KEGG   ENZYME: 2.1.1.364
Entry
EC 2.1.1.364                Enzyme                                 
Name
[histone H3]-lysine4 N-methyltransferase;
KMT7 (gene name);
SETD7 (gene name);
SET7/9 (gene name);
KIAA1717 (gene name);
KMT2A (gene name);
KMT2B (gene name);
KMT2C (gene name);
KMT2D (gene name);
KMT2F (gene name);
KMT2G (gene name);
MLL1 (gene name);
MLL2 (gene name);
MLL3 (gene name);
MLL4 (gene name);
SETD1A (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:[histone H3]-L-lysine4 N6-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + a [histone H3]-L-lysine4 = S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine4 [RN:R03875]
Reaction(KEGG)
R03875
Substrate
S-adenosyl-L-methionine [CPD:C00019];
[histone H3]-L-lysine4
Product
S-adenosyl-L-homocysteine [CPD:C00021];
[histone H3]-N6-methyl-L-lysine4
Comment
This entry describes enzymes that catalyse a single methylation of the L-lysine4 residue of histone H3 (H3K4), generating a monomethylated form. This modifications influence the binding of chromatin-associated proteins and result in gene activation or suppression. Some enzymes that catalyse this reaction continue to generate a dimethyated form, these enzymes are classified under EC 2.1.1.370, [histone H3]-lysine4 N-dimethyltransferase. Other enzymes continue to catalyse a third methylation, those are classified under EC 2.1.1.354, [histone H3]-lysine4 N-trimethyltransferase.
History
EC 2.1.1.364 created 1976 as EC 2.1.1.43, modified 1982, modified 1983, part transferred 2020 to EC 2.1.1.354
Pathway
ec00310  Lysine degradation
ec01100  Metabolic pathways
Orthology
K11431  [histone H3]-lysine4 N-methyltransferase
Genes
HSA80854(SETD7)
PTR737682(SETD7)
PPS100981554(SETD7)
GGO101136477(SETD7)
PON100449956(SETD7)
NLE100602353(SETD7)
MCC700426(SETD7)
MCF102140141(SETD7)
MTHB126954611
CSAB103236281(SETD7)
CATY105580796(SETD7)
PANU101000127(SETD7)
TGE112624982(SETD7)
RRO104654337(SETD7)
RBB108522758(SETD7)
TFN117085930(SETD7)
PTEH111551894(SETD7)
CJC100414241(SETD7)
SBQ101047679(SETD7)
CSYR103268843(SETD7)
MMUR105872354(SETD7)
LCAT123638556(SETD7)
OGA100945363(SETD7)
MMU73251(Setd7)
MCAL110291535(Setd7)
MPAH110320364(Setd7)
RNO689954(Setd7)
MCOC116094448(Setd7)
MUN110545142(Setd7)
CGE100767175(Setd7)
MAUA101833171(Setd7)
PLEU114695856(Setd7)
MORG121452703(Setd7)
MFOT126499295
AAMP119826811(Setd7)
NGI103742371(Setd7)
HGL101715832(Setd7)
CPOC100717030(Setd7)
CCAN109691464(Setd7)
DORD105995681(Setd7)
DSP122127063(Setd7)
NCAR124994431
OCU100347837(SETD7) 103347079
OPI101525115(SETD7)
TUP102470517(SETD7)
CFA476079(SETD7)
CLUD112669303(SETD7)
VVP112934919(SETD7)
VLG121493076(SETD7)
AML100472168(SETD7)
UMR103658074(SETD7)
UAH113255688(SETD7)
UAR123793270(SETD7)
ELK111149217
LLV125093407
MPUF101689867(SETD7)
ORO101368440(SETD7)
EJU114208204(SETD7)
ZCA113924298(SETD7)
MLX118022305(SETD7)
NSU110571226(SETD7)
FCA101091191(SETD7)
PYU121029498(SETD7)
PBG122497157(SETD7)
LRUF124520384
PTG102953445(SETD7)
PPAD109249505(SETD7)
AJU106976180(SETD7)
HHV120243120(SETD7)
BTA515928(SETD7)
BOM102281809(SETD7)
BIU109571070(SETD7)
BBUB102394548(SETD7)
CHX102191824(SETD7)
OAS101115990(SETD7) 114116628
ODA120870919(SETD7)
CCAD122452420(SETD7)
SSC100626704(SETD7)
CFR102506865(SETD7)
CBAI105068694(SETD7)
CDK105087090(SETD7)
VPC102524998(SETD7)
BACU103002269(SETD7)
LVE103071598(SETD7)
OOR101282114(SETD7)
DLE111179118(SETD7)
PCAD102986025(SETD7)
PSIU116754191(SETD7)
ECB100063257(SETD7)
EPZ103551020(SETD7)
EAI106838612(SETD7)
MYB102246482(SETD7)
MYD102760166(SETD7)
MMYO118658870(SETD7)
MLF102420812(SETD7)
