KEGG   ENZYME: 1.5.1.21
Entry
EC 1.5.1.21                 Enzyme                                 
Name
1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (NADPH);
Pyr2C reductase;
1,2-didehydropipecolate reductase;
P2C reductase;
1,2-didehydropipecolic reductase;
DELTA1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (ambiguous);
L-pipecolate:NADP+ 2-oxidoreductase;
DELTA1-piperideine-2-carboxylate reductase;
Delta1-piperideine-2-carboxylate reductase
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
L-pipecolate/L-proline:NADP+ 2-oxidoreductase
Reaction(IUBMB)
(1) L-pipecolate + NADP+ = 1-piperideine-2-carboxylate + NADPH + H+ [RN:R02203];
(2) L-proline + NADP+ = 1-pyrroline-2-carboxylate + NADPH + H+ [RN:R01249]
Reaction(KEGG)
R01249 R02203
Substrate
L-pipecolate [CPD:C00408];
NADP+ [CPD:C00006];
L-proline [CPD:C00148]
Product
1-piperideine-2-carboxylate [CPD:C04092];
NADPH [CPD:C00005];
H+ [CPD:C00080];
1-pyrroline-2-carboxylate [CPD:C03564]
Comment
The enzyme is involved in the catabolism of D-lysine and D-proline in bacteria that belong to the Pseudomonas genus. In contrast to EC 1.5.1.1, 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H], which shows similar activity with NADPH and NADH, this enzyme is specific for NADPH.
History
EC 1.5.1.21 created 1984 (EC 1.5.1.14 created 1976, incorporated 1989), modified 2015
Pathway
ec00310  Lysine degradation
ec00960  Tropane, piperidine and pyridine alkaloid biosynthesis
ec01100  Metabolic pathways
Orthology
K13609  delta1-piperideine-2-carboxylate reductase
Genes
EASEntas_0546
KPNKPN_04791
KPUKP1_0749
KPMKPHS_06400
KPPA79E_4358
KPHKPNIH24_03290
KPZKPNIH27_03165
KPVKPNIH29_03485
KPWKPNIH30_03445
KPYKPNIH31_04585
KPGKPNIH32_03450
KPCKPNIH10_03270
KPQKPR0928_03280
KPTVK055_2646(dpkA)
KPOKPN2242_02100
KPRKPR_0871
KPJN559_4502
KPID364_24450
KPAKPNJ1_04819
KPSKPNJ2_04768
KPXPMK1_02252(comC)
KPBFH42_20485
KPNEKU54_023300
KPNULI86_23140
KPNKBN49_4402
KVAKvar_4453
KPEKPK_4820
KPKA593_14050
KVDKR75_11500
KVQSP68_18135
KQUAVR78_07855
EAEEAE_10410
EARCCG31912
KQVB8P98_24145
KARLGL98_21745
RORRORB6_15470
RPLNB1209_23425
RAODSD31_22180
RTGNCTC13098_06399(ybiC_3)
CROROD_48381(allD)
CWECO701_18830
CYOCD187_21025
CPOTFOB25_08085
CSEDJY391_03480
CAMAF384_16275
CAFAL524_06725
CFARCI104_21370
CIRC2U53_13630
CTELGBC03_08450
PGELG71_25405
ESCEntcl_3787
KLEAO703_02980
KGOCEW81_21480
KIENCTC12125_03109(ybiC)
KASKATP_39370
BUFD8682_02975
BFTMNO13_12510
IZHFEM41_12835
PSGCG163CM_29690(lhpD)
EBFD782_3914
