KEGG   ENZYME: 2.1.1.367
Entry
EC 2.1.1.367                Enzyme                                 
Name
[histone H3]-lysine9 N-methyltransferase;
PRDM3 (gene name);
PRDM16 (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:[histone H3]-L-lysine9 N6-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + a [histone H3]-L-lysine9 = S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine9
Reaction(KEGG)
(other) R03875
Substrate
S-adenosyl-L-methionine [CPD:C00019];
[histone H3]-L-lysine9
Product
S-adenosyl-L-homocysteine [CPD:C00021];
[histone H3]-N6-methyl-L-lysine9
Comment
This entry describes several enzymes that methylate the L-lysine-9 residue of histone H3 (H3K9) only once, generating a monomethylated form. These modifications influence the binding of chromatin-associated proteins. cf. EC 2.1.1.368, [histone H3]-lysine9 N-dimethyltransferase, EC 2.1.1.355, [histone H3]-lysine9 N-trimethyltransferase, and EC 2.1.1.366, [histone H3]-N6,N6-dimethyl-lysine9 N-methyltransferase.
History
EC 2.1.1.367 created 2020
Pathway
ec00310  Lysine degradation
ec01100  Metabolic pathways
Orthology
K04462  [histone H3]-lysine9 N-methyltransferase (ecotropic virus integration site 1 protein)
K22410  [histone H3]-lysine9 N-methyltransferase
Genes
HSA2122(MECOM) 63976(PRDM16)
PTR457227(PRDM16) 460837(MECOM)
PPS100974472(PRDM16) 100994741(MECOM)
GGO101137489(PRDM16) 101143561(MECOM)
PON100431606(MECOM) 100435350(PRDM16)
NLE100591579(MECOM) 100592850(PRDM16)
MCC100430112(PRDM16) 698603(MECOM)
MCF102132224(PRDM16) 102139452(MECOM)
MTHB126948321 126962306
CSAB103221284(MECOM) 103225739(PRDM16)
CATY105586041(MECOM) 105594463(PRDM16)
PANU101001831(MECOM) 101003094(PRDM16)
TGE112618964(MECOM) 112631947(PRDM16)
RRO104661346(PRDM16) 104677766(MECOM)
RBB108516319(MECOM) 108535988(PRDM16)
TFN117074583 117083696(MECOM)
PTEH111543501(MECOM) 111544592(PRDM16)
CJC100403987(MECOM)
SBQ101028887(PRDM16) 101051357(MECOM)
CSYR103249480(PRDM16) 103274037(MECOM)
MMUR105877367(PRDM16) 105879179(MECOM)
LCAT123630238(MECOM) 123635985(PRDM16)
OGA100940836(PRDM16) 100951161(MECOM)
MMU14013(Mecom) 70673(Prdm16)
MCAL110290693(Mecom) 110292493(Prdm16)
MPAH110319807(Mecom) 110323056(Prdm16)
RNO100366024(Prdm16) 294924(Mecom)
MCOC116095046(Mecom) 116097116(Prdm16)
MUN110545680(Mecom) 110559746(Prdm16)
CGE100762301(Prdm16) 100768628(Mecom)
MAUA101840940(Prdm16) 101844454(Mecom)
PLEU114695325(Mecom) 114708286(Prdm16)
MORG121443532 121448261(Prdm16) 121452670(Mecom)
MFOT126499290 126508256
AAMP119817157(Prdm16) 119826790(Mecom)
NGI103731713(Mecom) 103749783(Prdm16)
HGL101718355(Mecom) 101721685(Prdm16)
CPOC100714489(Prdm16) 100727638(Mecom)
CCAN109682858(Prdm16) 109700158(Mecom)
DORD105985625(Mecom) 105998434(Prdm16)
DSP122107242(Mecom) 122127313(Prdm16)
NCAR124977451 124992923
OCU100343228(MECOM) 108176203(PRDM16)
OPI101517451(MECOM) 101533206(PRDM16)
TUP102488385(MECOM) 102500375(PRDM16)
CFA479582(PRDM16) 488148(MECOM)
CLUD112645928(MECOM) 112646959(PRDM16)
VVP112924714(PRDM16) 112926657(MECOM)
VLG121477369(MECOM) 121499519(PRDM16)