MNA107534917(SETD7)
PKL118711609(SETD7)
HAI109394201(SETD7)
DRO112312687(SETD7)
SHON118995450(SETD7)
AJM119035000(SETD7)
PDIC114502804(SETD7)
PHAS123813703(SETD7)
MMF118616067(SETD7)
RFQ117037595(SETD7)
PALE102890289(SETD7)
PGIG120613215(SETD7)
PVP105301564(SETD7)
RAY107515339(SETD7)
MJV108408880(SETD7)
TOD119233342(SETD7)
SARA101549012(SETD7)
LAV100653839(SETD7)
TMU101344981
DNM101421633(SETD7)
MDO100027436(SETD7)
GAS123252357(SETD7)
SHR100929261(SETD7)
PCW110194897(SETD7)
OAA100081674(SETD7)
GGA422443(SETD7)
PCOC116226098(SETD7)
MGP100541967(SETD7)
CJO107313101(SETD7)
NMEL110397503(SETD7)
APLA101800254(SETD7)
ACYG106040965(SETD7)
AFUL116488501(SETD7)
TGU100219994(SETD7)
LSR110468513(SETD7)
SCAN103822533(SETD7)
PMOA120496051(SETD7)
OTC121339860(SETD7)
PRUF121354681(SETD7)
GFR102040515(SETD7)
FAB101807375(SETD7)
PHI102106186(SETD7)
PMAJ107203381(SETD7)
CCAE111928908(SETD7)
CCW104697344(SETD7)
CBRC103614500(SETD7)
ETL114058383(SETD7)
ZAB102060643(SETD7)
ACHL103811991(SETD7)
FPG101917301(SETD7)
FCH102053523(SETD7)
CLV102087865(SETD7)
EGZ104134673(SETD7)
NNI104015980(SETD7)
PLET104615039(SETD7)
PCRI104025880(SETD7)
PCAO104043135(SETD7)
ACUN113479515(SETD7)
TALA104355912(SETD7)
PADL103920974(SETD7)
AFOR103908041(SETD7)
ACHC115340127(SETD7)
HALD104311811(SETD7)
CCRI104156546(SETD7)
CSTI104558150(SETD7)
EHS104506793(SETD7)
CMAC104482055(SETD7)
MUI104534099(SETD7)
FGA104071165(SETD7)
GSTE104261127(SETD7)
LDI104355035(SETD7)
MNB103777339
OHA104336712(SETD7)
NNT104399857(SETD7)
DPUB104296893(SETD7)
PGUU104466135(SETD7)
ACAR104518406(SETD7)
AVIT104277500(SETD7)
CVF104292760(SETD7)
CUCA104066446(SETD7)
AAM106491857(SETD7)
AROW112965423(SETD7)
NPD112950140(SETD7)
TGT104572216(SETD7)
DNE112986730(SETD7)
SCAM104153396(SETD7)
ASN102374512(SETD7)
AMJ102568755(SETD7)
CPOO109309619(SETD7)
GGN109300943(SETD7)
PSS102461649(SETD7)
CMY102943205(SETD7)
CPIC101930966(SETD7)
TST117878085(SETD7)
CABI116838884(SETD7)
MRV120406434(SETD7)
ACS100551939(setd7)
PVT110073660(SETD7)
SUND121931253(SETD7)
PBI103056555(SETD7)
PMUR107293153(SETD7)
CTIG120308391(SETD7)
TSR106552387(SETD7)
PGUT117654595(SETD7)
VKO123023767(SETD7)
PMUA114604135(SETD7)
ZVI118083714(SETD7)
GJA107110772(SETD7)
STOW125439932(SETD7)
XLA108699643(setd7.L)
XTR613102(setd7)
NPR108787523(SETD7)
RTEM120919160(SETD7)
BBUF120989985(SETD7)
BGAR122943234(SETD7)
DRE436729(setd7)
SRX107756477(setd7)
SANH107676520 107680671
SGH107550878(setd7)
CCAR109102488 109102490
CAUA113091145 113114054
PPRM120461020(setd7)
MAMB125258654(setd7)
IPU108268872(setd7)
PHYP113542848(setd7)
SMEO124386009(setd7)
TFD113646026(setd7)
AMEX103021629(setd7)
EEE113581529(setd7)
TRU101062805(setd7)
TNGGSTEN00006924G001
LCO104921509(setd7)
ELY117261475(setd7)
EFO125894079(setd7)
PLEP121948402(setd7)
SLUC116064266(setd7)
ECRA117951530(setd7)
ESP116696640(setd7)
PFLV114562736(setd7)
GAT120817395(setd7)
PPUG119210080(setd7)
MSAM119888249(setd7)
CUD121506619(setd7)
ALAT119008014(setd7)
MZE101473334(setd7)
ONL100690490(setd7)
OAU116315791(setd7)
OLA101168630(setd7)
OML112137845(setd7)
XMA102221628 111606868
XCO114138924 114138925 114138929 114139661
XHE116714746(setd7)
PRET103470998(setd7)
PFOR103131843(setd7)
PLAI106940589(setd7)
PMEI106911657
GAF122836555(setd7)
CVG107098607(setd7)
CTUL119791848(setd7)
GMU124860286(setd7)
NFU107387053(setd7)
KMR108240006(setd7)
ALIM106533608(setd7)
AOCE111573617(setd7)
MCEP125008622(setd7)
CSEM103391447(setd7)
POV109627395(setd7)
SSEN122778922(setd7)
HHIP117769700(setd7)
HSP118111964(setd7)
LCF108875518
SDU111230382(setd7)
SLAL111663588(setd7)
