KEGG   ENZYME: 1.5.8.4
Entry
EC 1.5.8.4                  Enzyme                                 
Name
dimethylglycine dehydrogenase;
N,N-dimethylglycine oxidase;
N,N-dimethylglycine:(acceptor) oxidoreductase (demethylating);
Me2GlyDH;
N,N-dimethylglycine:electron-transfer flavoprotein oxidoreductase (demethylating)
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With a flavin or flavoprotein as acceptor
Sysname
N,N-dimethylglycine,5,6,7,8-tetrahydrofolate:electron-transferflavoprotein oxidoreductase (demethylating,5,10-methylenetetrahydrofolate-forming)
Reaction(IUBMB)
N,N-dimethylglycine + 5,6,7,8-tetrahydrofolate + electron-transfer flavoprotein = sarcosine + 5,10-methylenetetrahydrofolate + reduced electron-transfer flavoprotein [RN:R01565]
Reaction(KEGG)
R01565
Substrate
N,N-dimethylglycine [CPD:C01026];
5,6,7,8-tetrahydrofolate [CPD:C00101];
electron-transfer flavoprotein [CPD:C04253]
Product
sarcosine [CPD:C00213];
5,10-methylenetetrahydrofolate [CPD:C00143];
reduced electron-transfer flavoprotein [CPD:C04570]
Comment
A flavoprotein, containing a histidyl(Npi)-(8alpha)FAD linkage at position 91 in the human protein. An imine intermediate is channeled from the FAD binding site to the 5,6,7,8-tetrahydrofolate binding site through a 40 A tunnel [5,8,9]. In the absence of 5,6,7,8-tetrahydrofolate the enzyme forms formaldehyde [5,9].
History
EC 1.5.8.4 created 1972 as EC 1.5.99.2, transferred 2012 to EC 1.5.8.4, modified 2017
Pathway
ec00260  Glycine, serine and threonine metabolism
ec01100  Metabolic pathways
Orthology
K00315  dimethylglycine dehydrogenase
Genes
HSA29958(DMGDH)
PTR471505(DMGDH)
PPS100985018(DMGDH)
GGO101138464(DMGDH)
PON100457567(DMGDH)
NLE100587925(DMGDH)
MCC709237(DMGDH)
MCF102117996(DMGDH)
CSAB103223602(DMGDH)
CATY105599277(DMGDH)
PANU101021742(DMGDH)
TGE112626239(DMGDH)
RRO104662973(DMGDH)
RBB108528899(DMGDH)
TFN117065309(DMGDH)
PTEH111544504(DMGDH)
CJC100393734(DMGDH)
SBQ101045195(DMGDH)
CSYR103271037(DMGDH)
MMUR105872621(DMGDH)
LCAT123648426(DMGDH)
OGA100945232(DMGDH)
MMU74129(Dmgdh)
MCAL110307602(Dmgdh)
MPAH110329016(Dmgdh)
RNO245961(Dmgdh)
MCOC116083192(Dmgdh)
MUN110539648(Dmgdh)
CGE100759503(Dmgdh)
MAUA101825798(Dmgdh)
PLEU114694633(Dmgdh)
MORG121455768(Dmgdh)
MFOT126508483
AAMP119810202(Dmgdh)
NGI103750305(Dmgdh)
HGL101722315(Dmgdh)
CPOC100724353(Dmgdh)
CCAN109675254(Dmgdh)
DORD105985323(Dmgdh)
DSP122117211(Dmgdh)
NCAR124986616
