KEGG   ENZYME: 2.1.1.2
Entry
EC 2.1.1.2                  Enzyme                                 
Name
guanidinoacetate N-methyltransferase;
GA methylpherase;
guanidinoacetate methyltransferase;
guanidinoacetate transmethylase;
methionine-guanidinoacetic transmethylase;
guanidoacetate methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:N-guanidinoacetate methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + guanidinoacetate = S-adenosyl-L-homocysteine + creatine [RN:R01883]
Reaction(KEGG)
R01883
Substrate
S-adenosyl-L-methionine [CPD:C00019];
guanidinoacetate [CPD:C00581]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
creatine [CPD:C00300]
History
EC 2.1.1.2 created 1961
Pathway
ec00260  Glycine, serine and threonine metabolism
ec00330  Arginine and proline metabolism
ec01100  Metabolic pathways
Orthology
K00542  guanidinoacetate N-methyltransferase
Genes
HSA2593(GAMT)
PTR749982(GAMT)
PPS100973784(GAMT)
GGO101150449(GAMT)
PON100434735(GAMT)
NLE100604929 115830901(GAMT)
MCC721263(GAMT)
MCF102120326(GAMT)
CSAB103233606(GAMT)
CATY105591715(GAMT)
TGE112613537(GAMT)
RRO104671415(GAMT)
RBB108530253(GAMT)
TFN117076662(GAMT)
PTEH111526807(GAMT)
CJC100394705(GAMT)
SBQ101034312(GAMT)
MMUR105860790(GAMT)
LCAT123632776(GAMT)
OGA100965714(GAMT)
MMU14431(Gamt)
MCAL110303213(Gamt)
MPAH110326803(Gamt)
RNO25257(Gamt)
MCOC116075722(Gamt)
MUN110551319(Gamt)
CGE100755964(Gamt)
MAUA101833877(Gamt)
PLEU114684128(Gamt)
MORG121459656(Gamt)
AAMP119821293(Gamt)
NGI103737328(Gamt)
HGL101701700(Gamt)
CPOC100735222(Gamt)
CCAN109691010(Gamt)
DORD105990418(Gamt)
DSP122122772(Gamt)
NCAR124968481
OPI101532561(GAMT)
TUP102486225(GAMT)
CFA485085(GAMT)
VVP112935562(GAMT)
VLG121495614(GAMT)
AML100478678(GAMT)
UMR103681783(GAMT)
UAH113242729(GAMT)
UAR123794023(GAMT)
ELK111161694
LLV125089119
MPUF101676213(GAMT)
ORO101373126(GAMT)
EJU114226197(GAMT)
ZCA113916152(GAMT)
MLX118005113(GAMT)
FCA101096703(GAMT)
PYU121021302(GAMT)
PBG122488598(GAMT)
PTG102972234(GAMT)
PPAD109257654(GAMT)
AJU106983718(GAMT)
HHV120242358(GAMT)
BTA515270(GAMT)
BOM102277266(GAMT)
BIU109561988(GAMT)
BBUB102411011(GAMT)
CHX102176603(GAMT)
OAS101114955(GAMT)
ODA120863702(GAMT)
CCAD122439961(GAMT)
SSC100625146(GAMT)
CFR102522185(GAMT)
CBAI105078135(GAMT)
CDK105104108(GAMT)
VPC102544140(GAMT)
BACU102999076(GAMT)
LVE103069008(GAMT)
OOR101289055(GAMT)
DLE111170486(GAMT)
PCAD102991016(GAMT)
PSIU116751826(GAMT) 116754479
ECB100068840(GAMT)
EPZ103544271(GAMT)
EAI106834186(GAMT)
MYB102240125(GAMT)
MYD102765033(GAMT)
MMYO118658661(GAMT)
MLF102424140(GAMT)
MNA107534553(GAMT)
PKL118711785(GAMT)
HAI109390668(GAMT)
DRO112312443(GAMT)
SHON118984405(GAMT)
AJM119044189(GAMT)
PDIC114503029(GAMT)
PHAS123813922(GAMT)
MMF118615577(GAMT)
RFQ117037420(GAMT)
PALE102878441(GAMT)
PGIG120583688(GAMT)
PVP105302239(GAMT)
RAY107500940(GAMT)
MJV108399435(GAMT)
TOD119240503(GAMT)
SARA101539449(GAMT)
TMU101353747
DNM101446379(GAMT)
MDO100015231(GAMT)
GAS123256775(GAMT)
SHR100926458(GAMT)
PCW110223482(GAMT)
OAA103164686(GAMT)
GGA770737(GAMT)
MGP100544992(GAMT)
CJO107325467(GAMT)
NMEL110388919(GAMT)
APLA101803779(GAMT)
ACYG106048218(GAMT)
AFUL116499105(GAMT)
TGU100218458(GAMT)
LSR110480203(GAMT)
SCAN103822054 115484542
PMOA120513507(GAMT)
OTC121341778(GAMT)
PRUF121355110 121361133(GAMT)
GFR102031970(GAMT)
FAB101818937(GAMT)
PHI102112087(GAMT)
PMAJ107215490(GAMT)
CCAE111940328(GAMT)
CCW104697066(GAMT)
ETL114066419(GAMT)
ZAB102070095(GAMT)
FPG101922263(GAMT)
FCH102052811(GAMT)
CLV102093632(GAMT)
EGZ104128293(GAMT)
NNI104016283(GAMT)
