KEGG ENZYME: 1.5.3.15

ENZYME: 1.5.3.15

Entry

EC 1.5.3.15                 Enzyme

Name

N8-acetylspermidine oxidase (propane-1,3-diamine-forming)

Class

Oxidoreductases;
Acting on the CH-NH group of donors;
With oxygen as acceptor

Sysname

N8-acetylspermidine:oxygen oxidoreductase (propane-1,3-diamine-forming)

Reaction(IUBMB)

N8-acetylspermidine + O2 + H2O = propane-1,3-diamine + 4-acetamidobutanal + H2O2 [RN:R09075]

Reaction(KEGG)

R09075

Substrate

N8-acetylspermidine [CPD:C01029];
O2 [CPD:C00007];
H2O [CPD:C00001]

Product

propane-1,3-diamine [CPD:C00986];
4-acetamidobutanal [CPD:C05936];
H2O2 [CPD:C00027]

Comment

Also active with N1-acetylspermine, weak activity with N1,N12-diacetylspermine. No activity with diaminopropane, putrescine, cadaverine, diaminohexane, norspermidine, spermine and spermidine. Absence of monoamine oxidase (EC 1.4.3.4) activity. Differs in specificity from EC 1.5.3.13 (N1-acetylpolyamine oxidase), EC 1.5.3.14 (polyamine oxidase (propane-1,3-diamine-forming)), EC 1.5.3.16 (spermine oxidase) and EC 1.5.3.17 (non-specific polyamine oxidase).

History

EC 1.5.3.15 created 2009

Reference

1 [PMID:1565141]

Authors

Shukla OP, Muller S, Walter RD

Title

Polyamine oxidase from Acanthamoeba culbertsoni specific for N8-acetylspermidine.

Journal

Mol Biochem Parasitol 51:91-8 (1992)
DOI:10.1016/0166-6851(92)90204-W

Other DBs

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