KEGG   ENZYME: 2.1.1.288
Entry
EC 2.1.1.288                Enzyme                                 
Name
aklanonic acid methyltransferase;
DauC;
AAMT
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:aklanonate O-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + aklanonate = S-adenosyl-L-homocysteine + methyl aklanonate [RN:R06680]
Reaction(KEGG)
R06680
Substrate
S-adenosyl-L-methionine [CPD:C00019];
aklanonate [CPD:C12421]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
methyl aklanonate [CPD:C12422]
Comment
The enzyme from the Gram-positive bacterium Streptomyces sp. C5 is involved in the biosynthesis of the anthracycline daunorubicin.
History
EC 2.1.1.288 created 2013
Pathway
ec01057  Biosynthesis of type II polyketide products
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K15942  O-methyltransferase / aklanonic acid methyltransferase
Genes
SPRISPRI_0206
STIRDDW44_27905
SKACP970_39700
SGALCP966_29095
SCINCP977_27945
STSUB7R87_22120
SCOECP976_32895
SPEUCGZ69_24295
SXNIAG42_36855
SDDD9753_08655
TALXFOF52_07515
PMADBAY61_07665
MAUMicau_3998
MILML5_4423
 » show all
Reference
1  [PMID:7836284]
  Authors
Dickens ML, Ye J, Strohl WR
  Title
Analysis of clustered genes encoding both early and late steps in daunomycin biosynthesis by Streptomyces sp. strain C5.
  Journal
J Bacteriol 177:536-43 (1995)
DOI:10.1128/JB.177.3.536-543.1995
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.288
IUBMB Enzyme Nomenclature: 2.1.1.288
ExPASy - ENZYME nomenclature database: 2.1.1.288
BRENDA, the Enzyme Database: 2.1.1.288

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