KEGG   ENZYME: 1.5.1.39
Entry
EC 1.5.1.39                 Enzyme                                 
Name
FMN reductase [NAD(P)H];
FRG
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
FMNH2:NAD(P)+ oxidoreductase
Reaction(IUBMB)
FMNH2 + NAD(P)+ = FMN + NAD(P)H + H+ [RN:R05705 R05706]
Reaction(KEGG)
R05705 R05706
Substrate
FMNH2 [CPD:C01847];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
FMN [CPD:C00061];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Contains FMN. The enzyme can utilize NADH and NADPH with similar reaction rates. Different from EC 1.5.1.42, FMN reductase (NADH) and EC 1.5.1.38, FMN reductase (NADPH). The luminescent bacterium Vibrio harveyi possesses all three enzymes [1]. Also reduces riboflavin and FAD, but more slowly.
History
EC 1.5.1.39 created 2011
Pathway
ec00740  Riboflavin metabolism
ec01100  Metabolic pathways
Orthology
K19286  FMN reductase [NAD(P)H]
Genes
EBTEBL_c27760
LAXAPT61_15525
LEIC2U54_11965
LEHC3F35_04505
LEEDVA44_16630
LERGNG29_07170
LEAGNG26_06810
LPNUKQ929_14020
SMAFD781_3978
SRZAXX16_1164
SERMCLM71_20450
SOFNCTC11214_02427(nfrA2)
SRHZFO014_13125
GQUAWC35_15390
ECAECA0351
PATREV46_01875
PATOGZ59_03810
PCTPC1_0338
PCCPCC21_003520
PCVBCS7_01755
PWAPecwa_0381
PPARA8F97_16530
PECW5S_0391
PWSA7983_09905
PPOABJK05_18485
PBRAB5S52_20075
PPUJE2566_01980
PARII2D83_20165
PAQUDMB82_0001645
PVZOA04_03910
PPAVLOZ86_20040
PQUIG609_002000
DDCDd586_0336
DZCW909_01750
CEDLH89_10405
DFNCVE23_01850
DAQDAQ1742_00432(nfrA)
DICDpoa569_003617
DDADd703_3602
LBQCKQ53_06870
LPOPI6N93_15335
ETAETA_14360
EPYEpC_15110
EPREPYR_01625
ERJEJP617_31920
EGEEM595_1786(nfrA2)
EPECI789_06245
ERWIGN242_11750
PAMPANA_4101(ycnD)
PLFPANA5342_p10256(nfsA)
PAJPAJ_p0190(ycnD)
PAQPAGR_p187
PVAPvag_pPag30453(nfsA)
PAGGAL522_01420
PANTPSNIH1_13335
PANPPSNIH2_08275
PAGCBEE12_21095
PSTWDSJ_26140
PALHB1H58_17560
PANSFCN45_09600
PEYEE896_19045
PDISD8B20_08360
PERLAC65_07360
PGZC2E15_10365
PCDC2E16_10390
MINTC7M51_01259(nfrA2)
MTHIC7M52_01487(nfrA2)
PAYPAU_03550(nfsA)
PDWBV82_3628
PTKEXN22_17190
CDIZCEDIAZO_02661(nfrA2)
NWESAMEA3174300_1074(nfrA2)
NZOSAMEA4504057_1390(nfrA2)
NCINCTC10296_01936(nfrA1)
NANINCTC12227_00606(nfrA2)
NWDH3L96_09525
NWXCGZ65_06140
NAWLVJ86_06230
PTESJQU52_06960
USULVJ78_06440
UTELVJ83_06975
CVICV_3500(nfsA)
CVCBKX93_08250
CHROCXB49_04045
CHRIDK842_02420
CHRBDK843_07900
CRZD1345_15760
CHRMFYK34_11905
CHAECH06BL_12120
PSENH8B_0873(nfsA)
AMAHDLM_2982
AQSDKK66_12120
CFONHZU75_10885
VOGLCH97_17575
BHZACR54_01072(nfrA2)
BPDZBBN53_16450
BGMCAL15_22185
DTSBI380_30420
FKUFGKAn22_17960
AIQAzoinq_08675
FLEKI610_13765
SDLSdel_1072
SBASulba_1190
SMULSMUL_3050
SHALSHALO_2816
SULSSdiek1_2822
SULJSJPD1_2729
SULTFA592_06415
ANTArnit_1586
AVPAVENP_1774(rdxA)
AHSAHALO_0021(rdxA)
AMARAMRN_0020(rdxA)
ACAAACAN_0019(rdxA)
