KEGG   ENZYME: 2.1.1.362
Entry
EC 2.1.1.362                Enzyme                                 

Name
[histone H4]-N-methyl-L-lysine20 N-methyltransferase;
KMT5B (gene name);
KMT5C (gene name);
SUV420H1 (gene name);
SUV420H2 (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:[histone H4]-N6-methyl-L-lysine20 N6-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + a [histone H4]-N6-methyl-L-lysine20 = S-adenosyl-L-homocysteine + a [histone H4]-N6,N6-dimethyl-L-lysine20
Reaction(KEGG)
(other) R04866
Substrate
S-adenosyl-L-methionine [CPD:C00019];
[histone H4]-N6-methyl-L-lysine20
Product
S-adenosyl-L-homocysteine [CPD:C00021];
[histone H4]-N6,N6-dimethyl-L-lysine20
Comment
This entry describes a group of enzymes that catalyse a single methylation of monomethylated lysine20 of histone H4 (H4K20m1, generated by EC 2.1.1.361, [histone H4]-lysine20 N-methyltransferase), forming the dimethylated form. This modification is broadly distributed across the genome and is likely important for general chromatin-mediated processes. The double-methylated form of lysine20 in histone H4 is the most abundant methylation state of this residue and is found on ~80% of all histone H4 molecules. Full activity of the enzyme requires that the lysine at position 9 of histone H3 is trimethylated.
History
EC 2.1.1.362 created 1976 as EC 2.1.1.43, modified 1982, modified 1983, part transferred 2019 to EC 2.1.1.362
Pathway
ec00310  Lysine degradation
ec01100  Metabolic pathways
Orthology
K11429  [histone H4]-N-methyl-L-lysine20 N-methyltransferase
Genes
HSA: 51111(KMT5B) 84787(KMT5C)
PTR: 451378(KMT5B) 735868(KMT5C)
PPS: 100984020(KMT5C) 100995372(KMT5B)
GGO: 101139439(KMT5C) 101151252(KMT5B)
PON: 100450271(KMT5B) 100450936(KMT5C)
NLE: 100583977(KMT5B) 100599527(KMT5C)
MCC: 699963(KMT5C) 710481(KMT5B)
MCF: 102117388(KMT5B) 102129054(KMT5C)
CSAB: 103215291(KMT5B) 103235303(KMT5C)
CATY: 105577329(SUV420H1) 105582752(SUV420H2)
PANU: 101000900(KMT5B) 101018573(KMT5C) 116268663
RRO: 104664716(KMT5B) 104674764(KMT5C)
RBB: 108518702(KMT5B) 108542541(KMT5C)
TFN: 117081487(KMT5B) 117091737(KMT5C)
PTEH: 111521169(KMT5C) 111522408(KMT5B)
CJC: 100393036(KMT5C) 100400804(KMT5B)
SBQ: 101047990(SUV420H2) 101053072(SUV420H1)
MMUR: 105863301 105867495(KMT5B) 105877204(KMT5C)
MMU: 225888(Kmt5b) 232811(Kmt5c)
MCAL: 110285500(Kmt5b) 110298763(Kmt5c)
MPAH: 110334213(Kmt5b) 110336454(Kmt5c)
RNO: 308345(Kmt5c) 361688(Kmt5b)
MCOC: 116101555(Kmt5c) 116103298(Kmt5b)