OCU100340207(DMGDH)
OPI101524954(DMGDH)
TUP102489576(DMGDH)
CFA488935(DMGDH)
CLUD112653283(DMGDH)
VVP112919589(DMGDH)
VLG121489124(DMGDH)
AML100466333(DMGDH)
UMR103681493(DMGDH)
UAH113254981(DMGDH)
UAR123791537(DMGDH)
ELK111148380
LLV125100500
MPUF101682529(DMGDH)
ORO101373953(DMGDH)
EJU114217588(DMGDH)
ZCA113929748(DMGDH)
MLX118016932(DMGDH)
NSU110587431(DMGDH)
FCA101089168(DMGDH)
PYU121014025(DMGDH)
PBG122490193(DMGDH)
LRUF124504400
PTG102963363(DMGDH)
PPAD109274942(DMGDH)
AJU106974795(DMGDH)
HHV120242009(DMGDH)
BTA504453(DMGDH)
BOM102287393(DMGDH)
BIU109564663(DMGDH)
BBUB102393250(DMGDH)
CHX102189681(DMGDH)
OAS101113594(DMGDH)
ODA120852578(DMGDH)
CCAD122443005(DMGDH)
SSC100525563(DMGDH)
CFR102522919(DMGDH)
CBAI105064350(DMGDH)
CDK105084826(DMGDH)
VPC102525581(DMGDH)
BACU103000721(DMGDH)
LVE103081304(DMGDH)
OOR101281736(DMGDH)
DLE111184963(DMGDH)
PCAD102991899(DMGDH)
PSIU116752240(DMGDH)
ECB100073267(DMGDH)
EPZ103548668(DMGDH)
EAI106841177(DMGDH)
MYB102246690(DMGDH)
MYD102758327(DMGDH)
MMYO118656692(DMGDH)
MLF102426434(DMGDH)
MNA107535045(DMGDH)
PKL118703203(DMGDH)
HAI109381891(DMGDH)
DRO112307504(DMGDH)
SHON118977291(DMGDH)
AJM119048139(DMGDH)
PDIC114508094(DMGDH)
PHAS123824645(DMGDH)
MMF118641668(DMGDH)
RFQ117024941(DMGDH)
PALE102895924(DMGDH)
PGIG120612467(DMGDH)
PVP105303565(DMGDH)
RAY107497232(DMGDH)
MJV108398417(DMGDH)
TOD119260223(DMGDH)
SARA101540926(DMGDH)
LAV100671550(DMGDH)
TMU101355257
DNM101441072(DMGDH)
MDO100032620(DMGDH)
GAS123251619(DMGDH)
SHR100931635(DMGDH)
PCW110216593(DMGDH)
OAA100088110(DMGDH)
GGA416370(DMGDH)
PCOC116239924(DMGDH)
CJO107305932(DMGDH)
NMEL110389379(DMGDH)
APLA101802594(DMGDH)
ACYG106042090(DMGDH)
AFUL116500625
TGU100231246(DMGDH)
LSR110470993(DMGDH)
SCAN103819544(DMGDH)
PMOA120502443(DMGDH)
OTC121341266(DMGDH)
PRUF121355471(DMGDH)
GFR102044591(DMGDH)
FAB101806587(DMGDH)
PHI102112577(DMGDH)
PMAJ107216431(DMGDH)
CCAE111941402(DMGDH)
CCW104695710(DMGDH)
CBRC103622044(DMGDH)
ETL114056907(DMGDH)
ZAB102071490(DMGDH)
ACHL103804225(DMGDH)
FPG101910969(DMGDH)
FCH102049188(DMGDH)
CLV102091750(DMGDH)
EGZ104124898(DMGDH)
NNI104017622(DMGDH)
PLET104622259(DMGDH)
ACUN113489761(DMGDH)
TALA104369114(DMGDH)
PADL103919764(DMGDH)
AFOR103899794(DMGDH)
ACHC115336615(DMGDH)
HALD104313141(DMGDH)
CCRI104161024(DMGDH)
CSTI104549619(DMGDH)
EHS104516007(DMGDH)
CMAC104482089(DMGDH)
MUI104547929(DMGDH)
FGA104076537(DMGDH)
GSTE104256601(DMGDH)
LDI104342607(DMGDH)