AMOLAMOL_0022(rdxA)
HEBRAEBR_1383(rdxA)
AANAAANAER_2189(rdxA)
ARCABLL_0970
VGOGJW-30_1_00134(nfrA2)
RHZRHPLAN_09810
RBMTEF_03350
JANJann_3965
RPONG3256_11725
SULIC1J05_16275
TOMBWR18_17200
GCEKYE46_03260
SRFLHU95_13530
SHUMSTHU_12800
SVCSTVA_36340
ELIOKO353_07770
BSUBSU03860(ycnD)
BSRI33_0443
BSLA7A1_3092
BSHBSU6051_03860(ycnD)
BSYI653_01960
BSUTBSUB_00437(ycnD)
BSULBSUA_00437(ycnD)
BSUSQ433_02300
BSOBSNT_06728(ycnD)
BSNBSn5_13535
BSQB657_03860(ycnD)
BSXC663_0379(ycnD)
BSPU712_02005
BSSBSUW23_01995(ycnD)
BSTGYO_0602
BLIBL01854(nfrA2)
BLDBLi00470(nfrA1)
BLHBaLi_c04910(ycnD)
BAYRBAM_004110(nfsA)
BAQBACAU_0347(ycnD)
BYABANAU_0347(ycnD)
BAMPB938_01820
BQYMUS_0374(nfrA1)
BAMLBAM5036_0370(nfrAB)
BAMARBAU_0384(nfrAB)
BAMNBASU_0369(nfrAB)
BAMBBAPNAU_0352(ycnD)
BAMTAJ82_02265
BAMYV529_03720(ycnD)
BMPNG74_00388(nfrA2)
BAOBAMF_0354(ycnD)
BAZBAMTA208_01795(ycnD)
BQLLL3_00369(ycnD)
BXHBAXH7_00372(ycnD)
BAMIKSO_017635
BAMCU471_03760
BAMFU722_02085
BSIACWD84_19970
BAEBATR1942_20640
BSONS101395_04550
BHTDIC78_08030
BMOJHC660_04280(nfrAB)
BTEQG4P54_02120
BIQAN935_02000
BGYBGLY_0483(nfrA2)
BWHA9C19_08475
BITBIS30_12510
BCABEFK13_02375(nfsA)
BRYM0696_02230(nfsA)
BJSMY9_0402
BACPSB24_07760
BACBOY17_04705
BACYQF06_00900
BACLBS34A_04440(ycnD)
BALMBsLM_0407
BACSAUL54_08795
BACQDOE78_02430
BCOBcell_0803
BCIRC2I06_12235 C2I06_17345
BMQBMQ_3033
BMDBMD_3058
BMHBMWSH_2145(ycnD)
BMEGBG04_5560(nfrA2)
BEOBEH_12430
BHABH2953
BLEBleG1_0728
BGIBGM20_17005
BPFBpOF4_02425
TAPGZ22_00705
TAIDKS242_01955
PASABAOM_2239
PRDF7984_10715
NDTL1999_12815
MEKUHUW50_25285
SLZB5P37_08160
LMNLM5578_2314
LMYLM5923_2265
LMTLMRG_01265
LMOCLMOSLCC5850_2176
LMOEBN418_2542
LMOBBN419_2548
LMODLMON_2185
LMOWAX10_04815
LMOQLM6179_2886(nfrA)
LMRLMR479A_2222(nfrA)
LMOMIJ09_14380
LMFLMOf2365_2144
LMCLm4b_02133
LMOGBN389_21420(nfrA2)
LMPMUO_10830
LMOLLMOL312_2127
LMOJLM220_14556
LMOZLM1816_17325
LMOXAX24_08420
LMHLMHCC_0435
LMQLMM7_2213(nfsA)
LMLlmo4a_2172
LMGLMKG_00206
LMSLMLG_0315
LMJLMOG_01108
LMWLMOSLCC2755_2175
LMXLMOSLCC2372_2179
LMZLMOSLCC2482_2173
LMONLMOSLCC2376_2068
LMOSLMOSLCC7179_2087
LMOOLMOSLCC2378_2139
LMOYLMOSLCC2479_2176
LMOTLMOSLCC2540_2208
LMOALMOATCC19117_2133
LMOKCQ02_10940
LMVY193_04965
LINlin2216
LSGlse_2100
LIVLIV_2102
LIIJL52_11035
LIWAX25_11215
LIAJL58_11210
LIOJL53_11710
LWIUE46_04395
LMARLAX80_010345
GOTAXE85_06405
GMONCTC11323_00788(nfrA2)
GEQCG018_00025 CG018_08330
GSAFOC50_00550
GHANCTC10459_00998(nfrA2)
PLVERIC2_c22420(nfrA)
PSABPSAB_09310
PDUPDUR_10515
PBDPBOR_29830
PGMPGRAT_26850
PODPODO_25615
PAENP40081_31390
PAEFR50345_25550
PAEQR50912_28210
PSTEPSTEL_10490
PAEAR70723_27045
PAEER70331_26140
PAEHH70357_28885
PAEJH70737_25355
PRIPRIO_5617(nfrA2)
PSONJI735_03070
PSWUSY83_09875
PDHB9T62_26040
PSOPKP014_13050
PTRIKDC22_27365
PTJJRJ22_24115