AML100481590(PRDM16) 100482997(MECOM)
UMR103678456(PRDM16) 103680825(MECOM)
UAH113255350(MECOM) 113270599(PRDM16)
UAR123786368(MECOM) 123796137(PRDM16)
ELK111148284 111154771
LLV125098367 125100039
MPUF101683225(PRDM16) 101684534(MECOM)
ORO101368160(PRDM16) 101384287(MECOM)
EJU114209093(MECOM) 114213223(PRDM16)
ZCA113912626(PRDM16) 113916913(MECOM)
MLX118006026(MECOM) 118019654(PRDM16)
NSU110575344 110591643(MECOM) 123323672
FCA101088775(MECOM) 101090880(PRDM16)
PYU121019580(PRDM16) 121033966(MECOM)
PBG122479836(PRDM16) 122491755(MECOM)
LRUF124515395 124526640
PTG102952036(PRDM16) 102955865(MECOM)
PPAD109262104(MECOM) 109273982(PRDM16)
AJU106984161(PRDM16) 106990036(MECOM)
HHV120234625(MECOM) 120242521(PRDM16)
BTA100137803(PRDM16) 532209(MECOM)
BOM102282884(PRDM16) 102288339(MECOM)
BIU109558403(MECOM) 109570163(PRDM16)
BBUB102403098(PRDM16) 102404893(MECOM)
CHX102182261(MECOM) 102183895(PRDM16)
OAS101120004(PRDM16) 101121055(MECOM)
ODA120869247(MECOM) 120880661(PRDM16)
CCAD122444956(MECOM) 122451981(PRDM16)
SSC100518275(MECOM) 100624476(PRDM16)
CFR102519252(MECOM) 106730153(PRDM16)
CBAI105066680(MECOM) 105071187(PRDM16)
CDK105085966(MECOM) 105104887(PRDM16)
VPC102545172(MECOM) 102546104(PRDM16)
BACU102999753(PRDM16) 103008158(MECOM)
LVE103072534(PRDM16) 103078502(MECOM)
OOR101285697(PRDM16) 101289893(MECOM)
DLE111174247(MECOM) 111187060(PRDM16)
PCAD102976185(MECOM) 102993206(PRDM16)
PSIU116742567(PRDM16) 116752976(MECOM)
ECB100057450(MECOM) 100060844(PRDM16)
EPZ103548757(PRDM16) 103558280(MECOM)
EAI106834666(MECOM) 106844756(PRDM16)
MYB102249519(MECOM) 102257120(PRDM16)
MYD102766636(MECOM)
MMYO118676683(MECOM) 118677054(PRDM16)
MLF102424289(MECOM)
MNA107537489(PRDM16) 107539280(MECOM)
PKL118723215(MECOM) 118731969(PRDM16)
HAI109383470(MECOM) 109391194(PRDM16)
DRO112299628(PRDM16) 112307202(MECOM)
SHON118987426(MECOM) 118998163(PRDM16)
AJM119043606(MECOM) 119050552(PRDM16)
PDIC114490488(MECOM) 114496387(PRDM16)
PHAS123826822(MECOM) 123831994(PRDM16)
MMF118617285(MECOM) 118626477(PRDM16)
RFQ117027275(PRDM16) 117037203(MECOM)
PALE102878481(MECOM) 102890420(PRDM16)
PGIG120585894(PRDM16) 120598778(MECOM)
PVP105299204(PRDM16) 105305980(MECOM)
RAY107510664(PRDM16) 107512516(MECOM)
MJV108402581(PRDM16) 108404714
TOD119235959(PRDM16) 119257641(MECOM)
SARA101539582(PRDM16) 101556018(MECOM)
LAV100664202(MECOM) 100673967(PRDM16)
TMU101347783 101350664
DNM101438899(MECOM) 101445231(PRDM16)
MDO100012479(MECOM) 100619344(PRDM16)
GAS123240938(PRDM16) 123242827(MECOM)
SHR100915676(PRDM16) 100928711(MECOM)
PCW110200307(PRDM16) 110203730(MECOM)
OAA100084365(MECOM) 100681161(PRDM16)
GGA419388(PRDM16) 424997(MECOM)
PCOC116242715(PRDM16) 116243427(MECOM)
MGP100541414(MECOM) 100549442(PRDM16)
CJO107318330(MECOM) 107323435(PRDM16)
NMEL110398567(MECOM) 110408633(PRDM16)
APLA101793295(MECOM) 101798424(PRDM16)
ACYG106031974(MECOM) 106044631(PRDM16)
AFUL116492753(MECOM) 116497539(PRDM16)
TGU100229260(PRDM16) 100230662(MECOM)
LSR110472547 110480337(MECOM)
SCAN103815279(MECOM) 103820814(PRDM16)