MUN: 110547082(Kmt5b) 110561067(Kmt5c)
CGE: 100761878(Kmt5b) 100772952(Kmt5c)
PLEU: 114687711(Kmt5c) 114694607(Kmt5b)
NGI: 103744517(Kmt5b) 103744814(Kmt5c)
HGL: 101707567(Kmt5c) 101719039(Kmt5b)
CPOC: 100713625(Kmt5c) 100727663(Kmt5b)
CCAN: 109692079(Kmt5b) 109696272(Kmt5c)
OCU: 100340037(KMT5B)
OPI: 101530071(KMT5B) 101531050(KMT5C)
TUP: 102474475 102497986(KMT5B) 102499452(KMT5C)
CFA: 483690(KMT5B) 484295(KMT5C)
VVP: 112909339(KMT5C) 112924166(KMT5B)
VLG: 121485831(KMT5C) 121501552(KMT5B)
AML: 100468595(KMT5B) 100478438(KMT5C)
UMR: 103679527 103680304(KMT5C)
UAH: 113244004(KMT5B) 113247443(KMT5C)
ORO: 101374708(SUV420H2) 101375610(SUV420H1)
MPUF: 101671221(SUV420H2) 101680981(SUV420H1)
EJU: 114202071(KMT5C) 114220184(KMT5B)
MLX: 117997814(KMT5C) 118016151(KMT5B)
FCA: 101091322(KMT5C) 101094702(KMT5B)
PYU: 121023446(KMT5C) 121023792(KMT5B)
PBG: 122484079(KMT5B) 122493730(KMT5C)
PTG: 102953097(KMT5C) 102963329(KMT5B)
PPAD: 109246874(KMT5B) 109259888(KMT5C)
AJU: 106971172(KMT5B) 106980935(KMT5C)
HHV: 120233920(KMT5B) 120239642(KMT5C)
BTA: 519777(KMT5C) 767828(KMT5B)
BOM: 102268312(KMT5B) 102288327(KMT5C)
BIU: 109572897(KMT5C)
BBUB: 102390793(KMT5C) 102405866(KMT5B)
CHX: 102185214(KMT5C) 102185720(KMT5B)
OAS: 101111001 101121289(KMT5C) 101121812(KMT5B)
ODA: 120871894(KMT5C) 120874128(KMT5B)
CCAD: 122421123(KMT5C) 122430562(KMT5B)
SSC: 100521358(KMT5B) 110261054(KMT5C)
CFR: 102520054(KMT5B) 116666001(KMT5C)
CBAI: 105070355(SUV420H1) 105074363(SUV420H2)
CDK: 105098743(KMT5C) 105104405(KMT5B)
BACU: 102997321(KMT5C) 103007228(KMT5B)
LVE: 103090973(KMT5C) 103091082(KMT5B)
OOR: 101269348(SUV420H2) 101270232(SUV420H1)
DLE: 111181001(KMT5C) 111183648(KMT5B)
PCAD: 102982740(KMT5C) 102994432(KMT5B)
PSIU: 116743805(KMT5C) 116757549(KMT5B)
ECB: 100053438(KMT5B) 100055743(KMT5C)
EPZ: 103551272(KMT5B) 103562880(KMT5C)
EAI: 106840934(KMT5C) 106844276(KMT5B)
MYB: 102257692(KMT5B)
MYD: 102762755(KMT5B)
MMYO: 118655158(KMT5C) 118665198(KMT5B)
MLF: 102423838(KMT5B)
MNA: 107537430(KMT5B) 107541336(KMT5C)
PKL: 118706936(KMT5B) 118718049(KMT5C)
HAI: 109373782(KMT5C) 109389302(KMT5B)
DRO: 112313746(KMT5C) 112317051(KMT5B)
SHON: 118981365(KMT5C) 118998385(KMT5B)
AJM: 119041826(KMT5B) 119059966(KMT5C)
PDIC: 114499232(KMT5B) 114511636(KMT5C)
MMF: 118628825(KMT5B) 118639430(KMT5C)
RFQ: 117030117(KMT5B) 117035542(KMT5C)
PALE: 102887326(KMT5B) 102887846(KMT5C)
PGIG: 120584736(KMT5B) 120598318(KMT5C)
RAY: 107503474(KMT5B) 107515406(KMT5C)
