KEGG   ENZYME: 2.1.1.322
Entry
EC 2.1.1.322                Enzyme                                 
Name
type IV protein arginine methyltransferase;
RMT2 (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:[protein]-L-arginine N-methyltransferase ([protein]-N5-methyl-L-arginine-forming)
Reaction(IUBMB)
S-adenosyl-L-methionine + [protein]-L-arginine = S-adenosyl-L-homocysteine + [protein]-N5-methyl-L-arginine [RN:R11221]
Reaction(KEGG)
R11221
Substrate
S-adenosyl-L-methionine [CPD:C00019];
[protein]-L-arginine [CPD:C00613]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
[protein]-N5-methyl-L-arginine [CPD:C21190]
Comment
This enzyme, characterized from the yeast Saccharomyces cerevisiae, methylates the the delta-nitrogen atom of arginine residues within proteins. Among its substrates are Arg67 of the ribosomal protein L12. cf. EC 2.1.1.319, type I protein arginine methyltransferase, EC 2.1.1.320, type II protein arginine methyltransferase, and EC 2.1.1.321, type III protein arginine methyltransferase.
History
EC 2.1.1.322 created 2015
Orthology
K18477  type IV protein arginine methyltransferase
Genes
SMMSmp_024380
OVIT265_13792
EGLEGR_07793
ATHAT5G65860
ALY9301058
CRB17875279
CSAT104727248 104744337 104762774
EUSEUTSA_v10005718mg
BRP103874022
BNA106346625 106348175
BOE106328863
RSZ108857199 108861753
THJ104807092
CPAP110818793
CIT102617746
CICCICLE_v10001599mg
PVY116129072
MINC123229941
TCC18592010
GRA105769321
GHI107905628 107958173
GAB108450487
DZI111312562
EGR104447825
GMX100527621 100796916
GSJ114408758 114414759
PVUPHAVU_009G070400g
VRA106761118
VAR108331651
VUN114162111
CCAJ109796001
APRC113865451
MTR25489940
CAM101504178
LJALj1g3v1720140.1(Lj1g3v1720140.1) Lj1g3v1720140.2(Lj1g3v1720140.2)
ADU107461180
AIP107606376
AHF112706449 112762445
LANG109343866
FVE101307454
RCN112174110
PPER18791164
PMUM103320401
PAVI110744880
PDUL117619808
MDM103441063
PXB103945293
ZJU107420557 107433653
MNT21393556
CSV101206863
CMO103487848
BHJ120075618
MCHA111004738
CMAX111495906
CMOS111454147
CPEP111798359
RCU8288515
HBR110671978
MESC110605917
POP18104803
PEU105128808
PALZ118036618
JRE108981343
QSU111991221 112020323 112023925
QLO115971948
TWL120008925
VVI100259168
VRI117907434
SLY101264002
SPEN107016038
SOT102604578
SSTN125856643
CANN107867217
NTA107765586 107792104
NSY104249239
NTO104107915
NAU109215478
INI109153010
ITR116026771
SIND105155586
OEU111389319
EGT105971363
SSPL121763244
HAN110885808
ECAD122579428
LSV111901692
CCAV112514525
DCR108192844
CSIN114291796
BVG104902325
SOE110786191
CQI110695543 110724407
NNU104611655
MING122085180
TSS122657333
PSOM113289222 113293666
NCOL116260042
OSA4334192
DOSAOs03t0761200-01(Os03g0761200)
OBR102707569
BDI100840055
ATS109743493
TDC119303236 119311910
TAES123105111 123113403 123122921
TUA125510744
SBI8062466
ZMA100286312
SITA101761593
SVS117838788
PVIR120690018
PHAI112873600
PDA103700807 120104061
EGU105058565
MUS103997354
DCT110099348
PEQ110023864
AOF109834172
ATR18431821
SMOSELMODRAFT_118824 SELMODRAFT_131773
PPP112294549
CRECHLRE_01g050050v5
VCNVOLCADRAFT_69095
MNGMNEG_11764
CSLCOCSUDRAFT_32480
CVRCHLNCDRAFT_144236
APROF751_6706
OLUOSTLU_86989
OTAOT_ostta04g02060
BPGBathy01g01620
MISMICPUN_56989
MPPMICPUCDRAFT_25272
SCEYDR465C(RMT2)
SEUBDI49_0631
SPAOSPAR_D06450
AGOAGOS_ADR161W
ERCEcym_2800
KLAKLLA0_E03631g
KMXKLMA_20552(RMT2)
LTHKLTH0G05170g
VPOKpol_1004p62
ZROZYRO0C06820g
CGRCAGL0K06457g
NCSNCAS_0A08140(NCAS0A08140)
NDINDAI_0H01030(NDAI0H01030)
TPFTPHA_0D02720(TPHA0D02720)
TBLTBLA_0J00700(TBLA0J00700)
TDLTDEL_0A04560(TDEL0A04560)
TGBHG536_0A06120
KAFKAFR_0A06740(KAFR0A06740)
KNGKNAG_0C06050(KNAG0C06050)
ZMKHG535_0D05550