MNB103779014(DMGDH)
OHA104331094(DMGDH)
NNT104411635(DMGDH)
DPUB104309468(DMGDH)
ACAR104529321(DMGDH)
AVIT104268283(DMGDH)
AROW112967364(DMGDH)
NPD112945129(DMGDH)
TGT104581209(DMGDH)
DNE112987054(DMGDH)
SCAM104152992(DMGDH)
ASN102383441(DMGDH)
AMJ102561678(DMGDH)
CPOO109307687(DMGDH)
GGN109297739(DMGDH)
PSS102445412(DMGDH)
CMY102947394(DMGDH)
CPIC101938519(DMGDH)
TST117878733(DMGDH)
CABI116821376(DMGDH) 116823757
MRV120408207(DMGDH)
ACS100564503(dmgdh)
PVT110073960(DMGDH)
SUND121921272(DMGDH)
PBI103049444(DMGDH)
PMUR107287877(DMGDH)
CTIG120312301(DMGDH)
TSR106544490(DMGDH)
PGUT117679271(DMGDH)
VKO123031610(DMGDH)
PMUA114606167(DMGDH)
ZVI118076697(DMGDH)
GJA107117472(DMGDH)
STOW125436278(DMGDH)
XLA446949(dmgdh.L)
XTR100492188(dmgdh)
NPR108799972(DMGDH)
RTEM120929326(DMGDH)
BBUF120992414(DMGDH)
BGAR122924737(DMGDH)
DRE100141496(dmgdh)
SRX107717757 107724713
SANH107694541(dmgdh)
SGH107574100(dmgdh)
CAUA113080753 113090445
PPRM120461889(dmgdh)
MAMB125252260(dmgdh)
IPU108279027(dmgdh)
PHYP113535384(dmgdh)
SMEO124398447(dmgdh)
TFD113646386(dmgdh)
AMEX103034486(dmgdh)
EEE113573718(dmgdh)
TRU101062880(dmgdh)
LCO104936285(dmgdh)
NCC104966861(dmgdh)
CGOB115016354(dmgdh)
ELY117269427(dmgdh)
EFO125905686(dmgdh)
PLEP121960316(dmgdh)
SLUC116062809(dmgdh)
ECRA117959334(dmgdh)
ESP116704779(dmgdh)
PFLV114570945(dmgdh)
GAT120832186(dmgdh)
PPUG119226901(dmgdh)
MSAM119914232(dmgdh)
CUD121525709(dmgdh)
ALAT119030451(dmgdh)
MZE101476130(dmgdh)
ONL100707764(dmgdh)
OAU116315576(dmgdh)
OLA101169624(dmgdh)
OML112162824(dmgdh)
XMA102227264(dmgdh)
XCO114150099(dmgdh)
XHE116724977(dmgdh)
PRET103473305(dmgdh)
PFOR103135836(dmgdh)
PLAI106937103(dmgdh)
PMEI106916209(dmgdh)
GAF122819376(dmgdh)
CVG107093770(dmgdh)
CTUL119788279(dmgdh)
GMU124872054(dmgdh)
NFU107374847(dmgdh)
KMR108251297(dmgdh)
ALIM106515070(dmgdh)
NWH119424604(dmgdh)
AOCE111570345(dmgdh)
MCEP124997064(dmgdh)
CSEM103390008(dmgdh)
POV109626536(dmgdh)
SSEN122758600(dmgdh)
HHIP117771689(dmgdh)
HSP118098095(dmgdh)
LCF108895442
SDU111239025(dmgdh)
SLAL111666799(dmgdh)
XGL120806343(dmgdh)
HCQ109517687(dmgdh)
BPEC110157318(dmgdh)
MALB109953004(dmgdh)
BSPL114867452(dmgdh)
SASA106568126(dmgdh)
STRU115159734
OTW112220276(dmgdh)
OMY110523447(dmgdh)
OGO124049092(dmgdh)
ONE115121049(dmgdh)
SALP111961762
SNH120025444
CCLU121541556 121582648(dmgdh)
ELS105015173(dmgdh)
SFM108925069(dmgdh)
PKI111849812(dmgdh)
AANG118213302(dmgdh)
LOC102682151(dmgdh)
