KEGG   ENZYME: 1.5.1.30
Entry
EC 1.5.1.30                 Enzyme                                 

Name
flavin reductase (NADPH);
NADPH:flavin oxidoreductase;
riboflavin mononucleotide (reduced nicotinamide adenine dinucleotide phosphate) reductase;
flavin mononucleotide reductase;
flavine mononucleotide reductase;
FMN reductase (NADPH);
NADPH-dependent FMN reductase;
NADPH-flavin reductase;
NADPH-FMN reductase;
NADPH-specific FMN reductase;
riboflavin mononucleotide reductase;
riboflavine mononucleotide reductase;
NADPH2 dehydrogenase (flavin);
NADPH2:riboflavin oxidoreductase
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
reduced-riboflavin:NADP+ oxidoreductase
Reaction(IUBMB)
reduced riboflavin + NADP+ = riboflavin + NADPH + H+ [RN:R05707]
Reaction(KEGG)
R05707;
(other) R09520
Substrate
reduced riboflavin [CPD:C01007];
NADP+ [CPD:C00006]
Product
riboflavin [CPD:C00255];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme reduces riboflavin, and, less efficiently, FMN and FAD. NADH is oxidized less efficiently than NADPH.
History
EC 1.5.1.30 created 1982 as EC 1.6.8.2, transferred 2002 to EC 1.5.1.30, modified 2011
Pathway
ec00740  Riboflavin metabolism
ec01100  Metabolic pathways
Orthology
K05901  biliverdin reductase / flavin reductase
Genes
HSA: 645(BLVRB)
PTR: 456039(BLVRB)
PPS: 100989093(BLVRB)
GGO: 101142015(BLVRB)
PON: 100446184(BLVRB)
NLE: 100587172(BLVRB)
MCC: 703020(BLVRB)
MCF: 102142962(BLVRB)
CSAB: 103234707(BLVRB)
CATY: 105597983(BLVRB)
PANU: 101021963(BLVRB)
RRO: 104676113(BLVRB)
RBB: 108539085(BLVRB)
TFN: 117091948(BLVRB) 117092438
PTEH: 111553962(BLVRB)
CJC: 100391206(BLVRB)
SBQ: 101043206(BLVRB)
MMUR: 105876763(BLVRB)
MMU: 233016(Blvrb)
MCAL: 110297893(Blvrb)
MPAH: 110331802(Blvrb)
RNO: 292737(Blvrb)
MCOC: 116101881(Blvrb)
MUN: 110556744(Blvrb)
CGE: 100768929(Blvrb)
PLEU: 114681553(Blvrb)
NGI: 103750766(Blvrb)
HGL: 101697384(Blvrb)
CCAN: 109688540(Blvrb)
OCU: 100340115(BLVRB)
TUP: 102490802(BLVRB)
CFA: 476456(BLVRB)
VVP: 112928368(BLVRB)
VLG: 121485710(BLVRB)
AML: 100467254(BLVRB)
UMR: 103661047(BLVRB)
UAH: 113243564(BLVRB)
ORO: 101371765(BLVRB)
ELK: 111161593
MPUF: 101682683(BLVRB)
EJU: 114202467(BLVRB)
MLX: 118022653(BLVRB)
FCA: 101092315(BLVRB)
PTG: 102957700(BLVRB)
PPAD: 109256587(BLVRB)
AJU: 106979604(BLVRB)
HHV: 120240932(BLVRB)
BTA: 281650(BLVRB)
BOM: 102277747(BLVRB)
BIU: 109572681(BLVRB)
BBUB: 102402107(BLVRB)
CHX: 102187796(BLVRB)
OAS: 101119750(BLVRB)
ODA: 120872449(BLVRB)
SSC: 100625219(BLVRB)
CFR: 102522968(BLVRB)
CBAI: 105062862(BLVRB)
CDK: 105093394(BLVRB)
BACU: 103014515(BLVRB)
LVE: 103082225(BLVRB)
OOR: 101269881(BLVRB)
DLE: 111180848(BLVRB)
PCAD: 102992855(BLVRB)
ECB: 100068145(BLVRB)
EPZ: 103560493(BLVRB)
EAI: 106843297(BLVRB)
MYB: 102251416(BLVRB)
MYD: 102759928(BLVRB)
MMYO: 118674559(BLVRB)
MNA: 107534172(BLVRB)
HAI: 109374869(BLVRB)
DRO: 112320111(BLVRB)
SHON: 118988083(BLVRB)
AJM: 119040590(BLVRB)
MMF: 118639318(BLVRB)
PALE: 102879551(BLVRB)
PGIG: 120595620(BLVRB)
RAY: 107521823(BLVRB)
MJV: 108404844(BLVRB)
TOD: 119249327(BLVRB)
LAV: 100665167(BLVRB)
TMU: 101354315
MDO: 100017892(BLVRB)
SHR: 100930351(BLVRB)
PCW: 110202810(BLVRB)
OAA: 100073853(BLVRB)
MGP: 100303679(BLVRB)
APLA: 113841036(BLVRB)
PHI: 102113532(BLVRB)
CCAE: 111943368(BLVRB)
AAM: 106493723(BLVRB)
ASN: 102387963(BLVRB)
AMJ: 102574563(BLVRB)
CMY: 114022374(BLVRB)
CPIC: 101948417(BLVRB)
TST: 117888630(BLVRB)