MJV: 108388709(KMT5C) 108405830(KMT5B)
TOD: 119249888(KMT5B) 119250478(KMT5C)
LAV: 100671600(KMT5B) 100671832(KMT5C)
MDO: 100010281(KMT5B)
GAS: 123252988(KMT5B) 123254396(KMT5C)
SHR: 100917457(KMT5B)
PCW: 110195350(KMT5B) 110219937(KMT5C)
OAA: 100088070(KMT5B) 114814778(KMT5C)
GGA: 101748081(KMT5C) 425119(KMT5B)
PCOC: 116238984(KMT5B) 116239624(KMT5C)
MGP: 100547012(KMT5B) 116217397
CJO: 107307235(KMT5C) 107314523(KMT5B)
NMEL: 110391343(KMT5C) 110401096(KMT5B)
APLA: 101803754(KMT5B)
ACYG: 106038840(SUV420H1)
TGU: 100222904(KMT5B)
LSR: 110484490(KMT5B)
SCAN: 103824088(KMT5B)
PMOA: 120511379(KMT5B)
OTC: 121344840(KMT5B)
PRUF: 121360949(KMT5B)
GFR: 102041210(KMT5B)
FAB: 101805731(KMT5B)
PHI: 102102011(KMT5B) 102106962(KMT5C)
PMAJ: 107205911(KMT5B)
CCAE: 111930710(KMT5B)
CCW: 104692390(KMT5B)
ETL: 114064814(KMT5B)
FPG: 101921673(KMT5B)
FCH: 102046441(KMT5B)
CLV: 102091143(KMT5B)
EGZ: 104132445(SUV420H1)
NNI: 104017300(SUV420H1)
ACUN: 113481137(KMT5B)
PADL: 103919876(SUV420H1)
AAM: 106494851 106494860(KMT5B)
AROW: 112962693(KMT5B)
NPD: 112948832(KMT5B)
DNE: 112987944(KMT5B)
ASN: 102378990(KMT5C) 102379587(KMT5B)
AMJ: 102559156(KMT5C) 102568601(KMT5B)
CPOO: 109318193(KMT5B)
GGN: 109299233(KMT5B)
PSS: 102456135(KMT5B)
CMY: 102946000(KMT5B) 119564929(KMT5C)
CPIC: 101932218 101950551(KMT5B)
TST: 117877341(KMT5B) 117888425
CABI: 116837275(KMT5B) 116840038(KMT5C)
MRV: 120404891(KMT5B)
ACS: 100553817(kmt5b) 100562840(suv420h2)
PVT: 110074171(KMT5B) 110078503(KMT5C)
SUND: 121928073(KMT5B) 121934852(KMT5C)
PBI: 103053694(KMT5B) 103066601(KMT5C)
PMUR: 107282452(KMT5C) 107295878(KMT5B) 107296922
TSR: 106547726 106553569(SUV420H1)
PGUT: 117665172(KMT5B) 117669086(KMT5C)
VKO: 123021166(KMT5B) 123032305(KMT5C)
PMUA: 114599913(KMT5B) 114608036(KMT5C)
ZVI: 118088653(KMT5B) 118094429(KMT5C)
GJA: 107118429(KMT5C) 107119069(KMT5B)
XLA: 108697809(kmt5c.S) 444204(kmt5b.S) 495826(kmt5b.L) 779432(kmt5c.L)
XTR: 100038141(kmt5b) 100145748(kmt5c)
NPR: 108784118(KMT5B) 108795144
DRE: 569041(kmt5c) 572849(kmt5b)
IPU: 108264420(suv420h1) 108271342 108280634
PHYP: 113534430(kmt5b) 113536364
AMEX: 103025343 103035158(kmt5b)
TRU: 101069597 101076428(kmt5b)
LCO: 104937792(kmt5b)
NCC: 104958752(suv420h1)
ELY: 117254537(kmt5b)
PLEP: 121964343(kmt5b)
SLUC: 116067275(kmt5b)
ECRA: 117936389(kmt5b)
PFLV: 114554902(kmt5b)
GAT: 120809098(kmt5b)
PPUG: 119194941(kmt5b)
CUD: 121507226(kmt5b) 121525183
MZE: 101471827(kmt5b) 101477849
ONL: 100691614 100700783(kmt5b)