PSPA121305151(dmgdh)
ARUT117403612 117404061
LCM102353346
CMK103177764(dmgdh)
BFO118409370 118409371 118409372
BBEL109475888 109476278
SPU587447
APLC110987881 110988117 110988587
SKO100377832 100377978
PVM113817447
PJA122247004
PCHN125035399
HAME121878893
PCLA123771694
PTRU123512442
HAZT108669472
EAF111708869
PPOI119096221 119096222
ISCIscW_ISCW001817
DSV119442633
RSAN119387354 119387359
RMP119188313
PTEP107451370
SDM118188531
CELCELE_Y37E3.17(Y37E3.17)
CBRCBG_22093
BMYBM_BM6398(Bm6398)
LOALOAG_05663
NAINECAME_09711
LAK106166448
NVE5512014
EPA110231395
ATEN116305412
ADF107342978
AMIL114953801
PDAM113682317 113683486
SPIS111324311 111327844
DGT114533878
HMG100209590
TADTRIADDRAFT_54121
SMINv1.2.028204.t1(symbB.v1.2.028204.t1) v1.2.028204.t2(symbB.v1.2.028204.t2) v1.2.028204.t3(symbB.v1.2.028204.t3)
SPARSPRG_07877
EHXEMIHUDRAFT_457242 EMIHUDRAFT_470504
GAIIMCC3135_12455(abo_3) IMCC3135_18055(abo_4) IMCC3135_27130(abo_5)
HAFC8233_04785
TSNW908_00470 W908_00955 W908_05595 W908_07550
THINCRN91_00510 CRN91_00900 CRN91_02465 CRN91_02630
BGOBM43_4044
AZAAZKH_p0176
DWDDSCW_61450
DALKDSCA_57620
MLOmll1517 mll1653 mll2449 mlr1213 mlr1280
MLNA9174_01365 A9174_12360 A9174_18060 A9174_18565 A9174_20015 A9174_20275 A9174_30160
MCIMesci_0276 Mesci_3080 Mesci_3179 Mesci_3332 Mesci_3392 Mesci_3401 Mesci_5747
MOPMesop_3464 Mesop_3570 Mesop_3782 Mesop_3823 Mesop_3876 Mesop_6323
MAMMesau_03350 Mesau_03612 Mesau_03663 Mesau_05797
MAMOA6B35_09220 A6B35_10505 A6B35_12565 A6B35_21685 A6B35_21955 A6B35_23330
MESWA9K65_001380 A9K65_016715 A9K65_017220 A9K65_018025 A9K65_018325 A9K65_018375
MESMEJ066_25580 EJ066_25820 EJ066_27085
MESPC1M53_21985 C1M53_24225 C1M53_24480
MHUAMCHK_0600 MCHK_2856 MCHK_2910 MCHK_3149 MCHK_3256 MCHK_4075 MCHK_6281
MJREB229_01390 EB229_12225 EB229_18325 EB229_18850 EB229_19775 EB229_20045 EB229_30760
MERDEB233_01470 EB233_12470 EB233_15650 EB233_16180 EB233_17110 EB233_17420 EB233_26985
MESRFGU64_05200 FGU64_05430
MOHIHQ72_13450 IHQ72_16530 IHQ72_17795 IHQ72_18020
MESOBSQ44_15470 BSQ44_15795
HOEIMCC20628_00539 IMCC20628_01684
AAKAA2016_2973 AA2016_3040
AMIHCO731_02954(gcvT_6) CO731_03008(gcvT_9) CO731_03534(gcvT_11)
PHTBLM14_05370 BLM14_05485 BLM14_08065
PHYLHB779_17815 HB779_17945
RPODE0E05_04465
NIYFQ775_22505
NKIKW403_01365 KW403_16460
ORMHTY61_02185
KMNHW532_09130 HW532_10840
SMESMa1483 SMc01663
SMKSinme_2255 Sinme_6001
SMQSinmeB_2099 SinmeB_6321
SMXSM11_chr0983 SM11_pC0842