PMOA120504251(MECOM) 120511129(PRDM16)
OTC121336547(MECOM) 121344079(PRDM16)
PRUF121353723(MECOM) 121358423(PRDM16)
GFR102034533(PRDM16) 102039580(MECOM)
FAB101806754(MECOM) 101819648(PRDM16)
PHI102102577(PRDM16) 102104707(MECOM)
PMAJ107208729(MECOM) 107213569(PRDM16)
CCAE111933313(MECOM) 111938476(PRDM16)
CCW104688053(MECOM) 104693385(PRDM16)
CBRC103622273(PRDM16) 103625072(MECOM)
ETL114068695(PRDM16)
ZAB102063184(MECOM) 102068102(PRDM16)
ACHL103804100(MECOM)
FPG101922605(PRDM16) 101924233(MECOM)
FCH102055141(MECOM) 102058719(PRDM16)
CLV102089407(MECOM) 102090083(PRDM16)
EGZ104129303(PRDM16) 104132485(MECOM)
NNI104008933(PRDM16) 104022029(MECOM)
PLET104623847(MECOM) 104624450(PRDM16)
PCRI104023981(PRDM16)
PCAO104047239(PRDM16) 104051221
ACUN113483543(MECOM) 113487928(PRDM16)
TALA104362631(PRDM16) 104365039(MECOM)
PADL103913951(PRDM16) 103924951(MECOM)
AFOR103894696(PRDM16) 103899975(MECOM)
ACHC115343079(PRDM16) 115347508(MECOM)
HALD104317780(PRDM16) 104321016(MECOM)
CCRI104157910(PRDM16) 104158944(MECOM)
CSTI104551300(MECOM) 104563014(PRDM16)
EHS104506195(MECOM) 104506988(PRDM16)
CMAC104482501(MECOM) 104483238(PRDM16)
MUI104534696(MECOM)
FGA104079897(MECOM) 104082135(PRDM16)
GSTE104256618(PRDM16) 104256885(MECOM)
LDI104343033(MECOM) 104344633(PRDM16)
MNB103776675(MECOM) 103779525(PRDM16)
OHA104327822(PRDM16) 104334394(MECOM)
NNT104402745(MECOM) 104409965(PRDM16)
DPUB104301922 104309927(PRDM16)
PGUU104464978(PRDM16) 104467130(MECOM)
ACAR104520704(MECOM) 104523487(PRDM16)
AVIT104271549(MECOM) 104277512(PRDM16)
CVF104285912(MECOM) 104290516(PRDM16)
CUCA104059840(PRDM16) 104062508
AAM106485721(PRDM16) 106486591
AROW112963835(MECOM) 112975487(PRDM16)
NPD112952459(MECOM) 112957475(PRDM16)
TGT104569464(PRDM16) 104571520(MECOM)
DNE112981149(PRDM16) 112986427(MECOM)
SCAM104142006(PRDM16) 104143307(MECOM)
ASN102383256(PRDM16) 102388244(MECOM)
AMJ102561786(MECOM) 102565647(PRDM16)
CPOO109308413(MECOM) 109314223(PRDM16)
GGN109287956(MECOM) 109293621(PRDM16)
PSS102446951(MECOM) 102457121(PRDM16)
CMY102933835(PRDM16) 102944134(MECOM)
CPIC101936261(PRDM16) 101944916(MECOM)
TST117867853(PRDM16) 117883099(MECOM)
CABI116815391(PRDM16) 116822706(MECOM)
MRV120372281(MECOM) 120387979(PRDM16)
ACS100555060(mecom) 100564351
PVT110085535(MECOM) 110086807
SUND121926171(MECOM) 121936468(PRDM16)
PBI103060962(PRDM16) 103065321(MECOM)
PMUR107290019(PRDM16) 107292215(MECOM)
CTIG120305498(MECOM) 120319206(PRDM16)
TSR106554440(PRDM16) 106556923(MECOM)
PGUT117660382(PRDM16) 117678211(MECOM)
VKO123025609(MECOM) 123031048(PRDM16)
PMUA114597957(MECOM) 114602574(PRDM16)
ZVI118087798(PRDM16) 118093525(MECOM)
GJA107110332(PRDM16) 107125967(MECOM)
STOW125438025(MECOM) 125445594(PRDM16)
XLA100301954(mecom.S) 108696629 108697710 734157(mecom.L)
XTR100485690(prdm16) 100496511(mecom)
NPR108784020(PRDM16) 108788059(MECOM)
RTEM120915717(PRDM16) 120936732(MECOM)
BBUF120997870(MECOM) 120999138(PRDM16)
BGAR122928850(PRDM16) 122934442(MECOM)
DRE497407(mecom) 796720(si:ch211-263k4.2)
SRX107710791 107730859 107748963(prdm16) 107752009
