KEGG   ENZYME: 2.1.1.368
Entry
EC 2.1.1.368                Enzyme                                 
Name
[histone H3]-lysine9 N-dimethyltransferase;
SUVH1 (gene name);
SUVR1 (gene name);
SET32 (gene name);
SDG32 (gene name);
SET13 (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:[histone H3]-L-lysine9 N6-dimethyltransferase
Reaction(IUBMB)
2 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 = 2 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine9 (overall reaction);
(1a) S-adenosyl-L-methionine + a [histone H3]-L-lysine9 = S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine9;
(1b) S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine9 = S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine9
Reaction(KEGG)
(other) R03875 R04866
Substrate
S-adenosyl-L-methionine [CPD:C00019];
[histone H3]-L-lysine9;
[histone H3]-N6-methyl-L-lysine9
Product
S-adenosyl-L-homocysteine [CPD:C00021];
[histone H3]-N6,N6-dimethyl-L-lysine9;
[histone H3]-N6-methyl-L-lysine9
Comment
This entry describes several enzymes, characterized from plants, that successively methylate the L-lysine-9 residue of histone H3 (H3K9) twice, ultimately generating a dimethylated form. These modifications influence the binding of chromatin-associated proteins. In general, the methylation of H3K9 leads to transcriptional repression of the affected target genes. cf. EC 2.1.1.367, [histone H3]-lysine9 N-methyltransferase, EC 2.1.1.366, [histone H3]-N6,N6-dimethyl-lysine9 N-methyltransferase, and EC 2.1.1.355, [histone H3]-lysine9 N-trimethyltransferase.
History
EC 2.1.1.368 created 2020
Pathway
ec00310  Lysine degradation
ec01100  Metabolic pathways
Orthology
K24405  [histone H3]-lysine9 N-dimethyltransferase
Genes
ATHAT5G04940(SUVH1)
ALY9307195
CRB17881599
CSAT104708619 104734501 104768691
EUSEUTSA_v10012854mg EUTSA_v10015751mg
BRP103847241 103855596
BNA106382993 106419316 106428185 106440647 106445541
BOE106317806 106334517
RSZ108815877 108846741
THJ104816485
CPAP110817121
CIT102614065 102620879
CICCICLE_v10000524mg CICLE_v10013410mg
PVY116126939 116138928
MINC123192327 123193142 123225962
TCC18586976
GRA105761557 105770657 105782469
GHI107904391 107935536 107938989 107954467 121217937 121223509
GAB108453504 108463804 108474127
DZI111295356 111296492 111311450
EGR104454490
GMX100786650 100800651 100805932 100812173 100817062
GSJ114376752 114387982 114399929 114406575 114409426
PVUPHAVU_001G103400g PHAVU_005G012600g PHAVU_011G190200g
VRA106753935 106761369 106772154
VAR108329311 108332488 108340788
VUN114168317 114182574
CCAJ109802112 109805879 109819246 109819247 109819249
APRC113854756 113861242 113864324
MTR11414786 25488531 25501124
CAM101495955 101497613 101507703
PSAT127075630 127085952 127126508 127127488
LJALj0g3v0128679.1(Lj0g3v0128679.1) Lj0g3v0266169.1(Lj0g3v0266169.1) Lj1g3v4059050.1(Lj1g3v4059050.1)
ADU107462763 107471926 107494232
AIP107604714 107613332 107622325
AHF112696800 112707587 112716924 112754666 112769399 112785051
LANG109330010 109337045 109341323 109345936 109350331 109358494
FVE101296037 101309275
RCN112192455 112194774
PPER18770807 18785263
PMUM103339115 103343462
PAVI110746751 110763839
PDUL117619283 117634255 117635814
MDM103409193 103438644 103449908 103454698
PXB103946162 103966211
ZJU107412844 107415080
MNT21410587
CSV101218938
CMO103502895
BHJ120072888
MCHA111021743
CMAX111465944 111477770
CMOS111432402 111453196
CPEP111781305 111803325
RCU8276339
JCU105631294
HBR110634595 110645389
MESC110613379 110625627
POP18099790 7462819 7463781 7476804
PEU105122871 105132691 105136886 105137319
PALZ118033160 118052969 118053956 118054714
JRE108980180 108989442
QSU112020905 112025017
QLO115952730 115983974
TWL119990874 119998685 120012928
VVI100262508 100263685
VRI117921131 117928570
SLY101243931 101258606
SPEN107002240 107031702
SOT102579046 102601580
SSTN125866370 125870652
CANN107844044 107864095
NTA107759396 107761901(NtSet1) 107777978
NSY104238051 104242035
NTO104089131 104119054
NAU109207938 109242162
INI109158965 109161718
ITR116024108 116029320
SIND105155786 105162817
OEU111369292 111375319 111391199
EGT105959953 105976645
SSPL121748405 121752105 121804908 121806821
HAN110884923 110898833 110940200
ECAD122582068 122607380
LSV111879372 111889461
CCAV112504406 112511969 112518153
DCR108202884 108218865 108223388
CSIN114269592 114276542
BVG104907436
SOE110778852
CQI110682666 110737374
NNU104593573
MING122084106
TSS122640460 122643988
PSOM113310054 113322088
NCOL116252425 116252925
OSA4327359 4339168 4350865
DOSAOs01t0811300-01(Os01g0811300) Os05t0490700-01(Os05g0490700) Os11t0602200-01(Os11g0602200)
OBR102703881 102704160 102710125 102720563
BDI100826372 100832905
ATS109744867 109746199 109749138 109751482
TDC119269346 119277343 119281805 119284650 119284655 119289024 119291505 119348763 119349242
TAES123062375 123065185 123066018 123071145 123079507 123079934 123084828 123093252 123098519 123137626 123142812 123182428 543460
TUA125522224 125526867 125545088 125552739
SBI8055276 8064166 8065992 8069112
ZMA100280164 541980 542085 542102
SITA101769814 101776606 101777191 101780099
SVS117843761 117851027 117852374 117857961
PVIR120659759 120665095 120667181 120673696 120698296 120708421
PHAI112880342 112886522 112892086
PDA103709040 103722129
EGU105045520
MUS103986232 103995163
DCT110091884 110100064
PEQ110024649 110027660
AOF109819621 109827134 109831339
ATR18426216
 » show all
Reference
1  [PMID:15546353]
  Authors
Yu Y, Dong A, Shen WH
  Title
Molecular characterization of the tobacco SET domain protein NtSET1 unravels its role in histone methylation, chromatin binding, and segregation.
  Journal
Plant J 40:699-711 (2004)
DOI:10.1111/j.1365-313X.2004.02240.x
  Sequence
[nta:107761901]
Reference
2  [PMID:15574848]
  Authors
Shen WH, Meyer D
  Title
Ectopic expression of the NtSET1 histone methyltransferase inhibits cell expansion, and affects cell division and differentiation in tobacco plants.
  Journal
Plant Cell Physiol 45:1715-9 (2004)
DOI:10.1093/pcp/pch184
Reference
3  [PMID:15775980]
  Authors
Naumann K, Fischer A, Hofmann I, Krauss V, Phalke S, Irmler K, Hause G, Aurich AC, Dorn R, Jenuwein T, Reuter G
  Title
Pivotal role of AtSUVH2 in heterochromatic histone methylation and gene silencing in Arabidopsis.
  Journal
EMBO J 24:1418-29 (2005)
DOI:10.1038/sj.emboj.7600604
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.368
IUBMB Enzyme Nomenclature: 2.1.1.368
ExPASy - ENZYME nomenclature database: 2.1.1.368
BRENDA, the Enzyme Database: 2.1.1.368

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