EBUCUC76_11990
SMARSM39_1303
SMACSMDB11_1084
SMWSMWW4_v1c17830
SPESpro_1835
SRRSerAS9_1782
SRLSOD_c16610
SRYM621_09200
SPLYQ5A_009085(lhpD)
SRSSerAS12_1782
SRASerAS13_1783
SMAFD781_1745
SLQM495_08540
SERFL085_19550
SERSSERRSCBI_08585
SFWWN53_20920
SFGAV650_16730
SRZAXX16_3377
SERMCLM71_08455
SQUE4343_07010
SFJSAMEA4384070_1859(ybiC_1)
SSURATE40_005720
SURIJ0X03_14790
SRHZFO014_01485
SENPKHA73_09180
SFOZ042_01715
SLIGGTU79_12565
EAMEAMY_2586
EAYEAM_2481
EPYEpC_10400
EPREPYR_01102
ERJEJP617_00490
TCIA7K98_02910
PFQQQ39_16045
XSASB85_05395
XTNFD63_07230
VZIG5S32_08740
PAEPA1252
PAEVN297_1291
PAEIN296_1291
PAUPA14_48020
PAPPSPA7_4140
PAGPLES_40601
PAFPAM18_3779
PNCNCGM2_2134
PAEBNCGM1900_1324
PDKPADK2_19390
PSGG655_18910
PRPM062_06815
PAEPPA1S_19655
PAERPA1R_gp4858
PAEMU769_19495
PAELT223_20745
PAESSCV20265_4162
PAEUBN889_01331
PAEGAI22_14310
PAECM802_1288
PAEOM801_1291
PFUWKF707C_2150 KF707C_24890
PALCA0T30_01530
PMUIG4G71_28425
PPUPP_3591(dpkA)
PPFPput_2181
PPGPputGB1_2325
PPWPputW619_2806
PPTPPS_3084
PPBPPUBIRD1_2201(dpkA)
PPIYSA_00209
PPXT1E_2270
PPUHB479_15340
PPUTL483_18820
PPUNPP4_22360
PPUDDW66_3356
PFVPsefu_0051
PMONX969_14820
PMOTX970_14465
PMOSO165_008495
PPJRK21_01556
PORAPT59_03175
PMOLCLJ08_00350
PSTPSPTO_2359(allD)
PSBPsyr_2143
PSYRN018_10045
PSPPSPPH_2118
PSAVPSA3335_18020
PAMGBKM19_013455
PCIPCH70_29380
PAVLBKM03_17540
PVDCFBP1590__2197
PCABJGS08_16140
PCOFPOR16_10205
PTREI9H09_14780
PSYIMME58_10980
PFLPFL_1416 PFL_2200 PFL_2905
PPRCPFLCHA0_c14530 PFLCHA0_c22600 PFLCHA0_c29510
PPROPPC_1470 PPC_2240 PPC_2937
PFEPSF113_2799
PFNHZ99_04060
PFOPfl01_2567
PFSPFLU_2704
PFCPflA506_2990
PPZH045_09725
PFBVO64_5794
PMANOU5_0213
PTVAA957_01750
PCGAXG94_03190
PVRPverR02_13630
PAZOAYR47_20360
POIBOP93_11095
PRXHRH33_12350
PMEDE3Z27_13345
PFWPF1751_v1c23680
PFFPFLUOLIPICF724880
PFXA7318_11000
PENPSEEN2669
PLULFOB45_15970
PBAPSEBR_a2990
PBCCD58_13450
PPUUPputUW4_02457
PDRH681_03695
PSVPVLB_11435
PSKU771_18280
PCHEY04_06365 EY04_13730
PCZPCL1606_31970 PCL1606_46950
PCPJM49_16210 JM49_23270
PFZAV641_10885 AV641_13400
PLQAA042_00120
PALKPSAKL28_27760 PSAKL28_28750
PRHLT40_09710
PSWLK03_17665
PPVNJ69_07345
PSEMTO66_07035 TO66_14500
PSECCCOS191_2401
PPSYAOC04_09930
PSOSPOS17_1439 POS17_2151 POS17_3175
PKRAYO71_16070
PFKPFAS1_24845 PFAS1_26870
PANRA7J50_3234
PPSLBJP27_17570
PSETTHL1_210 THL1_3349
PSILPMA3_13110
PYMAK972_2478
PKEDLD99_13515
PUMHGP31_13870 HGP31_16480
POJPtoMrB4_26280
PGGFX982_03383
PPSHG5J76_12940 G5J76_14145
PGYAWU82_14350
PLALFXN65_03325
