sarcosine dimethylglycine N-methyltransferase;
Transferring one-carbon groups;
S-adenosyl-L-methionine:sarcosine(or N,N-dimethylglycine) N-methyltransferase [N,N-dimethylglycine(or betaine)-forming]
2 S-adenosyl-L-methionine + sarcosine = 2 S-adenosyl-L-homocysteine + betaine (overall reaction) [RN:
(1a) S-adenosyl-L-methionine + sarcosine = S-adenosyl-L-homocysteine + N,N-dimethylglycine [RN:
(1b) S-adenosyl-L-methionine + N,N-dimethylglycine = S-adenosyl-L-homocysteine + betaine [RN:
Cells of the oxygen-evolving halotolerant cyanobacterium Aphanocthece halophytica synthesize betaine from glycine by a three-step methylation process. The first enzyme, EC
, glycine/sarcosine N-methyltransferase, leads to the formation of either sarcosine or N,N-dimethylglycine, which is further methylated to yield betaine (N,N,N-trimethylglycine) by the action of this enzyme. Both of these enzymes can catalyse the formation of N,N-dimethylglycine from sarcosine . The reactions are strongly inhibited by S-adenosyl-L-homocysteine.
EC 188.8.131.52 created 2005, modified 2010
ec00260 Glycine, serine and threonine metabolism
K18897 sarcosine/dimethylglycine N-methyltransferase
K24071 glycine/sarcosine/dimethylglycine N-methyltransferase
APP: CAP2UW1_2978 CAP2UW1_3536
RID: RIdsm_00428 RIdsm_00793
MALU: KU6B_49020 KU6B_49030
SALF: SMD44_05398 SMD44_06865
SAOV: G3H79_06490 G3H79_13800
MPRO: BJP34_03740 BJP34_03745 BJP34_29375
LOKI: Lokiarch_49740 Lokiarch_52720 » show all
Nyyssola A, Kerovuo J, Kaukinen P, von Weymarn N, Reinikainen T
Extreme halophiles synthesize betaine from glycine by methylation.
Nyyssola A, Reinikainen T, Leisola M
Characterization of glycine sarcosine N-methyltransferase and sarcosine dimethylglycine N-methyltransferase.
Waditee R, Tanaka Y, Aoki K, Hibino T, Jikuya H, Takano J, Takabe T, Takabe T
Isolation and functional characterization of N-methyltransferases that catalyze betaine synthesis from glycine in a halotolerant photosynthetic organism Aphanothece halophytica.
ExPASy - ENZYME nomenclature database: 184.108.40.206