KEGG   ENZYME: 1.8.1.13
Entry
EC 1.8.1.13                 Enzyme                                 
Name
bis-gamma-glutamylcystine reductase;
NADPH2:bis-gamma-glutamylcysteine oxidoreductase;
GSR
Class
Oxidoreductases;
Acting on a sulfur group of donors;
With NAD+ or NADP+ as acceptor
Sysname
gamma-glutamylcysteine:NADP+ oxidoreductase
Reaction(IUBMB)
2 gamma-glutamylcysteine + NADP+ = bis-gamma-glutamylcystine + NADPH + H+ [RN:R02742]
Reaction(KEGG)
R02742
Substrate
gamma-glutamylcysteine [CPD:C00669];
NADP+ [CPD:C00006]
Product
bis-gamma-glutamylcystine [CPD:C03646];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Contains FAD. The enzyme, which is found only in halobacteria, maintains the concentration of gamma-glutamylcysteine, the major low molecular weight thiol in halobacteria. Not identical with EC 1.8.1.7 (glutathione-disulfide reductase) or EC 1.8.1.14 (CoA-disulfide reductase).
History
EC 1.8.1.13 created 1992 as EC 1.6.4.9, transferred 2002 to EC 1.8.1.13, modified 2013
Pathway
ec00480  Glutathione metabolism
ec01100  Metabolic pathways
Orthology
K03423  bis-gamma-glutamylcystine reductase
Genes
HALVNG_0154G(merA)
HSLOE_1260R(merA)
HDLHALDL1_04685
HHBHhub_1338
HAGSJT689_02070
HABOJRZ79_00575
HNOLT974_01595
HLULT972_12075
HANRLJ422_00730
HJEHacjB3_14400
HSUHLASF_0242(lpdA1)
HSFHLASA_0242(lpdA1)
SALRFQU85_02820
HALREFA46_011060
HARAAArcS_2151
HAADMW046_09310
HALXM0R89_08050
HMArrnAC3381(lpdA1)
HHIHAH_0613(pdhD2)
HHNHISP_03165
HABSG26_10930
HTABVU17_03015
HALJG9465_16790
HSINKDQ40_10460
HUTHuta_0885
HTIHTIA_0745
HALAHrd1104_05185 Hrd1104_08065
HMUHmuk_1669
HALZE5139_11470
HALLLC1Hm_0710(lpd2)
HAZPGBQ70_11465
HDSHSR122_0913
HRRHZS55_11170
HPELHZS54_09550
HLTI7X12_02080
HARCHARCEL1_00360
HDOMUK72_08410
HWAHQ_1085A
HWCHqrw_1115
HBOHbor_26630
HALBEKH57_01495
HALQHrr1229_010250
SRUBC2R22_02600
HAEhalTADL_2087
HALNB4589_012330
HACBHbl1158_04895
HDFAArcSl_1786(lpd)
HAHHalar_1022
HTUHtur_3212
HSALJMJ58_12395
HAKZJ0X25_03270
HXAHalxa_2062
NVRFEJ81_03780
NAYHYG81_07215
NOUNatoc_2182
SAIMK0C01_11460
HLRHALLA_16620
HLCCHINAEXTREME07600
 » show all
Reference
1  [PMID:3136140]
  Authors
Sundquist AR, Fahey RC.
  Title
The novel disulfide reductase bis-gamma-glutamylcystine reductase and dihydrolipoamide dehydrogenase from Halobacterium halobium: purification by immobilized-metal-ion affinity chromatography and properties of the enzymes.
  Journal
J Bacteriol 170:3459-67 (1988)
DOI:10.1128/JB.170.8.3459-3467.1988
Reference
2  [PMID:2910862]
  Authors
Sundquist AR, Fahey RC.
  Title
The function of gamma-glutamylcysteine and bis-gamma-glutamylcystine reductase in Halobacterium halobium.
  Journal
J Biol Chem 264:719-25 (1989)
Reference
3  [PMID:23560638]
  Authors
Kim J, Copley SD
  Title
The orphan protein bis-gamma-glutamylcystine reductase joins the pyridine nucleotide disulfide reductase family.
  Journal
Biochemistry 52:2905-13 (2013)
DOI:10.1021/bi4003343
  Sequence
[hal:VNG_0154G]
Other DBs
ExplorEnz - The Enzyme Database: 1.8.1.13
IUBMB Enzyme Nomenclature: 1.8.1.13
ExPASy - ENZYME nomenclature database: 1.8.1.13
BRENDA, the Enzyme Database: 1.8.1.13
CAS: 117056-54-9

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