KEGG   ENZYME: 2.1.1.363
Entry
EC 2.1.1.363                Enzyme                                 

Name
pre-sodorifen synthase;
sodC (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
(2E,6E)-farnesyl diphosphate 10-C-methyltransferase (cyclyzing, pre-sodorifen diphosphate producing)
Reaction(IUBMB)
S-adenosyl-L-methionine + (2E,6E)-farnesyl diphosphate = S-adenosyl-L-homocysteine + pre-sodorifen diphosphate [RN:R12524]
Reaction(KEGG)
R12524
Substrate
S-adenosyl-L-methionine [CPD:C00019];
(2E,6E)-farnesyl diphosphate [CPD:C00448]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
pre-sodorifen diphosphate [CPD:C22209]
Comment
The enzyme, characterized from the bacterium Serratia plymuthica, participates in biosynthesis of sodorifen.
History
EC 2.1.1.363 created 2019
Orthology
K23973  pre-sodorifen synthase
Genes
SRR: SerAS9_2200
SRL: SOD_c20760
SRY: M621_11400
SPLY: Q5A_011540(rebM)
SRS: SerAS12_2200
SRA: SerAS13_2201
SERF: L085_13540
Reference
1  [PMID:27231241]
  Authors
Domik D, Magnus N, Piechulla B
  Title
Analysis of a new cluster of genes involved in the synthesis of the unique volatile organic compound sodorifen of Serratia plymuthica 4Rx13.
  Journal
FEMS Microbiol Lett 363:fnw139 (2016)
DOI:10.1093/femsle/fnw139
  Sequence
Reference
2  [PMID:28408760]
  Authors
Schmidt R, Jager V, Zuhlke D, Wolff C, Bernhardt J, Cankar K, Beekwilder J, Ijcken WV, Sleutels F, Boer W, Riedel K, Garbeva P
  Title
Fungal volatile compounds induce production of the secondary metabolite Sodorifen in Serratia plymuthica PRI-2C.
  Journal
Sci Rep 7:862 (2017)
DOI:10.1038/s41598-017-00893-3
  Sequence
[sply:Q5A_011540]
Reference
3  [PMID:30133268]
  Authors
von Reuss S, Domik D, Lemfack MC, Magnus N, Kai M, Weise T, Piechulla B
  Title
Sodorifen Biosynthesis in the Rhizobacterium Serratia plymuthica Involves Methylation and Cyclization of MEP-Derived Farnesyl Pyrophosphate by a SAM-Dependent C-Methyltransferase.
  Journal
J Am Chem Soc 140:11855-11862 (2018)
DOI:10.1021/jacs.8b08510
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.363
IUBMB Enzyme Nomenclature: 2.1.1.363
ExPASy - ENZYME nomenclature database: 2.1.1.363
BRENDA, the Enzyme Database: 2.1.1.363

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