OAU: 116328928(kmt5c) 116334293(kmt5b)
OLA: 101156070(kmt5b) 101165555
OML: 112160800(kmt5b)
XMA: 102220708(kmt5b) 102236356
XCO: 114143669(kmt5b) 114159982
XHE: 116719207(kmt5b)
PRET: 103460097(kmt5b) 103468964
GAF: 122823807(kmt5b)
CVG: 107085059(kmt5b) 107096940
CTUL: 119773604(kmt5b)
NFU: 107378497 107381531(kmt5b)
KMR: 108237783(kmt5c) 108250521(kmt5b)
ALIM: 106532050(suv420h1)
AOCE: 111578621(kmt5b)
CSEM: 103379016(kmt5b)
POV: 109634192 109645819(kmt5b)
SSEN: 122772416(kmt5b)
HHIP: 117779341(kmt5b)
LCF: 108894245(kmt5b)
SDU: 111217719 111224033(kmt5b)
SLAL: 111656626(kmt5b) 111660544
XGL: 120784195(kmt5c) 120803744(kmt5b)
HCQ: 109514373(kmt5b) 109527740
BPEC: 110168042(kmt5b)
MALB: 109951248(kmt5b) 109963137
ELS: 105023468 105029585(kmt5b)
SFM: 108934513(kmt5b) 108941728(kmt5c) 108942441
AANG: 118215224(kmt5b) 118228085
LOC: 102687526(kmt5b)
LCM: 102357247(KMT5C) 102357304(KMT5B)
CMK: 103174937(kmt5b) 103189530
RTP: 109912567(kmt5b) 109932362
BFO: 118413910
BBEL: 109482963
CIN: 100186975
SCLV: 120342400
SPU: 583266
APLC: 110975028
SKO: 100372808
DME: Dmel_CG13363(Hmt4-20)
DER: 6555511
DSE: 6615887
DSI: Dsimw501_GD16466(Dsim_GD16466)
DSR: 110178198
DPE: 6600100
DMN: 108164669
DWI: 6644812
DGR: 6569283
DAZ: 108618025
DNV: 108655611
DHE: 111596240
CCAT: 101453125
BOD: 106621763
MDE: 101897840
SCAC: 106085721
LCQ: 111679605
ACOZ: 120956120
CPII: 120422523
AME: 411906
ACER: 108002910
BIM: 100742553
BBIF: 117212202
BVK: 117236757
BVAN: 117155624
BTER: 100644080
BPYO: 122577827
CCAL: 108624513
OBB: 114881313
MGEN: 117229524
NMEA: 116430221
CGIG: 122397843
SOC: 105195127
MPHA: 105830481
AEC: 105144221
ACEP: 105627042
PBAR: 105427527
VEM: 105568890
HST: 105183369
DQU: 106749629
CFO: 105255356
FEX: 115246007
LHU: 105672756
PGC: 109853314
OBO: 105280691
PCF: 106793217
PFUC: 122523891
VPS: 122629202
CSOL: 105362524
CGLO: 123262315
FAS: 105263324
DAM: 107045329
AGIF: 122848923
CCIN: 107272637
TCA: 663776
DPA: 109533054
ATD: 109597721
AGB: 108911996
LDC: 111506674
NVL: 108569827
APLN: 108741460
PPYR: 116169470
OTU: 111417657
BMOR: 101735557
BMAN: 114248506
MSEX: 115445850
BANY: 112053522
PMAC: 106708893
PPOT: 106100398
PXU: 106123472
PRAP: 110992850
ZCE: 119833224
HAW: 110372275
TNL: 113508300
PXY: 105397967
RMD: 113549136
BTAB: 109030108
CLEC: 106669134
HHAL: 106691237
NLU: 111058049
FOC: 113204709
ZNE: 110835364
CSEC: 111870522
DMK: 116919653
HAME: 121865412
HAZT: 108673820
EAF: 111714029
DSV: 119450535
RSAN: 119383577
RMP: 119170614