PVKEPZ47_13395
PEZHWQ56_11090
PBZGN234_02470
PKHJLK41_24685
PATAJWU58_13960
PDWBV82_1485 BV82_3163
PZEHU754_015780
PMOEHV782_015910
PCAMHNE05_17005
PSEPC4K39_2523 C4K39_5176 C4K39_5251
PVWHU752_014575 HU752_024125
PTRTHU722_0013355
PXAKSS93_19090
PSAMHU731_003245
PTZHU718_016015
PQIKH389_13730 KH389_15905
PSHHHU773_014590
PXNHU772_014410
PHVHU739_004795
PPRGHU725_011750
PANHHU763_013470
PASGKSS96_16160
PFAKKSS94_14750
PMUYKSS95_16930
PMAMKSS90_13690
PAZEKSS91_13490 KSS91_13900
PALVKSS97_13330
PORYEJA05_14740
PTKEXN22_15135 EXN22_15885
PTWTUM18999_27440
PZAHU749_016110
PIEHU724_014550
PWYHU734_012495
PTAENCTC10697_02571(ybiC)
PGFJ0G10_15265
PJUL1P09_10485
PSTTCH92_01000
PINPing_2116
GAIIMCC3135_33065(lhpD)
HELHELO_3404(lhpD)
HAKKO116_03365
HAMHALO3638
HHUAR456_06200
HAFC8233_04235
HALKCUU95_10915
ZPLZBT109_2545
HAAA5892_01405
CMAIBFX80_10425
CAMHLCW13_07155
KUSB9G99_06295
MPCMar181_0040
MPRIMP3633_0050
MFOIJSY38_09525
CHJNCTC10426_00338(allD)
TSNW908_03175
THINCRN91_06575
IGNMMG00_00100
VITADP71_26950
VSTLVJ81_00970
VMSLVJ82_10735
PTESJQU52_05295
UTELVJ83_03150
RPJN234_36480
RMERmet_5095
BMABMAA1423
BMLBMA10229_2189
BMNBMA10247_A0876
BMAEDM78_4013
BMAIDM57_08740
BMAFDM51_5067
BMAZBM44_4895
BMABBM45_3797
BPSBPSS0328
BPMBURPS1710b_A1882
BPLBURPS1106A_A0467
BPDBURPS668_A0565
BPSEBDL_3560
BPSMBBQ_5871
BPSUBBN_3724
BPSDBBX_5398
BPZBP1026B_II0358
BPQBPC006_II0445
BPKBBK_5540
BPSHDR55_5019
BPSABBU_5789
BPSOX996_4788
BUTX994_4288
BTEBTH_II2071
BTQBTQ_5351
BTJBTJ_4003
BTZBTL_4827
BTDBTI_4403
BTVBTHA_5403
BTHEBTN_4477
BTHMBTRA_4743
BTHADR62_4591
BTHLBG87_4808
BOKDM82_4397
BOCBG90_3679
BUUWS70_19115
BSAVWS86_20465
BHGI6G56_31045
BVIBcep1808_4699
BVEAK36_4220
BURBcep18194_B1898
BCMBcenmc03_3383
BCHBcen2424_4136
BCJBCAM1263
BCENDM39_3738
BCEWDM40_4175
BCEOI35_5111
BAMBamb_3547
BACBamMC406_4028
BMUBmul_4451
BMKDM80_3615
BMULNP80_4164
BCTGEM_4480
BCEDDM42_3830
BCEPAPZ15_18370
BDLAK34_4217
BPYRABD05_29840
BCONNL30_06290
BUBBW23_4935
BDFWI26_19395
BLATWK25_23220
BTEIWS51_03990
BSEMWJ12_26160
BPSLWS57_07715
BMECWJ16_24790
BSTGWT74_25105
BSTLBBJ41_19295
BANNJFN94_23510
BGDbgla_2g05040
BGOBM43_7272
BUKMYA_4528
BULBW21_3936
BGPBGL_2c04320
BPLAbpln_2g04670
BUDAQ610_21220
BURKDM992_19550
BUZAYM40_16595
PTERC2L65_32785
PCAFDSC91_002498
PTROG5S35_34745
PACPFAZ97_21375
PLGNCTC10937_02096(ybiC)
BPEBP2521
BPCBPTD_2478
BPERBN118_1505
BPETB1917_1338
BPEUQ425_21020
BPARBN117_1157 BN117_2289
BPABPP1309 BPP3508
BBHBN112_0200 BN112_4460
BBRBB2374
BBMBN115_2739 BN115_3632
