KEGG   ENZYME: 1.8.1.14
Entry
EC 1.8.1.14                 Enzyme                                 
Name
CoA-disulfide reductase;
CoA-disulfide reductase (NADH2);
NADH2:CoA-disulfide oxidoreductase;
CoA:NAD+ oxidoreductase (misleading);
CoADR;
coenzyme A disulfide reductase
Class
Oxidoreductases;
Acting on a sulfur group of donors;
With NAD+ or NADP+ as acceptor
Sysname
CoA:NADP+ oxidoreductase
Reaction(IUBMB)
2 CoA + NADP+ = CoA-disulfide + NADPH + H+ [RN:R07175]
Reaction(KEGG)
R07175
Substrate
CoA [CPD:C00010];
NADP+ [CPD:C00006]
Product
CoA-disulfide [CPD:C02015];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
A flavoprotein. Not identical with EC 1.8.1.6 (cystine reductase), EC 1.8.1.7 (glutathione-disulfide reductase) or EC 1.8.1.13 (bis-gamma-glutamylcystine reductase). The enzyme from the bacterium Staphylococcus aureus has a strong preference for NADPH [3], while the bacterium Bacillus megaterium contains both NADH and NADPH-dependent enzymes [1].
History
EC 1.8.1.14 created 1992 as EC 1.6.4.10, transferred 2002 to EC 1.8.1.14, modified 2005, modified 2013
Orthology
K08255  CoA-disulfide reductase
Genes
SDOSD1155_07235
SAUSA0831(cdr)
SAVSAV0970(cdr)
SAWSAHV_0965(cdr)
SAHSaurJH1_0989
SAJSaurJH9_0970
SAMMW0852(cdr)
SASSAS0840
SARSAR0933
SACSACOL0975
SAXUSA300HOU_0929(cdr)
SAASAUSA300_0873(cdr)
SAOSAOUHSC_00908
SAENWMN_0841(cdr)
SADSAAV_0931
SUUM013TW_0889
SUVSAVC_04025
SUESAOV_0917c
SUJSAA6159_00830
SUKSAA6008_00923
SUCECTR2_826(cdr)
SUTSAT0131_01003
SUQHMPREF0772_12275(cdr)
SUZMS7_0926(cdr)
SUDST398NM01_0970
SUXSAEMRSA15_08000
SUWSATW20_09700
SUGSAPIG0970(cdr)
SUFSARLGA251_08880
SAUASAAG_01324
SAUERSAU_000847
SAUNSAKOR_00886
SAUSSA40_0837
SAUUSA957_0852
SAUGSA268_0852
SAUZSAZ172_0911
SAUTSAI1T1_2006800(cdr)
SAUJSAI2T2_1006820(cdr)
SAUKSAI3T3_1006810(cdr)
SAUQSAI4T8_1006800(cdr)
SAUVSAI7S6_1006810(cdr)
SAUWSAI5S5_1006770(cdr)
SAUXSAI6T6_1006780(cdr)
SAUYSAI8T7_1006810(cdr)
SAUFX998_0969
SABSAB0839c
SUYSA2981_0925(cdr)
SAUBC248_0996
SAUMBN843_8750
SAUCCA347_891(cdr)
SAURSABB_00939(cdr)
SAUIAZ30_04610
SAUDCH52_01025
SAMSNI36_04595
SUHSAMSHR1132_08220
SERSERP0560
SEPSE_0669
SEPPSEB_00649
SEPSDP17_1962(cdr)
SHASH1979(cdr)
SHHShL2_01842
SSPSSP1804
SCASCA_0578(cdr)
SLGSLGD_01888
SLNSLUG_18820
SSDSPSINT_0657
SDTSPSE_1865(cdr)
SDPNCTC12225_02092(cdr)
SWAA284_08865
SPASSTP1_2052
SXYBE24_02255
SXLSXYLSMQ121_1802
SXOSXYL_01950(cdr)
SHUSHYC_09425(cdr)
SCAPAYP1020_0240(cdr)
SSCHLH95_08910
SSCZRN70_09390
SAGQEP23_00565
SEQOSE1039_07350
SSIFAL483_07085
SCVA4G25_05030
SPETCEP67_11705
SLZB5P37_08835
SCOHBZ166_00940
SNLBJD96_09995
SKLC7J89_11105
SFQC7J90_06605
SHOMEGX58_01970
SMUSC7J88_10125
SCARDWB96_09730
SCHRDWB92_09185
SARLSAP2_18420(cdr)
SPICSAMEA4384060_1990(cdr)
SSHNCTC13712_00915(cdr)
SSIMSAMEA4384339_0828(cdr)
SDBCNQ82_04635
SLLOISP08_09075
SAULI6G39_08385
SSCUCEP64_08820
SFFFOB90_10580
SSTESAMEA4384403_1887(cdr)
MLENH3V22_13190
MVTI6J10_01935
MCLMCCL_0597(cdr)
MCAKMCCS_08170(cdr_2)
MACRBHM04_06480
MBOEHT586_04335
MARYLAU42_03495
MBRUMGG13_03740
SHVAAT16_03300
SBACBVH56_06530
JEAJEM45_04705
NAMPKPF49_01840
 » show all
Reference
1  [PMID:410791]
  Authors
Setlow B, Setlow P.
  Title
Levels of acetyl coenzyme A, reduced and oxidized coenzyme A, and coenzyme A in disulfide linkage to protein in dormant and germinated spores and growing and sporulating cells of Bacillus megaterium.
  Journal
J Bacteriol 132:444-52 (1977)
DOI:10.1128/JB.132.2.444-452.1977
Reference
2  [PMID:9488707]
  Authors
delCardayre SB, Stock KP, Newton GL, Fahey RC, Davies JE
  Title
Coenzyme A disulfide reductase, the primary low molecular weight disulfide reductase from Staphylococcus aureus. Purification and characterization of the native enzyme.
  Journal
J Biol Chem 273:5744-51 (1998)
DOI:10.1074/jbc.273.10.5744
  Sequence
Reference
3  [PMID:10052943]
  Authors
Luba J, Charrier V, Claiborne A.
  Title
Coenzyme A-disulfide reductase from Staphylococcus aureus: evidence for asymmetric behavior on interaction with pyridine nucleotides.
  Journal
Biochemistry 38:2725-37 (1999)
DOI:10.1021/bi9825899
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.8.1.14
IUBMB Enzyme Nomenclature: 1.8.1.14
ExPASy - ENZYME nomenclature database: 1.8.1.14
BRENDA, the Enzyme Database: 1.8.1.14
CAS: 206770-55-0

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