KEGG   ENZYME: 1.7.1.6
Entry
EC 1.7.1.6                  Enzyme                                 
Name
azobenzene reductase;
new coccine (NC)-reductase;
NC-reductase;
azo-dye reductase;
orange II azoreductase;
NAD(P)H:1-(4'-sulfophenylazo)-2-naphthol oxidoreductase;
orange I azoreductase;
azo reductase;
azoreductase;
nicotinamide adenine dinucleotide (phosphate) azoreductase;
NADPH2-dependent azoreductase;
dimethylaminobenzene reductase;
p-dimethylaminoazobenzene azoreductase;
dibromopropylaminophenylazobenzoic azoreductase;
N,N-dimethyl-4-phenylazoaniline azoreductase;
p-aminoazobenzene reductase;
methyl red azoreductase;
NADPH2:4-(dimethylamino)azobenzene oxidoreductase
Class
Oxidoreductases;
Acting on other nitrogenous compounds as donors;
With NAD+ or NADP+ as acceptor
Sysname
N,N-dimethyl-1,4-phenylenediamine, aniline:NADP+ oxidoreductase
Reaction(IUBMB)
N,N-dimethyl-1,4-phenylenediamine + aniline + 2 NADP+ = 4-(dimethylamino)azobenzene + 2 NADPH + 2 H+ [RN:R05711]
Reaction(KEGG)
R05711
Substrate
N,N-dimethyl-1,4-phenylenediamine [CPD:C04203];
aniline [CPD:C00292];
NADP+ [CPD:C00006]
Product
4-(dimethylamino)azobenzene;
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The reaction occurs in the reverse direction to that shown above. Other azo dyes, such as Methyl Red, Rocceline, Solar Orange and Sumifix Black B can also be reduced [2].
History
EC 1.7.1.6 created 1961 as EC 1.6.6.7, transferred 2002 to EC 1.7.1.6
Orthology
K03206  azobenzene reductase
Genes
PPUJE2566_16735
XBOXBJ1_2341
XBVXBW1_2113
XDOXDD1_2148
XPOXPG1_1741
XHOA9255_05310
XBUHGO23_10245
VNAPN96_17525
VEJVEJY3_17001
VNIVIBNI_A1968
VTUIX91_23490
VEUIXK98_04170
VFLAL536_11160
VMIAL543_00945
VCCFAZ90_17080
PGHFH974_18860
PMANOU5_1136
PBAPSEBR_a2845
PSETTHL1_2442
POJPtoMrB4_21530
SONSO_3585(azr)
SAZSama_2787
SBLSbal_1010
SBMShew185_1079
SBNSbal195_1112
SBPSbal223_3279
SBTSbal678_1141
SBSSbal117_1113
SBBSbal175_3254
SLOShew_0914
SPCSputcn32_1017
SHPSput200_1016
SPLSpea_0887
SHEShewmr4_2999
SHMShewmr7_3080
SHNShewana3_3177
SHWSputw3181_3148
SWDSwoo_1047
SWPswp_0891
SHFCEQ32_21270
SBJCF168_04925
SHEWCKQ84_02400
SALGBS332_11850
SKHSTH12_02663(azr)
SLITJQC75_14415
SCAATUM17387_30930(azr)
SEURFM038_004995
SCYPJYB88_03365
SSEMJYB85_03545
SXMMKD32_04985
SHEJMZ182_04795
CPSCPS_0090
COMCMT41_00390
LSDEMK97_10940
PSYMJ1N51_13235
MVSMVIS_1143
MMAAFR932_11775
SAGAM5M_14905
MMOBF6R98_13075
PSALPSLF89_2520
THISHZT40_21750
TUNJ9260_14910
TOLTOL_2666
TORR615_04300
BSANCHH28_18425
BMARHF888_06430
ASRWL1483_651
TBNTBH_C2416
SEDSAAY24_06865
SCUSCE1572_09345
EHHEHF_0234
BGRBgr_17550
BSUBSU09340(yhdA)