VDE: 111253391
VJA: 111268338
TUT: 107371540
DPTE: 113794752
CSCU: 111636078
PTEP: 107455782
SDM: 118193236
CEL: CELE_C32D5.5(set-4)
CBR: CBG_02629(Cbr-set-4)
PCAN: 112560425
BGT: 106072944
GAE: 121380962
CRG: 105319029
MYI: 110457084
PMAX: 117335663
OBI: 106875752
OSN: 115211617
EGL: EGR_03818
NVE: 5514661
EPA: 110245633
ATEN: 116291058
ADF: 107353716
AMIL: 114956880
PDAM: 113667740
SPIS: 111325445
DGT: 114533764
HMG: 100207998
QSU: 112005838
NCR: NCU08551
NTE: NEUTE1DRAFT82859(NEUTE1DRAFT_82859)
MGR: MGG_07393
SSCK: SPSK_07036
NHE: NECHADRAFT_12117(SDG2118)
MAW: MAC_03332
MAJ: MAA_07113
CMT: CCM_08113
MBE: MBM_09131
ANI: AN6147.2
ANG: ANI_1_476104(An12g03880)
ABE: ARB_04917
TVE: TRV_05893
PTE: PTT_18535
CNE: CNC03710
CNB: CNBC3500
TASA: A1Q1_07214
ABP: AGABI1DRAFT119579(AGABI1DRAFT_119579)
ABV: AGABI2DRAFT185465(AGABI2DRAFT_185465)
MGL: MGL_1066
MRT: MRET_3089
 » show all
Reference
1  [PMID:15145825]
  Authors
Schotta G, Lachner M, Sarma K, Ebert A, Sengupta R, Reuter G, Reinberg D, Jenuwein T
  Title
A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin.
  Journal
Genes Dev 18:1251-62 (2004)
DOI:10.1101/gad.300704
  Sequence
Reference
2  [PMID:23345616]
  Authors
Jorgensen S, Schotta G, Sorensen CS
  Title
Histone H4 lysine 20 methylation: key player in epigenetic regulation of genomic  integrity.
  Journal
Nucleic Acids Res 41:2797-806 (2013)
DOI:10.1093/nar/gkt012
Reference
3  [PMID:24396869]
  Authors
Wu H, Siarheyeva A, Zeng H, Lam R, Dong A, Wu XH, Li Y, Schapira M, Vedadi M, Min J
  Title
Crystal structures of the human histone H4K20 methyltransferases SUV420H1 and SUV420H2.
  Journal
FEBS Lett 587:3859-68 (2013)
DOI:10.1016/j.febslet.2013.10.020
  Sequence
[hsa:51111 84787]
Reference
4  [PMID:24049080]
  Authors
Southall SM, Cronin NB, Wilson JR
  Title
A novel route to product specificity in the Suv4-20 family of histone H4K20 methyltransferases.
  Journal
Nucleic Acids Res 42:661-71 (2014)
DOI:10.1093/nar/gkt776
  Sequence
Reference
5  [PMID:27105552]
  Authors
Weirich S, Kudithipudi S, Jeltsch A
  Title
Specificity of the SUV4-20H1 and SUV4-20H2 protein lysine methyltransferases and  methylation of novel substrates.
  Journal
J Mol Biol 428:2344-2358 (2016)
DOI:10.1016/j.jmb.2016.04.015
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.362
IUBMB Enzyme Nomenclature: 2.1.1.362
ExPASy - ENZYME nomenclature database: 2.1.1.362
BRENDA, the Enzyme Database: 2.1.1.362

DBGET integrated database retrieval system