ANXACH33_05035
ATHEK3F53_13870
PABSJIR001_21310(nfrA2)
LMELEUM_1770
LMMMI1_07670
LMKLMES_1537
LCILCK_01452
LKILKI_07275
LECLGMK_04870
LCNC270_01495
LGSLEGAS_0410
LGEC269_01980
LLFBCR17_05385
LGCA9176_03925
LSUA6B45_08470
LPSEFGL85_04270
WCBAO080_04595
ECASECBG_01384
EGAAL523_06375
ESSATZ33_02170 ATZ33_05405
EGVEGCR1_05905
EAVEH197_15855
ESGEsVE80_23160
ERAFJ9537_08145
EIEENLAB_20930(nfnB_3)
VAHG7081_05190
CACCA_C0718
CAESMB_G0733(nfrA2)
CAYCEA_G0729
CBECbei_2778
CBZCbs_2778
CBEILF65_02693
CSRCspa_c24470(nfrA2)
CSBCLSA_c18180(nfrA)
CSQCSCA_2118
CCKCcar_03960 Ccar_12565
CEUA7L45_20090
CDRKB9W14_08975
CDYF3K33_14040
CGASJ1C67_17845(nfsA)
CMAHC1I91_02900
CNNCNEO_2181(nfrA)
FPRFP2_26480
FPAFPR_06350
ACELacsn021_01520
CSTCLOST_2291(ycnD)
TEBT8CH_3034(nfrAB)
DSYDSY4001
DHDDhaf_1363
DDHDesde_1288
DDLDesdi_1073
AWOAwo_c31780(ycnD)
AFTBBF96_04370
DHODia5BBH33_16730
PUFUFO1_1217
AFNAcfer_0191
ERLAOC36_02845
EBMSG0102_24590
MAMPMAMA39_02190
MTAUJS510_02855
MMIRHLA87_01615
MMIOHLA92_02815
MPHEHGG69_01240
MCMMCAL160_0118(nfnB)
MAAMAG4830
MALMAGa5300
MBVMBOVPG45_0332
MBHMMB_0518
MBIMbov_0557(nfsA)
MBQK668_02595
MBOVMBVG596_0774
MPHIEG856_00230
MPEMYPE6430(MYPE6430)
MIWEER00_01505
CPLCp3995_0072(noxC)
CPPCpP54B96_0074(noxC)
CPKCP1002_00355
CPXCPI19_00355
CODCp106_0070(noxC)
CPSECPTA_00595
CPSUCPTB_00937
CPSFCPTC_00598
CUCCULC809_00117
CUSCulFRC11_0113(noxC)
CCGCCASEI_00720
NBRO3I_010610
SALAESZ53_04855
LEULeucomu_08020
SROSros_4170
AHWNCTC11636_02565(nfrA2)
TIOINP52_06185
ERZER308_20105
OBTOPIT5_26535
TPHGFUT81_02860
SPEREW093_04175
SCCSpico_1094
LBALebu_0572
LOTAXF11_01915
LEQBCB68_06900
LHFJCM16775_0682
LSZJCM16776_0544
LHGJMUB5056_0530
LTEJMUB4039_1795
LWDJCM16777_0562
LGOJCM16774_0985 JCM16774_0986
STRSterm_0690
SMFSmon_1230
SNSVC03_01295
BOABovatus_01450(nfrA2_2)
BCELBcellWH2_01611(nfrA2_2)
BISDXK01_000135
PCOPI6J50_10355
PCAGNCTC12856_00837(nfrA2_1)
PARYA4V02_04830
DUNFDZ78_03220
BVSBARVI_11570
COPRCop2CBH44_12120(nfrA2)
PRUPRU_1288
PDNHMPREF9137_2494
PDTPrede_2711
PJECRM71_14205
POCNCTC13071_02248(nfrA2)
ALQC7Y71_010890
ALDGFH31_09690
AITAI2BBH_18350(nfrA2)
MPIMpet_2012
HBUHbut_1016
PFMPyrfu_1980
PDLPyrde_1861
NIRNSED_03660
NKRNKOR_03635
NIDNPIRD3C_1535
NINNADRNF5_1431
NIWNisw_01265
NCLC5F47_05515
NOXC5F49_05390
NUEC5F50_05335
 » show all
Reference
1  [PMID:6981058]
  Authors
Watanabe H, Hastings JW
  Title
Specificities and properties of three reduced pyridine nucleotide-flavin mononucleotide reductases coupling to bacterial luciferase.
  Journal
Mol Cell Biochem 44:181-7 (1982)
DOI:10.1007/bf00238506
Other DBs
ExplorEnz - The Enzyme Database: 1.5.1.39
IUBMB Enzyme Nomenclature: 1.5.1.39
ExPASy - ENZYME nomenclature database: 1.5.1.39
BRENDA, the Enzyme Database: 1.5.1.39

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