KEGG   ENZYME: 1.7.1.6
Entry
EC 1.7.1.6                  Enzyme                                 

Name
azobenzene reductase;
new coccine (NC)-reductase;
NC-reductase;
azo-dye reductase;
orange II azoreductase;
NAD(P)H:1-(4'-sulfophenylazo)-2-naphthol oxidoreductase;
orange I azoreductase;
azo reductase;
azoreductase;
nicotinamide adenine dinucleotide (phosphate) azoreductase;
NADPH2-dependent azoreductase;
dimethylaminobenzene reductase;
p-dimethylaminoazobenzene azoreductase;
dibromopropylaminophenylazobenzoic azoreductase;
N,N-dimethyl-4-phenylazoaniline azoreductase;
p-aminoazobenzene reductase;
methyl red azoreductase;
NADPH2:4-(dimethylamino)azobenzene oxidoreductase
Class
Oxidoreductases;
Acting on other nitrogenous compounds as donors;
With NAD+ or NADP+ as acceptor
Sysname
N,N-dimethyl-1,4-phenylenediamine, aniline:NADP+ oxidoreductase
Reaction(IUBMB)
N,N-dimethyl-1,4-phenylenediamine + aniline + 2 NADP+ = 4-(dimethylamino)azobenzene + 2 NADPH + 2 H+ [RN:R05711]
Reaction(KEGG)
R05711
Substrate
N,N-dimethyl-1,4-phenylenediamine [CPD:C04203];
aniline [CPD:C00292];
NADP+ [CPD:C00006]
Product
4-(dimethylamino)azobenzene;
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The reaction occurs in the reverse direction to that shown above. Other azo dyes, such as Methyl Red, Rocceline, Solar Orange and Sumifix Black B can also be reduced [2].
History
EC 1.7.1.6 created 1961 as EC 1.6.6.7, transferred 2002 to EC 1.7.1.6
Orthology
K03206  azobenzene reductase
Genes
PPUJ: E2566_16735
XBO: XBJ1_2341
XBV: XBW1_2113
XDO: XDD1_2148
XPO: XPG1_1741
XHO: A9255_05310
XBU: HGO23_10245
VNA: PN96_17525
VEJ: VEJY3_17001
VNI: VIBNI_A1968
PMAN: OU5_1136
PSET: THL1_2442
SON: SO_3585(azr)
SAZ: Sama_2787
SBL: Sbal_1010
SLO: Shew_0914
SPL: Spea_0887
SWD: Swoo_1047
SWP: swp_0891
SKH: STH12_02663(azr)
SCAA: TUM17387_30930(azr)
CPS: CPS_0090
MVS: MVIS_1143
SAGA: M5M_14905
TOL: TOL_2666
TBN: TBH_C2416
EHH: EHF_0234
BGR: Bgr_17550
BSU: BSU09340(yhdA)
BSR: I33_1061
BSL: A7A1_3793
BSH: BSU6051_09340(yhdA)
BSUT: BSUB_01029(yhdA)
BSUL: BSUA_01029(yhdA)
BSUS: Q433_05305
BSO: BSNT_07366(yhdA)
BSQ: B657_09340(yhdA)
BSS: BSUW23_04715(yhdA)
BST: GYO_1222
BLI: BL02896(azr)
BLD: BLi01002(yhdA)
BLH: BaLi_c11070(yhdA)
BAQ: BACAU_0920(yhdA)
BYA: BANAU_0865(yhdA)
BAMP: B938_04585
BAML: BAM5036_0862(yhdA)
BAMA: RBAU_0923(yhdA)
BAMN: BASU_0899(yhdA)
BAMB: BAPNAU_2842(yhdA)
BAMT: AJ82_05370
BAMY: V529_08950(yhdA)
BMP: NG74_00967(azr_1)
BAO: BAMF_1030(yhdA)
BAZ: BAMTA208_04360(yhdA)
BQL: LL3_01015(yhdA)
BXH: BAXH7_00910(azr)
BQY: MUS_0972(azr)
BAMI: KSO_015075