SMIBN406_02099 BN406_04544
SMEGC770_GR4Chr2334 C770_GR4pC0569
SMELSM2011_a1483 SM2011_c01663
SMERDU99_12730 DU99_21970
SMDSmed_2198 Smed_5112
RHINGR_b16530 NGR_c21820
SFHSFHH103_02078
SFDUSDA257_c45740(gcvT5)
SIXBSY16_102 BSY16_4802 BSY16_522
SAMESAMCFNEI73_Ch2544
SINOSS05631_c23310
EADOV14_3709 OV14_4043 OV14_a0111
EAHFA04_11570 FA04_13205
ESJSJ05684_c23260
EAKEKH55_2257
EMXFKV68_14760
ATUAtu1632
ARAArad_3491 Arad_7067
ATAAWN88_13155
AGRAGROH133_06455
ATFAch5_15600
AVIAvi_2727
AGCBSY240_4127
AROB0909_04860
AGTEYD00_06215
ALFCFBP5473_07370
ARUIG6M88_01705
AVQHRR99_08460
RLTRleg2_3310
RTRRTCIAT899_CH13890
RIRBN877_I1595
RPUSCFBP5875_06765
RHLLPU83_2074
RHVBA939_02800
RJGCCGE525_12245 CCGE525_15975
RHRCKA34_16800
RADCO657_17030
ROYG3A56_02985
RROSD4A92_00005
NGLRG1141_CH19670
NGGRG540_CH20470
NEOCYG48_06565
NENNCHU2750_25890 NCHU2750_44930
RHTNT26_1995
RFVRFYW14_02071
SHZshn_12225 shn_14410
SZOK8M09_10925
SOJK6301_09700 K6301_11200 K6301_20490
ABAWD5400_09000
PDESFE840_016960
OINIAR37_13385
OCHCES85_4737
PSCQKHQ08_09115 KHQ08_11380
LNEFZC33_05130 FZC33_07605 FZC33_17220 FZC33_19170
MMYRMXMO3_00053
MEYTM49_20070
MAADAZF01_13610
MMEDMame_04001(gcvT_3)
MLUTJET14_14775
AUZSa4125_28800
AUBLXB15_10385
NOHG5V57_01050 G5V57_25045 G5V57_32635
RBMTEF_07375 TEF_16760
PSFPSE_p0029
LAPACP90_05180
LABRCHH27_14530 CHH27_15475 CHH27_24580
LABPFJ695_07950 FJ695_09645 FJ695_25365
LABTFIU93_10825(mlr1)
LAGGB0E33_16735
SIWGH266_01350
LIZLGH83_00890 LGH83_07170
CAULKCG34_01975
SILSPO0207 SPO0544 SPO0564 SPO0635 SPO1592 SPO1628 SPO3400 SPOA0063 SPOA0310
SITTM1040_0486 TM1040_1426 TM1040_2063
RUAD1823_00950 D1823_02745 D1823_06845 D1823_08205 D1823_10250 D1823_12790 D1823_16990 D1823_20780
RUTFIU92_00690(mlr1) FIU92_03040(mlr3) FIU92_05050(mlr4) FIU92_06380(mlr5) FIU92_10495(mlr6) FIU92_12160(mlr7) FIU92_14470(mlr9) FIU92_18060(mlr10) FIU92_20150(mlr14)
JANJann_0919 Jann_1481 Jann_1596 Jann_2488 Jann_2805
RDERD1_0019 RD1_0607 RD1_1345 RD1_3093 RD1_3434
RLIRLO149_c023240(dmgdh1) RLO149_c027920(dmgdh2) RLO149_c034400(dmgdh3) RLO149_c039110(dmgdh4) RLO149_p940550(dmgdh)
RPONG3256_01370 G3256_09520 G3256_09530 G3256_10965 G3256_14570 G3256_16305
DSHDshi_1485 Dshi_2967
PGAPGA1_262p01400(dmgdH) PGA1_c14040(dmgdH1) PGA1_c25540(dmgdH2) PGA1_c28230(dmgdH3) PGA1_c33130(dmgdH4)
PGLPGA2_239p1580(dmgdH) PGA2_c13940(dmgdH1) PGA2_c26230(dmgdH2) PGA2_c31400(dmgdH3)
PGDGal_00601 Gal_01999 Gal_03372 Gal_03876
