KEGG   ENZYME: 2.1.1.350
Entry
EC 2.1.1.350                Enzyme                                 
Name
menaquinone C8-methyltransferase;
mqnK (gene name);
menK (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:menaquinone C8-methyltransferase
Reaction(IUBMB)
(1) 2 S-adenosyl-L-methionine + a menaquinone + reduced flavodoxin = S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + an 8-methylmenaquinone + oxidized flavodoxin [RN:R12238];
(2) 2 S-adenosyl-L-methionine + a 2-demethylmenaquinone + reduced flavodoxin = S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + a 2-demethyl-8-methylmenaquinone + oxidized flavodoxin [RN:R12239]
Reaction(KEGG)
R12238 R12239
Substrate
S-adenosyl-L-methionine [CPD:C00019];
menaquinone [CPD:C00828];
reduced flavodoxin [CPD:C02745];
2-demethylmenaquinone [CPD:C05818]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
L-methionine [CPD:C00073];
5'-deoxyadenosine [CPD:C05198];
8-methylmenaquinone [CPD:C22027];
oxidized flavodoxin [CPD:C02869];
2-demethyl-8-methylmenaquinone [CPD:C22028]
Comment
The enzyme, found in a wide range of bacteria and archaea, is a radical SAM (AdoMet) enzyme that utilizes two molecules of S-adenosyl-L-methionine, one as the methyl group donor, and one for the creation of a 5'-deoxyadenosine radical that drives the reaction forward.
History
EC 2.1.1.350 created 2018
Orthology
K23078  menaquinone C8-methyltransferase
Genes
SONSO_4520
SFRSfri_0076
SAZSama_3604
SBLSbal_0219
SBMShew185_4118
SBNSbal195_4239
SBPSbal223_0221
SBTSbal678_4272
SBSSbal117_0320
SBBSbal175_4025
SLOShew_0073
SPCSputcn32_3506
SHPSput200_0365
SSESsed_4414
SPLSpea_2394 Spea_4126
SHEShewmr4_3730
SHMShewmr7_3801
SHNShewana3_3926
SHWSputw3181_0400
SHLShal_0116
SWDSwoo_3397 Swoo_4806
SWPswp_5018
SHFCEQ32_14785
SJASJ2017_2848 SJ2017_4065
SPSWSps_05512
SBJCF168_19775
SMAVCFF01_00350
SHEWCKQ84_06350
SALGBS332_06445
SLJEGC82_01525 EGC82_12775
SMAIEXU30_07885 EXU30_09715
SPOLFH971_00395 FH971_03420 FH971_08795
SBKSHEWBE_0429 SHEWBE_1745
SKHSTH12_03590(hemN_2)
SAESHBH39_00365
SLITJQC75_18535
SDKKHX94_09650
SCAATUM17387_37720
SPSHFM037_07180 FM037_27360
SEURFM038_006715 FM038_024580
SYKKDN34_16765
SAVIJYB87_17905
SGLAFJ709_00365 FJ709_12595
SINVK8B83_02535
SXMMKD32_19415
SVMKDH10_002975
FBLFbal_3716
FESHER31_16205
SUTTSUTMEG_01440
SUTKFG381_07675
SWSI6J16_10820
BBAYA4V04_09060
HWIA0Z60_07775
WSUWS0113
CJECj0363c
CJBBN148_0363c
CJJCJJ81176_0386
CJUC8J_0339
CJNICDCCJ07001_331
CJICJSA_0336
CJMCJM1_0341
CJSCJS3_0353
CJPA911_01760
CJEJN564_00346
CJEUN565_00396
CJENN755_00396
CJEIN135_00407
CJERH730_02375
CJVMTVDSCj20_0334(hemN1)
CJYQZ67_00365(hemN_1)
CJQUC78_0350(hemN_1)
CJLPJ17_01760