XGL120784942
HCQ109529075(setd7)
BPEC110173499(setd7)
MALB109966416(setd7)
SASA106604693(setd7)
STRU115172267(setd7)
OTW112220930(setd7)
OMY110488800(setd7)
OGO123993393(setd7)
ONE115130681(setd7)
SALP111965713(setd7)
SNH120048113(setd7)
CCLU121542657(setd7)
ELS105029145(setd7)
SFM108930830(setd7)
PKI111847325(setd7)
AANG118232021(setd7)
LOC102697545(setd7)
PSPA121330524(setd7)
ARUT117408888(setd7)
LCM102350182(SETD7)
CMK103181297(setd7)
RTP109919566(setd7)
BFO118404594
BBEL109465143
EAF111695370 111696847 111696982 111698467 111699076 111699086 111699142 111699255 111699286 111702283 111703155 111704142 111707436 111707507 111708353 111713289 111713722 111715041 111716513 111716541 111716720 111716793 111717795 111718349
LSM121115289 121115290 121115291 121115870 121116800 121117501 121119313 121119989 121121197 121121404 121121906 121122188 121123424 121124562 121125595 121126320 121126321 121128528
HMG101238060
TADTRIADDRAFT_26073
AQU105311972
MBRMONBRDRAFT_17496
DDIDDB_G0288227
DPPDICPUDRAFT_154738
DFADFA_11520
ACANACA1_399220
SMINv1.2.013565.t1(symbB.v1.2.013565.t1)
EHXEMIHUDRAFT_196287
GTTGUITHDRAFT_99101
 » show all
Reference
1  [PMID:11779497]
  Authors
Wang H, Cao R, Xia L, Erdjument-Bromage H, Borchers C, Tempst P, Zhang Y
  Title
Purification and functional characterization of a histone H3-lysine 4-specific methyltransferase.
  Journal
Mol Cell 8:1207-17 (2001)
DOI:10.1016/s1097-2765(01)00405-1
  Sequence
[hsa:80854] [mmu:73251]
Reference
2  [PMID:11850410]
  Authors
Nishioka K, Chuikov S, Sarma K, Erdjument-Bromage H, Allis CD, Tempst P, Reinberg D
  Title
Set9, a novel histone H3 methyltransferase that facilitates transcription by precluding histone tail modifications required for heterochromatin formation.
  Journal
Genes Dev 16:479-89 (2002)
DOI:10.1101/gad.967202
  Sequence
[hsa:80854]
Reference
3  [PMID:12372304]
  Authors
Wilson JR, Jing C, Walker PA, Martin SR, Howell SA, Blackburn GM, Gamblin SJ, Xiao B
  Title
Crystal structure and functional analysis of the histone methyltransferase SET7/9.
  Journal
Cell 111:105-15 (2002)
DOI:10.1016/s0092-8674(02)00964-9
  Sequence
[hsa:80854]
Reference
4  [PMID:12540855]
  Authors
Xiao B, Jing C, Wilson JR, Walker PA, Vasisht N, Kelly G, Howell S, Taylor IA, Blackburn GM, Gamblin SJ
  Title
Structure and catalytic mechanism of the human histone methyltransferase SET7/9.
  Journal
Nature 421:652-6 (2003)
DOI:10.1038/nature01378
  Sequence
[hsa:80854]
Reference
5  [PMID:16433545]
  Authors
Hu P, Zhang Y
  Title
Catalytic mechanism and product specificity of the histone lysine methyltransferase SET7/9: an ab initio QM/MM-FE study with multiple initial structures.
  Journal
J Am Chem Soc 128:1272-8 (2006)
DOI:10.1021/ja056153+
Reference
6  [PMID:19556245]
  Authors
Patel A, Dharmarajan V, Vought VE, Cosgrove MS
  Title
On the mechanism of multiple lysine methylation by the human mixed lineage leukemia protein-1 (MLL1) core complex.
  Journal
J Biol Chem 284:24242-56 (2009)
DOI:10.1074/jbc.M109.014498
Reference
7  [PMID:25561738]
  Authors
Shinsky SA, Monteith KE, Viggiano S, Cosgrove MS.
  Title
Biochemical reconstitution and phylogenetic comparison of human SET1 family core complexes involved in histone methylation.
  Journal
J Biol Chem 290:6361-75 (2015)
DOI:10.1074/jbc.M114.627646
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.364
IUBMB Enzyme Nomenclature: 2.1.1.364
ExPASy - ENZYME nomenclature database: 2.1.1.364
BRENDA, the Enzyme Database: 2.1.1.364

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