SANH107683385 107687110(prdm16) 107691062 107704745
SGH107582226 107587798 107595763 107602466(prdm16)
CCAR109094668 109094669 109103379 109103380
CAUA113058632 113078801 113097232 113107828 113114962
PPRM120469521 120477584(prdm16)
MAMB125248870(mecom) 125280292(prdm16)
IPU108265022(prdm16) 108269179 108278348
PHYP113533631(prdm16) 113544589(mecom)
SMEO124394478(mecom) 124399917(prdm16)
TFD113648358(mecom) 113656267(prdm16)
AMEX103028334(prdm16) 103042447(mecom)
EEE113568060(mecom) 113578193(prdm16)
TRU101064167(prdm16) 101069476(mecom)
TNGGSTEN00022523G001
LCO104920227(prdm16) 104936038(mecom)
NCC104948658(prdm16) 104952759
CGOB115010881(prdm16) 115017293(mecom)
ELY117259822(mecom) 117266695(prdm16)
EFO125888762(mecom) 125891644(prdm16)
PLEP121943517(mecom) 121946755(prdm16)
SLUC116040810(prdm16) 116045529(mecom)
ECRA117940932(mecom) 117947311(prdm16)
ESP116678806(mecom) 116692394(prdm16)
PFLV114553079(mecom) 114559119
GAT120823708(mecom) 120829022(prdm16)
PPUG119215775(mecom) 119222497(prdm16)
MSAM119883057(mecom) 119906040(prdm16)
CUD121517475(prdm16) 121520079(mecom)
ALAT119012450(mecom) 119022312(prdm16)
MZE101468114(mecom) 101472744(prdm16)
ONL100697246(prdm16) 100699103
OAU116309756(prdm16) 116330361(mecom)
OLA101156011(prdm16) 101169474(mecom)
OML112149673(mecom) 112159255(prdm16)
XMA102224242(mecom) 102232494(prdm16)
XCO114133278(mecom) 114146334(prdm16)
XHE116707997(mecom) 116725545
PRET103467987(prdm16) 103474425(mecom)
PFOR103139020(prdm16) 103152917(mecom)
PLAI106937298(prdm16) 106945686(mecom)
PMEI106922470(mecom) 106931565(prdm16)
GAF122832390(mecom) 122835953(prdm16)
CVG107094210(mecom) 107096740(prdm16)
CTUL119773273(prdm16) 119775271(mecom)
GMU124874798(prdm16) 124883767(mecom)
NFU107380509(mecom) 107390703(prdm16)
KMR108236815(prdm16) 108240489(mecom)
ALIM106523993(mecom) 106524184(prdm16)
NWH119410524(mecom) 119417675(prdm16)
AOCE111570893(prdm16) 111573022(mecom)
MCEP125004427(prdm16) 125013663(mecom)
CSEM103377560(mecom) 103384944(prdm16)
POV109630615(prdm16) 109634633(mecom)
SSEN122773299(mecom) 122776837(prdm16)
HHIP117764484(prdm16) 117772924(mecom)
HSP118106548(mecom) 118111321(prdm16)
LCF108886333 108891704
SDU111219051(prdm16) 111224094(mecom)
SLAL111649993(mecom) 111670668(prdm16)
XGL120792306(mecom) 120804141(prdm16)
HCQ109525487(mecom) 109526576(prdm16)
BPEC110174294(mecom) 110174717(prdm16)
MALB109960327(mecom) 109969283(prdm16)
BSPL114858910(prdm16) 114868635(mecom)
SASA106566953 106572198(prdm16) 106580920 106612562
STRU115163229 115166095(prdm16) 115168976 115206170
OTW112233035(prdm16) 112247400 112265381 112267385
OMY110491048 110503751 110507082 110532167(prdm16)
OGO123992868 124006191 124031842(prdm16) 124046197
ONE115120562 115132052(prdm16) 115136895 115141695
SALP111949772 111966356(prdm16) 111976939 111982777
SNH120018783 120028738 120058705(prdm16) 120060937
CCLU121538233(prdm16) 121545990 121564826 121567563
ELS105013856(prdm16) 105024028(mecom)
SFM108922168(mecom) 108924879(prdm16)
PKI111834017(mecom) 111859128(prdm16)