CJWPJ18_01760
CJRCJE0412
CJZM635_06120
CJXBN867_03370
CFFCFF8240_1666
CFTCFF04554_1668(hemN3)
CFVCFVI03293_1690(hemN3)
CFXCFV97608_1793(hemN3)
CFZCSG_18010
CAMPCFT03427_1618(hemN3)
CFPCR44_08220
CCVCCV52592_1538(hemN1)
CHACHAB381_0047
CCOCCC13826_1654(hemN1)
CCOCCCON33237_0218(hemN1)
CLACLA_1562(hemN3)
CLRUPTC16701_1531(hemN3)
CLMUPTC16712_1565(hemN3)
CLQUPTC4110_1538(hemN3)
CLNUPTC3659_1773(hemN3)
CLLCONCH_1507(hemN3)
CCOLBN865_00630
CCCG157_06825
CCQN149_0360
CCFYSQ_08070
CCYYSS_01590
CCOIYSU_07070
CCOFVC76_01910(hemN_1)
CCOOATE51_03488(hemN_3)
CAJCIG1485E_1563(hemN3)
CISCINS_1496(hemN3)
CVOCVOL_1544(hemN3)
CPELCPEL_1663(hemN3)
CAMRCAQ16704_1568(hemN3)
CSMCSUB8521_1773(hemN3)
CSFCSUB8523_1875(hemN3)
CGRACGRAC_0306(hemN1)
CURECUREO_1484(hemN3)
CHYOCHH_1647(hemN3)
CHVCHELV3228_1122(hemN1)
CSPFCSF_1445(hemN3)
CPINCPIN18020_0428(hemN1)
CLXCLAN_1392(hemN3)
CAVICAV_0263(hemN1)
CHWA2J15_007325
CAMZCVIC12175_1403(hemN3)
CAMYCSUIS_1438(hemN3)
COJCORN_1645(hemN3)
CUXCUP3940_0923(hemN3)
CRXCRECT_2254(hemN3)
CGEOCGEO_0161(hemN1)
CBLACBLAS_0115(hemN1)
CCORCCORG_0062(hemN1)
CARMCARM_1639(hemN3)
CMUCCMCT_0148(hemN1)
CSHOCSHOW_0152(hemN1)
CINFCINF_0176(hemN2)
CNVCNZW441b_1322(hemN3)
SDLSdel_0275
SBASulba_0291
SMULSMUL_0352
SHALSHALO_0317
SULSSdiek1_0311
SULJSJPD1_0315
SULTFA592_08655
AHSAHALO_2059(hemN3)
AMARAMRN_2162(hemN3)
ACAAACAN_2183(hemN3)
AMOLAMOL_1119(hemN1)
HEBRAEBR_1183(hemN1) AEBR_2109(hemN3)
SATSYN_01802
DTIDesti_1526
CBNCbC4_2070
CSQCSCA_0406
CDRKB9W14_16460
CSEPCP523_01720
OVAOBV_44160
LUAD4A81_05025
TEMJW646_14855
TGCL0P85_12815
SEDZJYG23_13785
MANAMAMMFC1_00559(hemN_1)
CCUCcur_00440 Ccur_11490
SHIShel_27820
ELEElen_0037 Elen_1710
EYYEGYY_01090(HemN)
EGDGS424_000175 GS424_009750
GPAGPA_12440
AEQAEQU_0025 AEQU_1016
AHATADCFC_01500 ADCFC_13290
DDTAAY81_01700
CBACJI75_00160 JI75_05040
RTSCE91St31_06080 CE91St31_32630
ATMANT_30420
OPROcepr_0292
TPHGFUT81_05315
KOLKole_0725
KPFIX53_07330
MPGTheba_1816
MINFMESINF_0463
DAPDacet_1135
GTLEP073_03565
FSIFlexsi_0573
IHOIgni_0340
PFMPyrfu_0016
PDLPyrde_0835
TTNTTX_0250(hemN)
ASCASAC_0728
ACIASE86_03530
CLGCalag_0776
 » show all
Reference
1  [PMID:28164386]
  Authors
Hein S, Klimmek O, Polly M, Kern M, Simon J
  Title
A class C radical S-adenosylmethionine methyltransferase synthesizes 8-methylmenaquinone.
  Journal
Mol Microbiol 104:449-462 (2017)
DOI:10.1111/mmi.13638
  Sequence
[wsu:WS0113] [son:SO_4520] [aeq:AEQU_0025]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.350
IUBMB Enzyme Nomenclature: 2.1.1.350
ExPASy - ENZYME nomenclature database: 2.1.1.350
BRENDA, the Enzyme Database: 2.1.1.350

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