Reference
Authors
Moore MR, O'Brien WE, Ljungdahl LG.
Title
Purification and characterization of nicotinamide adenine dinucleotide-dependent methylenetetrahydrofolate dehydrogenase from Clostridium formicoaceticum.
Journal
J Biol Chem 249:5250-3 (1974)
Other DBs
ExplorEnz - The Enzyme Database: 1.5.1.15
ExPASy - ENZYME nomenclature database: 1.5.1.15