KEGG   ENZYME: 1.8.2.7
Entry
EC 1.8.2.7                  Enzyme                                 
Name
thiocyanate desulfurase;
TcDH;
thiocyanate dehydrogenase
Class
Oxidoreductases;
Acting on a sulfur group of donors;
With a cytochrome as acceptor
Sysname
thiocyanate:cytochrome c oxidoreductase (cyanate and sulfur-forming)
Reaction(IUBMB)
thiocyanate + 2 ferricytochrome c + H2O = cyanate + sulfur + 2 ferrocytochrome c + 2 H+ [RN:R12631]
Reaction(KEGG)
R12631
Substrate
thiocyanate [CPD:C01755];
ferricytochrome c [CPD:C00125];
H2O [CPD:C00001]
Product
cyanate [CPD:C01417];
sulfur [CPD:C00087];
ferrocytochrome c [CPD:C00126];
H+ [CPD:C00080]
Comment
The enzyme, characterized from the haloalkaliphilic sulfur-oxidizing bacterium Thioalkalivibrio paradoxus, contains three copper ions in its active site. It catalyses the direct conversion of thiocyanate into cyanate and elemental sulfur without involvement of molecular oxygen.
History
EC 1.8.2.7 created 2020
Orthology
K24299  thiocyanate desulfurase
Genes
TIGTHII_0490
TNITVNIR_2760
TTITHITH_13335
TTCFOKN1_0541
THICTspCOW1_21980
TBDTbd_0914
SNOSnov_1008
MSLMsil_3892
MTUNMTUNDRAET4_0051.1
MSCBN69_2544
MBRYB1812_06360
MROSEHO51_17375
SYJD082_31920
SYNESyn6312_0702
HTHHTH_1020
HTEHydth_1016
 » show all
Reference
1  [PMID:32094184]
  Authors
Tikhonova TV, Sorokin DY, Hagen WR, Khrenova MG, Muyzer G, Rakitina TV, Shabalin IG, Trofimov AA, Tsallagov SI, Popov VO
  Title
Trinuclear copper biocatalytic center forms an active site of thiocyanate dehydrogenase.
  Journal
Proc Natl Acad Sci U S A 117:5280-5290 (2020)
DOI:10.1073/pnas.1922133117
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.8.2.7
IUBMB Enzyme Nomenclature: 1.8.2.7
ExPASy - ENZYME nomenclature database: 1.8.2.7
BRENDA, the Enzyme Database: 1.8.2.7

DBGET integrated database retrieval system