PLET104625874(GAMT)
ACUN113489307(GAMT)
TALA116960396(GAMT)
ACHC115348863(GAMT)
AAM106486552(GAMT)
AROW112965667(GAMT)
NPD112946913(GAMT)
DNE112993212(GAMT)
ASN102376844(GAMT)
AMJ102571343(GAMT)
CPOO109312314(GAMT)
GGN109294948(GAMT)
PSS102458769(GAMT)
CMY102941606(GAMT)
CPIC101931504(GAMT)
TST117868860(GAMT)
CABI116831036(GAMT)
MRV120391569(GAMT)
ACS100566527(gamt)
PVT110072519(GAMT)
SUND121937122(GAMT)
PMUR107282878(GAMT)
TSR106546392(GAMT)
PGUT117668564(GAMT)
VKO123036596(GAMT)
PMUA114588427(GAMT)
ZVI118087963(GAMT)
GJA107115757(GAMT)
STOW125433489(GAMT)
XLA380384(gamt.S) 733150(gamt.L)
XTR394491(gamt)
NPR108792400(GAMT)
RTEM120913463(GAMT)
BBUF120989441(GAMT)
BGAR122930178(GAMT)
DRE796865(gamt)
SRX107747596 107747770 107757934
SANH107680536 107685360
SGH107553529 107597217
CCAR109063324 109106221
CAUA113110737(gamt)
PPRM120476410(gamt)
MAMB125256963(gamt)
IPU100528342(gamt)
PHYP113531337(gamt)
SMEO124391541(gamt)
TFD113657791(gamt)
AMEX103023041(gamt)
EEE113574537(gamt)
TRU101067635(gamt)
TNGGSTEN00019326G001
LCO104928396(gamt)
NCC104946919(gamt)
CGOB115007149(gamt)
ELY117253519(gamt)
PLEP121941105(gamt)
SLUC116053066(gamt)
ECRA117950909(gamt)
PFLV114561283(gamt)
GAT120824493(gamt)
PPUG119216832(gamt)
MSAM119900510(gamt)
CUD121512853(gamt)
ALAT119028000(gamt)
MZE101466486(gamt)
ONL100693706(gamt)
OAU116318306(gamt)
OLA101166292(gamt)
OML112150104(gamt)
XMA102217090(gamt)
XCO114150327(gamt)
XHE116726186(gamt)
PRET103463348(gamt)
PFOR103143846(gamt)
PLAI106962614(gamt)
PMEI106920103(gamt)
GAF122839102(gamt)
CVG107096976(gamt)
CTUL119783843(gamt)
GMU124873691(gamt)
NFU107392816(gamt)
KMR108234267(gamt)
ALIM106519249(gamt)
NWH119407686(gamt)
AOCE111582783(gamt)
CSEM103395941(gamt)
POV109636527(gamt)
SSEN122780964(gamt)
HHIP117759723(gamt)
HSP118120656(gamt)
LCF108877437(gamt)
SDU111216321(gamt)
SLAL111670011(gamt)
XGL120790433(gamt)
HCQ109519128(gamt)
BPEC110167651(gamt)
MALB109966838(gamt)
BSPL114854827(gamt)
SASA100196494(gamt) 106573878
OTW112250754 112252153
OMY110495805 110524165(gamt)
OGO123991489 123998045
ONE115108197 115109169
SALP111952574 111975887
SNH120053391(gamt) 120054431
ELS105029301(gamt)
SFM108930551(gamt)
PKI111860201(gamt)
AANG118224621(gamt)
LOC102690964(gamt)
PSPA121301522 121301551
ARUT117401388 117966392
LCM102360926(GAMT)
CMK103181936(gamt)
RTP109915729 109915730
BFO118405309 118406015 118411989
BBEL109468742 109472687
CIN100176150 100181581
SCLV120340781
SPU115919361 578397
APLC110978082
SKO100376150
FAS105269314
GAE121392167
LAK106178783
NVE5518556
EPA110239991
ATEN116298450
ADF107336691
AMIL114957391
PDAM113672541
SPIS111335936
DGT114525313
XEN124450373
AQU100636366
BVG104885916
AAFAURANDRAFT_68827
PIFPITG_10477
PSOJPHYSODRAFT_462469
SPARSPRG_14186
THISHZT40_06130
THIPN838_28140
DMMdnm_038680 dnm_076910
SKYD0C37_30560
SQZFQU76_03570
FRAFrancci3_3001
FREFranean1_1949
AOIAORI_2931
AJAAJAP_12340
PFLAPflav_057100
PSUUPsuf_016690
MPROBJP34_00295
WINWPG_0392
 » show all
Reference
1
  Authors
Cantoni, G.L. and Scarano, E.
  Title
The formation of S-adenosylhomocysteine in enzymatic transmethylation reactions.
  Journal
J Am Chem Soc 76:4744 (1954)
Reference
2  [PMID:13192118]
  Authors
CANTONI GL, VIGNOS PJ Jr.
  Title
Enzymatic mechanism of creatine synthesis.
  Journal
J Biol Chem 209:647-59 (1954)
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.2
IUBMB Enzyme Nomenclature: 2.1.1.2
ExPASy - ENZYME nomenclature database: 2.1.1.2
BRENDA, the Enzyme Database: 2.1.1.2
CAS: 9029-75-8

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