BSRI33_1061
BSLA7A1_3793
BSHBSU6051_09340(yhdA)
BSYI653_04695
BSUTBSUB_01029(yhdA)
BSULBSUA_01029(yhdA)
BSUSQ433_05305
BSOBSNT_07366(yhdA)
BSNBSn5_16550
BSQB657_09340(yhdA)
BSPU712_04755
BSSBSUW23_04715(yhdA)
BSTGYO_1222
BLIBL02896(azr)
BLDBLi01002(yhdA)
BLHBaLi_c11070(yhdA)
BAYRBAM_009600
BAQBACAU_0920(yhdA)
BYABANAU_0865(yhdA)
BAMPB938_04585
BQYMUS_0972(azr)
BAMLBAM5036_0862(yhdA)
BAMARBAU_0923(yhdA)
BAMNBASU_0899(yhdA)
BAMBBAPNAU_2842(yhdA)
BAMTAJ82_05370
BAMYV529_08950(yhdA)
BMPNG74_00967(azr_1)
BAOBAMF_1030(yhdA)
BAZBAMTA208_04360(yhdA)
BQLLL3_01015(yhdA)
BXHBAXH7_00910(azr)
BAMIKSO_015075
BAMCU471_09420
BAMFU722_04840
BSIACWD84_16970
BAEBATR1942_02270
BVMB9C48_04785
BSONS101395_03831
BHTDIC78_04980
BMOJHC660_09930(azr)
BIQAN935_04885
BANBA_2276
BARGBAA_2276
BATBAS2122
BAHBAMEG_2317
BAIBAA_2341
BAXH9401_2164
BANTA16_23150
BANRA16R_23410
BANSBAPAT_2177
BANHHYU01_11355
BANVDJ46_1075(azr)
BCEBC2229
BCABCE_2310
BCZBCE33L2056(azr)
BCRBCAH187_A2386
BCBBCB4264_A2259
BCUBCAH820_2302
BCGBCG9842_B3066
BCQBCQ_2213(azr)
BCXBCA_2358
BALBACI_c22390(azr)
BNCBCN_2204
BCFbcf_11405
BCERBCK_23455
BCYBcer98_1668
BTKBT9727_2060(azr)
BTLBALH_2037
BTBBMB171_C2006
BTTHD73_2517
BTHRYBT1520_12310
BTHIBTK_12480
BTCCT43_CH2195
BTFYBT020_11650
BTMMC28_1448(azr)
BTGBTB_c23090(azr)
BTIBTG_08730
BTNBTF1_08650
BTHTH175_ch2229
BTHUYBT1518_12380
BTWBF38_3479(azr)
BTHYAQ980_18475
BWEBcerKBAB4_2096
BWWbwei_2769(azr)
BMYOBG05_3765(azr)
BTYBtoyo_4861
BMYCDJ92_4824(azr)
BBYCY96_10270
BWDCT694_12080
BTROFJR70_08255
BMOBMLA2C4_11380
BNTGSN03_10925
BPACLMD38_15365
BPANNLJ82_10990
BIFN288_06240
BGYBGLY_1031(azr2)
BWHA9C19_16125
BITBIS30_15360
BSHILGQ02_10715
BCABEFK13_05315(yhdA)
BRYM0696_05280(yhdA)
BJSMY9_1030
BACPSB24_05080
BACBOY17_07480
BACYQF06_03610
BACLBS34A_10540(yhdA)
BALMBsLM_0974
BACSAUL54_05810
BCOBcell_0307
BHKB4U37_05830
BCOHBC6307_03250
BMQBMQ_2501
BMDBMD_2488
BMHBMWSH_2707(yhdA)
BMEGBG04_4948(azr)
BEOBEH_03225
PKSIE339_03025
BHABH2050
BGIBGM20_19950
BONA361_06560
CSUAIM538_03800
CFIRNAF01_06220
GWCGWCH70_0533
PTBDER53_07345
PCALBV455_01196(azr)
ANMGFC28_1971(azr)
AAMYGFC30_959(azr)
ANLGFC29_3463(azr)
ANDGRQ40_03375
ACAIISX45_00235
ASEDIRT44_16865
HMNHM131_17095
HLIHLI_20990
FPNABE65_002665
FARABE41_002580
BSJUP17_04685
BMURABE28_004860
PBUTDTO10_17155
PASABAOM_0840(azr)
PFRIL8956_05065
POFGS400_03955
MEKUHUW50_12430
MDGK8L98_04125
MLITKDJ21_001395
BVQFHE72_07200
RMFD5E69_07875
MCUIG8O30_02185
GAJMY490_11890 MY490_20380
SAVSAV0560
SAWSAHV_0558
SAHSaurJH1_0597
SAJSaurJH9_0583
SAMMW0515
SASSAS0518
SARSAR0565
SACSACOL0607
SAXUSA300HOU_0554
SAENWMN_0522
SADSAAV_0523
SUUM013TW_0547