PHPPhaeoP97_00680(dmgdH3) PhaeoP97_01401(dmgdH1) PhaeoP97_03223(dmgdH4) PhaeoP97_03709(dmgdH)
PPICPhaeoP14_01307(dmgdH1) PhaeoP14_02584(dmgdH3) PhaeoP14_03111(dmgdH4) PhaeoP14_03603(dmgdH)
PHQD1820_03020 D1820_08825 D1820_11350 D1820_17765
OATOAN307_c07010(dmgdh5) OAN307_c24050(dmgdh3) OAN307_c24060(dmgdh1) OAN307_c42890(dmgdh2) OAN307_c46320(dmgdh4)
OAROA238_c04890(dmgdh2) OA238_c19930(dmgdh1) OA238_c19940(dmgdh3) OA238_c34950(dmgdh5) OA238_c40910(dmgdh4)
OTMOSB_05340(mlr_1) OSB_15100(mlr_2) OSB_15120(mlr_3) OSB_26970(mlr_5) OSB_30270(mlr_7)
OCTFTO60_03970 FTO60_07420 FTO60_07425 FTO60_12415 FTO60_13430 FTO60_15110
LMDMETH_03735 METH_03940 METH_10325 METH_15465 METH_18800 METH_19120 METH_21940 METH_22240
LEJETW24_01830 ETW24_04590 ETW24_05260 ETW24_11035 ETW24_15600 ETW24_18640 ETW24_20765 ETW24_21005
LAQUR2C4_02365 R2C4_03560 R2C4_07700 R2C4_13145 R2C4_19080
LEVETW23_01350 ETW23_14330 ETW23_14920 ETW23_15480 ETW23_21115 ETW23_22940
LCAEK3721_03965 K3721_09475 K3721_15285 K3721_16875 K3721_19865 K3721_20370
REDroselon_00386 roselon_02666 roselon_03053
MALGMALG_00176 MALG_02067 MALG_02872 MALG_05031
CONTQ29_02695 TQ29_08680
YANAYJ57_04365
SUAMBOO69_09345 BOO69_09355 BOO69_14040 BOO69_14970 BOO69_16555
SULZC1J03_02070 C1J03_02180 C1J03_12000 C1J03_12980 C1J03_12985 C1J03_18530 C1J03_24870
SULIC1J05_00620 C1J05_01555 C1J05_03595 C1J05_03615 C1J05_06305 C1J05_09340 C1J05_09350 C1J05_17060 C1J05_17365
SULDB5M07_03755 B5M07_09395 B5M07_10375
SPOTG6548_05775
SMEDJNX03_03690 JNX03_03695 JNX03_10375 JNX03_12625 JNX03_14895 JNX03_17695
SINLDSM14862_01486(abo_1) DSM14862_01603(abo_3) DSM14862_02797(abo_4)
SPSESULPSESMR1_00305(abo) SULPSESMR1_01729(abo) SULPSESMR1_01730(abo) SULPSESMR1_02942(abo)
TOMBWR18_06035 BWR18_06045 BWR18_12820 BWR18_14145 BWR18_15290 BWR18_17915
RMMROSMUCSMR3_00197(abo) ROSMUCSMR3_00199(abo) ROSMUCSMR3_01611(dmg) ROSMUCSMR3_02526(abo) ROSMUCSMR3_03060(abo)
ROKRAK1035_0653 RAK1035_1554 RAK1035_1955 RAK1035_3049 RAK1035_3051
RIDRIdsm_01012(gcvT_2) RIdsm_01919(gcvT_6) RIdsm_02570(gcvT_9) RIdsm_02572(gcvT_10) RIdsm_02862(gcvT_11) RIdsm_04377(gcvT_13) RIdsm_04955(gcvT_17) RIdsm_05137(gcvT_18) RIdsm_05412(gcvT_19)
ROMEI983_07495 EI983_07510 EI983_08870 EI983_10870 EI983_11245 EI983_15160 EI983_16220 EI983_18010
ROHFIU89_01700(mlr1) FIU89_04725(mlr3) FIU89_05485(mlr5) FIU89_09085(mlr6) FIU89_09090(mlr7)