BBXBBS798_2214 BBS798_3736
BPTBpet1261(mdh3)
ACHBDVB37_19055
ADYHLG70_00895
PUTPT7_1266
PUSCKA81_16785
AJSAjs_3134
CTTCtCNB1_4592
CODOLAD35_08690
ADNAlide_2587
ADKAlide2_2904
DPYBA022_01300
DIHG7047_15045
DAERH9K75_05580
DRGH9K76_06765
DIADtpsy_2481
SIMPC6571_14955
MELMC7H73_11965
MELAC6568_14630
MJELVC68_06010 LVC68_12445
JAJEKL02_06225
ACOMCEW83_14275
MCIMesci_6229
MOPMesop_2813
MESPC1M53_22650
MESRFGU64_14840
RPODE0E05_15290
NKIKW403_08920
SMESM_b20261
SMKSinme_3912
SMQSinmeB_4409
SMXSM11_pD1350
SMIBN406_06405
SMEGC770_GR4pD1336
SMELSM2011_b20261
SMERDU99_32065
SMDSmed_3870
SIXBSY16_2976
EADOV14_a1330(mdh)
EAHFA04_26835
EMXFKV68_18800
ATUAtu4676
ARAArad_12145
ATAAWN88_02330
AGRAGROH133_09610
ATFAch5_43990
AVIAvi_7014(mdh)
AROB0909_14140
AGTEYD00_22600
RLTRleg2_6385
RLURLEG12_06340
RTRRTCIAT899_PC02210
RIRBN877_II1771
RPUSCFBP5875_22495
RHLLPU83_0072
RHVBA939_17465
RHKKim5_CH01332
RJGCCGE525_00875 CCGE525_22370
RHRCKA34_24570
RADCO657_33180
RHIDFFM81_021630
RLNJ0663_14710
RBANJ2J98_05895
NENNCHU2750_41890
RHTNT26_0738
RFVRFYW14_00931
SHZshn_20835
SZOK8M09_18880
SOJK6301_15685
KAIK32_32390
BMEBMEII1005
BMELDK63_2251
BMIBMEA_B0241
BMZBM28_B0233
BMGBM590_B0233
BMWBMNI_II0229
BMEEDK62_3156
BMFBAB2_0960
BMBBruAb2_0939
BMCBAbS19_II08900
BAABAA13334_II01710
BABODK55_2904
BABRDO74_2219
BABTDK49_2335
BABBDK48_2893
BABUDK53_2907
BABSDK51_2393
BABCDO78_2150
BMSBRA0240
BSIBS1330_II0237
BSFBSS2_II0226
BSUIBSSP1_II0205
BSUPBSPT1_II0205
BSUVBSPT2_II0206
BSUCBSSP2_II0210
BMTBSUIS_B0246
BSZDK67_2261
BSVBSVBI22_B0236
BSWIY71_12275
BSGIY72_11815
BOVBOV_A0219
BCSBCAN_B0242(mdh)
BSKBCA52141_II0857
BOLBCOUA_II0240
BCARDK60_3115
BCASDA85_11655
BMRBMI_II236
BPVDK65_2236
BCETV910_200970
BCEEV568_201127
BVLBF3285c2_0915
BRUBFS01_14885
BRJBKD03_05210
OINIAR37_20635
BIOBR141012304_20714
OANOant_2899
OAHDR92_3606
OPSA8A54_15900
OCHCES85_4599
OCRHGK82_17590
OCLGTN27_20270
BGQX265_39455
BGZXH91_38655
BOIBLM15_24180
BOFFQV39_32665
SNOSnov_0154
STARG3545_19445
LNEFZC33_04645
ANCGBB76_15625
APRAG3A50_11665
APOLK9D25_02040
PHLKKY_1203
DEQXM25_15055
YTIFNA67_18760
MEYTM49_09965
MAADAZF01_00795
MMEDMame_00343(comC)
MLUTJET14_02000
AUAM673_01880
AALAIGS74_06025
AALMLUX29_06795
PSTGE8M01_13700
ACUTMRB58_03870 MRB58_09210(uraD)
CHQAQ619_05605
CAUFCSW63_04770
BNEDA69_11460
BDMEQG53_10115
BVYNCTC9239_01937(ybiC)
AEXAstex_1229
TSVDSM104635_03484(ybiC)
SITTM1040_3323
RUAD1823_08210
RUTFIU92_05045(comC1)
KVLKVU_PB0044
KVUEIO_3229
LMDMETH_17520
CEHCEW89_00380
YPACCEW88_21645
YANAYJ57_20035
