KEGG   ENZYME: 1.5.99.15
Entry
EC 1.5.99.15                Enzyme                                 
Name
dihydromethanopterin reductase (acceptor);
DmrX
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With unknown physiological acceptors
Sysname
5,6,7,8-tetrahydromethanopterin:acceptor 5,6-oxidoreductase
Reaction(IUBMB)
5,6,7,8-tetrahydromethanopterin + oxidized acceptor = 7,8-dihydromethanopterin + reduced acceptor [RN:R10802]
Reaction(KEGG)
R10802
Substrate
5,6,7,8-tetrahydromethanopterin [CPD:C01217];
oxidized acceptor
Product
7,8-dihydromethanopterin [CPD:C05927];
reduced acceptor [CPD:C00030]
Comment
This archaeal enzyme catalyses the last step in the biosynthesis of tetrahydromethanopterin, a coenzyme used in methanogenesis. The enzyme, characterized from the archaea Methanosarcina mazei and Methanocaldococcus jannaschii, is an iron-sulfur flavoprotein. cf. EC 1.5.1.47, dihydromethanopterin reductase [NAD(P)+].
History
EC 1.5.99.15 created 2014
Pathway
ec00790  Folate biosynthesis
Orthology
K18853  dihydromethanopterin reductase (acceptor)
Genes
MMTMetme_1237
MDNJT25_000420
MDHAYM39_08130
MKOMKLM6_1700
METLU737_09955
MPADKEF85_13940
MELLIVG45_13805
MAHMEALZ_1628
MBUREQU24_12275
MPSYCEK71_07200
MEINmethR_P0790
MEJQ7A_317
MECQ7C_1997
MPINLGT42_001330
BLEPAL038_02455
TSYTHSYN_32925
SEDSAAY24_01730
COXE0W60_31950
BYIBYI23_B014400
BUEBRPE67_BCDS01380
BPHBphy_5942
BCAIK788_0001560
PHSC2L64_21795 C2L64_38260
PTERC2L65_26200
VAPVapar_3076
VPDVAPA_1c31400
MPTMpe_A2615
METPC1M51_15065
RGERGE_40310
LCHLcho_3144
AONDEH84_18975
MFAMfla_1582
MMBMmol_0896
MEHM301_0950
MEIMsip34_1685
MEPMPQ_1685
MBACBN1209_0839
MEUACJ67_07090
MPAUZMTM_14840
SPLBSFPGR_25830
AZAAZKH_p0267
AZDCDA09_11345
THUAC731_004865
THKCCZ27_13230
MCIMesci_4268
MESWA9K65_023660
MESMEJ066_29785
MOHIHQ72_13835
PHTBLM14_23830
RGARGR602_PC01576
XAUXaut_4101
XDIEZH22_22940
SNOSnov_0764
STARG3545_09705
LNEFZC33_09375
ANCGBB76_00815
APRAG3A50_16560
APOLK9D25_20120
FILBN1229_v1_0578
FIYBN1229_v1_0580
MSCBN69_1046
MBRYB1812_10070
MROSEHO51_11415
MHEYH2LOC_018400
MPARF7D14_11875
MTWCQW49_15585
HDIHDIA_2296
GBEGbCGDNIH1_0764
GBHGbCGDNIH2_0764
GBCGbCGDNIH3_0764
GBSGbCGDNIH4_0764
ALIAZOLI_p10902
AOZHUE56_08975
FWADCMF_03865
AMOAnamo_1804
MJAMJ_0208
MFEMefer_0472
MVUMetvu_1597
MFSMFS40622_0016
MJHJH146_1595
MESGMLAUSG7_0445(dmrX)
MESAMLASG1_0063(dmrX)
MIGMetig_0591
MTHMTH_1379
MMGMTBMA_c17660
MWOMWSIV6_1760(dmrX)
MTEEMTTB_15510
METCMTCT_1253
METEtca_01333
METZMETMT2_0031
METKFVF72_04685
MTHMFZP57_08615
METJFZP68_02110
MSTMsp_1473
METBAW729_08040
MRUmru_0123(afpA)
MSIMsm_1338
MEBAbm4_1689(afpA)
MMILsm9_2248(afpA)
MEYETL18_00390
MOLYLM1_1552
MAROMarbSA_12740
METVK4897_04635
MELMetbo_0161
MEWMSWAN_2323
METHMBMB1_1960
MFCBRM9_2301(afpA3)
MFIDSM1535_1235
MCUBMCBB_2245(dmrX)
MSUBBK009_09065
METNBK008_04685
METTCIT01_05265
METOCIT02_07725
MEMEHYG87_06115
MFVMfer_0803
MKAMK1484
TSITSIB_0734
TBATERMP_00681
TLTOCC_04872
THSTES1_0923
THVADU37_CDS11180
PPACPAP_04215
MBAMbar_A1610
MBYMSBRM_2843
MBWMSBRW_3121
MBARMSBR2_2801
MBAKMSBR3_1897
MACMA_0696
MMAMM_1854
MMAZMmTuc01_1929
MMJMSMAS_2830
MMACMSMAC_1600
MVCMSVAZ_2783
MEKMSKOL_2775
MLSMSLAZ_0417
METMMSMTP_2728
MEFMSWH1_0446
MEQMSWHS_0457
MSJMSSAC_0632
MSZMSSIH_0583
MSWMSSIT_0615
MTHRMSTHT_2252
MTHEMSTHC_1028
MHORMSHOH_3527
MFZAOB57_004565
MZIHWN40_03795
MTPMthe_1166
MHIMhar_0340
MPDMCP_1352
MEZMtc_1049
RCIRRC38
MEAMMU439_06155
SHCShell_1373
IHOIgni_0932
IISEYM_03085
DKADKAM_0424
DFDDesfe_0335
DMUDesmu_0823
TAGTagg_0595
IAGIgag_0279
THGTCELL_0838
PFMPyrfu_0994
PSYTDSAG12_01802
 » show all
Reference
1  [PMID:23995635]
  Authors
Wang S, Tiongson J, Rasche ME
  Title
Discovery and characterization of the first archaeal dihydromethanopterin reductase, an iron-sulfur flavoprotein from Methanosarcina mazei.
  Journal
J Bacteriol 196:203-9 (2014)
DOI:10.1128/JB.00457-13
  Sequence
[mma:MM_1854]
Other DBs
ExplorEnz - The Enzyme Database: 1.5.99.15
IUBMB Enzyme Nomenclature: 1.5.99.15
ExPASy - ENZYME nomenclature database: 1.5.99.15
BRENDA, the Enzyme Database: 1.5.99.15

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