AHTANTHELSMS3_00322 ANTHELSMS3_02047 ANTHELSMS3_02167 ANTHELSMS3_03636 ANTHELSMS3_03637 ANTHELSMS3_04119(gcvT)
SAGUCDO87_04200 CDO87_04815 CDO87_18660
THAACFI11_10575 CFI11_10585 CFI11_17605 CFI11_17875 CFI11_21505
OCDFHY55_05645 FHY55_10830
MARUFIU81_03420(mlr)
ROTFIV09_01580(mlr1)
RMHLVO79_13600
MALUKU6B_16150 KU6B_29170 KU6B_29180 KU6B_41430 KU6B_42750 KU6B_44080
TGLHFZ77_01210
HATRC74_01400
LSALKBK07_01945
RSPRSP_3566
RSHRsph17029_3249
RSQRsph17025_3155
RSKRSKD131_3734
CAZTLV780_15740
RCPRCAP_rcc00526
RHPLPB142_03920
RBLB6K69_00135 B6K69_00670 B6K69_07415
PDEPden_1940
PAMIJCM7686_0185
PYEA6J80_15065
PZHCX676_08395 CX676_11705
PAROCUV01_18175
PARSDRW48_15525
PARREOJ32_13270
PAAKFIU66_08115
PKDF8A10_07450
PPANESD82_13955
PLIAE4191_12060
PMAUCP157_00951(abo)
PTPRCA23_c00660 RCA23_c01560 RCA23_c15530 RCA23_c15540 RCA23_c20240 RCA23_c21230
RSUNHU_00780
RHMB5V46_04750
RMBK529_002195 K529_003550 K529_006445
DAAAKL17_0631 AKL17_1896
DONBSK21_11185
THWBMG03_16345
TECAKL02_016090
LVSLOKVESSMR4R_00303(abo) LOKVESSMR4R_02748(abo)
RBGBG454_17160 BG454_17495 BG454_17960
GEHHYN69_00790 HYN69_09150
GFUKM031_00015 KM031_00510 KM031_13160
TAWEI545_00905 EI545_01500 EI545_13050
SALOEF888_02530
SEDIEBB79_09265 EBB79_11090 EBB79_17395 EBB79_23745
HMLHmaOT1_07020
BOOE2K80_03410 E2K80_06725 E2K80_08300 E2K80_09280 E2K80_14235
PSEBEOK75_17315
PPRUFDP22_07225 FDP22_17495
PAEDG5B38_00855 G5B38_01410 G5B38_03515 G5B38_03530 G5B38_08335 G5B38_08835 G5B38_12785
MONG8E03_14350
PAMOBAR1_13035 BAR1_14675
PSHQF3W81_04160 F3W81_20390
POZI0K15_02065 I0K15_05420
PALWPSAL_009130(abo_1) PSAL_018780(abo_2)
PPAFI8N54_09580 I8N54_15200
PGVSL003B_2784
CACTHZ995_04745 HZ995_05725 HZ995_06915 HZ995_07390 HZ995_10220 HZ995_10555 HZ995_15380
RBZB9057_02430
THASC6Y53_03320 C6Y53_08730 C6Y53_16540
HDHG5B40_00965 G5B40_01990 G5B40_17880
CMAGCBW24_01220
GCEKYE46_08385 KYE46_11150 KYE46_13420 KYE46_15840 KYE46_17050
NSMJO391_07230 JO391_08970 JO391_15875
ACROK3J57_02380 K3J57_13150
FAQG5B39_05390 G5B39_14330 G5B39_16070
AMAQGO499_13745 GO499_19135
SWISwit_0939
SPHDHY78_21825
SMICSmB9_18450
ANHA6F65_00140(mlr_2)
HTQFRZ44_31630 FRZ44_34370 FRZ44_36700
HADHFRZ61_16050 FRZ61_33550
NACINUH88_07300 NUH88_15070
PUBSAR11_1253
PEGE5R92_06935
APMHIMB5_00008670 HIMB5_00008920
APBSAR116_0544 SAR116_1059 SAR116_1184 SAR116_2173
SNEANBZ79_06220 NBZ79_06330 NBZ79_08355 NBZ79_08560
ORNDV701_04675
 » show all
Reference
1  [PMID:13895406]
  Authors
FRISELL WR, MACKENZIE CG.