PPAPAS_chr1-4_0106
DHADEHA2E19228g
PICPICST_66076(RMT2)
PGUPGUG_03413
SPAASPAPADRAFT_61117
LELLELG_03736
CALCAALFM_C500680WA(RMT2)
CTPCTRG_05285
COTCORT_0E05920
CDUCD36_50680
CTENCANTEDRAFT_114589
YLIYALI0C14718g
CLUCLUG_04928
CLUSA9F13_03g03025
CAURCJI97_001153
SLBAWJ20_2397(RMT2)
PKZC5L36_0B07540
BNNFOA43_003317
BBRXBRETT_004162
OPAHPODL_00552
SLUDSCDLUD_004911
NCRNCU08111
NTENEUTE1DRAFT125124(NEUTE1DRAFT_125124)
SMPSMAC_08035
PANPODANSg09947
TTTTHITE_2114023
MTMMYCTH_2295764
CTHRCTHT_0057220
MGRMGG_09290
PPEIPpBr36_07629
TMNUCRPA7_1231
SSCKSPSK_10638
FGRFGSG_00501
FPUFPSE_04406
FVRFVEG_00958
FOXFOXG_00555
NHENECHADRAFT_31691
TRETRIREDRAFT_53796
TRRM419DRAFT_67962
MAWMAC_02976
MAJMAA_04208
CMTCCM_06279
PLJVFPFJ_05055
VALVDBG_04543
VDAVDAG_04088
CFJCFIO01_13485
CLUPCLUP02_05715
CHIGCH63R_00762
SAPOSAPIO_CDS3344
ELAUCREL1_5435
PFYPFICI_01109
SSLSS1G_01272
BFUBCIN_11g05680(Bcrmt2)
MBEMBM_09897
PSCOLY89DRAFT_502650
GLZGLAREA_02283
ANIAN6072.2
AFMAFUA_2G09080
ACTACLA_080890
NFINFIA_084610
AORAO090011000791
ANGANI_1_1792104(An12g04740)
AFVAFLA_008183
ALUCAKAW2_60866A(RMT2)
ACHEACHE_50460A(RMT2)
APUUAPUU_11164A(RMT2)
PCSPc16g10470
PDPPDIP_19700
TMFPMAA_029060
TRGTRUGW13939_06032
CIMCIMG_01019
CPWCPC735_053400
UREUREG_00965
PBLPAAG_01039
PBNPADG_03791
ABEARB_05048
TVETRV_01451
AJEHCAG_03681
BGHBDBG_05448
PNOSNOG_02787 SNOG_15549
PTEPTT_09392 PTT_15349
BZECOCCADRAFT_112323 COCCADRAFT_96483
BSCCOCSADRAFT_105599
BORCOCMIDRAFT_21364 COCMIDRAFT_81956
AALTCC77DRAFT_1016203 CC77DRAFT_374429
ZTRMYCGRDRAFT_100619
PFJMYCFIDRAFT_38502
FFUCLAFUR5_08805
BCOMBAUCODRAFT_71929
NPAUCRNP2_8449
TMLGSTUM_00004878001
SPOSPAC26A3.17c
CNECNA04170
CNBCNBA4000
CNGCNAG_00434
CGICGB_A4280C
TMSTREMEDRAFT_73009
TASAA1Q1_00168
TVSTRAVEDRAFT_112907
DSQDICSQDRAFT_99226
PCOPHACADRAFT_123415
SHSSTEHIDRAFT_143419 STEHIDRAFT_163146 STEHIDRAFT_92135
HIRHETIRDRAFT_389401
FMEFOMMEDRAFT_133950
GTRGLOTRDRAFT_38096
LBCLACBIDRAFT_256162
CCICC1G_14139
ABPAGABI1DRAFT71703(AGABI1DRAFT_71703)
ABVAGABI2DRAFT204671(AGABI2DRAFT_204671)
PCUBJR316_0002347
MPRMPER_11317
MRRMoror_6340
MOREE1B28_000552
SCMSCHCO_02634853(SCHCODRAFT_02634853)
CPUTCONPUDRAFT_121194
SLASERLADRAFT_361134
WSEWALSEDRAFT_60904
WICJ056_001249
UMAUMAG_11334
PFPPFL1_04152
MGLMGL_2081
MRTMRET_1613
MSYMMSY001_1151
PGRPGTG_08661
MLRMELLADRAFT_46233 MELLADRAFT_74296
MBRMONBRDRAFT_33022
SREPTSG_00809
SMINv1.2.008584.t1(symbB.v1.2.008584.t1)
PTIPHATR_46736
FCYFRACYDRAFT_238326
EHXEMIHUDRAFT_246103 EMIHUDRAFT_68769
MRIMal4_55900
 » show all
Reference
1  [PMID:9873020]
  Authors
Niewmierzycka A, Clarke S
  Title
S-Adenosylmethionine-dependent methylation in Saccharomyces cerevisiae. Identification of a novel protein arginine methyltransferase.
  Journal
J Biol Chem 274:814-24 (1999)
DOI:10.1074/jbc.274.2.814
  Sequence
[sce:YDR465C]
Reference
2  [PMID:11856739]
  Authors
Chern MK, Chang KN, Liu LF, Tam TC, Liu YC, Liang YL, Tam MF
  Title
Yeast ribosomal protein L12 is a substrate of protein-arginine methyltransferase  2.
  Journal
J Biol Chem 277:15345-53 (2002)
DOI:10.1074/jbc.M111379200
  Sequence
[sce:YDR465C]
Reference
3  [PMID:17448464]
  Authors
Olsson I, Berrez JM, Leipus A, Ostlund C, Mutvei A
  Title
The arginine methyltransferase Rmt2 is enriched in the nucleus and co-purifies with the nuclear porins Nup49, Nup57 and Nup100.
  Journal
Exp Cell Res 313:1778-89 (2007)
DOI:10.1016/j.yexcr.2007.03.007
  Sequence
[sce:YDR465C]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.322
IUBMB Enzyme Nomenclature: 2.1.1.322
ExPASy - ENZYME nomenclature database: 2.1.1.322
BRENDA, the Enzyme Database: 2.1.1.322

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