SUVSAVC_02395
SUESAOV_0595
SUJSAA6159_00514
SUKSAA6008_00567(azo1)
SUCECTR2_514
SUTSAT0131_00614
SUQHMPREF0772_12629(azo)
SUZMS7_0550(azo1)
SUDST398NM01_0635
SUXSAEMRSA15_04870
SUWSATW20_06300(azo1)
SUGSAPIG0635
SUFSARLGA251_04960(azo1)
SAUASAAG_00978
SAUERSAU_000512
SAUNSAKOR_00547
SAUSSA40_0500(azo1)
SAUUSA957_0515(azo1)
SAUGSA268_0513(azo1)
SAUZSAZ172_0563
SAUTSAI1T1_2004300
SAUJSAI2T2_1004300
SAUKSAI3T3_1004300
SAUQSAI4T8_1004300
SAUVSAI7S6_1004290(azo1)
SAUWSAI5S5_1004270(azo1)
SAUXSAI6T6_1004280(azo1)
SAUYSAI8T7_1004290(azo1)
SAUFX998_0602
SUYSA2981_0537
SAUBC248_0635
SAUMBN843_5540
SAUCCA347_576
SAURSABB_00611(azo1)
SAUIAZ30_02835
SAUDCH52_02955
SAMSNI36_02785
SUHSAMSHR1132_05040
SLGSLGD_02323
SLNSLUG_22420
SXYBE24_00555
SXLSXYLSMQ121_2144
SXOSXYL_02298(azo1)
SAGQEP23_11325
SPETCEP67_09840
SNLBJD96_12070
SFQC7J90_01840
SMUSC7J88_08250
SSCUCEP64_11465
SSTESAMEA4384403_2296(azo1)
MLENH3V22_10350
MVTI6J10_12030
SHVAAT16_01075
SBACBVH56_01175
BCOPJD108_00045
PLVERIC2_c11770
PODPODO_29435
PAEFR50345_29545
PAEJH70737_29195
PBJVN24_23845
PBVAR543_14960
PXLBS614_10005
PSWUSY83_20665
PIBBBD41_26100
PVOPVOR_21019
PLWD5F53_10785
PPSCEHS13_30510
PALBEJC50_09795 EJC50_11835
PCHIPC41400_09985
PBKBack11_42060
PPRTET464_17930
PBACHUB98_22900
PRZGZH47_06835
PLYCGXP70_09545
TCOTheco_2882
ANXACH33_08170
ATHEK3F53_10665
SACAFFV09_01410
PAEKD3873_10075
PANCE2636_04315
LFBC1X05_06860
SQZFQU76_01580
STSUB7R87_31430
ACITHPK19_06305 HPK19_16115
LEDBBK82_30475
CYJCyan7822_5758
LIELIF_B021
LICLIC_20022
LISLIL_20022
LBJLBJ_4022
LBLLBL_4022
LSTLSS_08534
LMAYDPV73_19140
LWLFHG68_19570
CBAECOR50_11525
ECHIFKX85_13020
RTIDC20_07770
ADDHUW48_11030
FBTD770_08085
HXAHalxa_1449
NOUNatoc_4047
NAGAArcMg_0024
NANAArc1_0025
 » show all
Reference
1  [PMID:18139207]
  Authors
MUELLER GC, MILLER JA
  Title
The reductive cleavage of 4-dimethylaminoazobenzene by rat liver; the intracellular distribution of the enzyme system and its requirement for triphosphopyridine nucleotide.
  Journal
J Biol Chem 180:1125-36 (1949)
Reference
2  [PMID:11134015]
  Authors
Suzuki Y, Yoda T, Ruhul A, Sugiura W
  Title
Molecular cloning and characterization of the gene coding for azoreductase from Bacillus sp. OY1-2 isolated from soil.
  Journal
J Biol Chem 276:9059-65 (2001)
DOI:10.1074/jbc.M008083200
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.7.1.6
IUBMB Enzyme Nomenclature: 1.7.1.6
ExPASy - ENZYME nomenclature database: 1.7.1.6
UM-BBD (Biocatalysis/Biodegradation Database): 1.7.1.6
BRENDA, the Enzyme Database: 1.7.1.6
CAS: 9029-31-6

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