BAMC: U471_09420
BAMF: U722_04840
BMOJ: HC660_09930(azr)
BAN: BA_2276
BAR: GBAA_2276
BAT: BAS2122
BAI: BAA_2341
BANT: A16_23150
BANR: A16R_23410
BANS: BAPAT_2177
BANV: DJ46_1075(azr)
BCE: BC2229
BCA: BCE_2310
BCZ: BCE33L2056(azr)
BCQ: BCQ_2213(azr)
BCX: BCA_2358
BAL: BACI_c22390(azr)
BNC: BCN_2204
BCF: bcf_11405
BCER: BCK_23455
BTK: BT9727_2060(azr)
BTL: BALH_2037
BTT: HD73_2517
BTHI: BTK_12480
BTM: MC28_1448(azr)
BTG: BTB_c23090(azr)
BTI: BTG_08730
BTW: BF38_3479(azr)
BWW: bwei_2769(azr)
BMYO: BG05_3765(azr)
BMYC: DJ92_4824(azr)
BJS: MY9_1030
BACP: SB24_05080
BACB: OY17_07480
BACY: QF06_03610
BACL: BS34A_10540(yhdA)
BALM: BsLM_0974
BGY: BGLY_1031(azr2)
BMQ: BMQ_2501
BMD: BMD_2488
BMH: BMWSH_2707(yhdA)
BMEG: BG04_4948(azr)
BEO: BEH_03225
BHA: BH2050
PCAL: BV455_01196(azr)
ANM: GFC28_1971(azr)
AAMY: GFC30_959(azr)
ANL: GFC29_3463(azr)
HLI: HLI_20990
PASA: BAOM_0840(azr)
SAV: SAV0560
SAW: SAHV_0558
SAM: MW0515
SAS: SAS0518
SAR: SAR0565
SAC: SACOL0607
SAE: NWMN_0522
SAD: SAAV_0523
SUE: SAOV_0595
SUJ: SAA6159_00514(azo1)
SUK: SAA6008_00567(azo1)
SUC: ECTR2_514
SUQ: HMPREF0772_12629(azo)
SUZ: MS7_0550(azo1)
SUW: SATW20_06300(azo1)
SUG: SAPIG0635
SUF: SARLGA251_04960(azo1)
SAUA: SAAG_00978
SAUS: SA40_0500(azo1)
SAUU: SA957_0515(azo1)
SAUG: SA268_0513(azo1)
SAUV: SAI7S6_1004290(azo1)
SAUW: SAI5S5_1004270(azo1)
SAUX: SAI6T6_1004280(azo1)
SAUY: SAI8T7_1004290(azo1)
SAUF: X998_0602
SAUB: C248_0635
SAUM: BN843_5540
SAUC: CA347_576
SAUR: SABB_00611(azo1)
SAUI: AZ30_02835
SAUD: CH52_02955
SAMS: NI36_02785
SXO: SXYL_02298(azo1)
SAGQ: EP23_11325
SSTE: SAMEA4384403_2296(azo1)
PSWU: SY83_20665
LIE: LIF_B021
LIC: LIC_20022
LIS: LIL_20022
LBJ: LBJ_4022
LBL: LBL_4022
LST: LSS_08534
HHB: Hhub_3680
 » show all
Reference
1  [PMID:18139207]
  Authors
MUELLER GC, MILLER JA
  Title
The reductive cleavage of 4-dimethylaminoazobenzene by rat liver; the intracellular distribution of the enzyme system and its requirement for triphosphopyridine nucleotide.
  Journal
J Biol Chem 180:1125-36 (1949)
Reference
2  [PMID:11134015]
  Authors
Suzuki Y, Yoda T, Ruhul A, Sugiura W
  Title
Molecular cloning and characterization of the gene coding for azoreductase from Bacillus sp. OY1-2 isolated from soil.
  Journal
J Biol Chem 276:9059-65 (2001)
DOI:10.1074/jbc.M008083200
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.7.1.6
IUBMB Enzyme Nomenclature: 1.7.1.6
ExPASy - ENZYME nomenclature database: 1.7.1.6
UM-BBD (Biocatalysis/Biodegradation Database): 1.7.1.6
BRENDA, the Enzyme Database: 1.7.1.6
CAS: 9029-31-6

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