  Title
Separation and purification of sarcosine dehydrogenase and dimethylglycine dehydrogenase.
  Journal
J Biol Chem 237:94-8 (1962)
Reference
2  [PMID:13716069]
  Authors
HOSKINS DD, MACKENZIE CG.
  Title
Solubilization and electron transfer flavoprtein requirement of mitochondrial sarcosine dehydrogenase and dimethylglycine dehydrogenase.
  Journal
J Biol Chem 236:177-83 (1961)
Reference
3  [PMID:6163777]
  Authors
Wittwer AJ, Wagner C
  Title
Identification of the folate-binding proteins of rat liver mitochondria as dimethylglycine dehydrogenase and sarcosine dehydrogenase. Purification and folate-binding characteristics.
  Journal
J Biol Chem 256:4102-8 (1981)
Reference
4  [PMID:6163778]
  Authors
Wittwer AJ, Wagner C
  Title
Identification of the folate-binding proteins of rat liver mitochondria as dimethylglycine dehydrogenase and sarcosine dehydrogenase. Flavoprotein nature and enzymatic properties of the purified proteins.
  Journal
J Biol Chem 256:4109-15 (1981)
Reference
5  [PMID:2417560]
  Authors
Porter DH, Cook RJ, Wagner C
  Title
Enzymatic properties of dimethylglycine dehydrogenase and sarcosine dehydrogenase from rat liver.
  Journal
Arch Biochem Biophys 243:396-407 (1985)
DOI:10.1016/0003-9861(85)90516-8
Reference
6  [PMID:15358367]
  Authors
Brizio C, Brandsch R, Bufano D, Pochini L, Indiveri C, Barile M
  Title
Over-expression in Escherichia coli, functional characterization and refolding of rat dimethylglycine dehydrogenase.
  Journal
Protein Expr Purif 37:434-42 (2004)
DOI:10.1016/j.pep.2004.06.011
  Sequence
[rno:245961]
Reference
7  [PMID:18423846]
  Authors
Brizio C, Brandsch R, Douka M, Wait R, Barile M
  Title
The purified recombinant precursor of rat mitochondrial dimethylglycine dehydrogenase binds FAD via an autocatalytic reaction.
  Journal
Int J Biol Macromol 42:455-62 (2008)
DOI:10.1016/j.ijbiomac.2008.03.001
  Sequence
[rno:245961]
Reference
8  [PMID:24858690]
  Authors
Luka Z, Pakhomova S, Loukachevitch LV, Newcomer ME, Wagner C
  Title
Folate in demethylation: the crystal structure of the rat dimethylglycine dehydrogenase complexed with tetrahydrofolate.
  Journal
Biochem Biophys Res Commun 449:392-8 (2014)
DOI:10.1016/j.bbrc.2014.05.064
  Sequence
[rno:245961]
Reference
9  [PMID:27486859]
  Authors
Augustin P, Hromic A, Pavkov-Keller T, Gruber K, Macheroux P
  Title
Structure and biochemical properties of recombinant human dimethylglycine dehydrogenase and comparison to the disease-related H109R variant.
  Journal
FEBS J 283:3587-3603 (2016)
DOI:10.1111/febs.13828
  Sequence
[hsa:29958]
Other DBs
ExplorEnz - The Enzyme Database: 1.5.8.4
IUBMB Enzyme Nomenclature: 1.5.8.4
ExPASy - ENZYME nomenclature database: 1.5.8.4
BRENDA, the Enzyme Database: 1.5.8.4
CAS: 37256-30-7

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