AANG118207605(prdm16) 118209957(mecom)
LOC102685573(prdm16) 102695548(mecom)
PSPA121322874 121326704 121328269 121328807
ARUT117417159 117423468 117425596 117426089
LCM102358043(MECOM) 102363350(PRDM16)
CMK103180852(mecom) 103184259(prdm16)
RTP109935105
BFO118430266
BBEL109479987
CIN723797(ci-zf(c2h2)-87)
SCLV120336371
SPU100892779
APLC110987571
SKO100375728
DMEDmel_CG31753(ham)
DER6549240
DSE6614589
DSIDsimw501_GD21809(Dsim_GD21809)
DYADyak_GE12705
DAN6497312
DSR110176918
DPO6902953
DPE113565837
DMN108161703
DWI6642468
DGR116806194
DMODmoj_GI18122
DAZ108611799
DNV115564378
DHE111605541
DVI6629252
CCAT101452911
BOD106618426
RZE108371300
MDE101890702
SCAC106080816
LCQ111685049
LSQ119610968
HIS119646135
AGAAgaP_AGAP008232
ACOZ120957437
AARA120902375
ASTE118513003
AAG23687649
AALB109402239 109415858
CQUCpipJ_CPIJ012100
CPII120431590
CNS116348136
BCOO119078851
AME725792
ACER107998058
ALAB122712215
BIM100741168
BBIF117206020
BVK117235525
BVAN117154093
BTER100649991
BPYO122565703
CCAL108628568
OBB114876584
MGEN117218726
NMEA116430705
CGIG122398234
SOC105201991
MPHA105839733
AEC105148914
ACEP105627074
PBAR105427721
VEM105565473
HST105181576
DQU106744786
CFO105256434
FEX115241463
LHU105667426
PGC109861821
OBO105276834
PCF106787643
PFUC122517902
VPS122635399
NVI100122721
CSOL105368679
TPRE106658245
MDL103575493
CGLO123272549
FAS105266197
DAM107035925
AGIF122856598
CCIN107273888
TCA664087
DPA109536933
SOY115884211
ATD109598666
CSET123317296
AGB108903722
LDC111515167
NVL108561063
APLN108742153
PPYR116177656
OTU111426225
BMOR101735622
BMAN114248966
MSEX115440240
DPLKGM_200421
BANY112048263 112048943
NIQ126771914
PMAC106721039
PPOT106110943
PXU106126851
PRAP111003498
ZCE119840034
HAW110375373
HZE124638756
TNL113493168
SLIU111353764
PXY105380101
API100166991
DNX107169860
RMD113554894
BTAB109041352
DCI103512025 103523811
CLEC106665084
HHAL106689181
NLU111046016
PHUPhum_PHUM496070
TPAL117652700
ZNE110831782
CSEC111874828
FCD110847627
DPXDAPPUDRAFT_113201(HAM)
DMK116915368 123469617
PVM113827214
PJA122260131
PCHN125030615 125035985
HAME121864391
PCLA123748158
PTRU123506675
HAZT108680046
EAF111695237 111718379
LSM121124317
DSV119445235
RSAN119389430
RMP119163959
VDE111252225
VJA111267019
DFR124494978
CSCU111618434
PTEP122269602
SDM118189072
PCAN112555872
BGT106064780
GAE121390328
HRF124152259
HRJ124271401
CRG105330257 105345377
MYI110452387
PMAX117344918
MMER123526931
LAK106161219
 » show all
Reference
1  [PMID:22939622]
  Authors
Pinheiro I, Margueron R, Shukeir N, Eisold M, Fritzsch C, Richter FM, Mittler G, Genoud C, Goyama S, Kurokawa M, Son J, Reinberg D, Lachner M, Jenuwein T
  Title
Prdm3 and Prdm16 are H3K9me1 methyltransferases required for mammalian heterochromatin integrity.
  Journal
Cell 150:948-60 (2012)
DOI:10.1016/j.cell.2012.06.048
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.367
IUBMB Enzyme Nomenclature: 2.1.1.367
ExPASy - ENZYME nomenclature database: 2.1.1.367
BRENDA, the Enzyme Database: 2.1.1.367

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