CABI: 116833857(BLVRB)
ACS: 100564796(blvrb)
PVT: 110075662(BLVRB)
PBI: 103053858(BLVRB)
PMUR: 107285666(BLVRB)
TSR: 106541075(BLVRB)
PGUT: 117677851(BLVRB)
PMUA: 114603071(BLVRB)
ZVI: 118078075 118086651(BLVRB)
GJA: 107107369(BLVRB)
XLA: 443881(blvrb.L)
XTR: 100124834(blvrb) 116406791
NPR: 108791950(BLVRB)
DRE: 436959(blvrb)
SRX: 107717620(blvrb)
SGH: 107602119(blvrb)
IPU: 108264654(blvrb)
PHYP: 113526426(blvrb)
AMEX: 103040962(blvrb)
EEE: 113580124(blvrb)
TRU: 101061122(blvrb)
LCO: 104927805(blvrb)
NCC: 104965039(blvrb)
CGOB: 115018241(blvrb)
ELY: 117259444(blvrb)
PLEP: 121943190(blvrb)
SLUC: 116053283(blvrb)
ECRA: 117942519(blvrb)
PFLV: 114552606(blvrb)
GAT: 120829425(blvrb)
MSAM: 119882831(blvrb)
CUD: 121526977(blvrb)
MZE: 101484658(blvrb)
ONL: 100702669(blvrb)
OAU: 116320348(blvrb)
OLA: 101163919(blvrb)
OML: 112149783(blvrb)
XMA: 102228591(blvrb)
XCO: 114133538(blvrb)
PRET: 103475161(blvrb)
CVG: 107094869(blvrb)
CTUL: 119796633(blvrb)
NFU: 107379787(blvrb)
KMR: 108247879(blvrb)
ALIM: 106522783(blvrb)
AOCE: 111586211(blvrb)
CSEM: 103377891(blvrb)
POV: 109630121(blvrb)
LCF: 108876241(blvrb)
SDU: 111216890(blvrb)
SLAL: 111662215(blvrb)
XGL: 120792571(blvrb)
HCQ: 109529422(blvrb)
BPEC: 110172712(blvrb)
MALB: 109963258(blvrb)
SASA: 106580739(blvrb) 106612705(BLVRB)
ELS: 105023068(blvrb)
SFM: 108928749(blvrb)
PKI: 111844029(blvrb)
AANG: 118209415(blvrb)
LOC: 102698532(blvrb)
PSPA: 121303818 121304996(blvrb)
LCM: 102358034(BLVRB)
CMK: 103173572(blvrb)
RTP: 109926910(blvrb)
CIN: 100185152
SKO: 100374763
DER: 6552273
DSI: Dsimw501_GD20759(Dsim_GD20759)
DSR: 110188190
DPE: 6588134
DMN: 108156553
DWI: 6647397
DAZ: 108618551
DNV: 108659243
DHE: 111602756
DVI: 6630042
MDE: 101892800
LCQ: 111676095
ACOZ: 120949584
AAG: 5565330
CPII: 120431012
AME: 412445
BIM: 100749252
BTER: 100646178
CCAL: 108630984
OBB: 114877540
MGEN: 117219339
NMEA: 116423944
MPHA: 105830426
AEC: 105144797
ACEP: 105624072
PBAR: 105426660
VEM: 105557622
HST: 105187135
DQU: 106744067
CFO: 105252649
FEX: 115234327
LHU: 105674651
PGC: 109861802
OBO: 105281931
PCF: 106793889
NVI: 100113525
CSOL: 105360908
TCA: 664311
DPA: 109534878
ATD: 109595167
NVL: 108556546
BMOR: 101736226
BMAN: 114248437
BANY: 112054677
PMAC: 106708927
PPOT: 106101151
PXU: 106120319
PRAP: 111001233
ZCE: 119828598
HAW: 110382146
TNL: 113504959
PXY: 105393340
API: 100168586(Blvrb) 100574136
DNX: 107162985
AGS: 114130365
RMD: 113557849
BTAB: 109043576
NLU: 111052374
ZNE: 110828593
CSEC: 111868350
DMK: 116929398
PVM: 113830326
HAZT: 108664641
DSV: 119458384
RSAN: 119373566
RMP: 119167602
CSCU: 111640897
PTEP: 107444427
SDM: 118193070
CRG: 105333834
NVE: 5503663
ADF: 107351009
AMIL: 114961956
 » show all
Reference
1  [PMID:3453680]
  Authors
Yubisui T, Tamura M, Takeshita M.
  Title
Characterization of a second form of NADPH-flavin reductase purified from human erythrocytes.
  Journal
Biochem Int 15:1-8 (1987)
Reference
2  [PMID:10620517]
  Authors
Cunningham O, Gore MG, Mantle TJ
  Title
Initial-rate kinetics of the flavin reductase reaction catalysed by human biliverdin-IXbeta reductase (BVR-B).
  Journal
Biochem J 345 Pt 2:393-9 (2000)
DOI:10.1042/bj3450393
  Sequence
[hsa:645]
Other DBs
ExplorEnz - The Enzyme Database: 1.5.1.30
IUBMB Enzyme Nomenclature: 1.5.1.30
ExPASy - ENZYME nomenclature database: 1.5.1.30
BRENDA, the Enzyme Database: 1.5.1.30
CAS: 56626-29-0

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