TPROGa0080559_TMP2154
SULDB5M07_16930
SINLDSM14862_03930
RMMROSMUCSMR3_03764
ROKRAK1035_2604
ROMEI983_04780
SAGUCDO87_15280
HATRC74_17870
LSALKBK07_17565
RHPLPB142_00830
PDEPden_4855 Pden_4866
PAMIJCM7686_1699 JCM7686_pAMI5p173
PCONB0A89_11830
PARUCYR75_05665 CYR75_12425
PARSDRW48_01980
PKDF8A10_10040
PPANESD82_08915 ESD82_09045 ESD82_09100
PTPRCA23_c06800
RMBK529_019950
GEHHYN69_18940
GFUKM031_16545
HMLHmaOT1_15355
PSEBEOK75_09090 EOK75_15760 EOK75_17390
LITFPZ52_12385
PAEDG5B38_02495
PALWPSAL_037700
PPAFI8N54_14310
HDHG5B40_11225
FAPGR316_11060
GCEKYE46_16020
FAQG5B39_15225
NDRHT578_09505
SMAGAN936_21730
SMAZLH19_24995
SPHUSPPYR_0556
STAXMC45_12620
SSANNX02_14845
SPLMBXU08_00175
SPLKAV944_11740
SPHCCVN68_06035
SPHFDM480_08810
SPAUDRN02_003880
SECHB18_17995
SPAPH3Z74_00320
SBINSBA_ch1_16540
SSYSLG_18160
SYAA6768_06500
SPYGYGS_C2P1173
SPHSETR14_21105
ANHA6F65_00113(comC)
SHUMSTHU_40240
ABSAZOBR_p460065
ABQABAZ39_32100
ABFAMK58_25030
AZTTSH58p_20790
TIIDY252_03365
THAIIT893_17410
NACINUH88_13610
PUBSAR11_0966(yiaK)
PEGE5R92_01190
APMHIMB5_00006230
APBSAR116_1388
PARHI5S86_15500 I5S86_28205
BLYA2T55_15700
PRLBCB70_00850
MPHMLP_36600
PAUTPdca_13340(lhpD)
KBSEPA93_01195
PLHVT85_24400(comC)
TALBFTW19_05755
 » show all
Reference
1  [PMID:6801013]
  Authors
Payton CW, Chang YF
  Title
delta1-piperideine-2-carboxylate reductase of Pseudomonas putida.
  Journal
J Bacteriol 149:864-71 (1982)
DOI:10.1128/JB.149.3.864-871.1982
Reference
2  [PMID:15561717]
  Authors
Muramatsu H, Mihara H, Kakutani R, Yasuda M, Ueda M, Kurihara T, Esaki N
  Title
The putative malate/lactate dehydrogenase from Pseudomonas putida is an NADPH-dependent delta1-piperideine-2-carboxylate/delta1-pyrroline-2-carboxylate reductase involved in the catabolism of D-lysine and D-proline.
  Journal
J Biol Chem 280:5329-35 (2005)
DOI:10.1074/jbc.M411918200
  Sequence
Reference
3  [PMID:24649405]
  Authors
Watanabe S, Tanimoto Y, Yamauchi S, Tozawa Y, Sawayama S, Watanabe Y
  Title
Identification and characterization of trans-3-hydroxy-l-proline dehydratase and Delta(1)-pyrroline-2-carboxylate reductase involved in trans-3-hydroxy-l-proline metabolism of bacteria.
  Journal
FEBS Open Bio 4:240-50 (2014)
DOI:10.1016/j.fob.2014.02.010
  Sequence
[pae:PA1252]
Other DBs
ExplorEnz - The Enzyme Database: 1.5.1.21
IUBMB Enzyme Nomenclature: 1.5.1.21
ExPASy - ENZYME nomenclature database: 1.5.1.21
BRENDA, the Enzyme Database: 1.5.1.21
CAS: 52037-88-4

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